I am excited to have Siim Land on the show with me for the third time today. Siim is a bestselling author, anthropologist, keynote speaker, and longevity enthusiast who is exceptionally bright and knows how to simplify complex research into actionable insights. In our discussion today, we explore his latest book, The Longevity Leap, and dive into mTOR, how to activate and decrease it, and the physical consequences of an mTOR imbalance. We look into NAD, supplementation, frailty, and the critical role of exercise, discussing VO2 Max, heart rate variability, and the advantages of saunas and cold therapy. We also share strategies for optimizing sleep, cover how sleep impacts aging, and discuss biomarkers for longevity, why normal is not always optimal, melatonin, and the effects of shift work and jet lag. I am confident you will find this conversation with Siim Land as enlightening as I did.IN THIS EPISODE YOU WILL LEARN: What mTOR does in the body Why maintaining mTOR balance is crucial for longevity Lifestyle factors and supplements to support mTOR  The significance of NAD for energy production Why circadian rhythm alignment is vital for energy production and longevity The benefits of melatonin supplementation How artificial light impacts sleep, and why we need regular sleep patterns How regular exercise can extend health and reduce the risk of chronic diseases What heart rate variability is, and how to improve it biomarkers for health and longevity  Bio: Siim Land is an eight-time best-selling author, keynote speaker, and anthropologist from Estonia. He is the author of several landmark books, such as Metabolic Autophagy, Stronger by Stress, The Immunity Fix, The Mineral Fix, WIN, The Collagen Cure, The Blood Sugar Fix, and The Obesity Fix. Siim has a bachelor's degree in anthropology.Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Siim Land On his website  On Instagram and YouTube The Longevity Leap is available on Amazon

Step into the world of metabolic health and fasting as we embark on a captivating journey with the renowned Canadian clinical educator Megan Ramos!In an era when chronic illness and obesity have become alarmingly prevalent, and dieting has become a lifelong struggle for many, Megan is on a mission to revolutionize our understanding of metabolic health. Known for her expertise in therapeutic fasting and low-carb diets, she co-founded the revolutionary Fasting Method alongside the renowned Dr. Jason Fung and co-authored the bestselling book Life in the Fasting Lane. Now, she returns with her latest work, delving into the untold stories of women and fasting. In today’s captivating discussion, Megan and I explore the staggering statistics that reveal a nation plagued by chronic illness and weight issues, where even the average person has tried 126 diets in their lifetime. Megan shares her groundbreaking insights on women and fasting, unveiling the truth behind misdiagnosis, the myths surrounding intermittent fasting, the role of macros and insulin secretion, and the profound impact of the pandemic on our hormones, sleep, and stress levels. Prepare yourself for a thought-provoking episode as we tackle pressing questions from listeners, covering the dawn effect, gout, insomnia, and invaluable strategies for achieving fasting success!IN THIS EPISODE YOU WILL LEARN: My journey with PCOS Why does body composition matter so much? PCOS, the number one endocrine disorder in Westernized countries Common myths about intermittent fasting The fertility aspect of postmenopausal women The slippery slope of perimenopause Is fasting just an extreme form of calorie restriction? The impact of sleep and stress on glucose and insulin levels How to integrate intermittent fasting into your lifestyle Magnesium supplementation for insulin resistance How to deal with gout Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Connect with Megan Ramos The Fasting Method Find Megan on social media @Megan J. Ramos Purchase a copy of Life in the Fasting Lane  Purchase a copy of The Essential Guide to Intermittent Fasting For Women Previous Episodes Featuring Megan Ep. 116 – Using Intermittent Fasting to Reverse Chronic Illnesses – with Megan Ramos Ep. 188 – Troubleshooting Your Fasting Method with Megan Ramos

Kiran Krishnan, a research microbiologist and health expert, dives deep into the fascinating world of gut health. He explains the implications of leaky gut, especially for women during perimenopause and menopause, revealing how hormones and diet play a key role. The conversation explores the connection between gut health and cognitive function, highlighting risks like postprandial endotoxemia. Kiran also discusses the importance of gut microbiome diversity, fiber intake, and advanced stool testing for personalizing health strategies. It's a must-listen for anyone interested in holistic wellness!

Cynthia Thurlow, a nurse practitioner specializing in wellness and nutrition, shares her insights on essential supplements for various health concerns. She discusses the benefits of Vitamin B12 and adaptogenic herbs for managing stress and sleep issues. Thurlow highlights supplements to support cognitive function, hormone balance during perimenopause, and inflammation relief. Listeners also benefit from her advice on post-vacation recovery and the importance of fresh produce, plus recommendations tailored for teenagers and menopausal women.

I am delighted to reconnect with Dr. Jason Fung today. We last connected in October 2020 for Episode 121. Dr. Fung is a nephrologist and a prominent figure in the intermittent fasting and low-carb space. He has made significant contributions as a founding member of The Fasting Method with his evidence-based guidance on weight loss and blood glucose management through low-carb diets and intermittent fasting. He has written several books, including The Obesity Code, The Complete Guide to Fasting, The Diabetes Code, and The Cancer Code. In our discussion today, we look at the forecast for metabolic health in 2024, exploring how the growth of the diabetes population relates to the effects of the pandemic and addressing the conflict of interest with organizations like the ADA and registered dieticians. Dr. Fung shares some of his biggest frustrations, including the shallow and myopic thinking amongst those focusing on calories in and calories out, and we get into various facets of metabolic health, from the nuanced influences of gender, puberty, perimenopause, and menopause to hedonistic eating, sarcopenia, bio-individuality, and therapeutic fasting. Dr. Fung also shares his perspective on GLP-1s, shiftwork, supplements, and more.Join us for valuable insights on various aspects of metabolic health and how they impact our well-being.IN THIS EPISODE YOU WILL LEARN How the influence of food companies has led dieticians and diabetes associations to focus on moderation instead of a balanced diet Dr. Fung shares his frustration with the lack of progress in addressing the diabetes issue How hormones impact weight gain and hunger Why does focusing on calories in and out not provide the solution to weight loss? How intermittent fasting can help to control hormonal issues How middle-aged women need to find balance when fasting to maintain muscle mass and avoid sarcopenia How intermittent fasting can lead to increased strength despite losing muscle mass  What causes shift workers to gain weight? The potential drawbacks of using GLP-1 drugs for weight loss Why magnesium deficiency is a common problem in modern society Connect with Cynthia Thurlow Follow on Twitter, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Jason Fung Website Twitter and YouTube The Fasting Method Dr. Fung's books Previous Episode Featuring Dr. Jason FungEp. 121 – The Truth About Diabetes, Kidney Disease and Insulin Resistance with Dr. Jason Fung

I have the privilege of connecting with Dr. Suzanne Fenske today. She is an integrative gynecologist, double-board certified in obstetrics, gynecology, and integrative medicine, and fellowship-trained in minimally invasive gynecologic surgery and functional medicine. She established her practice, Tara MD, to empower women to take charge of their health and well-being by combining modern and integrative medicine to offer enhanced care, more time, and improved services.In our discussion today, we explore menopausal advocacy, addressing the lesser-known symptoms of perimenopause and menopause and medical gaslighting. We discuss detoxification, looking at the significance of the vaginal, uterine, and urinary tract microbiome and factors that could negatively impact it. We also cover the critical role of the estrobolome, the importance of nourishing the body during perimenopause and menopause, and common reasons for weight loss resistance. I am confident you will find this conversation with Dr. Suzanne Fenske as insightful and enjoyable as I did.IN THIS EPISODE YOU WILL LEARN: Some of the less common symptoms of perimenopause and menopause and how they affect the lives of women   How estrogen metabolism can impact gut health  Identifying and addressing underlying causes of inflammation How inflammation and food intolerances can lead to weight gain Modern lifestyles practices that can disrupt the vaginal microbiome Dietary recommendations for improving hormone metabolism Why women should focus on nourishing their bodies instead of following trendy diets The benefits of tracking macros to identify areas for improvement How cortisol imbalances in perimenopausal women can lead to cravings and fatigue How alcohol impacts sleep quality The benefits and risks of testosterone for women Bio:Dr. Suzanne Fenske is an integrative gynecologist. She is double board-certified in obstetrics and gynecology as well as integrative medicine. She is also fellowship-trained in minimally invasive gynecologic surgery and functional medicine. Dr. Fenske is also a certified menopause provider through the menopause society. Dr. Fenske founded Tara MD in 2021 to help women take control of their health and well-being by blending the best of modern and integrative medicine through more care, time, and services.Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Suzanne Fenske On the Tara MD website On Instagram

I am delighted to reconnect with my good friend, Vinnie Tortorich, today, who was a guest on episodes 133 and 191. For those who may not be familiar with Vinnie, he is a truth-teller and disrupter who prompts people to think outside of their comfort zones in an easy and non-confrontational way. He is host of the Fitness Confidential Podcast, author of Fitness Confidential, and documentary film expert. His most recent documentary is Dirty Keto.In our conversation today, Vinnie and I dive into the impact of the processed food industry on metabolic health, looking at the issue with net carbs, the dangers of sugar and artificial sweeteners, and their role in the ongoing metabolic health crisis. We discuss the consequences of instant gratification, sedentary lifestyles, and the addictive nature of processed sugars and grains, also exploring various medical therapies, including GLP-1s. I am confident you will enjoy this discussion with Vinnie Tortorich as much as I did.IN THIS EPISODE YOU WILL LEARN: How the processed food industry created the term net carbs to make processed foods appear healthier The importance of addressing sugar addiction The lack of discussion around the health risks associated with society celebrating obesity How instant gratification has impacted people’s food choices and health The importance of recognizing true hunger versus boredom or stress-induced cravings How uncomfortable feelings can lead to food addiction Why it is essential to make exercise a daily habit Why it is crucial to avoid non-vegetable carbohydrates for metabolic health A strategy for enjoying sweet treats while maintaining a ketogenic diet How food influences metabolism and brain function Weighing up the risks and benefits of GLP-1 therapies for metabolic health Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Vinnie Tortorich On his website Instagram and Twitter (@vinnietortorich) Vinnie’s documentaries on Amazon (Not Dirty Keto) Previous Episode MentionedEp. 191 Benefits of an Animal-Based Diet vs a Plant-Based Diet with Vinnie Tortorich

Today, I have the privilege of connecting with Dr. Sara Gottfried! Dr. Sara is a board-certified physician who graduated from Harvard and MIT. She practices evidence-based integrative, precision, and functional medicine. She is a Clinical Assistant Professor in the Department of Integrative Medicine and Nutritional Sciences at Thomas Jefferson University and Director of Precision Medicine at the Marcus Institute of Integrative Health. She has written four New York Times bestselling books, including her latest book called WOMEN, FOOD, AND HORMONES. Dr. Sara is one of my favorite doctors in integrative medicine and GYN! In this episode, we dive into the infodemic, how stress impacts hormones, the impact of age-related changes on hormonal regulation, alcohol, and gender differences with ketogenic lifestyles. We discuss some of the lesser-known hormones, including growth hormone, and how to support it properly. We touch on disordered eating, how trauma influences our relationship with food, epigenetics, and the role of a lifetime relationship with food. We also look at methylation, glutathione, detox reactions, supporting physical detoxification, and our toxic diet culture.I hope you benefit as much from this episode as I did! IN THIS EPISODE YOU WILL LEARN: Dr. Sara explains what the infodemic is and discusses the impact it has had on how she communicates with her patients.  What happens to our hormones as we age? The impact of stress on hormone regulation. Dr. Sara busts the myth that testosterone is a male hormone and discusses what testosterone means for women. How does alcohol consumption impact women’s hormones? Why do men tend to have an easier time with the ketogenic diet than women? The dramatic changes that occur in women’s bodies as they transition from perimenopause to menopause. Looking at the interrelationship between trauma, stress, and autoimmunity. The changes that occur with growth hormones as we age. How trauma affects the genes. How disordered eating impacts metabolism. How to support physical detoxification naturally, without going to extremes. How to address weight-loss plateaus.  Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website  Connect with Dr. Sara Gottfried On her website On Facebook, Twitter, Instagram Dr. Sara’s books are available at Amazon and major bookstores.

I am delighted to have Michelle Shapiro joining me on the show today. She is a Native New Yorker and an integrative and functional registered dietitian who has worked with thousands of clients, holistically reducing anxiety, healing longstanding gut health issues, and lovingly approaching weight problems.In our conversation today, we explore shame and eating behaviors, looking at self-empathy and the inner dialogue that usually accompanies weight-loss resistance. We examine whether or not obesity is a disease and the effects of adverse childhood experiences and dive into fasting, hormesis, autoimmunity, and the concept of surrender. We also clarify what intuitive eating involves, the role of highly sensitive bodies, and some common causes of digestive distress and bloating. Michelle brings a wealth of knowledge to today’s insightful and engaging discussion. I know you will love it!IN THIS EPISODE YOU WILL LEARN: Why kindness and sensitivity matter when it comes to discussing the sensitive topic of weight  Why clinicians should view obesity as a symptom of underlying metabolic issues rather than a disease How internal dialogue and protection mechanisms influence people’s food choices  How adverse childhood events and high-pressure social environments can increase the risk of eating disorders How food allergies and fear can lead to disordered relationships with food  Why safety is the key to hormone regulation Is intermittent fasting a dangerous practice? The benefits of practices like grounding, Reiki, and acupuncture for overcoming anxiety and feeling safe in the body  The importance of self-reliance in healing, and the role of practitioners in guiding their clients toward self-awareness What you need to focus on when implementing intuitive eating The unique challenges that highly sensitive people are likely to face Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Michelle Shapiro On her website Quiet the Diet Podcast The Highly Sensitive Body Hub

I am excited to connect with Dr. Nicola Sykes today. Dr. Sykes received her Ph.D. in Computational Biology from MIT. After experiencing hypothalamic amenorrhea and discovering a shortage of information about the condition in the public domain, she wrote a comprehensive guide to help people understand it and recover.In our discussion today, we dive into the nature of hypothalamic amenorrhea and explore its physiology. We address the effects of amenorrhea on eating habits, discuss caloric restrictions, fasting, exercise, and chronic stress, clarify the distinctions between eating disorders and disordered eating, and examine the role of genetics. Dr. Sykes also explains why she does not believe in post-pill amenorrhea, and our conversation touches on differentiators with polycystic ovarian syndrome, symptoms, and lab evaluations.  Given the frequent concerns from listeners about losing their menstrual cycles, this conversation with Dr. Sykes promises to be particularly valuable for those affected by prolonged fasting and similar issues.IN THIS EPISODE YOU WILL LEARN: Dr. Sykes explains what hypothalamic amenorrhea is and why it is essential for women to understand it How a lack of exercise and energy deficits can impact menstruation Why we must support our bodies with exercise and proper nutrition rather than focusing on weight loss How stress impacts the body, particularly during perimenopause and menopause Why rest and recovery are essential when doing high-intensity workouts How we need to eat enjoyable foods and focus on moderation instead of striving for an ideal standard How disordered eating differs from eating disorders The difference between hypothalamic amenorrhea and PCOS Some common symptoms of hormone imbalance The benefits of tracking menstrual and ovulation cycles Bio:Dr Sykes (formerly Rinaldi) has a PhD in computational biology from MIT. After experiencing hypothalamic amenorrhea herself and finding a lack of information about the condition in the public sphere, she set out to write a comprehensive guide to understanding the condition and how to recover. Her book, "No Period. Now What?" has helped thousands of people recover from missing periods and better understand their bodies and hormonal systems. The book has been translated into multiple languages and serves as a guide for numerous dietitians and medical professionals helping those experiencing missing periods.Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Nicola Sykes On her website Instagram  Support group Buy ebook: No Period. Now what? Schedule a one-on-one session with Dr. Sykes