eanCast: Weekly Neurology

Moderator: Francesco Di Lorenco (Rome, Italy) Guest: Dag Aarsland (London, United Kingdom) Francesco Di Lorenco and Prof. Dag Aarsland discuss managing behavioral symptoms in dementia, highlighting the burden on patients and families. They stress the im Moderator: Francesco Di Lorenco (Rome, Italy)Guest: Dag Aarsland (London, United Kingdom)Francesco Di Lorenco and Prof. Dag Aarsland discuss managing behavioral symptoms in dementia, highlighting the burden on patients and families. They stress the importance of timely treatment and challenges in diagnosis. They mention brexpiprazole's FDA approval for Alzheimer's agitation and the need for careful monitoring. Early detection of psychiatric symptoms in neurological diseases is crucial, but distinguishing between disorders is challenging. Therapeutic options like clozapine and cholinesterase inhibitors are mentioned, calling for more research and collaboration.

Moderator: Massimo Filippi (Milan, Italy) Guest: Federica Agosta (Milan, Italy) In this week’s episode Prof. Massimo Filippi and Prof. Federica Agosta discuss frontotemporal dementia (FTD) emphasizing the role of neuroimaging (MRI and FDG PET) in early Moderator: Massimo Filippi (Milan, Italy)Guest: Federica Agosta (Milan, Italy)In this week’s episode Prof. Massimo Filippi and Prof. Federica Agosta discuss frontotemporal dementia (FTD) emphasizing the role of neuroimaging (MRI and FDG PET) in early diagnosis. They highlight MRI for identifying crucial patterns and FDG PET for detecting metabolic changes. Early detection is crucial for future treatments. Connectomics, studying brain networks, aids in predicting FTD progression. Emerging PET tracers, like UCBJ, show promise for early neurodegeneration markers. The episode is a valuable resource for neurologists interested in FTD diagnostics and monitoring.

Moderator: Youssuf Saleh (Oxford, United Kingdom) Guest: Sebastiaan Engelborghs (Brussel, Belgium) Youssuf Saleh interviews Prof. Sebastiaan Engelborghs on Alzheimer's biomarkers, focusing on amyloid and tau. They discuss diagnostic challenges, the need f Moderator: Youssuf Saleh (Oxford, United Kingdom)Guest: Sebastiaan Engelborghs (Brussel, Belgium)Youssuf Saleh interviews Prof. Sebastiaan Engelborghs on Alzheimer's biomarkers, focusing on amyloid and tau. They discuss diagnostic challenges, the need for prognostic markers, and potential serum markers like neurofilament light. Engelborghs highlights Alzheimer's complexity and the role of omics studies in patient subpopulations. The interview concludes with optimism for blood-based biomarkers revolutionizing diagnosis in the next five years, contingent on clinical validation and evolving therapies.

Moderator: Svetlana Tomic (Osijek, Croatia) Guest: Veronica Cabreira (Edinburgh, United Kingdom) In this episode of eanCast, Prof. Svetlana Tomic and Dr. Veronica Cabreira delve into the definition functional cognitive impairment. This disorder, affecting Moderator: Svetlana Tomic (Osijek, Croatia)Guest: Veronica Cabreira (Edinburgh, United Kingdom)In this episode of eanCast, Prof. Svetlana Tomic and Dr. Veronica Cabreira delve into the definition functional cognitive impairment. This disorder, affecting a significant number of patients at memory clinics, is marked by severe attention and concentration issues, and excessive self-monitoring of cognitive performance. Diagnosis hinges on cognitive symptoms, distress, and internal inconsistency. Treatments range from explaining the diagnosis to cognitive restructuring, cognitive behavioral therapy, and managing comorbidities.

Moderator: Federica Montagnese (Munich, Germany) Guest: John Vissing (Copenhagen, Denmark) In this week's episode, Federica Montagnese hosts Professor John Vissing as they delve into the intricate world of diagnosing muscular dystrophies. The discussion Moderator: Federica Montagnese (Munich, Germany)Guest: John Vissing (Copenhagen, Denmark)In this week's episode, Federica Montagnese hosts Professor John Vissing as they delve into the intricate world of diagnosing muscular dystrophies. The discussion revolves around the crucial role of neuromuscular examinations and the significance of medical history, including school performance. Specific signs like myotonia and facial signs are explored, alongside the evolving landscape of genetic testing, advanced imaging techniques (MRI and ultrasound), and the potential of artificial intelligence in diagnostics. The speakers also touch on extra-muscular manifestations, expanding the understanding of these conditions.

Moderator: Gabriele Siciliano (Pisa, Italy) Guest: Antonio Toscano (Messina, Italy) Prof. Antonio Toscano is hosted by Prof. Gabriele Siciliano as he emphasizes the enduring significance of muscle biopsy in diagnosing neuromuscular disorders, particularl Moderator: Gabriele Siciliano (Pisa, Italy)Guest: Antonio Toscano (Messina, Italy)Prof. Antonio Toscano is hosted by Prof. Gabriele Siciliano as he emphasizes the enduring significance of muscle biopsy in diagnosing neuromuscular disorders, particularly in cases of progressive muscle weakness. The episode stresses the need for a comprehensive diagnostic strategy, combining genetic testing with muscle biopsy, guided by clinical and imaging assessments. Overall, the episode underscores the continued importance of muscle biopsy for a thorough understanding of muscular dystrophies.

Moderator: Gabriele Siciliano (Pisa, Italy) Guest: Tiziana Mongini (Torino, Italy) In this episode, Prof. Gabriele Siciliano and Prof. Tiziana Mongini discuss a recent paper on Bag3 gene mutations linked to neurogenic distal muscle atrophy. They explore Moderator: Gabriele Siciliano (Pisa, Italy)Guest: Tiziana Mongini (Torino, Italy)In this episode, Prof. Gabriele Siciliano and Prof. Tiziana Mongini discuss a recent paper on Bag3 gene mutations linked to neurogenic distal muscle atrophy. They explore the evolving understanding of muscle dystrophies, the importance of genetic and molecular aspects, and challenges in diagnosis. Mongini underscores the significance of ancillary exams like neurophysiology and muscle MRI. They emphasize the complexity of genetic testing, advocating for a multidimensional approach involving clinical, genetic, and imaging data. Collaboration between basic and clinical researchers is stressed to comprehend neuromuscular complexities. The podcast concludes with a reminder to interpret genetic results cautiously and remain open-minded to diverse clinical presentations.

Moderator: Federica Montagnese (Munich, Germany) Guest: Magda Mroczek (Basel, Switzerland) In this podcast, Dr. Federica Montagnese interviews Dr. Magdalena Mroczek about gene mutations and variants in neuromuscular disorders, with a focus on muscular dys Moderator: Federica Montagnese (Munich, Germany)Guest: Magda Mroczek (Basel, Switzerland)In this podcast, Dr. Federica Montagnese interviews Dr. Magdalena Mroczek about gene mutations and variants in neuromuscular disorders, with a focus on muscular dystrophies. They discuss the impact of advanced technologies on genetic testing, highlighting the importance of clinical data and collaboration between clinicians and geneticists. The conversation touches on challenges in interpreting variants, the role of epigenetic factors, and initiatives to enhance access to genetic tools in low-income countries through international collaborations. The podcast underscores the dynamic nature of genetic diagnostics, emphasizing the importance of continuous research and education in the field.

Moderator: Barbara Tettenborn (St.Gallen, Switzerland) Guest: Matthias Endres (Berlin, Germany) In this episode, Barbara Tettenborn interviews Professor Matthias Endres, professor and chair of Neurology at the Charité Hospital in Berlin. The conversatio Moderator: Barbara Tettenborn (St.Gallen, Switzerland)Guest: Matthias Endres (Berlin, Germany)In this episode, Barbara Tettenborn interviews Professor Matthias Endres, professor and chair of Neurology at the Charité Hospital in Berlin. The conversation delves into the connection between stroke and cardiology. Endres introduces the concept of stroke-induced atrial fibrillation, distinguishing it from pre-existing AF. They discuss the stroke heart syndrome, underlining the increased risk of cardiac events post-stroke. Troponin elevation is highlighted as a crucial biomarker, and the role of insular lesions in the brain in the syndrome is explored. The podcast concludes by emphasizing the importance of an interdisciplinary approach between neurology and cardiology for comprehensive patient care.

Moderator: Benedetta Storti (Milan, Italy) Guest: Anita Arsovska (Skopje, North Macedonia) Benedetta Storti hosts Prof. Arsovska as they explore rare causes of strokes, covering conditions like cardiomyopathy, fibromuscular dysplasia, and immune-related Moderator: Benedetta Storti (Milan, Italy)Guest: Anita Arsovska (Skopje, North Macedonia)Benedetta Storti hosts Prof. Arsovska as they explore rare causes of strokes, covering conditions like cardiomyopathy, fibromuscular dysplasia, and immune-related factors. Arsovska stresses the significance of a comprehensive diagnostic approach, discussing specific features in tests and advocating for thorough investigations. The podcast addresses potential errors in diagnostic pathways and underscores the importance of biopsy in certain cases. Arsovska shares insights into tailored treatment options based on underlying conditions.