eanCast: Weekly Neurology

Moderator: Johann Sellner (Mistelbach, Austria) Guest: Tamuna Akhvlediani (Tbilisi, Georgia) In this podcast episode, Prof. Johann Sellner interviews Prof. Tamuna Akhvlediani about the neurological aspects of new antiviral drugs for SARS-CoV-2. They dis Moderator: Johann Sellner (Mistelbach, Austria)Guest: Tamuna Akhvlediani (Tbilisi, Georgia)In this podcast episode, Prof. Johann Sellner interviews Prof. Tamuna Akhvlediani about the neurological aspects of new antiviral drugs for SARS-CoV-2. They discuss drugs like monoclonal antibodies, paxlovid, and remdesivir, emphasizing their mechanisms and potential applications beyond COVID-19. Prof. Akhvlediani details neurological side effects observed in trials and significant drug interactions, especially in chronic neurological patients. The episode closes with insights into managing these interactions in clinical practice.

Moderator: Johann Sellner (Mistelbach, Austria) Guest: Tamuna Akhvlediani (Tbilisi, Georgia) In this last episode on Infectious Diseases, Prof. Johann Sellner and Prof. Tamuna Akhvlediani explore nosocomial infections of the central nervous system (CNS) Moderator: Johann Sellner (Mistelbach, Austria)Guest: Tamuna Akhvlediani (Tbilisi, Georgia)In this last episode on Infectious Diseases, Prof. Johann Sellner and Prof. Tamuna Akhvlediani explore nosocomial infections of the central nervous system (CNS). They cover the definition, common pathogens, and prevention methods like infection control and standardized surgery. Prof. Akhvlediani specifies prevalent CNS infections and addresses challenges in prevention and treatment, notably due to antimicrobial resistance. The conversation concludes with insights into treatment strategies, emphasizing the increasing challenge of antimicrobial resistance in healthcare-associated infections.

Moderator: Tamuna Akhvlediani (Tbilisi, Georgia) Guest: Johann Sellner (Mistelbach, Austria) In this week’s podcast hosted by Dr. Tamuna Akhvlediani, Prof. Johann Sellner discusses the connection between Epstein-Barr virus (EBV) and multiple sclerosis ( Moderator: Tamuna Akhvlediani (Tbilisi, Georgia)Guest: Johann Sellner (Mistelbach, Austria)In this week’s podcast hosted by Dr. Tamuna Akhvlediani, Prof. Johann Sellner discusses the connection between Epstein-Barr virus (EBV) and multiple sclerosis (MS). They explore the immune-mediated nature of MS, focusing on the impact of EBV and recent studies linking its infection to MS development. The episode delves into the controversies, hypotheses, and potential therapies related to EBV and MS, concluding with information on ongoing clinical trials and the influence of existing MS treatments on EBV.

Moderator: Tamuna Akhvlediani (Tbilisi, Georgia) Guest: Johann Sellner (Mistelbach, Austria) Dr. Tamuna Akhvlediani hosts Professor Johann Sellner in a podcast discussing the impact of COVID-19 on neuro infections. Professor Sellner covers global neuro Moderator: Tamuna Akhvlediani (Tbilisi, Georgia)Guest: Johann Sellner (Mistelbach, Austria)Dr. Tamuna Akhvlediani hosts Professor Johann Sellner in a podcast discussing the impact of COVID-19 on neuro infections. Professor Sellner covers global neuro infections, the decline during lockdowns, and the effectiveness of measures like face masks and vaccination. The episode emphasizes lessons learned, including insights into chronic neuro infection care disruptions and challenges, such as neuro-AIDS management during the pandemic. It concludes with findings from a study on how COVID-19 affected different neurological subspecialties.

Moderator: Yildiz Değirmenci (Istanbul, Turkey) Guest: Antonio Farina (Florence, Italy) This week, Dr. Yildiz Değirmenci and Dr. Antonio Farina discuss life-threatening neurological toxicities from immune checkpoint inhibitors. Dr. Farina highlights hig Moderator: Yildiz Değirmenci (Istanbul, Turkey)Guest: Antonio Farina (Florence, Italy)This week, Dr. Yildiz Değirmenci and Dr. Antonio Farina discuss life-threatening neurological toxicities from immune checkpoint inhibitors. Dr. Farina highlights high fatality rates, long-term disabilities, and the urgency of early recognition and treatment. The episodeexplores management, including discontinuation and corticosteroids, and factors influencing outcomes. It touches on the association between adverse events and treatment response, resuming inhibitors, and stresses a multidisciplinary approach for informed decision-making. The conclusion emphasizes the importance of neurologists' awareness in addressing these rare yet significant neurological complications.

Moderator: Antonio Malvaso Guest: Stefania Cuzzubbo Dr. Antonio Malva hosts Dr. Stefania Cuzzubbo to discuss neurological complications from cancer immunotherapy. Dr. Cuzzubbo highlights immune-related adverse events, focusing on peripheral nervous syst Moderator: Antonio MalvasoGuest: Stefania CuzzubboDr. Antonio Malva hosts Dr. Stefania Cuzzubbo to discuss neurological complications from cancer immunotherapy. Dr. Cuzzubbo highlights immune-related adverse events, focusing on peripheral nervous system issues. The importance of early diagnosis using MRI, lumbar puncture, and nerve studies is emphasized. Treatment involves promptly stopping the drug and using steroids, with alternative therapies explored for steroid-refractory cases. Continued research in this evolving field is crucial.

Moderator: Antonio Malvaso (Pavia, Italy) Guest: Alberto Vogrig (Udine, Italy) In this episode of EAN Cast Weekly Neurology, Dr. Antonio Malvaso, a neurology resident, welcomes Dr. Alberto Vogrig, an international expert in the field of paraneoplastic neu Moderator: Antonio Malvaso (Pavia, Italy)Guest: Alberto Vogrig (Udine, Italy)In this episode of EAN Cast Weekly Neurology, Dr. Antonio Malvaso, a neurology resident, welcomes Dr. Alberto Vogrig, an international expert in the field of paraneoplastic neurological syndromes. They discuss the definition of these syndromes, emphasizing the causal relationship with cancer and their immune-mediated pathogenesis. They also talk about the revised diagnostic criteria and the importance of clinical diagnosis, laboratory techniques, and oncologic screening. The treatment for these syndromes includes immunosuppression, cancer therapy, and symptomatic treatment, tailored to the specific symptoms.

Moderator: Alberto Vogrig (Udine, Italy) Guest: Giulia Berzero (Milan, Italy) In this episode Dr. Alberto Vogrig is joined by Dr. Giulia Berzero to discuss the clinical approach to neurological symptoms in patients with cancer. She highlights the increa Moderator: Alberto Vogrig (Udine, Italy)Guest: Giulia Berzero (Milan, Italy)In this episode Dr. Alberto Vogrig is joined by Dr. Giulia Berzero to discuss the clinical approach to neurological symptoms in patients with cancer. She highlights the increasing occurrence of neurological complications in cancer patients due to improved survival rates and novel cancer treatments. Dr. Berzero emphasizes the importance of considering patient-related factors, tumor-related factors, and treatment modalities in assessing the risk of developing neurological symptoms. She also explains the signs that may prompt suspicion of brain metastasis and provides guidance on assessing and diagnosing CNS dissemination in cancer patients. Dr. Berzero stresses the need for a multidisciplinary approach and collaboration with oncologists to optimize patient care.

Moderator: Panagiotis Zis (Nicosia, Cyprus) Guest: Peter Van den Bergh (Brussels, Belgium) In this episode of the EAN Cast, Prof. Zis is joined by Prof. Van den Bergh to discuss the recently updated guidelines for diagnosing and treating Chronic Inflamm Moderator: Panagiotis Zis (Nicosia, Cyprus)Guest: Peter Van den Bergh (Brussels, Belgium)In this episode of the EAN Cast, Prof. Zis is joined by Prof. Van den Bergh to discuss the recently updated guidelines for diagnosing and treating Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP). The existing guidelines were last revised over a decade ago, and this new version aims to reflect the latest advancements in clinical and basic research. Prof. Van den Bergh highlights the common pitfalls in CIDP diagnosis and emphasizes the need for accurate diagnostic criteria.The guidelines include flowcharts, tables, and criteria for different CIDP variants, as well as suggestions for supportive criteria to upgrade the diagnosis from possible CIDP to CIDP. The episode also delves into the treatment approaches, with an emphasis on corticosteroids, IVIG, and plasma exchange, and when to consider nerve biopsy.

Moderator: Thomas Berger (Vienna, Austria) Guest: Wolfgang Grisold (Vienna, Austria) In this podcast episode of EAN Cast, Professor Thomas Berger, Chair of the Department of Neurology at the Medical University in Vienna, and Professor Wolfgang Grisold, Moderator: Thomas Berger (Vienna, Austria)Guest: Wolfgang Grisold (Vienna, Austria)In this podcast episode of EAN Cast, Professor Thomas Berger, Chair of the Department of Neurology at the Medical University in Vienna, and Professor Wolfgang Grisold, the current president of the World Federation of Neurology, discuss two important topics. First, they delve into the history and implementation of the World Health Organization's (WHO) Intersectoral Global Action Plan for epilepsy and other neurological disorders (ICAP). They emphasize that ICAP is a global effort to improve neurological services, and while epilepsy is a key focus, it covers various neurological disorders across countries, regardless of their income level. They highlight the importance of ICAP's five points: policy, treatment, prevention, research and innovation, and public health.Secondly, they discuss the concept of brain health, a mission closely related to ICAP, and its importance. They mention the need to raise awareness, address stigma associated with neurological diseases, and work towards individualized care for patients. They stress that these initiatives require collaboration at all levels, from global organizations to individual neurologists.