New Books in Biology and Evolution

Our brains are the most complex machines known to humankind, but they have an Achilles heel: the very molecules that allow us to exist can also sabotage our minds. Here are gripping accounts of unruly molecules and the diseases that form in their wake.A college student cannot remember if she has eaten breakfast. By dinner, she is strapped to a hospital bed, convinced she is battling zombies. A man planning to propose marriage instead becomes violently enraged, gripped by body spasms so severe that he nearly bites off his own tongue. One after another, poor farmers in South Carolina drop dead from a mysterious epidemic of dementia.With an intoxicating blend of history and intrigue, Sara Manning Peskin invites readers to play medical detective, tracing each diagnosis from the patient to an ailing nervous system. Along the way, Peskin entertains with tales of the sometimes outlandish, often criticized, and forever devoted scientists who discovered it all.Peskin never loses sight of the human impact of these conditions. Alzheimer's Disease is more than the gradual loss of a loved one; it can be a family's multigenerational curse. The proteins that abound in every cell of our bodies are not simply strings of oxygen, hydrogen, nitrogen, and carbon; they are the building blocks of our personalities and relationships. A Molecule Away from Madness: Tales of the Hijacked Brain (Norton, 2022) is an unputdownable journey into the deepest mysteries of our brains.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. Learn more about your ad choices. Visit megaphone.fm/adchoices

The form and function of a sprinting cheetah are quite unlike those of a rooted tree. A human being is very different from a bacterium or a zebra. The living world is a realm of dazzling variety, yet a shared set of physical principles shapes the forms and behaviors of every creature in it. So Simple a Beginning: How Four Physical Principles Shape Our Living World (Princeton UP, 2022) shows how the emerging new science of biophysics is transforming our understanding of life on Earth and enabling potentially lifesaving but controversial technologies such as gene editing, artificial organ growth, and ecosystem engineering.Raghuveer Parthasarathy explains how four basic principles—self-assembly, regulatory circuits, predictable randomness, and scaling—shape the machinery of life on scales ranging from microscopic molecules to gigantic elephants. He describes how biophysics is helping to unlock the secrets of a host of natural phenomena, such as how your limbs know to form at the proper places, and why humans need lungs but ants do not. Parthasarathy explores how the cutting-edge biotechnologies of tomorrow could enable us to alter living things in ways both subtle and profound.Featuring dozens of original watercolors and drawings by the author, this sweeping tour of biophysics offers astonishing new perspectives on how the wonders of life can arise from so simple a beginning. Learn more about your ad choices. Visit megaphone.fm/adchoices

Listen to this interview of Adam Marcus and Ivan Oransky, cofounders of Retraction Watch. We talk about lots of things, retracting very few.Ivan Oransky : "Accountability in science certainly does not come down to only retracting papers, because there are just lots of issues. And by the way, just to remind everyone, science is very much a human endeavor. It doesn't exist outside of humans doing the science. I mean, facts exist, and there is truth out there, and we'd very much appear to be getting close and closer to it — that's not what I'm talking about. I'm talking about the actual process, like, how do we learn these things. How — as this podcast more generally looks at — how does knowledge get known. Basically, epistemology. But that requires human beings. It requires human beings interpreting, talking and listening, collaborating, and so that's one part of science that is really critical. Therefore, of course, the issue of accountability is multifactorial."The Retraction Watch database is here. You might also be interested in this article: "Repeat Offenders: When Scientific Fraudsters Slip Through the Cracks." You can learn more about retraction here. Watch Daniel edit your science here. Contact Daniel at writeyourresearch@gmail.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

There is a logical flaw in the statistical methods used across experimental science. This fault is not a minor academic quibble: it underlies a reproducibility crisis now threatening entire disciplines. In an increasingly statistics-reliant society, this same deeply rooted error shapes decisions in medicine, law, and public policy with profound consequences. The foundation of the problem is a misunderstanding of probability and its role in making inferences from observations.Aubrey Clayton traces the history of how statistics went astray, beginning with the groundbreaking work of the seventeenth-century mathematician Jacob Bernoulli and winding through gambling, astronomy, and genetics. Clayton recounts the feuds among rival schools of statistics, exploring the surprisingly human problems that gave rise to the discipline and the all-too-human shortcomings that derailed it. He highlights how influential nineteenth- and twentieth-century figures developed a statistical methodology they claimed was purely objective in order to silence critics of their political agendas, including eugenics.Clayton provides a clear account of the mathematics and logic of probability, conveying complex concepts accessibly for readers interested in the statistical methods that frame our understanding of the world. He contends that we need to take a Bayesian approach--that is, to incorporate prior knowledge when reasoning with incomplete information--in order to resolve the crisis. Ranging across math, philosophy, and culture, Bernoulli's Fallacy: Statistical Illogic and the Crisis of Modern Science (Columbia UP, 2021) explains why something has gone wrong with how we use data--and how to fix it.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. Learn more about your ad choices. Visit megaphone.fm/adchoices

Today I talked to Leonard Mdlodinow about his new book Emotional: How Feelings Shape Our Thinking (Pantheon, 2022)."On or around December 1910, human character changed,” Virginia Woolf memorably wrote, citing the rise of Modernism. Take things ahead a century, and Leonard Mdlodinow is making a similarly striking statement that advances in how neuroscientists can trace the connectivity of neurons has led to another striking advancement in intellectual life since approximately 2010. From the 1980s until that date, psychologists and neuroscientists were both appreciating and refining the concept of emotions as inherited from Charles Darwin. Since then, what emotions are and how they operate has undergone a conceptual revolution. This episode follows Mlodinow’s guidance as he outlines how scientists today focus on emotions as functional agents, thoroughly emmeshed in how we selectively perceive and adapt to the circumstances we find ourselves in. One tangible example of the revolution: now we know that childhood can literally change our DNA as we react and adjust to emotionally-laden experiences that leave their emotional fingerprint on us all.Leonard Mlodinow received his PhD in theoretical physics from the University of California, Berkeley, was a fellow at the Max Planck Institute, and has been on the faculty at CalTech. His previous, award-winning books include two written with Stephen Hawking, and another written with Deepak Chopra.Dan Hill, PhD, is the author of nine books and leads Sensory Logic, Inc. (https://www.sensorylogic.com). His new book is Blah, Blah, Blah: A Snarky Guide to Office Lingo. To check out his related “Dan Hill’s EQ Spotlight” blog, visit https://emotionswizard.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

The average person produces about four hundred pounds of excrement a year. More than seven billion people live on this planet. Holy crap!Because of the diseases it spreads, we have learned to distance ourselves from our waste, but the long line of engineering marvels we've created to do so--from Roman sewage systems and medieval latrines to the immense, computerized treatment plants we use today--has also done considerable damage to the earth's ecology. Now scientists tell us: we've been wasting our waste. When recycled correctly, this resource, cheap and widely available, can be converted into a sustainable energy source, act as an organic fertilizer, provide effective medicinal therapy for antibiotic-resistant bacterial infection, and much more.In The Other Dark Matter: The Science and Business of Turning Waste Into Wealth and Health (U Chicago Press, 2021), Lina Zeldovich documents the massive redistribution of nutrients and sanitation inequities across the globe. She profiles the pioneers of poop upcycling, from startups in African villages to innovators in American cities that convert sewage into fertilizer, biogas, crude oil, and even life-saving medicine. She breaks taboos surrounding sewage disposal and shows how hygienic waste repurposing can help battle climate change, reduce acid rain, and eliminate toxic algal blooms. Ultimately, she implores us to use our innate organic power for the greater good. Don't just sit there and let it go to waste.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. Learn more about your ad choices. Visit megaphone.fm/adchoices

Walter Tschinkel has spent much of his career investigating the hidden subterranean realm of ant nests. This wonderfully illustrated book takes you inside an unseen world where thousands of ants build intricate homes in the soil beneath our feet.Tschinkel describes the ingenious methods he has devised to study ant nests, showing how he fills a nest with plaster, molten metal, or wax and painstakingly excavates the cast. He guides you through living ant nests chamber by chamber, revealing how nests are created and how colonies function. How does nest architecture vary across species? Do ants have “architectural plans”? How do nests affect our environment? As he delves into these and other questions, Tschinkel provides a one-of-a-kind natural history of the planet’s most successful creatures and a compelling firsthand account of a life of scientific discovery.Offering a unique look at how simple methods can lead to pioneering science, Ant Architecture: The Wonder, Beauty, and Science of Underground Nests (Princeton UP, 2021) addresses the unsolved mysteries of underground ant nests while charting new directions for tomorrow’s research, and reflects on the role of beauty in nature and the joys of shoestring science.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. Learn more about your ad choices. Visit megaphone.fm/adchoices

Inside our heads we carry around an infinite and endlessly unfolding map of the world. Navigation is one of the most ancient neural abilities we have―older than language. In Dark and Magical Places: The Neuroscience of Navigation (Norton, 2022), Christopher Kemp embarks on a journey to discover the remarkable extent of what our minds can do.Fueled by his own spatial shortcomings, Kemp describes the brain regions that orient us in space and the specialized neurons that do it. Place cells. Grid cells. He examines how the brain plans routes, recognizes landmarks, and makes sure we leave a room through a door instead of trying to leave through a painting. From the secrets of supernavigators like the indigenous hunters of the Bolivian rainforest to the confusing environments inhabited by people with place blindness, Kemp charts the myriad ways in which we find our way and explains the cutting-edge neuroscience behind them.How did Neanderthals navigate? Why do even seasoned hikers stray from the trail? What spatial skills do we inherit from our parents? How can smartphones and our reliance on GPS devices impact our brains? In engaging, engrossing language, Kemp unravels the mysteries of navigating and links the brain’s complex functions to the effects that diseases like Alzheimer’s, types of amnesia, and traumatic brain injuries have on our perception of the world around us.A book for anyone who has ever felt compelled to venture off the beaten path, Dark and Magical Places is a stirring reminder of the beauty in losing yourself to your surroundings. And the beauty in understanding how our brains can guide us home.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. Learn more about your ad choices. Visit megaphone.fm/adchoices

From mosquito-borne diseases such as malaria and dengue to chronic bacterial infections such as yaws, Southeast Asia is home to a wide range of tropical diseases. For a long time, the arrival in the region of these and other dangerous tropical diseases was believed to be connected to the introduction of agriculture. But how long have these diseases really been around for? How are they connected to the region’s fluctuating social and environmental conditions? And how have they impacted the human populations of Southeast Asia over time?Joining Dr Natali Pearson on SSEAC Stories, bioarchaeologist Dr Melandri Vlok sheds light on the complex science of paleoepidemiology and its use of advanced analytical practices such as DNA ancestry, skeletal studies, and teeth calculus to uncover ancient stories of illness and disease. She explains that far from being mere remnants of the past, archaeological human remains can help us understand the evolution and spread of pathogens, and inform strategies to curb the spread of infectious diseases in human populations.About Melandri Vlok:Dr Melandri Vlok is a Postdoctoral Research Associate at the Sydney Southeast Asia Centre. Melandri specialises in palaeopathology/ bioarchaeology and researches the implications for migration and trade on the presence of infectious and nutritional diseases in past populations in Asia. Melandri's work, funded by grant bodies including National Geographic and the Royal Society of New Zealand, has involved the analysis of human skeletal remains from Vietnam, Indonesia, Thailand, Japan, Mongolia, New Zealand and the Philippines. She is also involved with repatriation efforts focused on returning Māori and Moriori ancestral remains to iwi and imi (tribes) in New Zealand.For more information or to browse additional resources, visit the Sydney Southeast Asia Centre’s website: www.sydney.edu.au/sseac. Learn more about your ad choices. Visit megaphone.fm/adchoices

Lives of Weeds: Opportunism, Resistance, Folly (Cornell UP, 2021) explores the tangled history of weeds and their relationship to humans. Through eight interwoven stories, John Cardina offers a fresh perspective on how these tenacious plants came about, why they are both inevitable and essential, and how their ecological success is ensured by determined efforts to eradicate them. Linking botany, history, ecology, and evolutionary biology to the social dimensions of humanity's ancient struggle with feral flora, Cardina shows how weeds have shaped—and are shaped by—the way we live in the natural world.Weeds and attempts to control them drove nomads toward settled communities, encouraged social stratification, caused environmental disruptions, and have motivated the development of GMO crops. They have snared us in social inequality and economic instability, infested social norms of suburbia, caused rage in the American heartland, and played a part in perpetuating pesticide use worldwide. Lives of Weeds reveals how the technologies directed against weeds underlie ethical questions about agriculture and the environment, and leaves readers with a deeper understanding of how the weeds around us are entangled in our daily choices.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoices