Big Picture Science

(Repeat) The biotech tool CRISPR lets us do more than shuffle genes. Researchers have embedded an animated GIF into a living organism’s DNA, proving that the molecule is a great repository for information. This has encouraged speculation that DNA could be used by aliens to send messages. Meanwhile, nature has seized on this powerful storage system in surprising ways. Scientists have learned that the 98% of our genome – once dismissed as “junk” – contains valuable genetic treasure. Find out what project ENCODE is learning about the “dark genome.”Plus, how viruses became the original stealth coders, inserting their DNA into ancient bacteria and eventually leading to the development of CRISPR technology. Discover the potential of this powerful tool, from curing disease to making pig organs transplant-friendly, and the possible dark side of quick-and-easy gene editing.  Guests: Paul Davies- Director of the Beyond Center for Fundamental Concepts in Science at Arizona State University Yin Shen- Assistant professor, Department of Neurology, Institute for Human Genetics, University of California – San Francisco, member of ENCODE team  Sam Sternberg- Assistant professor, Department of Biochemistry and Molecular Biophysics, Columbia University, and co-author of “A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution”   Hank Greely- Director, Center for Law and the Biosciences; Chair of the Steering Committee of the Center for Biomedical Ethics; and Director, Stanford Program in Neuroscience and Society Learn more about your ad choices. Visit megaphone.fm/adchoices

(repeat) Changed your computer password recently? We all try to stay one step ahead of the hackers, but the fear factor is increasing. The risks can range from stolen social security numbers to sabotaging a national power grid. Sixty years ago, when hacking meant nosing around the telephone network, it seemed innocent enough. And not all modern hacking has criminal intent. Today, there are biohackers who experiment with implanted electronic devices to improve themselves, and geoengineers who propose to hack the climate. But in our efforts to cool an overheated planet, might we be going down a dangerous path?In this second of two episodes on hacking, the modern variations of “hacking,” and their consequences. Plus: when does hacking a system improve it?   Learn more about your ad choices. Visit megaphone.fm/adchoices

(repeat)  Long before cyber criminals were stealing ATM passwords, phone phreaks were tapping into the telephone system. Their motivation was not monetary, but the thrill of defeating a complex, invisible network. Today “hacking” can apply to cyberwarfare, biological tinkering, or even geoengineering. Often it has negative connotations, but the original definition of “hacking” was something else.In this first of two episodes on hacking, we look at the original practitioners – the teenagers and mavericks who hacked Ma Bell for thrills - and the difference between hacking for fun and for profit. Guests: Phil Lapsley- Author of “Exploding the Phone: The Untold Story of the Teenagers and Outlaws Who Hacked Ma Bell”  Learn more about your ad choices. Visit megaphone.fm/adchoices

(Repeat) Celebrations are in order for the physicists who won the 2017 Nobel Prize, for the detection of gravitational waves. But the road to Stockholm was not easy. Unfolding over a century, it went from doubtful theory to daring experiments and even disrepute. 100 years is a major lag between a theory and its confirmation, and new ideas in physics may take even longer to prove.Why it may be your great, great grandchildren who witness the confirmation of string theory. Plus, the exciting insights that gravitational waves provide into the phenomena of our universe, beginning with black holes.And, physics has evolved - shouldn’t its rewards? A case for why the Nobel committee should honor collaborative groups rather than individuals, and the scientific breakthroughs it’s missed. Guests:  Janna Levin- Physicist and astronomer at Barnard College at Columbia University, and the author of the story of LIGO, “Black Hole Blues and Other Songs from Outer Space.” Roland Pease- BBC reporter, producer, and host of “Science in Action.”  David Gross- Theoretical physicist, string theorist, University of California, Santa Barbara, Kavli Institute for Theoretical Physics, winner, 2004 Nobel Prize in Physics.  Learn more about your ad choices. Visit megaphone.fm/adchoices

(Repeat) Astronauts are made of the “right stuff,” but what about their spacesuits?  NASA’s pressurized and helmeted onesies are remarkable, but they need updating if we’re to boldly go into deep space.  Suiting up on Mars requires more manual flexibility, for example. Find out what innovative materials might be used to reboot the suit.Meanwhile, strange new materials are in the pipeline for use on terra firma: spider silk is kicking off the development of biological materials that are inspiring ultra-strong, economical, and entirely new fabrics. And, while flesh-eating bacteria may seem like an unlikely ally in materials science, your doctor might reach for them one day. The bacterium’s proteins are the inspiration for a medical molecular superglue.Plus, an overview of more innovative materials to come, from those that are 3D printed to self-healing concrete.  Guests: Nicole Stott– Retired NASA astronaut, artist  Dava Newman– Professor of Astronautics and Engineering Systems, Massachusetts Institute of Technology Andrew Dent– Vice President of Library and Materials Research, Material ConneXion Mark Howarth– Biochemist, Oxford University Mark Miodownik– Materials scientist, University College London, author of “Stuff Matters; Exploring the Marvelous Materials that Shape Our Man-Made World”  Learn more about your ad choices. Visit megaphone.fm/adchoices

ENCORE Water is essential for life – that we know. But the honeycomb lattice that forms when you chill it to zero degrees Celsius is also inexorably intertwined with life.Ice is more than a repository for water that would otherwise raise sea levels. It’s part of Earth’s cooling system, a barrier preventing decaying organic matter from releasing methane gas, and a vault entombing ancient bacteria and other microbes. From the Arctic to the Antarctic, global ice is disappearing. Find out what’s at stake as atmospheric CO2 threatens frozen H2O. Guests: Peter Wadhams- Emeritus Professor of Ocean Physics at Cambridge University in the U.K. and the author of A Farewell to Ice: A Report from the Arctic Eric Rignot- Earth systems scientist, University of California, Irvine, senior research scientist, NASA Jet Propulsion Laboratory Åsmund Asdal- Biologist, Nordic Genetic Resource Center, coordinator for operations and management of the Svalbard Global Seed Vault, Svalbard, Norway John Priscu- Polar biologist, Montana State University Learn more about your ad choices. Visit megaphone.fm/adchoices

ENCORE It’s not just tin cans and newspapers. One man says that, from a technical standpoint, everything can be recycled – cigarette butts, yoga mats, dirty diapers. Even radioactive waste. You name it, we can recycle it. But we choose not to. Find out why we don’t, and how we could do more. Plus, a solar-powered device that pulls water from the air – even desert air. And, something upon which life depends that seems dirt cheap, but can’t be replenished: soil. What happens when we pave over this living resource?  Learn more about your ad choices. Visit megaphone.fm/adchoices

ENCORE It’s one of the most bizarre biological experiments ever. In the 18th century, a scientist fitted a pair of tailor-made briefs on a male frog to determine the animal’s contribution to reproduction. The process of gestation was a mystery and scientists had some odd-ball theories. Today, a 5th grader can tell you how babies are made, but we still don’t know exactly what life is. In our quest to understand, we’re still at the frogs’ pants stage.Find out why conception took centuries to figure out. Also, why the 1970s Viking experiments, specifically designed to detect life on Mars, couldn’t give us a definitive answer. Plus, can knowing where life isn’t help define what it is? Take a tour of the world’s barren places. Guests: Jay Gallentine - Author of books about space and space history. Edward Dolnick - Author and former science writer at the Boston Globe. His book is The Seeds of Life: From Aristotle to Da Vinci, from Shark’s Teeth to Frogs’ Pants. Chris McKay - Planetary scientist, NASA Ames Research Center.  Learn more about your ad choices. Visit megaphone.fm/adchoices

ENCORE Get ready for compassionate computers that feel your pain, share your joy, and generally get where you’re coming from. Computers that can tell by your voice whether you’re pumped up or feeling down, or sense changes in heart rate, skin, or muscle tension to determine your mood. Empathetic electronics that you can relate to.But wait a minute – we don’t always relate to other humans. Our behavior can be impulsive and even self-sabotaging – our emotions are often conflicted and irrational.  We cry when we’re happy. Frown when we’re pensive. A suite of factors, much of them out of our control, govern how we behave, from genes to hormones to childhood experience. One study says that all it takes for a defendant to receive a harsher sentence is a reduction in the presiding judge’s blood sugar.So grab a cookie, and find out how the heck we can build computers that understand us anyway. Guests: Rosalind Picard – Professor at the MIT Media Lab and co-founder of the companies Affectiva and Empatica.  Robert Sapolsky – Professor of neuroscience at Stanford University, and author of Behave: The Biology of Humans at Our Best and Worst.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Pluto, we hardly knew ye. Well, not anymore! Until recently, Pluto and Mars were respectively the least-known and best-known planet-sized bodies in our Solar System. Thanks to the New Horizons spacecraft, our picture of Pluto has changed from a featureless dot to a place where we can name the geologic features. And with rovers and orbiters surveying the red planet, we now know much more about Mars than our parents ever did. Examining our planetary backyard has provided insight into the trillion other planets in our galaxy.Dive into a mountain lake and trek though the driest desert on Earth with a scientist who’s had not one but two near-fatal incidents in these extreme environments. Find out what questions compel her to keep returning.And scientists on the New Horizons mission remember why the nail-biting Pluto flyby almost failed at the last minute. Find out what surprises Pluto offered and what the mission might uncover as it heads to its next, outer solar-system target.Also, from Earth-like planets to super Earths and water worlds: a tour of some of Kepler’s most intriguing extrasolar planets.Guests: Nathalie Cabrol- Planetary scientist at the SETI Institute. Alan Stern- Principal Investigator for NASA’s New Horizon mission, and co-author with David Grinspoon of “Chasing New Horizons: Inside the Epic First Mission to Pluto.” David Grinspoon- Senior scientist at the Planetary Science Institute, and co-author with Alan Stern of “Chasing New Horizons: Inside the Epic First Mission to Pluto.” Jack Lissauer- Space scientist at the NASA Ames Research Center. Learn more about your ad choices. Visit megaphone.fm/adchoices