a16z Podcast

Amira Yahyaoui, Founder and CEO of Mos, discusses how her platform simplifies access to college financial aid for students. A fintech partner at a16z, Seema Amble shares insights into the shifting expectations of Millennials and Gen Z from traditional banking, focusing on trust and transparency. Anish Acharya, also at a16z, delves into innovative solutions tailored to tackle student debt and promote financial literacy. They explore how fintech can empower young consumers, transforming their financial futures amidst economic challenges.

Discover the groundbreaking world of protein degradation, where innovative drugs tackle previously undruggable extracellular proteins. Learn about LYTACs, the new-class drugs that effectively send disease-related proteins to the cellular trash. Delve into the challenges of traditional pharmacology and how advanced modalities like PROTACs are changing the landscape. The hosts discuss the evolution of therapeutic antibodies and their enhanced capabilities in treating serious conditions like liver fibrosis and Alzheimer's.

Kristen Fortney, co-founder of BioAge, dives into the revolutionary science of aging and healthspan. The conversation covers groundbreaking research on aging-related drugs and their potential to transform healthcare. They explore how insights from aging can reshape our understanding of diseases like Alzheimer’s and cancer. The group discusses innovative therapies, the significance of biomarkers, and the importance of diverse founders in the longevity sector. Fortney's insights highlight a new era where biology meets technology, paving the way for a healthier future.

Eugene Wei, former head of product at Hulu and Flipboard, dives into the fascinating world of TikTok's algorithm and its impact on creativity. He discusses how the platform's unique algorithm fosters a culture of innovation and meme evolution, allowing new creators to shine alongside established ones. Wei also contrasts TikTok's meritocratic model with traditional social networks, highlighting its approach to personalized content delivery. Additionally, he explores the future of video and how it reshapes social networking and entertainment.

Kayvon Tehranian, CEO of Foundation Labs, and Jesse Walden, founder of Variant, dive into the transformative potential of decentralized technology in the creator economy. They discuss how crypto empowers creators by eliminating traditional gatekeepers and enabling direct fan engagement. The conversation explores the dynamics of creator tokens, speculation, and the cultural vs. financial motivations driving market growth. They emphasize starting small in the crypto space to explore innovative revenue streams while fostering a supportive community.

Join Patrice Peck, a freelance journalist known for her COVID-focused newsletter, Zach Haigney, an acupuncturist illuminating the world of medicinal psychedelics, Edith Zimmerman, an artist sharing life through comics, and Lenny Rachitsky, a former Airbnb product manager, as they discuss their newsletter journeys. They delve into the nuances of audience engagement, the decision-making ballet of monetization, and the challenges of standing out in a crowded market. Their insights highlight the transformative power of independent voices in today's media landscape.

Reed Hastings, co-founder and CEO of Netflix, shares insights from his book "No Rules Rules". He discusses Netflix's evolution from DVD rental to streaming giant and the essential qualities of a culture that embraces reinvention. Hastings highlights lessons learned about balancing efficiency with creativity, the significance of open feedback across cultures, and the strategic focus required for growth. He also dives into leadership challenges and how adaptability can foster long-term success, especially in a global market.

Guy Raz, an award-winning NPR host and author of "How I Built This," delves into the messy realities of entrepreneurship. He challenges the classic hero's journey narrative, pointing out that success is riddled with failures and crises. Raz discusses the power of storytelling in shaping brand identities and engaging communities. He also contrasts strategic buzz with genuine word of mouth, emphasizing the authenticity that drives customer connections. Ultimately, he redefines entrepreneurship, celebrating everyday creators who understand market needs.

Dylan Field, CEO of Figma and a visionary in design, discusses the current education system's monopoly and its implications. He critiques rising costs and the value of degrees in today’s job market, posing questions about the true benefits of a college education versus practical skills. Field also shares insights on the impact of the pandemic, innovative educational alternatives, and career advice, particularly for those reconsidering traditional paths like college. Tune in for a thought-provoking take on the future of education!

Bharat Ramamurti, an original member of the COVID-19 Congressional Oversight Commission, discusses the challenges of the Paycheck Protection Program (PPP) and its susceptibility to fraud. Naftali Harris, CEO of SentiLink, highlights innovative technologies to combat synthetic fraud in relief efforts. Alex Rampell, a fintech expert, critiques the inequitable distribution of funds, favoring large corporations over small businesses. Together, they explore lessons from international responses, flaws in government disbursement, and the pressing need for improved oversight in future relief efforts.