Profile

The creator of Mrs Brown's Boys has had a bumpy ride to stardom. Becky Milligan charts the journey - born the youngest of 11 children in Dublin, he faced bankruptcy and serial disappointments before finding success as the the matriarch of his very own family sitcom. This year it returns - for the 10th consecutive year - to our TV screens over Christmas. Producer: Ben Crighton Editor: Rosamund Jones

The academy award winning actor’s latest film, Ma Rainey’s Black Bottom, is one of the first big budget releases since the pandemic closed cinemas. Viola Davis is the first black actor to win an Oscar, Emmy and Tony award – a triple crown of the most prestigious awards in film, television and theatre. Born on her grandmother’s farm, a former slave plantation in South Carolina. Davis was raised on the East Coast – in Providence, Rhode Island. As a child growing up in poverty, acting became a means of escape.After a decades-long career as a respected theatre actor, she was propelled to international attention in 2008, when she was nominated for an Oscar for her performance in a single scene; alongside Meryl Streep in the film Doubt. Since then, she’s starred in a great many films and TV series; becoming widely recognised as one of the greatest actors of stage and screen this century. Becky Milligan explores her life and career and talks to her sister, Deloris, to find out what motivates an actor whose meteoric rise is symbolic of a deeper shift in how the film industry values black artists. Producers: Tom Wright and Ben Crighton Editor: Rosamund Jones

After a 30 year career of quiet public service, Dr June Raine has found herself in the spotlight when the UK became the first country to approve the Pfizer/BioNTech vaccine. As the head of the MHRA she has ultimate responsibility for the process of approving any new Covid-19 vaccines in the UK, and when the eminent American immunologist Dr Anthony Fauci cast doubt over the speed of UK's approval process Dr Raine was forced to make a public response. Becky Milligan finds out more about her life, character and career.Producers: Viv Jones, Ben Crighton Editor: Rosamund Jones

The British artificial intelligence lab DeepMind have made an astonishing breakthrough in one of biology’s toughest problems. The firm announced this week that it had largely cracked the problem of predicting how proteins folds into unique shapes, a challenge scientists have been working on for 50 years. The discovery is expected to accelerate research into illnesses like cancer and Alzheimer’s, and could even help find solutions to climate change. Behind the project is DeepMind’s co-founder, Demis Hassabis. A former chess prodigy, Hassabis has always been captivated by games and the mental agility needed to play them. This fascination with the human mind inspired his determination to use artificial intelligence to solve the world’s problems.Producers: Ben Crighton, Viv Jones Editor: Rosamund Jones

This week the political turmoil at Number 10 has made the headlines. One of the prime minister's aides whose star appears to be on the rise is former journalist Allegra Stratton, the government's new press secretary. She'll be fronting televised briefings shortly. Becky Milligan examines her life and her career so far. Producers: Bethan Head and Sally Abrahams.

Early results from the world's first effective coronavirus vaccine showed it could prevent more than 90% of people from getting Covid-19.The vaccine had been developed by pharmaceutical companies Pfizer and BioNTech and was one of 11 vaccines that had reached the final stages of testing.Mark Coles explores the lives and careers of Ugur Sahin and Ozlem Tureci - the little known Turkish-German husband-and-wife team responsible for the development of the vaccine. First broadcast on Saturday 14th November 2020.Producers: Sally Abrahams and Ben Carter Editor: Rosamund Jones

As Wales eases its covid restrictions, Profile explores the life and various careers of the country's First Minister. Born and brought up in rural Wales, before entering the world of Labour politics Mark Drakeford worked as a social worker and an academic. And Mark Coles discovers that those are not his only interests. Tending his allotment, playing music and body boarding in all weathers also loom large. Presenter: Mark Coles Producers: Luke Radcliff and Ben Carter

The business woman and Great British Bake Off judge now working with the government to improve NHS food - her independent review demanding healthier meals for hospital patients. Born in South Africa, it was time spent in Paris which sparked Prue Leith's love of food. Transferring to London, she started a food empire in her bedsit, going on to open a catering college and a Michelin star restaurant. She took on public roles too, becoming the first woman on the board of British Rail, charged with fixing the network's food which had become a laughing stock.Prue built her media profile alongside roles in the arts, charity sector and education. Then after controversial team-changes in The Great British Bake Off, she's now become a bona fide celebrity, helping the hit programme reach record audiences. Producers: Richard Fenton-Smith & Ben Crighton Editor: Ros jones

The chief strategic advisor to PM Boris Johnson who thrives on getting things done and who was once regarded as Margaret Thatcher's favourite council leader.A former alarms company executive, Edward Lister's political career began in the London Borough of Wandsworth which was at the forefront of Thatcherism at the turn of the 1980s.A council leader for nearly two decades, he made the leap to City Hall when Boris Johnson made him his deputy - and he's been a trusted aide and fixer ever since.Despite his position, Sir Edward has kept a low public profile, working behind the scenes resolving recent Brexit stalemates. This week he's been the go-between in the negotiations between the government and city mayors in the North of England in the debate over the financial cost of Covid-19. Mark Coles profiles the life of the man described as the 'grown-up' at Number 10 who thrives on solving problems. Producers: Richard Fenton-Smith & Ben Crighton

The former bricklayer steering Liverpool through the latest coronavirus lockdown. Liverpool was the first region to face the toughest restrictions as the second wave of the pandemic takes hold. The man in charge of dealing with this new crisis is the first mayor of the city region, Steve Rotheram. Becky Milligan charts his rise, from a 16-year-old school leaver to prominent politician. Producer: Ben Crighton Researcher: Luke Radcliff