The chief strategic advisor to PM Boris Johnson who thrives on getting things done and who was once regarded as Margaret Thatcher's favourite council leader.A former alarms company executive, Edward Lister's political career began in the London Borough of Wandsworth which was at the forefront of Thatcherism at the turn of the 1980s.A council leader for nearly two decades, he made the leap to City Hall when Boris Johnson made him his deputy - and he's been a trusted aide and fixer ever since.Despite his position, Sir Edward has kept a low public profile, working behind the scenes resolving recent Brexit stalemates. This week he's been the go-between in the negotiations between the government and city mayors in the North of England in the debate over the financial cost of Covid-19. Mark Coles profiles the life of the man described as the 'grown-up' at Number 10 who thrives on solving problems. Producers: Richard Fenton-Smith & Ben Crighton

The former bricklayer steering Liverpool through the latest coronavirus lockdown. Liverpool was the first region to face the toughest restrictions as the second wave of the pandemic takes hold. The man in charge of dealing with this new crisis is the first mayor of the city region, Steve Rotheram. Becky Milligan charts his rise, from a 16-year-old school leaver to prominent politician. Producer: Ben Crighton Researcher: Luke Radcliff

The man from Indiana who's "a heartbeat away" from the US presidency. Mark Coles tells the story of how a Catholic boy with Democratic Party leanings became a born-again evangelical and a hero of the Republican right. With President Donald Trump's recent bout with Covid-19, there has been more and more attention paid to the man next in line for the Oval Office. But there are doubts about whether a majority of the American public agree with the vice-president's strictly socially conservative views. Producer: Ben Crighton Researcher: Luke Radcliff

Billionaire Chuck Feeney said he would give away all of his money by 2020 – and he’s done it. An entrepreneur from childhood, he amassed a huge fortune in the duty-free business, before spending it on projects ranging from concert halls in Ireland to AIDS support in South Africa. For many years the money was only given out on condition of secrecy, that his name should never be mentioned in connection with the donations. Mark Coles finds out what’s driven this unique mission - and what his family think. Producer: Ben Crighton Researchers: Benita Barden & Beth Sagar-Fenton

Lewis Hamilton could be about to equal Michael Schumacher's incredible record of 91 Grand Prix wins - but can he achieve even more? The first black Formula 1 driver has been a champion since childhood, when he ran rings around the adults with his remote control car. Three decades on he's tipped to equal and even exceed the long standing record - but is he now determined to achieve as much off the track as on it? We hear from those who know Hamilton best, including an exclusive interview with his father, Anthony. Presenter: Becky Milligan Producer: Ben Crighton Researchers: Beth Sagar-Fenton & Benita Barden

The woman who could soon be "a heartbeat away" from the presidency. This week voters in some states started sending in their ballot papers for the US presidential election. If the Democrats win when results are announced in November, it's vice presidential candidate Kamala Harris who'll be second in line to the Oval Office. She would be the first black person, the first woman and the first person of Indian descent to become VP. But what is Kamala Harris really like? Why has she attracted criticism in some circles for her record as a prosecutor and a legislator, while being hailed a hero by others? And is she likely to attract voters to Joe Biden's presidential campaign, or drive them away? Presenter: Mark Coles Producer: Ben Crighton Researcher: Beth Sagar-Fenton

Why is the former Australian Prime Minister Tony Abbott such a controversial choice for trade adviser? Appointed by the Government to help negotiate post-Brexit deals for the UK, his supporters say he's a persuasive political operator and already has three free trade agreements under his belt. But others have been staggered by his appointment, saying he has a track record of sexism and homophobia, and will prove an "embarrassment" to the UK. Mark Coles speaks to colleagues, critics and even Abbott's sister to find out what drives the so-called "Mad Monk", and whether he'll make a success of the job. Presenter: Mark Coles Producer: Ben Crighton Researchers: Charlotte McDonald & Beth Sagar-Fenton Editor: Penny Murphy

Those in the know say he's "the ultimate keeper of secrets" - Simon Case was announced this week as the new Cabinet Secretary and head of the Civil Service. Aged just 41 and with a CV that takes him from GCHQ to Kensington Palace, he's now set to take on a role at the heart of government, heading up a workforce of more than 400,000 people. But with Covid an ongoing problem and Brexit on the cards - and without any experience of running a department - has the so-called "Rolls Royce of Sir Humphreys" got what it takes? Presenter: Mark Coles Producers: Ben Crighton & Beth Sagar-Fenton Editor: Penny Murphy

Health secretary Matt Hancock announced last week that Public Health England will be replaced with a new National Institute for Health Protection. Baroness Dido Harding, who ran NHS Test and Trace in England, will be heading up this new agency too, for now. Who is she? And why are some cynical about whether she'll be able to handle the new role?Dido Harding started out on a pig farm in Dorset, and has spent most of her adult life splitting her time between the corporate world and her beloved horses. Married to Conservative MP John Penrose, she's spent the last three years working in the public sector, and recently been a regular feature at Number 10’s daily coronavirus briefings. Mark Coles speaks to her best friend and former boss, amongst others, to find out more. Producer: Beth Sagar-Fenton Researcher: May Cameron Editor: Kirsty Reid

The no-nonsense scientist whose team is developing a coronavirus vaccine at record speed. Mark Coles discovers the many talents of Oxford University vaccine specialist, Professor Sarah Gilbert.Producer: Ben Crighton Researcher: Di Richardson