Barbara Wendelberger, PhD, Berry Consultants, discusses Futility in Clinical Trials with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content: Futility in Clinical Trials

William J. Meurer, MD, MS, University of Michigan Medical School, discusses Interim Analyses During Group Sequential Trials with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content: Interim Analyses During Group Sequential Clinical Trials

Jerome I. Rotter, an expert in translational genomics, joins JAMA Statistical Editor Roger J. Lewis to dive into Genome-Wide Association Studies (GWAS). They explore the differences between Mendelian and complex diseases, discussing how single base mutations lead to conditions like sickle cell anemia. The conversation covers polygenic diseases, highlighting the genetic variants behind ailments such as type 2 diabetes. They also tackle advancements in GWAS and the significance of SNPs, emphasizing the importance of diverse ethnic inclusion for reliable findings.

Benjamin R. Saville, PhD, president and lead statistical scientist of Adaptix Trials, LLC and adjoint associate professor of biostatistics at Vanderbilt University Medical Center, discusses Conditional Power: How Likely Is Trial Success? with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content: Conditional Power

Anna E. McGlothlin, PhD, Berry Consultants, LLC, discusses Bayesian Hierarchical Models with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content: Bayesian Hierarchical Models

Kelley Kidwell, PhD, professor of biostatistics, University of Michigan, discusses Sequential, Multiple Assignment, Randomized Trial Designs with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content: Sequential, Multiple Assignment, Randomized Trial Designs

Dr. Miguel A. Hernán, professor of epidemiology at Harvard T.H. Chan School of Public Health, discusses target trial emulation for causal inference from observational data with JAMA Statistical Editor. They explore the concept of target trial emulation, the importance of randomized clinical trials, estimating the effectiveness of Tocilizumab in ICU patients with COVID-19, and the complementary role of randomized trials and observational studies in generating evidence.

Dr. Lawrence Carin discusses deep learning for medical image analysis with a focus on machine interpretation of medical images, the evolution of neural networks in medical image analysis, immediate applications in clinical care enhancement, and the risks and benefits of machine learning in healthcare.

JAMA Statistical Editor Roger J. Lewis, MD, PhD, discusses Patient-Reported Outcome Measures in Clinical Research with Kevin P. Weinfurt, PhD, and Bryce B. Reeve, PhD. Related Content: Patient-Reported Outcome Measures in Clinical Research

Dr Kabir Yadav, Statistical Editor, discusses immortal time bias in observational studies with Dr Roger Lewis. They explore the misclassification of immortal time in observational studies compared to randomized trials, address the bias in the UK Biobank study, and examine the higher risk of cardiovascular events in women with premature menopause.