POD OF JAKE

Noor is the Founder and CEO of Orchid, a reproductive technology company measuring genetic predisposition to disease for the purpose of helping people have healthier babies. Prior to creating Orchid, Noor was a Thiel Fellow and an AI researcher at Stanford where she worked on applications of deep learning to genomics. Follow Noor on X @noor_siddiquiz_ and Orchid @OrchidInc. [0:16] - The personal motivation behind Noor’s interest in genomics [11:31] - Embracing “weirdness” as a child [15:42] - The Thiel Fellowship and Stanford experiences [22:30] - How and why Noor got interested in crypto in college [24:30] - How Orchid measures risks at the embryo stage [28:12] - Using Orchid’s data to make informed health decisions [38:47] - Comparing Orchid to other existing embryo screening tech [42:52] - How Orchid accomplished a 100x technological improvement [51:25] - Current costs of embryo screening and paths to lower them [57:55] - Noor’s thoughts on the future of genomic technologies [1:03:47] - How reproductive tech relates to human longevity For more episodes, go to ⁠⁠podofjake.com⁠⁠. Previous guests include ⁠⁠Mark Cuban⁠⁠, ⁠⁠Vitalik Buterin⁠⁠, ⁠⁠Brian Armstrong⁠⁠, ⁠⁠Balaji Srinivasan⁠⁠, ⁠⁠Keith⁠⁠ ⁠⁠Rabois⁠⁠, ⁠⁠Ali Spagnola⁠⁠, ⁠⁠Anthony Pompliano⁠⁠, ⁠⁠Raoul Pal⁠⁠, ⁠⁠Julia Galef⁠⁠, ⁠⁠Jack Butcher⁠⁠, ⁠⁠Tim Draper⁠⁠, and over 100 others alike. Learn from founders and CEOs of companies like ⁠⁠OpenAI⁠⁠, ⁠⁠Coinbase⁠⁠, ⁠⁠Solana⁠⁠, ⁠⁠Polygon⁠⁠, ⁠⁠AngelList⁠⁠⁠, ⁠⁠Oura⁠⁠⁠, and ⁠⁠Replit⁠⁠, and investors from ⁠⁠Founders⁠⁠ ⁠⁠Fund⁠⁠, ⁠⁠a16z⁠⁠, ⁠⁠Union Square Ventures⁠⁠, and many more. I appreciate your support and hope you enjoy. Thanks to ⁠⁠⁠Chase Devens⁠⁠⁠ for the show notes and ⁠⁠⁠Yiction⁠⁠⁠ for the music. Lastly, I love hearing from fans of the pod. Feel free to email me any time at ⁠⁠jake@blogofjake.com⁠⁠. Thank you!

Experienced product leader Shreyas Doshi shares insights on time management, online teaching success, writing benefits, brilliance curse, luck vs. talent, stack ranking for prioritization, and using mental simulations for decision-making.

Vitalik Buterin, inventor and co-founder of Ethereum, discusses AI, techno-optimism, and the role of crypto in countering surveillance. They explore the dangers of rushing technology like AI, the importance of decentralized solutions, and the potential risks AI poses to humanity. They also touch upon crypto's role in privacy, defense, and fighting misinformation.

Jake is a Thiel Fellow and Founder of Pilgrim Labs⁠ where he is working on building biotechnology for warfighters. Previously, he was in high school (Jake is 19). Follow him on X @jakeradler. [0:16] - How Jake’s got into human-computer interfaces [7:52] - Transitioning a sleep wearables product into a biological interface for warfighters [15:16] - The current state of the consumer wearables market for sleep improvement [20:13] - The neurotech wearables landscape [24:09] - Pilgrim’s mission to merge wearable data with adaptive solutions for soldiers [29:55] - Why Jake chose to build products for human soldiers rather than machine warfare [36:23] - Becoming a Thiel fellow and lessons learned from the program [43:02] - Jake’s focus and mentality for building Pilgrim Labs For more episodes, go to ⁠⁠podofjake.com⁠⁠. Previous guests include ⁠⁠Mark Cuban⁠⁠, ⁠⁠Vitalik Buterin⁠⁠, ⁠⁠Brian Armstrong⁠⁠, ⁠⁠Balaji Srinivasan⁠⁠, ⁠⁠Keith⁠⁠ ⁠⁠Rabois⁠⁠, ⁠⁠Ali Spagnola⁠⁠, ⁠⁠Anthony Pompliano⁠⁠, ⁠⁠Raoul Pal⁠⁠, ⁠⁠Julia Galef⁠⁠, ⁠⁠Jack Butcher⁠⁠, ⁠⁠Tim Draper⁠⁠, and over 100 others alike. Learn from founders and CEOs of companies like ⁠⁠OpenAI⁠⁠, ⁠⁠Coinbase⁠⁠, ⁠⁠Solana⁠⁠, ⁠⁠Polygon⁠⁠, ⁠⁠AngelList⁠⁠⁠, ⁠⁠Oura⁠⁠⁠, and ⁠⁠Replit⁠⁠, and investors from ⁠⁠Founders⁠⁠ ⁠⁠Fund⁠⁠, ⁠⁠a16z⁠⁠, ⁠⁠Union Square Ventures⁠⁠, and many more. I appreciate your support and hope you enjoy. Thanks to ⁠⁠⁠Chase Devens⁠⁠⁠ for the show notes and ⁠⁠⁠Yiction⁠⁠⁠ for the music. Lastly, I love hearing from fans of the pod. Feel free to email me any time at ⁠⁠jake@blogofjake.com⁠⁠. Thank you!

Jim is a legendary investor and pioneer in the field of quantitative investing. He is the Founder & CEO of O’Shaughnessy Ventures (OSV). Prior to OSV, Jim was the Founder & CEO of O’Shaughnessy Asset Management (acquired by Franklin Templeton). He also hosts the Infinite Loops podcast and serves as the Executive Chair of the board of directors at Stability AI. Follow Jim on X @jposhaughnessy. [0:16] - How Jim kickstarted his career with “Invest Like the Best” [7:11] - Learning from mistakes [14:36] - Lessons learned from refusing a large acquisition offer [25:09] - How Jim listens to and learns from young people [31:28] - How O'Shaughnessy Fellowships empower techno-optimists [42:31] - Jim’s approach to investing in technological frontiers [51:17] - The career impact of starting a family at a young age For more episodes, go to ⁠⁠podofjake.com⁠⁠. Previous guests include ⁠⁠Mark Cuban⁠⁠, ⁠⁠Vitalik Buterin⁠⁠, ⁠⁠Brian Armstrong⁠⁠, ⁠⁠Balaji Srinivasan⁠⁠, ⁠⁠Keith⁠⁠ ⁠⁠Rabois⁠⁠, ⁠⁠Ali Spagnola⁠⁠, ⁠⁠Anthony Pompliano⁠⁠, ⁠⁠Raoul Pal⁠⁠, ⁠⁠Julia Galef⁠⁠, ⁠⁠Jack Butcher⁠⁠, ⁠⁠Tim Draper⁠⁠, and over 100 others alike. Learn from founders and CEOs of companies like ⁠⁠OpenAI⁠⁠, ⁠⁠Coinbase⁠⁠, ⁠⁠Solana⁠⁠, ⁠⁠Polygon⁠⁠, ⁠⁠AngelList⁠⁠⁠, ⁠⁠Oura⁠⁠⁠, and ⁠⁠Replit⁠⁠, and investors from ⁠⁠Founders⁠⁠ ⁠⁠Fund⁠⁠, ⁠⁠a16z⁠⁠, ⁠⁠Union Square Ventures⁠⁠, and many more. I appreciate your support and hope you enjoy. Thanks to ⁠⁠⁠Chase Devens⁠⁠⁠ for the show notes and ⁠⁠⁠Yiction⁠⁠⁠ for the music. Lastly, I love hearing from fans of the pod. Feel free to email me any time at ⁠⁠jake@blogofjake.com⁠⁠. Thank you!

Jules is the CEO of ⁠OTOY⁠, the definitive cloud graphics company, and founder of ⁠⁠Render Network (RNDR)⁠⁠, which facilitates distributed GPU rendering on the blockchain. He is a pioneer in computer graphics, streaming, and 3D rendering with more than 25 years of industry experience. Follow Jules on X @JulesUrbach. [0:16] - How Dragon's Lair and Star Trek sparked Jules’ career in computer graphics and rendering [7:15] - The potential for holograms and AR [14:43] - Why Jules remains hard at work in the same space he's been obsessed with since his teenage years [21:51] - Jules’ perspective on how the metaverse will manifest [33:36] - The importance of digital provenance in a generated future [40:14] - How the Render Network functions and enables an efficient, decentralized market for GPUs [49:24] - The future of RNDR For more episodes, go to ⁠⁠podofjake.com⁠⁠. Previous guests include ⁠⁠Mark Cuban⁠⁠, ⁠⁠Vitalik Buterin⁠⁠, ⁠⁠Brian Armstrong⁠⁠, ⁠⁠Balaji Srinivasan⁠⁠, ⁠⁠Keith⁠⁠ ⁠⁠Rabois⁠⁠, ⁠⁠Ali Spagnola⁠⁠, ⁠⁠Anthony Pompliano⁠⁠, ⁠⁠Raoul Pal⁠⁠, ⁠⁠Julia Galef⁠⁠, ⁠⁠Jack Butcher⁠⁠, ⁠⁠Tim Draper⁠⁠, and over 100 others alike. Learn from founders and CEOs of companies like ⁠⁠OpenAI⁠⁠, ⁠⁠Coinbase⁠⁠, ⁠⁠Solana⁠⁠, ⁠⁠Polygon⁠⁠, ⁠⁠AngelList⁠⁠⁠, ⁠⁠Oura⁠⁠⁠, and ⁠⁠Replit⁠⁠, and investors from ⁠⁠Founders⁠⁠ ⁠⁠Fund⁠⁠, ⁠⁠a16z⁠⁠, ⁠⁠Union Square Ventures⁠⁠, and many more. I appreciate your support and hope you enjoy. Thanks to ⁠⁠⁠Chase Devens⁠⁠⁠ for the show notes and ⁠⁠⁠Yiction⁠⁠⁠ for the music. Lastly, I love hearing from fans of the pod. Feel free to email me any time at ⁠⁠jake@blogofjake.com⁠⁠. Thank you!

Ana Lorena Fabrega, an edupreneur, discusses the flaws in traditional education systems, advocating for personalized learning approaches. She explores the evolution of education, the importance of making mistakes for learning, and the role of technology in improving education. Ana also talks about Synthesis' game-based approach to education and the use of AI tutors to augment kids' learning.

Ross is the Co-Founder, President and CEO of Gerber Kawasaki Wealth and Investment Management. He is well known for his investments in Tesla, Bitcoin, Nvidia, and Netflix and has become one of the most influential investors on social media and in traditional media. Follow Ross on X @GerberKawasaki. [0:16] - How Ross first got into investing when he was a kid [6:30] - The origin story of Gerber Kawasaki Wealth and Investment Management (GK) [13:06] - How GK is differentiated from other wealth management firms [20:48] - GK’s “index + alpha” investing strategy [30:44] - Ross’s outlook on Tesla [35:43] - Why Tesla needs advertising [40:10] - Ross’s conviction in Bitcoin as digital gold For more episodes, go to ⁠⁠podofjake.com⁠⁠. Previous guests include ⁠⁠Mark Cuban⁠⁠, ⁠⁠Vitalik Buterin⁠⁠, ⁠⁠Brian Armstrong⁠⁠, ⁠⁠Balaji Srinivasan⁠⁠, ⁠⁠Keith⁠⁠ ⁠⁠Rabois⁠⁠, ⁠⁠Ali Spagnola⁠⁠, ⁠⁠Anthony Pompliano⁠⁠, ⁠⁠Raoul Pal⁠⁠, ⁠⁠Julia Galef⁠⁠, ⁠⁠Jack Butcher⁠⁠, ⁠⁠Tim Draper⁠⁠, and over 100 others alike. Learn from founders and CEOs of companies like ⁠⁠OpenAI⁠⁠, ⁠⁠Coinbase⁠⁠, ⁠⁠Solana⁠⁠, ⁠⁠Polygon⁠⁠, ⁠⁠AngelList⁠⁠⁠, ⁠⁠Oura⁠⁠⁠, and ⁠⁠Replit⁠⁠, and investors from ⁠⁠Founders⁠⁠ ⁠⁠Fund⁠⁠, ⁠⁠a16z⁠⁠, ⁠⁠Union Square Ventures⁠⁠, and many more. I appreciate your support and hope you enjoy. Thanks to ⁠⁠⁠Chase Devens⁠⁠⁠ for the show notes and ⁠⁠⁠Yiction⁠⁠⁠ for the music. Lastly, I love hearing from fans of the pod. Feel free to email me any time at ⁠⁠jake@blogofjake.com⁠⁠. Thank you!

Phil Mohun, co-creator of Bright Moments, discusses his early interests in computers and blue collar entrepreneurship. He shares his perspective on the crypto industry and explains why he likes Farcaster. Phil also talks about managing social media and phone usage, his interest in generative art, and the three phases of in-person events at Bright Moments. He concludes by sharing other crypto sectors and industry ideas that excite him.

Alan Patricof is a venture capital pioneer. He has worked in the industry since 1970 when he founded Alan Patricof Associates later known as Apax. In 2006, Alan founded his second venture capital firm, Greycroft. Most recently, in 2020, Alan founded Primetime Partners at the age of 86. Alan was an early investor in Apple, AOL, New York Magazine, Audible, SunglassHut, Venmo, Huff Post, Axios, and many other successful startups. He recently released his memoir, No Red Lights. Follow Alan on X @alanjpatricof. For more episodes, go to ⁠⁠podofjake.com⁠⁠. Previous guests include ⁠⁠Mark Cuban⁠⁠, ⁠⁠Vitalik Buterin⁠⁠, ⁠⁠Brian Armstrong⁠⁠, ⁠⁠Balaji Srinivasan⁠⁠, ⁠⁠Keith⁠⁠ ⁠⁠Rabois⁠⁠, ⁠⁠Ali Spagnola⁠⁠, ⁠⁠Anthony Pompliano⁠⁠, ⁠⁠Raoul Pal⁠⁠, ⁠⁠Julia Galef⁠⁠, ⁠⁠Jack Butcher⁠⁠, ⁠⁠Tim Draper⁠⁠, and over 100 others alike. Learn from founders and CEOs of companies like ⁠⁠OpenAI⁠⁠, ⁠⁠Coinbase⁠⁠, ⁠⁠Solana⁠⁠, ⁠⁠Polygon⁠⁠, ⁠⁠AngelList⁠⁠⁠, ⁠⁠Oura⁠⁠⁠, and ⁠⁠Replit⁠⁠, and investors from ⁠⁠Founders⁠⁠ ⁠⁠Fund⁠⁠, ⁠⁠a16z⁠⁠, ⁠⁠Union Square Ventures⁠⁠, and many more. I appreciate your support and hope you enjoy. Thanks to ⁠⁠⁠Chase Devens⁠⁠⁠ for the show notes and ⁠⁠⁠Yiction⁠⁠⁠ for the music. Lastly, I love hearing from fans of the pod. Feel free to email me any time at ⁠⁠jake@blogofjake.com⁠⁠. Thank you!