Ashley Flowers, host of 'Crime Junkie,' chats with Rob Lowe about true crime cases, Caitlin Clark, and naming her company after her dog. They discuss ongoing trials, cult involvement in murder, memorable experiences in Indiana, and work-life balance tips. The conversation also covers OJ Simpson, aliens, and mysterious creatures, including Valiant Thor's alleged visit to Earth.

Conan O'Brien, Will Arnett, Jane Fonda, Billy Eichner, and Kristen Bell join Ted Danson and Woody Harrelson on their new podcast discussing reconnecting with old friends and making new ones. Guests share stories and insights in entertaining conversations, giving listeners a sneak peek into the fun and laughter that ensues.

VC investor, attorney, and fisherman Matthew Lowe joins Rob to discuss golfing with his mom Sheryl Lowe in Hawaii, appearing in 'The West Wing,' watching Dad’s movies as a family, 'Parks & Rec' suggestions, 'The Lowe Files' ghostly experiences, and future media predictions.

Wildlife biologist and outdoor adventurer Forrest Galante joins Rob Lowe to discuss rediscovering extinct animals, 'Shark Week' shoots, the real-life story behind 'Jaws', Rob's stingray sting, and suggestions for the next Netflix Roast recipient.

Comedian and podcaster Adam Carolla joins Rob Lowe to discuss odd jobs before showbiz, meeting Jimmy Kimmel, success in podcasting, love for woodshop class, and his new animated show, “Mr. Birchum.”

Legendary investor and entrepreneur Marc Andreessen joins Rob Lowe to discuss the future of TikTok in the U.S., three major ways AI will improve lives, Kenny G's photo trouble, secrets of the algorithm, his IBM internship, and more. They explore AI in professions like doctors and lawyers, the impact of social media algorithms, and the evolution of technology from Web 1.0 to Web 2.0.

Things get very silly when Thomas and Rob are together. Actor, writer, and comedian Thomas Lennon joins Rob Lowe to discuss the new Netflix film “Unfrosted,” receiving notes from Jerry Seinfeld, Thomas and Rob's ridiculous on-set jokes from the filming of “Monster Trucks,” getting fired gracefully, how studio lot parking spaces reveal your true standing in Hollywood, and much more.Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

Jeff and Rob both love performing drama AND comedy! Jeff Daniels joins Rob Lowe to discuss how working with Jim Carrey on “Dumb and Dumber” taught him fearlessness, committing to his thick accent in Netflix’s “A Man in Full,” his memories of the brilliant James Gandolfini, their experiences performing Aaron Sorkin dialogue, watching Shirley MacLaine and Debra Winger's process on "Terms of Endearment,” and why Jeff settled down in Michigan. Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

Rob is entering his 60s and committing to a better diet…with the help of the esteemed Dr. Mark Hyman! Dr. Mark Hyman (renowned physician, medical advisor to the Clintons, and the host of “The Doctor's Farmacy” podcast) joins Rob Lowe to discuss the Ozempic revolution, the real key to longevity, the obesity statistic that shocked Rob, what foods to avoid, and the easy-to-find snacks that just might help you live longer.  Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

Comedian, actor, and podcaster Paul Scheer joins Rob Lowe to discuss celebrity-owned restaurants, the “M*A*S*H” theme song, why the team behind “The League” decided to end the show while they were still on top, Rob’s traumatic childhood talent show memory, the greatest audition story ever, and Paul’s new memoir, “Joyful Recollections of Trauma.” Pre-order “Joyful Recollections of Trauma” now - out May 21st! Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!