Clinician's Roundtable

Guest: Sujith Cherian MD, FCCP, DAABIP With obesity rates rising to unprecedented levels, clinicians face critical challenges in managing associated complications. Hear from Dr. Sujith Cherian as he explores obesity’s systemic impact, from cardiovascular and infectious risks to medication dosing and hospital care complexities. Dr. Cherian is an Associate Professor in the Divisions of Critical Care, Pulmonary, and Sleep Medicine at University of Texas Health-McGovern Medical School. He also serves as the Director of Interventional Pulmonology and Pleural Diseases at Lyndon B. Johnson Hospital in Houston.

Guest: Sujith Cherian MD, FCCP, DAABIP Obesity introduces distinct changes to respiratory physiology that ripple across care settings—from subtle outpatient symptoms to complex ventilatory challenges in the ICU and heightened perioperative risks. Dr. Sujith Cherian explains real-world scenarios and physiologic insights to show how excess weight influences not just lung mechanics, but length of stay, postoperative recovery, and cardiopulmonary complications. Dr. Cherian is an Associate Professor in the Divisions of Critical Care, Pulmonary, and Sleep Medicine at University of Texas Health-McGovern Medical School. He also serves as the Director of Interventional Pulmonology and Pleural Diseases at Lyndon B. Johnson Hospital in Houston.

Guest: Peter Buch, MD, FACG, AGAF, FACP Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing liver health concern that's closely linked to obesity and other cardiometabolic risk factors, yet it remains underrecognized in clinical practice. That's why Dr. Peter Buch joins us to discuss how emerging perspectives are changing the way we think about metabolic-related liver disease. Dr. Buch is a board-certified clinical gastroenterologist and Associate Professor at the Frank H. Netter, MD School of Medicine at Quinnipiac University in Connecticut.

Host: Hallie Blevins, PhD A new preclinical study investigated whether Roseburia hominis, a gut microbe often depleted in individuals with obesity, could play a direct role in regulating metabolism. Learn more as Dr. Hallie Blevins explores these findings and their potential implications for future treatment of obesity and related metabolic disorders in this AudioAbstract.

Guest: Michael Greenberg, MD Host: Ryan Quigley What does it really mean to humanize medicine? In this candid conversation, Ryan Quigley and Dr. Michael Greenberg explore how clinicians can revive empathy, trust, and emotional connection in patient care, from intentional language shifts to brief yet meaningful moments of authentic connection. Dr. Greenberg is a dermatologist at the Illinois Dermatology Institute.

Host: Steve Jackson, PharmD Guest: Anna Miller, MD Guest: Michael Weaver, MD Timely surgical intervention is critical for reducing mortality and complications in high-risk hip fracture patients. However, anticoagulation therapy often presents barriers to prompt care, requiring careful coordination and clinical judgment. Joining Dr. Steve Jackson to discuss anticoagulant reversal strategies and multidisciplinary approaches for managing high-risk fracture patients are Drs. Anna Miller and Michael Weaver. Dr. Miller is a Professor of Orthopedics and the Chair of the Department of Orthopedics at Dartmouth-Hitchcock Medical Center and the Geisel School of Medicine at Dartmouth in Lebanon, New Hampshire. Dr. Weaver is an Associate Professor of Orthopedic Surgery at Harvard Medical School, as well as the Chief of Orthopedic Trauma and Distinguished Chair in Orthopedic Surgery at Brigham and Women's Hospital in Boston.

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Caterina Garone, MD, PhD What if a rare, progressive neuromuscular disease like thymidine kinase 2 deficiency (TK2d) could not only be stabilized, but partially reversed? Based on findings from a pooled analysis of pediatric patients, pyrimidine nucleoside or nucleotide therapy reduced mortality risk up to 95%, with nearly 75% of patients regaining at least one motor milestone. Joining Dr. Charles Turck to explore these survival and functional outcomes is Dr. Caterina Garone, Associate Professor of Medical Genetics in the Department of Medical and Surgical Sciences at the Alma Mater Studiorum University of Bologna in Italy.

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Philip Yeske, PhD Caring for individuals with thymidine kinase 2 (TK2) deficiency can place extraordinary demands on families, yet caregiver experiences are often overlooked in clinical care. To shed light on this burden, a mixed-methods study explored the physical, emotional, and financial impacts on caregivers. Here with Dr. Charles Turck to share the findings and how we can better support these families is Dr. Philip Yeske, the United Mitochondrial Disease Foundation Science and Alliance Officer.

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: John B. Hertig, PharmD, MS, CPPS, FASHP, FFIP From minimizing wrong-drug and dosing errors to easing cognitive burden in the OR, ready-to-administer (RTA) medications are enhancing both safety and efficiency in anesthesiology and perioperative care. Join Dr. Charles Turck and Dr. John Hertig as they explore key medication safety challenges, compare FDA-approved versus 503B compounded products, and share strategies for effectively integrating RTA medications into clinical workflows. Dr. Hertig is a member of both the Board of Directors for the Alliance for Safe Online Pharmacies and the U.S. Food and Drug Administration Drug Safety and Risk Management Advisory Committee.

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Cristina Domínguez González, MD, PhD How fast does thymidine kinase 2 deficiency (TK2d) progress without intervention? That’s the question explored by the largest dataset to date on untreated pediatric-onset TK2d, and the results reveal a median survival of just 2.6 years from symptom onset. Additionally, more than 80% lost at least one motor milestone, and many experienced escalating care needs, including ventilatory and feeding tube support. Here with Dr. Charles Turck to discuss the findings that highlight the urgent need for earlier diagnosis and intervention is Dr. Cristina Dominguez-Gonzalez, a physician in the Department of Neurology at the University Hospital 12 de Octubre in Madrid.