The Swyx Mixtape

From Lex Fridman: https://lexfridman.com/demis-hassabis/Transcripts from Karpathy's https://karpathy.ai/lexicap/0299-large.htmllink | 00:37:13.160 So let's go to the basic building blocks of biologylink | 00:37:16.960 that I think is another angle at which you can startlink | 00:37:20.200 to understand the human mind, the human body,link | 00:37:22.280 which is quite fascinating,link | 00:37:23.400 which is from the basic building blocks,link | 00:37:26.640 start to simulate, start to modellink | 00:37:28.960 how from those building blocks,link | 00:37:30.480 you can construct bigger and bigger, more complex systems,link | 00:37:33.080 maybe one day the entirety of the human biology.link | 00:37:35.820 So here's another problem that thoughtlink | 00:37:39.680 to be impossible to solve, which is protein folding.link | 00:37:42.720 And Alpha Fold or specifically Alpha Fold 2 did just that.link | 00:37:48.840 It solved protein folding.link | 00:37:50.320 I think it's one of the biggest breakthroughs,link | 00:37:53.400 certainly in the history of structural biology,link | 00:37:55.140 but in general in science,link | 00:38:00.240 maybe from a high level, what is it and how does it work?link | 00:38:04.840 And then we can ask some fascinating questions after.link | 00:38:08.700 Sure.link | 00:38:09.980 So maybe to explain it to people not familiarlink | 00:38:12.880 with protein folding is, you know,link | 00:38:14.400 first of all, explain proteins, which is, you know,link | 00:38:16.980 proteins are essential to all life.link | 00:38:18.840 Every function in your body depends on proteins.link | 00:38:21.520 Sometimes they're called the workhorses of biology.link | 00:38:23.920 And if you look into them and I've, you know,link | 00:38:25.340 obviously as part of Alpha Fold,link | 00:38:26.660 I've been researching proteins and structural biologylink | 00:38:30.200 for the last few years, you know,link | 00:38:31.760 they're amazing little bio nano machines proteins.link | 00:38:34.760 They're incredible if you actually watch little videoslink | 00:38:36.460 of how they work, animations of how they work.link | 00:38:39.000 And proteins are specified by their genetic sequencelink | 00:38:42.600 called the amino acid sequence.link |

Listen: https://twitter.com/sourcegraph/status/1577687896814911488Steve's post about Sourcegraph: https://about.sourcegraph.com/blog/introducing-steve-yeggehttps://www.youtube.com/watch?v=viNB7v3bgx8

Watch/listen: https://www.youtube.com/watch?v=a5vkE7mmWJ0

Listen to 3 Books: https://www.3books.co/chapters/111 (about 1hr 20mins in)5 hour walks: https://www.youtube.com/watch?v=mp_MKrnSdaM&list=PLbsKh5N-eR063R9VopWCM_SZ5ccxhNGLm&index=26

Listen to Colin & Samir: https://overcast.fm/+6Z2pphyiU/25:00

Listen to Lenny's pod: https://www.listennotes.com/podcasts/lennys-podcast/growth-tactics-retention-M7Vx8YjC0Ei/

Listen to MFM: https://overcast.fm/+rTsWDbyUc/10:04PG's essay http://paulgraham.com/fn.htmlHN response: https://news.ycombinator.com/item?id=27194284

Listen to Cloudcast: https://www.thecloudcast.net/2022/01/2022-look-ahead-developer-careers.htmlSHOW NOTES:Shawn’s homepageTemporal.io (homepage) - open source microservice orchestrationLearning in Public - The Coding Career HandbookThe Coding Career (community)Topic 1 - Welcome to the show. You seem to be at the center of (or around) so many developer-centric conversations. Tell us a little bit about your background, and some of the areas you’ve been focused on. Topic 2 - You’re well known for The Coding Career Handbook. With so many options out there for developers, how do you frame conversations about where people should focus? Topic 3 - At some point, developers (like many engineers) get bored of working on the same things. Right now it seems like we’re in the middle of big changes. What should they think about the transition process? Cloud distros https://www.swyx.io/cloud-distros/Self provisioning runtimes https://www.swyx.io/self-provisioning-runtime/ Video in DevRel https://sacra.com/research/lenny-bogdanoff-milk-video-infrastructure/?highlight=ecommerce Topic 4 - As a developer, what are some of the best ways to get visibility of your projects? How do you find the right balance of public projects, side projects, and whatever you’re currently getting paid for (main company job)?Topic 5 - Any tips or tricks that you’ve learned to accelerate your learning process? Topic 6 - How is WFH changing the developer work-life-balance?

2017 Why Hadoop is Dying: https://www.youtube.com/watch?v=QngDInV2ino2020 Hadoop Death Roundtable: https://www.listennotes.com/podcasts/the-on-premise-it/hadoop-is-dead-the-on-PuYEm57yaqZ/

Watch the presentaiton: https://www.youtube.com/watch?v=9s-vSeWej1UWatch the followup: https://www.youtube.com/watch?v=MfF750YVDxM