Joy Milne, a Scottish retiree, possesses a rare ability to smell Parkinson's disease, which she first detected in her husband, Les. Their emotional journey sheds light on the profound impact of the condition and highlights Joy’s unique role in advancing early diagnosis research. The discussion delves into how olfactory clues could revolutionize medical diagnostics, linking scent to disease in a way that opens new possibilities in healthcare. Joy's remarkable story not only uncovers the mysteries of smell but also emphasizes the challenges faced by caregivers.

Senator James Lankford, a United States Senator from Oklahoma and former Baptist youth minister, dives into the political hurdles that thwarted his immigration bill. He shares insights on how Trump's rhetoric reshaped GOP dynamics and explores the balance between security and moral considerations in immigration policy. Lankford reflects on the interplay of personal faith and political responsibility, emphasizing the importance of dialogue in a divided landscape while preparing for the future of the party beyond Trump.

Jonathan Abrams, a New York Times reporter specializing in sports and culture, breaks down the history and significance of breaking’s Olympic debut. He discusses how this dance form, born in the 1970s Bronx, reflects the cultural empowerment of marginalized youth. Abrams also explores the excitement and skepticism surrounding its Olympic inclusion, particularly how it might impact the identity of breaking as an art form. The conversation highlights key figures, the evolution of breaking into a competitive sport, and the balance between authenticity and global appeal.

The podcast dives into Kamala Harris's campaign strategies as she seeks to unite the Democratic Party and engage uncertain voters in swing states like Wisconsin. It highlights her efforts to build a new coalition, contrasting her approach with that of Joe Biden. Listeners hear about grassroots mobilization, especially among former Republicans, and the challenges in appealing to key demographics. The show captures the atmosphere of the campaign office, filled with both anxiety and hope, and features candid conversations with voters expressing skepticism and their concerns.

Ernesto Londoño, a seasoned reporter for The New York Times in Minnesota, delves into the surprising rise of Governor Tim Walz as Vice President Kamala Harris's running mate. He discusses Walz's journey from a geography teacher to a prominent gubernatorial figure known for his progressive policies. Londoño explores the strategic implications of this choice for the campaign, highlighting Walz's appeal to both moderate and liberal voters. The conversation also touches on the challenges and dynamics he faces as the election approaches.

Jeanna Smialek, a New York Times reporter focused on the Federal Reserve and U.S. economy, dives into the recent dramatic downturn in stock markets. She explains how fears of recession and rising interest rates dismantled investor confidence. The conversation touches on critical economic indicators, the Fed's policies, and the ripple effects of government actions during the pandemic. Jeanna also discusses the intricate link between economics and politics, revealing how decisions made today shape the economic landscape for the future.

Sofia Nelson, a public defender in Detroit and a former classmate of JD Vance at Yale Law School, shares the story of their once-close friendship that unraveled over political differences. She reveals how their bond shifted drastically as Vance embraced more aggressive stances and became a polarizing figure. Nelson discusses their emotional email exchanges, reflecting on the challenges of maintaining a friendship amidst diverging beliefs. The conversation dives into the larger implications of political discourse and the fragility of relationships in a polarized world.

Dive into the world of online dating after 50, where heartbreak meets hope. Discover the journey of those re-entering the dating scene after long marriages. Explore how resilience shapes their romantic adventures, and the freedom they find in meaningful connections. Personal stories unravel the humor and challenges faced, as they navigate societal expectations and desires for intimacy. Experience a fresh perspective that celebrates love, authenticity, and the joy of companionship at any age.

Joining the discussion is Vince Vaughn, a beloved actor known for his comedic roles in classics like Old School and Wedding Crashers, as well as more serious performances. He dives deep into the evolution of R-rated comedies, addressing the impact of cultural shifts on storytelling. Vaughn shares insights on the balancing act of personal struggles and success, emphasizing empathy in relationships. The conversation also touches on the complexities of loss, love, and how parenting can transform perspectives, leaving listeners with heartfelt reflections and a glimpse into his upcoming project.

Jim Rutenberg, a writer at large for The New York Times, dives deep into the power struggles within the Murdoch family. He reveals how Rupert Murdoch’s secret changes to his succession plan triggered fierce rivalries among his children. The podcast discusses shifts in editorial control at Fox News, emphasizing a push for responsible journalism alongside conservative values. Tensions between brothers James and Lachlan are examined, alongside the legal troubles facing their media empire that cast a shadow on the future of journalism.