Behind the Breakthroughs
Inside Precision Medicine
Join host Jonathan D. Grinstein, PhD, North American Editor for Inside Precision Medicine, as he uncovers the stories behind the pioneers driving the precision medicine revolution. Behind the Breakthroughs features candid interviews with seasoned veterans and rising stars, exploring their origin stories and groundbreaking contributions advancing the frontiers of patient diagnosis, treatment, and care.In every episode, Jonathan goes beyond the science, diving deep into the personal and professional journeys of those striving to make these incredible new therapies more equitable and accessible globally. You'll discover how emerging technologies in molecular diagnostics, next-generation sequencing, genetic medicines (e.g., cell and gene therapies), and AI/ML are transforming treatment and bringing precision medicine closer to the forefront of healthcare. Whether you’re a researcher at a large pharma company or small biotech startup, a clinician at a major health system or community setting, a laboratory technician in the clinic or academia, an investor at a premier or venture capital firm, or just interested in the latest in medicine and healthcare, these interviews will inspire and inform you about personalized medicine's future. Hosted on Acast. See acast.com/privacy for more information.
Episodes
Mentioned books
Nov 21, 2024 • 34min
Michael Severino: Towards In Vivo Genome Editing of Humans
Michael Severino, MD, discusses the approaches for developing "genome writers" at Tessera Therapeutics, where he joined as CEO in 2022, and the advantages of performing in vivo genome editing over ex vivo approaches. Severino explains where the company is in utilizing its genome writing platform to perform edits in vivo on its journey toward the clinic.Stay up to date with the latest episodes of Behind the Breakthroughs by subscribing to the IPM eNewsletter here.Produced by Bill LevineHosted by Jonathan D. Grinstein, PhDMusic provided by Artem HramushkinAudio mixed and mastered by Jason Mack Hosted on Acast. See acast.com/privacy for more information.
Nov 13, 2024 • 27min
Jane Gibson: AMP and Molecular Diagnostics’ Existential Crisis
This special edition episode for the upcoming Association for Molecular Pathology (AMP) annual meeting in Vancouver, Jane Gibson, PhD, opens up the dialogue about how the evolving field of molecular pathology is taking on major challenges, including how the FDA’s ruling on laboratory developed tests (LDTs) is affecting clinical labs. Dr. Gibson is a Professor of Pathology at the University of Central Florida, Editor-in-chief of Genetic Testing and Molecular Biomarkers, and President Elect of AMP.Stay up to date with the latest episodes of Behind the Breakthroughs by subscribing to the IPM eNewsletter here.Produced by Bill LevineHosted by Jonathan D. Grinstein, PhDMusic provided by Artem HramushkinAudio mixed and mastered by Jason Mack Hosted on Acast. See acast.com/privacy for more information.
Oct 30, 2024 • 30min
Helen Sabzevari: How to Turn $1,000,000 CAR Ts into “Real” Precision Medicines
Helen Sabzevari, PhD, President and CEO of Precigen, discusses the barriers to implementing cell and gene therapies that impede the accessibility and implementation of these precision medicines. Dr. Sabzevari also explains how key cell and gene therapy platforms and tools can provide safety measures, such as guardrails to cellular toxicity, and address cost by offering “off-the-shelf” efficient gene delivery vectors that can be used on-site, cutting out centralized manufacturing.Stay up to date with the latest episodes of Behind the Breakthroughs by subscribing to the IPM eNewsletter here.Produced by Bill LevineHosted by Jonathan D. Grinstein, PhDMusic provided by Artem HramushkinAudio mixed and mastered by Jason Mack Hosted on Acast. See acast.com/privacy for more information.
Oct 25, 2024 • 17min
Luca Quagliata: Weaving Genomic Profiling into Personalized Cancer Care
Luca Quagliata, PhD, global head of medical affairs for clinical NGS and oncology at Thermo Fisher Scientific, shares how his career has been intertwined with precision medicine, beginning with his time as a student in Italy during the early 2000s. Quagliata examines the significance of genomic profiling within the cancer care continuum, outlining the essential steps and touchpoints necessary to ensure the accessibility of personalized oncology treatment for all individuals. Stay up to date with the latest episodes of Behind the Breakthroughs by subscribing to the IPM eNewsletter here.7Q4XKpRvPIvPZPkK6RbZProduced by Bill LevineHosted by Jonathan D. Grinstein, PhDMusic provided by Artem HramushkinAudio mixed and mastered by Jason Mack Hosted on Acast. See acast.com/privacy for more information.
Oct 17, 2024 • 35min
Geoff Oxnard: The Tipping Point for Adopting Precision Medicine
In the premiere episode of Behind the Breakthroughs, Geoff Oxnard, MD, VP of Clinical Development at Lilly and a Thoracic Oncologist at Boston Medical Center, shares his journey in precision medicine, beginning with his introduction to genetic testing as a Medical Oncology Fellow at Memorial Sloan-Kettering Cancer Center and as an academic researcher. Oxnard discusses how differences in impact and reach influenced his decision to move from academia to industry. He also explains how the adoption of precision testing in the United States is influenced by perspective rather than accessibility. This episode also covers flexible enrollment in clinical trials, adapting to patient perspectives on clinical research as care, the current state of precision medicine, particularly precision oncology, in the United States and elsewhere, and more. Stay up to date with the latest episodes of Behind the Breakthroughs by subscribing to the IPM eNewsletter here.Produced by Bill LevineHosted by Jonathan D. Grinstein, PhDMusic provided by Artem HramushkinAudio mixed and mastered by Jason Mack Hosted on Acast. See acast.com/privacy for more information.
