Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt  Plenty more at https://chrismasterjohnphd.com/support! Question: Vitamin K and Clotting Risk When Not on Anticoagulants There's essentially not a trade-off because if you're not on vitamin K antagonist anticoagulants; in theory, there shouldn't be any effect of vitamin K supplements on clotting at all. The one caveat to that is that you might be relatively vitamin K deficient now and not realize it. So it is within possibility that you're not meeting your own personal vitamin K requirement to maximize clotting, but that's very, very unlikely because in population studies, almost no one falls into this category. But if that were true, then essentially, vitamin K supplementation would bring you up to a normal level of clotting, which may or may not affect the cardiologist's assessment of whether you should be on anticoagulants.  If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here.

Question: Do some people do well on ketosis because they have defective glucose metabolism?I doubt that that's the majority of people that feel good in ketosis, but certainly people with GLUT1 defects need to be on a low-glycemic index diet at least, if not a keto diet in order to not have seizures, and that's the best example of what would fit with that. People who do poorly with glucose, maybe in more moderate ways are going to do better on fat. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here.

Question: What to do when different folate markers don’t line upYou know, if you have high figlu on the NutrEval, which is Formiminoglutamic acid, which rises when there is Tetrahydrofolate THF, unmethylated folate, to metabolize figlu, and in that case, I would be thinking about maybe you have a B12 deficiency that is leading to the trapping of folate as the methylfolate form, so that THF isn't regenerated for that reaction. So I would absolutely never use figlu as the only marker of folate. I would look at serum folate and red blood cell folate always as the first markers of folate. So in this case, I would look at your serum folate and your red blood cell folate. So before I would get folate injections, I would be looking at all those markers to see whether there's a coherent story between all of them that are agreeing that your folate status is low despite supplements, versus a divergence story between them that is telling me that one form of folate is the one that's missing rather than a total folate. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here.

Question: Can sulforaphane hurt the thyroid?What I can say is that sulforaphane does generate thiocyanate ions, which do inhibit uptake of iodine into the thyroid and mammary glands. Although that is a matter of the ratio between isothiocyanate, or between thiocyanate ions and iodine. And so in principle, most uses of sulforaphane, in the context of adequate iodine shouldn't be an issue. I believe at some dose you're going to run into a problem with balancing with iodine, especially in people who have marginal iodine status, but I don't have any studies to back up what point that is. But I have seen cases of people where they got brain fog when they were taking sulforaphane and it went away when they took iodine.If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here.

Question: Are the PUFAs in phosphatidylcholine supplements a concern?I don't think so. I think that you're looking at fairly low levels of PUFAs in there, but the way that I see it is yes, we want to restrict PUFA beyond what's needed, but what's needed is defined by what do we need to get our essential nutrients in. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here.

Question: Is dairy safe for overmethylators?There's so little methylcobalamin in milk that I think that it is totally insignificant with regards to methyl groups, coming into the methylation cycle. Generally, if you're experiencing over-methylation symptoms from methylcobalamin or methylfolate, I think the big issue is partly that you don't have enough glycine in the system, very likely, and partly that your body is over-accustomed to low methyl supply and putting more suddenly into it leading into the system being adapted to a different state than the one you're putting into it. But if you find it is, you're reacting to dairy, I would be very surprised if it was the methylcobalamin, but if you're very convinced of that, then titrate up slowly with the dairy.If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here.

Question: Should different macronutrients be eaten at different times of day?No, I don't agree with the principle. I think you want protein spaced out at every meal. And that's because your efficiency in extracting protein for muscle synthesis is limited in any given hour or any given unit time. And so you need a lot more protein if you're going to put all your protein in one meal, then you are not going to get optimal body composition results from that. Body composition plays into every other metabolic thing we care about. If I were to shift protein around in emphasis, I would put protein bias towards the morning and biased away from night. And that would be on the basis that protein is the basis for every single neurotransmitter involved in wakefulness. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here.

Question: Is it OK to take two milligrams a day of MK-4?Two milligrams, I don't have major safety concerns over, but I would prefer for most people who aren't dealing with a clinical soft-tissue calcification issue take more like 200 micrograms. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here.

Question: How to feel great on a poor night’s sleep?I would say get rid of the poor night's sleep. And so that's go through the checklist of two to four hours of blue light blocking before bed, up to two to four hour, depending on your needs, psychological winding down routine, in which you clear everything off your to-do list, everything off your problem-solving list, focus on a paperback fiction, TV, video games, movies, et cetera. Deal with all those things first, because I don't think there is any magical one-off cure for poor night's sleep. And then if cold exposure helps, then that tells me that boosting norepinephrine is what's helping. So how do you boost norepinephrine? There's a lot of micronutrients involved in norepinephrine synthesis. So vitamin C, copper, salt, lots of things come into play, antioxidants that is. Cold exposure, maca root, coffee are probably the biggest things that you could use. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here.

Question: What supplements should be taken by someone on PPIs?I would first consider what you should do to get off the PPI. And so PPIs Are targeting stomach acid. And so I would first and foremost be thinking of excess histamine might be leading to excess stomach acid. You should probably try to eat a higher-protein diet, unless you're getting negative consequences from poor protein digestion. But if you're poorly digesting your protein, you are going to need more protein to nourish yourself. So I would think a higher protein diet and a multivitamin would really be the best things because there's too many nutrients whose absorption is going to be compromised by that. And then I don't really consider myself a gut specialist, but I would read up on what other people who are specializing in the gut are saying about how to compensate for PPI's with the microbiome, because I would think that would also come into play. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here.