Sci Guys

Explore the intriguing connection between ADHD and the gut microbiome, unveiling the complexities and myths surrounding this neurodevelopmental disorder. Dive into humorous anecdotes about societal perceptions, the role of dopamine in task completion, and how gut health impacts mental well-being. Discover the gut-brain axis and its influence on emotions alongside witty exchanges about microbial mischief. With light-hearted banter, the hosts navigate serious scientific discussions while keeping the audience engaged and entertained.

Narcissistic Personality Disorder is one of the most maligned and misunderstood of mental conditions, so this week we're dipping our toes into the science behind the disorder! Check out Noah’s music: https://tr.ee/f9DikNPhdQ You can WATCH the podcast over on our YouTube channel Help keep the show running by supporting us on Patreon! If you'd like to see more of us, follow our socials! sciguys.co.uk TikTok Twitter Instagram Facebook If you spot any points that need correcting, head to sciguys.co.uk/corrections Follow the Sci Guys @notcorry / @lukecutforth References & Further Reading https://openpsychometrics.org/tests/NPI/1.php https://openpsychometrics.org/tests/NPI/1.php https://www.ncbi.nlm.nih.gov/books/NBK556001/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819598/ https://www.uchicagomedicine.org/forefront/research-and-discoveries-articles/study-shows-narcissistic-personality-disorder-may-have-a-biological-component https://www.scientificamerican.com/article/what-is-narcissism-science-confronts-a-widely-misunderstood-phenomenon1/ https://www.google.com/search?gs_ssp=eJzj4tVP1zc0zDIpSSrJKy4wYPQSLU7OTM1LTlXIT1PISyxKziwuzizOBQDxCQ0z&q=science+of+narcissism&rlz=1C5CHFA_enGB727GB727&oq=science+of+narciss&gs_lcrp=EgZjaHJvbWUqBwgBEC4YgAQyCggAEAAY4wIYgAQyBwgBEC4YgAQyBggCEEUYOTIHCAMQABiABDIICAQQABgWGB4yCAgFEAAYFhgeMggIBhAAGBYYHjIGCAcQRRg90gEINDI5M2owajeoAgCwAgA&sourceid=chrome&ie=UTF-8 https://pubmed.ncbi.nlm.nih.gov/?term=narcissism&sort=pubdate https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2014.14060723 https://www.britannica.com/science/narcissism/Narcissistic-pathology-and-behaviour https://www.mind.org.uk/information-support/types-of-mental-health-problems/personality-disorders/types-of-personality-disorder/#NarcissisticPersonalityDisorder https://www.mayoclinic.org/diseases-conditions/narcissistic-personality-disorder/symptoms-causes/syc-20366662 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735512/

What is depression? If you're a listener there's a solid chance you already know, but there's also a good chance you'll listen anyway... You can WATCH the podcast over on our YouTube channel Help keep the show running by supporting us on Patreon! If you'd like to see more of us, follow our socials! sciguys.co.uk TikTok Twitter Instagram Facebook If you spot any points that need correcting, head to sciguys.co.uk/corrections Follow the Sci Guys @notcorry / @lukecutforth References & Further Reading https://www.who.int/news-room/fact-sheets/detail/depression https://www.nimh.nih.gov/health/publications/depression https://www.nhs.uk/mental-health/conditions/depression-in-adults/overview/ https://www.nimh.nih.gov/health/topics/depression https://www.mind.org.uk/information-support/types-of-mental-health-problems/depression/causes/ https://icd.who.int/browse/2024-01/mms/en#1563440232 https://cks.nice.org.uk/topics/depression/diagnosis/assessment/ https://www.sciencenews.org/article/chemical-imbalance-explain-depression https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/mentalhealth/articles/costoflivinganddepressioninadultsgreatbritain/29septemberto23october2022 https://www.cdc.gov/aging/depression/index.html https://www.nimh.nih.gov/health/publications/depression-in-women https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646325/

Feeling worried? This week we're diving into the topic of Generalised Anxiety Disorder... You can WATCH the podcast over on our YouTube channel Help keep the show running by supporting us on Patreon! If you'd like to see more of us, follow our socials! sciguys.co.uk TikTok Twitter Instagram Facebook If you spot any points that need correcting, head to sciguys.co.uk/corrections Follow the Sci Guys @notcorry / @lukecutforth References & Further Reading https://www.nhs.uk/mental-health/conditions/generalised-anxiety-disorder/overview/ https://www.nimh.nih.gov/health/publications/generalized-anxiety-disorder-gad https://www.mind.org.uk/information-support/types-of-mental-health-problems/anxiety-and-panic-attacks/anxiety-disorders/ https://www.ncbi.nlm.nih.gov/books/NBK441870/ https://cks.nice.org.uk/topics/generalized-anxiety-disorder/diagnosis/diagnosis/ https://www.nhs.uk/mental-health/conditions/panic-disorder/

Check out Noah’s music! Massive thanks to Evan for vision mixing and keeping us relatively sane: https://youtube.com/evan You can WATCH the podcast over on our YouTube channel Help keep the show running by supporting us on Patreon! If you'd like to see more of us, follow our socials! sciguys.co.uk TikTok Twitter Instagram Facebook If you spot any points that need correcting, head to sciguys.co.uk/corrections Follow the Sci Guys @notcorry / @lukecutforth References & Further Reading Background https://www.cancer.gov/publications/dictionaries/cancer-terms/def/double-blind-study https://www.rcpch.ac.uk/about-us/our-team/dr-hilary-cass https://www.theguardian.com/society/2024/apr/18/hilary-cass-report-and-the-trans-rights-debate https://www.theguardian.com/society/2024/apr/20/doctor-hilary-cass-warned-of-threats-to-safety-after-vile-abuse-over-nhs-gender-services-review https://www.youtube.com/watch?v=aeY1BkCxwoI Puberty Blockers https://tavistockandportman.nhs.uk/news/early-intervention-study-shows-puberty-blockers-are-a-well-received-intervention-in-carefully-selected-patients/ https://pubmed.ncbi.nlm.nih.gov/33529227/ https://www.plannedparenthood.org/learn/teens/puberty/what-are-puberty-blockers https://www.scientificamerican.com/article/what-are-puberty-blockers-and-how-do-they-work/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793415/ https://www.nytimes.com/2021/05/11/well/family/what-are-puberty-blockers.html https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218488 https://www.ncbi.nlm.nih.gov/books/NBK547863/ https://ncbi.nlm.nih.gov/pmc/articles/PMC9577333/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344188/ https://www.ncbi.nlm.nih.gov/books/NBK551662/ https://www.nejm.org/doi/full/10.1056/NEJM198112243052602 https://wayback.archive-it.org/7993/20170112031859/http:/www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm209842.htm Cass Review https://cass.independent-review.uk/ https://cass.independent-review.uk/home/publications/final-report/ file:///Users/notcorry/Desktop/CassReview_Final.pdf https://www.england.nhs.uk/commissioning/spec-services/npc-crg/gender-dysphoria-clinical-programme/implementing-advice-from-the-cass-review/ Criticisms https://www.youtube.com/watch?v=qGZ1Gfu7XXw https://www.thepinknews.com/2022/11/03/tavistock-experts-criticise-acp-uk/ https://www.advocate.com/health/hilary-cass-nhs-report-debunked https://stonewall.org.uk/cass-review https://www.equalityhumanrights.com/statement-final-report-cass-review

The 5th anniversary of Sci Guys means it’s high time we spoke about marijuana. Literally… It’s high time. Check out Noah’s music: https://tr.ee/f9DikNPhdQ Massive thanks to Evan for vision mixing and keeping us relatively sane: https://youtube.com/evan You can WATCH the podcast over on our YouTube channel Help keep the show running by supporting us on Patreon! If you'd like to see more of us, follow our socials! sciguys.co.uk TikTok Twitter Instagram Facebook If you spot any points that need correcting, head to sciguys.co.uk/corrections Follow the Sci Guys @notcorry / @lukecutforth References & Further Reading Cannabis Background & Basics Cannabis | WHO https://www.who.int/teams/mental-health-and-substance-use/alcohol-drugs-and-addictive-behaviours/drugs-psychoactive/cannabis Marijuana | History, Effects, THC, & Legality | Britannica https://www.britannica.com/science/marijuana Hashish | Cannabis, THC, Intoxication | Britannica https://www.britannica.com/science/hashish Cannabis (Marijuana) DrugFacts | National Institute on Drug Abuse (NIDA) https://nida.nih.gov/publications/drugfacts/cannabis-marijuana What We Know About Marijuana https://www.cdc.gov/marijuana/what-we-know.html The Name of Cannabis: A Short Guide for Nonbotanists - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531363/ Hemp | Description, Products, Seeds, Fiber, & Uses | Britannica https://www.britannica.com/plant/hemp Marijuana and the Brain - How Marijuana Works | HowStuffWorks https://science.howstuffworks.com/marijuana3.htm Legality of cannabis - Wikipedia https://en.wikipedia.org/wiki/Legality_of_cannabis History of Cannabis History of cannabis and the endocannabinoid system - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605027/ On the Preparations of the Indian Hemp, or Gunjah (Cannabis Indica), Their Effects on the Animal System in Health, and Their Utility in the Treatment of Tetanus and Other Convulsive Diseases https://pubmed.ncbi.nlm.nih.gov/30161735/ Oldest evidence of marijuana use discovered in 2500-year-old cemetery in peaks of western China | Science https://www.science.org/content/article/oldest-evidence-marijuana-use-discovered-2500-year-old-cemetery-peaks-western-china Effects of Cannabis Use Adverse Health Effects of Marijuana Use - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827335/ Use of Marijuana: Effect on Brain Health: A Scientific Statement From the American Heart Association https://pubmed.ncbi.nlm.nih.gov/35142225/ Edible marijuana products and potential risks for pediatric populations https://pubmed.ncbi.nlm.nih.gov/35634702/ The Scientific History of Cannabinoids | Science| Smithsonian Magazine https://www.smithsonianmag.com/science-nature/the-scientific-history-of-cannabinoids-180981561/ Health Effects | Marijuana | CDC https://www.cdc.gov/marijuana/health-effects/index.html How does marijuana affect the brain? Psychological researchers examine impact on different age groups over time https://www.apa.org/monitor/2023/06/marijuana-effects-brain Can cannabis kill? Characteristics of deaths following cannabis use in England (1998–2020) - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716494 https://www.cancer.org/cancer/managing-cancer/treatment-types/complementary-and-integrative-medicine/marijuana-and-cancer.html https://www.dea.gov/drug-information/drug-scheduling

You can WATCH the podcast over on our YouTube channel Help keep the show running by supporting us on Patreon! If you'd like to see more of us, follow our socials! sciguys.co.uk TikTok Twitter Instagram Facebook If you spot any points that need correcting, head to sciguys.co.uk/corrections Follow the Sci Guys @notcorry / @lukecutforth References & Further Reading https://www.britannica.com/science/fungus https://www.britannica.com/science/fungus https://pubmed.ncbi.nlm.nih.gov/22887928/ https://www.britannica.com/science/sclerotium https://science.howstuffworks.com/magic-mushroom6.htm https://www.dea.gov/sites/default/files/2020-06/Psilocybin-2020_0.pdf https://science.howstuffworks.com/magic-mushroom6.htm https://www.canada.ca/en/health-canada/services/substance-use/controlled-illegal-drugs/magic-mushrooms.html https://asm.org/articles/2023/february/psilocybin-and-mental-health-the-magic-in-the-mush https://adf.org.au/drug-facts/psilocybin/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277578/ https://idp.nature.com/authorize?response_type=cookie&client_id=grover&redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41598-020-59282-y https://www.standard.co.uk/news/health/trial-magic-mushrooms-psilocybin-depression-maudsley-hospital-london-b1120423.html https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901083/ https://adf.org.au/insights/magic-mushrooms-medicine/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007659/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156539/ https://www.theguardian.com/society/2023/dec/14/magic-mushroom-use-grows-in-england-and-wales-ons-figures-show https://www.amsterdam.info/drugs/ https://en.wikipedia.org/wiki/Legal_status_of_psilocybin_mushrooms

This week we're talking about Molly, and Mandy, or whatever woman's name you want to call MDMA... You can WATCH the podcast over on our YouTube channel Help keep the show running by supporting us on Patreon! If you'd like to see more of us, follow our socials! sciguys.co.uk TikTok Twitter Instagram Facebook If you spot any points that need correcting, head to sciguys.co.uk/corrections Follow the Sci Guys @notcorry / @lukecutforth References & Further Reading https://www.history.com/topics/crime/history-of-mdma https://nida.nih.gov/publications/research-reports/mdma-ecstasy-abuse/what-are-mdmas-effects-on-brain https://nida.nih.gov/publications/research-reports/mdma-ecstasy-abuse/what-are-mdmas-effects-on-brain https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878040/ https://www.youtube.com/watch?v=jEAr7ThsYew https://www.ncbi.nlm.nih.gov/books/NBK538482/ https://www.hopkinsmedicine.org/news/newsroom/news-releases/2019/04/psychedelic-drug-mdma-may-reawaken-critical-period-in-brain-to-help-treat-ptsd https://pubmed.ncbi.nlm.nih.gov/34708874/ https://www.nature.com/articles/s41591-021-01336-3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820588/ https://pubmed.ncbi.nlm.nih.gov/24006318/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639540/ https://www.ncbi.nlm.nih.gov/books/NBK482377/

People are using a diabetes drug to lose weight, but does it actually owrk? Are there any risks? Should we even be using drugs for fat loss at all? You can WATCH the podcast over on our YouTube channel Help keep the show running by supporting us on Patreon! If you'd like to see more of us, follow our socials! sciguys.co.uk TikTok Twitter Instagram Facebook If you spot any points that need correcting, head to sciguys.co.uk/corrections Follow the Sci Guys @notcorry / @lukecutforth References & Further Reading https://www.ncbi.nlm.nih.gov/books/NBK562269/ https://healthmedia.blog.gov.uk/2023/09/04/accessing-wegovy-for-weight-loss-everything-you-need-to-know/ https://tspace.library.utoronto.ca/bitstream/1807/129409/2/AMED.2023.9946924.pdf https://www.ncbi.nlm.nih.gov/books/NBK551568/ https://health.ucdavis.edu/blog/cultivating-health/ozempic-for-weight-loss-does-it-work-and-what-do-experts-recommend/2023/07 https://www.diabetes.org.uk/about-us/news-and-views/ozempic-and-weight-loss-facts-behind-headlines https://www.nytimes.com/2022/11/22/well/ozempic-diabetes-weight-loss.html https://pubmed.ncbi.nlm.nih.gov/38300808/ https://pubmed.ncbi.nlm.nih.gov/38230266/ https://www.nice.org.uk/guidance/ta875/chapter/2-Information-about-semaglutide https://www.youtube.com/watch?v=laPaezEsteI https://www.who.int/health-topics/obesity#tab=tab_3 https://www.nhs.uk/conditions/obesity/ https://www.niddk.nih.gov/health-information/diabetes/overview/what-is-diabetes/type-2-diabetes https://www.nhs.uk/conditions/type-2-diabetes/symptoms/ https://www.pewresearch.org/science/2024/02/26/how-americans-view-weight-loss-drugs-and-their-potential-impact-on-obesity-in-the-u-s/ https://medlineplus.gov/druginfo/meds/a618008.html https://www.nhs.uk/conditions/type-1-diabetes/about-type-1-diabetes/what-is-type-1-diabetes/

Use code SCIGUYS at the link below to get an exclusive 60% off an annual Incogni plan: https://incogni.com/SCIGUYS Alexithymia is the inability to understand or recognise emotions, so this week Noah joins us to talk about his feelings... You can WATCH the podcast over on our YouTube channel Help keep the show running by supporting us on Patreon! If you'd like to see more of us, follow our socials! sciguys.co.uk TikTok Twitter Instagram Facebook If you spot any points that need correcting, head to sciguys.co.uk/corrections Follow the Sci Guys @notcorry / @lukecutforth References & Further Reading https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456171/ https://www.bbc.co.uk/news/uk-england-suffolk-64253360 https://neuro.psychiatryonline.org/doi/10.1176/appi.neuropsych.14070169 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056680/ https://www.britannica.com/science/emotion/The-structure-of-emotions https://www.sciencefocus.com/the-human-body/what-are-emotions https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005782/