
Training Data
Join us as we train our neural nets on the theme of the century: AI. Sonya Huang, Pat Grady and more Sequoia Capital partners host conversations with leading AI builders and researchers to ask critical questions and develop a deeper understanding of the evolving technologies—and their implications for technology, business and society.The content of this podcast does not constitute investment advice, an offer to provide investment advisory services, or an offer to sell or solicitation of an offer to buy an interest in any investment fund.
Latest episodes

124 snips
May 6, 2025 • 48min
Workday CEO Carl Eschenbach: Building the System of Record for the AI Era
Carl Eschenbach, CEO of Workday and former Sequoia partner, shares insights on evolving workplace dynamics as AI becomes integral to operations. He discusses a three-pronged monetization strategy for AI, emphasizing domain-specific agents over general models. Eschenbach highlights the importance of a collaborative environment between human workers and AI, assuring that job displacement fears can be mitigated. He also touches on innovative recruitment strategies powered by AI, advocating for a skills-based approach while preserving human judgment.

84 snips
Apr 29, 2025 • 56min
The Quest to ‘Solve All Diseases’ with AI: Isomorphic Labs’ Max Jaderberg
Max Jaderberg, Chief AI Officer of Isomorphic Labs and former DeepMind pioneer, discusses revolutionary advancements in drug discovery with AI. He highlights AlphaFold 3's potential to redefine molecular understanding and predicts we are nearing a 'Move 37 moment', where AI can surpass human intuition in drug design. Jaderberg envisions general AI capable of solving all diseases, emphasizing the need for innovative agents to navigate the vast potential of molecular designs, revolutionizing both biology and pharmacology.

264 snips
Apr 22, 2025 • 45min
Pricing in the AI Era: From Inputs to Outcomes, with Paid CEO Manny Medina
Manny Medina, former Outreach CEO and founder of Paid, shares insights on pricing for AI companies with a focus on unit economics. He argues that traditional SaaS models fail in the AI realm, advocating for outcome-based and agent-based pricing strategies. Manny emphasizes the success of niche AI applications over broad platforms and discusses the critical need for AI firms to refine their understanding of profitability. He also highlights the importance of quality customer focus and innovative company culture in driving growth.

116 snips
Apr 15, 2025 • 58min
Arc Institute's Patrick Hsu on Building an App Store for Biology with AI
Patrick Hsu, co-founder of Arc Institute and a pioneer in genome editing and CRISPR technologies, shares insights on merging AI with biology. He discusses Evo 2, a groundbreaking model that analyzes genomic data to identify disease-causing mutations and design new biological systems. Patrick highlights the transformative potential of AI in drug discovery, emphasizing collaboration between academia and industry. He also explores the gut-brain connection and advocates for holistic health approaches, illustrating how AI can personalize medicine and enhance wellness.

226 snips
Apr 8, 2025 • 1h 26min
Replit CEO Amjad Masad on 1 Billion Developers: A Better End State than AGI?
Amjad Masad, the CEO and founder of Replit, a platform empowering a billion software creators, dives into his vision of accessible programming for all. He discusses how LLMs could revolutionize the developer landscape, enhancing productivity and social impact. Masad shares his journey from programming in Jordan to leading a tech company in Silicon Valley. He also reflects on the delicate balance of innovative management and the importance of diverse talent in tech. The conversation touches on the optimistic potential of AI, emphasizing empowerment over replacement.

167 snips
Apr 1, 2025 • 1h 11min
Why CRM Needs an AI Revolution, with Day.ai Founder Christopher O’Donnell
Christopher O’Donnell, Founder of Day.ai and former Chief Product Officer at HubSpot, discusses the transformative power of AI in CRM. He shares insights on overcoming common CRM issues like data silos and complex workflows. O’Donnell explains how Day.ai's approach captures customer context effortlessly, enhancing user engagement. He reflects on building HubSpot’s CRM, emphasizing the need for a careful, quality-focused development process. The conversation highlights revolutionary strategies and the ethical considerations in AI-driven product evolution.

202 snips
Mar 25, 2025 • 43min
From Software Engineers to AI Word Artisans: Filip Kozera of Wordware
Filip Kozera, co-founder of Wordware, inspires a new generation of 'word artisans' by bridging human creativity and AI development. He draws fascinating parallels between Excel's democratization of data analytics and Wordware's mission. The discussion dives into using natural language as a programming tool, emphasizing effective communication to enhance AI control. Filip envisions a future where unstructured data fosters creativity, and tools like Lovable and Gemini enhance productivity. Excitingly, he hints at innovations like the Limitless pendant for personalized AI experiences.

184 snips
Mar 18, 2025 • 51min
Josh Woodward: Google Labs is Rapidly Building AI Products from 0-to-1
Josh Woodward, VP of Google Labs, leads teams at the forefront of AI innovation. He discusses the rapid development of tools, with AI now writing 25% of Google’s code. Woodward emphasizes the need for taste and design in AI products and the importance of evolving coding practices this year. Key topics include transforming video generation through models like Veo 2, exploring human-computer interaction with Project Mariner, and the optimistic future where costs of AI solutions will dramatically decrease, enhancing creativity and productivity.

159 snips
Mar 11, 2025 • 54min
How AI Breakout Harvey is Transforming Legal Services, with CEO Winston Weinberg
Winston Weinberg, Co-founder and CEO of Harvey, brings his expertise in legal AI to the forefront. He discusses the necessity of deep process knowledge for success in legal tech, beyond just powerful models. Weinberg details how Harvey fosters trust with law firms through tailored demos and focuses on complex tasks like international mergers. The conversation dives into the role of AI in reshaping legal practices, enhancing access to services, and the urgent need for innovation in the industry.

120 snips
Mar 4, 2025 • 1h 5min
The AI Product Going Viral With Doctors: OpenEvidence, with CEO Daniel Nadler
Daniel Nadler, CEO and co-founder of OpenEvidence, discusses his revolutionary AI-powered medical knowledge platform designed to aid doctors in real-time. He highlights how smaller, specialized AI models can outperform larger ones in healthcare applications. The conversation covers the app's rapid adoption—growing from 1,000 to over 100,000 users in a year—and its role in democratizing access to medical information. Nadler also emphasizes the significance of accurate, transparent AI in healthcare, and the beneficial partnerships with publishers to improve patient outcomes.
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