This discussion features Bill Gates, co-founder of Microsoft and philanthropy pioneer, known for his transformative impact on technology and global health. Gates shares hilarious anecdotes about the early days of personal computing and discusses the journey from tech mogul to a global health advocate. He delves into the role of AI in accelerating medical breakthroughs and the importance of addressing global health disparities. Amid serious topics, he emphasizes enjoying simple pleasures like Reese's Peanut Butter Cups, reminding us that joy can be found in everyday delights.

Ariana Grande, the incredibly talented singer, actress, and businesswoman, shares her captivating journey through music and film. She talks about her unique vocal training techniques and blends humor with heartfelt anecdotes about her transition from acting to music. Ariana dives into the challenges of fame, discussing the importance of authenticity and genuine connections. The playful chat also touches on quirky habits, dietary preferences, and the unexpected joy found in spontaneity, making for an entertaining and insightful conversation.

Join Jesse Eisenberg, acclaimed actor and writer known for his roles in The Social Network and Zombieland, as he dives into a whirlwind of intriguing discussions. He playfully explores the art of 'businesstry' and shares hilarious anecdotes about magic, anthropology, and the quirks of social networks. Eisenberg reflects on his creative journey, revealing insights about the filmmaking process and the complexities of human relationships in the digital age. This candid conversation is packed with humor and thoughtful commentary that keeps you engaged throughout.

In this delightful conversation, Tig Notaro, a celebrated comedian and actress, shares her journey from managing bands to stand-up comedy, revealing her early fears and first performances. She brings humor to her challenges acting in 'Army of the Dead' alongside imaginary zombies. The dialogue also dances through spontaneous improv moments and nostalgic memories, while Tig's whimsical tales of helicopter flying and playful banter add charm. Their laughter-filled reflections on life, love, and community make for an engaging and heartwarming discussion.

Join Peter Berg, the talented director and actor renowned for his work on 'Friday Night Lights' and 'Lone Survivor.' He shares insights into his transformation from a struggling actor to a successful filmmaker. Discover his unique approach to storytelling, emphasizing authenticity and deep cultural research. Berg also humorously discusses the chaotic world of filmmaking, the thrill of casting, and the creative flow that performers experience. With a special nod to his upcoming project 'American Primeval,' it’s a lively dive into the art of cinema!

Selena Gomez, a multi-talented Grammy and Emmy-nominated musician and actress known for her roles in Wizards of Waverly Place and Only Murders in the Building, shares her journey in a delightful conversation. She discusses her nostalgic experiences at Disney and her surprising transition into music. Selena also opens up about balancing her acting and music careers, her philanthropic efforts with UNICEF, and the importance of mental health discussions. Enjoy her amusing takes on pet ownership, her morning routine, and the funny quirks of fame.

Jason Blum, a renowned film producer and founder of Blumhouse Productions, shares his journey in the film industry, stressing resilience in both real estate and movie production. He discusses the evolving landscape of horror films, the importance of audience reactions, and the challenges of working with major studios. The conversation also touches on upcoming releases like 'Black Phone 2' and 'Five Nights at Freddy's 2', while blending humor with insights about the qualities needed for success in the competitive film world.

Luis Elizondo, former director of the Pentagon's Advanced Aerospace Threat Identification Program, dives deep into the world of Unidentified Aerial Phenomena (UAPs). He discusses the challenges of government transparency, the implications of advanced technologies, and rising UFO sightings shared by pilots. Elizondo reflects on societal indifference towards UAPs and explores provocative questions about humanity's response to the unknown. With a mix of humor and insight, he showcases how these phenomena could unify us or reshape our understanding of reality.

Conan O'Brien, renowned comedian and television host, shares light-hearted tales with the hosts. They kick off the holiday season with playful banter about cookies and festive plans. Nostalgia hits as they recount hilarious past parties and the nuances of invitations. The discussion shifts to the magic of in-person interviews, peppered with entertaining anecdotes. The atmosphere grows warmer with shared memories of Christmas mishaps and relationship dynamics, highlighting their close-knit camaraderie and the joy of collaboration.

Kieran Culkin, known for his roles in "Succession" and "Scott Pilgrim vs. the World," joins the hosts for a lively discussion. They dive into the hilarity of theater mishaps, including auditioning with food poisoning. Kieran shares anecdotes about balancing parenthood with a demanding career and opens up about navigating insecurities in the entertainment industry. The conversation also touches on the quirks of family dynamics in a famous acting clan. With humor and nostalgia, they explore the ups and downs of life in showbiz.