Finding Genius Podcast

Vivek Jha, a nephrologist for over 35 years, discusses kidney function, acute and chronic kidney disease, and efforts to bring better treatments to disadvantaged communities. He explores the connections between kidney health and other organ systems, the role of kidneys in blood pressure regulation, and the impact of chronic dehydration on kidney health. Jha emphasizes the need for global education and research on kidney disease.

Amy Waterman directs the Transplant Research and Education Center at UCLA. She works with patients navigating any disease of the kidney and helps educate them on corresponding choices, from dialysis treatment to getting on a transplant list. She discusses: How the general process works as a patient enters their center, from considering treatment options to seeking a donor, What the statistics are in the donor-transplant relationship and the range of donor options, and How the physical process works for transplantation and what are risk factors compared to the dialysis process. In addition to directing the Transplant Center, Amy D. Waterman is a Professor in Residence at the University of California in Los Angeles in the division of nephrology. She's a psychologist with an expertise on managing patient behavior toward healthy goals. At the center, she works alongside nephrologists and other professionals to guide patents through choices and the complicated process of facing kidney disease. She researches and tests methods that might help educate and engage patients and evaluates how to work more effectively with providers. online pharmacy buy neurontin over the counter online pharmacy She describes for listeners the process a patient moves through, from typical questions they have to choices they can make, and for those that need a transplant, how to enter into searches for a donation from family members to strangers to someone who has passed away. She adds that there is a donor contingent called non-directed donors. online pharmacy buy singulair over the counter online pharmacy These are strangers who step forward and offer a kidney as a living donor. online pharmacy buy clomiphene over the counter online pharmacy In fact, over 6,000 living people donate a kidney each year. Dr. Waterman also describes the physical process of donation, what might be in the works for kidney disease cures, and how she became involved with this important work in the first place.  Find out more about her work at exploretransplant.org or explorelivingdonation.org. Available on Apple Podcasts: apple.co/2Os0myK

Without glycogen, we couldn't go very far. Dr. Sullivan is a specialist in the glycogen molecule, which stores glucose, our energy source. In this podcast, he describes exciting discoveries and future research centered on glycogen presence that might help explain the connection between diabetes and kidney disease. Listen and hear answers to these questions and more: How does diabetes affect the kidneys? How do glycogen molecules differ in the liver of diabetic patients and why is that important? buy symbicort online buy symbicort over the counter online pharmacy What does glycogen do to the kidney that might lead to diabetic kidney disease stages? Mitchell Sullivan is pursuing a postdoc at the University of Queensland in a group that investigates glycation, diabetes, and how diabetic bodily systems handle extra glucose. Dr. Sullivan in particular follows glycogen formation in the organs. He's just setting out on a new study connecting diabetes and kidney health by focusing on glycogen presence in the kidneys of diabetics. Normally, glycogen is in the liver and muscle tissue, waiting to supply us with different kinds of energy needs. buy fildena online buy fildena over the counter online pharmacy But microscopy shows glycogen in the kidneys of diabetic patients that likely leads to damage and inflammation. The findings may lead to better therapeutics and prevention measures, from a more effective diabetes and kidney disease diet to medical interventions. buy aciphex online buy aciphex over the counter online pharmacy Listeners will have the privilege of hearing straight from Dr. Mitchell the hypothesis for this study that's just begun. He explains with clarity why the structure of this glycogen in diabetic kidneys differs from its normal form and is significantly insoluble in this form. Furthermore, it sticks together in clumps of starch-like granules in the thick ascending limb of the nephron. He's investigating if these cells that aren't accustomated to glycogen become overwhelmed and the glycogen gets stuck, leading to damage and inflammation that make for one of the common kidney failure causes. What's most interesting is that his PhD work on glycogen in the liver and muscle tissue of diabetics makes this hypothesis seem more likely. Listen in to hear why that's the case and more about this study that might bring scientists that much closer to improving diabetes and kidney health. To find out more about Dr. Mitchell's work, search his name in research aggregates, see his information page with Queensland University, and feel free to email him: mitchell.sullivan@mater.uq.edu.au. Available on Apple Podcasts: apple.co/2Os0myK

While chronic kidney disease diagnosis is rare in children, its effects are profound. Furthermore, there's so much scientists don't know about kidney function. Keia Sanderson is hoping to change that. She specializes in chronic kidney disease treatment in pediatric patients and discusses avenues to advance treatment and prevention. This podcast gives her the perfect platform to explain How kidney disease is especially challenging to identity in children because chronic kidney disease stages are often asymptomatic in pediatric patients, Why preterm babies are vulnerable to certain conditions because of the development timing of the nephrons, and Why it's important to identity intervention measures before dialysis and kidney transplantation provide the only recourse. Keia Sanderson, MD, is an assistant professor of medicine in the Division of Nephrology and Hypertension at the University of North Carolina School of Medicine. Her job is a mix of teaching, clinical work, and research. In her clinical work, she takes care of children with kidney disease at all stages, including kids who receive transplants. Her current research is focused on kidney outcomes in children with complex medical histories, in particular children who've been born prematurely. She says that the challenge is oftentimes the asymptomatic nature of kidney disease in children. Therefore, she and other clinicians are often meeting kids with disease states that are irreversible and are turning toward dialysis treatment and transplantation.  Dr. Sanderson gives listeners a special focus on the risks from preterm birth. Because preterm babies tend to have less nephron development, the nephrons that are present have to work overtime and are subject to hyper filtration. But because doctors have been able to identify this as a critical time, they are looking at ways to better manage preterm infant treatment. For example, what medications are they receiving that could affect kidney development? How are we feeding infants in this active development stage? How are we handling their oxygenation? While a clear pathway is not yet evident, she is hopeful she and other researches will find one. Currently, she's hoping to develop mathematical models to make better predications about the risk levels for different babies. For more information, see the UNC Kidney Center, the National Kidney Foundation, and talk to your primary doctor. Available on Apple Podcasts: apple.co/2Os0myK 

An implantable bioartificial kidney system that does what dialysis can’t do; this is what’s being developed as part of The Kidney Project at University of California, San Francisco and Vanderbilt University. Press play to learn: How healthy kidneys function, and what dialysis does What causes the symptoms associated with advanced kidney failure What to consider in terms of the tradeoff between a kidney transplant and the need for immunosuppressants, and a bioartificial kidney and no need for immunosuppressants Lynda Frassetto is Professor Emeritus of Medicine in the Division of Nephrology at the University of California, San Francisco. She spends some of her time taking care of nephrology patients, and some of her time working with William Fissell, MD and Shuvo Roy, PhD, who lead The Kidney Project. Dialysis can keep patients alive by filtering toxins out of the blood, which is what healthy kidneys do. But what happens to the fluid after it’s been filtered? In healthy bodies, the fluid goes through kidney tubules, where it responds to chemical signals which might dictate that more water or salt be resorbed, and/or that more creatinine, phosphorus, urea, or other acids be removed. After the toxins have been filtered, the fluid is subjected to the feedback systems of the body, which is essential to keeping the body’s water and chemical levels where they should be. This is something that dialysis simply cannot accomplish, but it’s not too great a task for the artificial system being created; this system has renal tubular cells, so it can keep the body’s water and chemistry levels in check, which translates to better quality of life for patients. Press play for the details of all this and more, including where in the body it is placed, how it stacks up against transplanted kidneys in terms of normal kidney function, when it might receive FDA approval for testing in humans, and what the first clinical trials will look like. Available on Apple Podcasts: apple.co/2Os0myK

In this episode, we sit down with David Selman of Savvy Organics Farm to discuss modern homesteading, sustainable living, organic gardening, and more… Started by David and his wife Alice, Savvy Organics Farm is a modern homestead that produces health-centered, sustainable, regenerative farm-to-table foods. Leading by example, they want to show others that living a simpler, sustainable, regenerative lifestyle in our present-day society is possible. Both David and Alice have experienced health issues over the years, leading to their distrust of modern medicine and commercial farming. By taking their health and nutrition into their own hands, they have created a lifestyle that is not dependent on the global food and medical systems – resulting in a healthier and more sustainable way of life. Join the discussion now to find out: How to begin homesteading over time.  The biggest health benefits associated with eating farm-to-table food.  How to tailor your gardening to your climate.  You can learn more about David and his work with Savvy Organics Farm by clicking here! Episode also available on Apple Podcast: http://apple.co/30PvU9C

How do soil health and compost impact plant growth? What if there was a way to get nutrient-rich soil designed to enhance your garden? Jeremy Silva, the founder of BuildASoil, joins us to explain how his company curates natural ingredients from around the world to help consumers grow sustainably and efficiently… BuildASoil is a website that provides handmade, small-batch, custom soils to growers across the country. Using the highest quality products and free education, Jeremy and his team are on a mission to help living soil enthusiasts achieve the best results possible for their gardens – all at a reasonable price. In this conversation, we cover: What it takes to create healthy soil. How to test soil for different nutrients.  The role that soil texture plays in plant growth.  To uncover more about BuildASoil, click here now! Episode also available on Apple Podcast: http://apple.co/30PvU9C

In this episode, we are joined by Dr. Rebecca Larson, a postdoctoral research associate in RIT's School of Physics and Astronomy. As an astronomer who studies galaxies from the early Universe, Dr. Larson wants to discover how those galaxies – and the Universe itself – evolved into what we see today. Astronomers across the globe are utilizing the groundbreaking power of the James Webb Telescope. How are experts like Dr. Larson reshaping our understanding of astronomy using this cutting-edge technology? Jump in now to uncover the fascinating history of our Universe… Click play to learn more about: What makes the James Webb Telescope so powerful. What the phenomenon of “Redshift” is, and what it tells us about the evolution of our Universe.  How galactic images are painting a more detailed picture of our Universe. You can find out more about Dr. Larson and her research here! Episode also available on Apple Podcast: http://apple.co/30PvU9C

This episode offers listeners an expert view on diabetes and kidney damage treatments. Richard interviews researcher David J. online pharmacy https://doctorsquarters.com/wp-content/themes/twentytwentytwo/inc/patterns/php/cymbalta.html no prescriptionLeehey, who has focused on diabetic kidney disease for the last 30 years. Listeners will learn: What types of cells make up the kidney and how diabetic kidney disease stages progresses through these cells, How hemodynamic factors, like blood pressure, also contribute to kidney stress, and What drugs are making headway as effective treatment and what advances are needed.   Diabetes' prevalence has made it the most common cause of kidney disease. How does diabetes affect the kidneys? Professor David Leehey has the answers and catches listeners up with the latest in effective medications and discusses the lagging technology of dialysis. He's a nephrologist, professor, and Medical Director of Acute Dialysis at Loyola University. He's also the Associate Chief of Staff of Clinical Affairs of Hines VA in Illinois. Dr. Leehey presents various pathways to kidney disease that necessitate dialysis and kidney transplantation with an emphasis on the primary cause of diabetes.  He explains exactly how high blood sugar creates the complications that lead to disease. He tells listeners to think of it like caramel formation—glucose molecules becomes large glycated molecules that get incorporated into base membranes of glomeruli, which are important to the filtering process. A characteristic pathology is therefore thickening of these membranes from the glycated proteins that accumulate. online pharmacy https://doctorsquarters.com/wp-content/themes/twentytwentytwo/inc/patterns/php/strattera.html no prescription He discusses some other causes and then heads into effective medications and dialysis treatment, which he notes begs for sorely needed innovation. online pharmacy https://doctorsquarters.com/wp-content/themes/twentytwentytwo/inc/patterns/php/aciphex.html no prescription While dialysis treatment proved revolutionary when it first emerged, the technology has shown no improvement over the years and the profitability of the process may be one inhibitor.  For more about Dr. Leehey, see his information on Loyola's web page: loyolamedicine.org/doctor/david-leehey. Available on Apple Podcasts: apple.co/2Os0myK

The kidney may be one of the most underestimated organs: it’s incredibly complex, and responsible for five to seven key functions in the body. In addition to producing urine and removing toxins from the blood, it regulates blood pressure, produces hormones, protects the body’s immune system, and controls blood pH levels. When kidneys fail, all of these functions are lost. Press play to discover: How an organoid differs from a bioartificial organ like the kidney being developed as part of The Kidney Project In what ways the approach taken by The Kidney Project fundamentally differs from other approaches to the treatment of kidney failure What’s needed in order to get this artificial kidney in clinical trials, and when it might be available to patients Shuvo Roy is a professor of bioengineering at UCSF whose work is centered around the development of a surgically implantable bioartificial kidney capable of providing constant treatment to patients who are currently on dialysis, and eventually performing all of the functions of a natural kidney. Roy’s work is part of The Kidney Project, which is a national effort to improve the lives of those with kidney failure. While dialysis can act as a proxy for the kidney in filtering the blood, it does not provide the other functions nearly as well as a natural kidney. To date, no one has been able to replicate a human kidney capable of performing all of the functions of a natural kidney, but that’s the goal of Roy’s work. First, the artificial kidney will combine a mechanical filter made from silicon wafers, and cadaver kidney cells to provide mechanical filtration, produce important hormones, and perform other key functions of the proximal tubule, such as salt and water reabsorption. This will liberate people from the necessity of going to a dialysis center multiple times a week, allow them to eat and drink freely, and enhance the overall quality of their lives. As the device enters the clinical realm, the technology will be further refined to eventually capture all of the functions of a natural kidney. Roy dives into the details of all this and more, including the specific benefits of artificial organs, microfabrication technology and applications, and the manufacturing and engineering processes of medical devices like the artificial kidney. Learn more at https://pharm.ucsf.edu/kidney. Available on Apple Podcasts: apple.co/2Os0myK