Finding Genius Podcast

Nearly 200 million metric tons of production come from global aquaculture and fisheries combined. Dr. Bill McGraw discusses the science, strategy, and logistics behind it all. Tune in to learn: The difference between aquaponics and aquaculture Why salmon are particularly hard to grow in aquaculture systems The many (and surprising) applications of seaweeds        Why there is a threat of blue-green algae contamination in catfish Returning guest, Dr. Bill McGraw, joins the show to discuss an area of his expertise: zeo water exchange and disease free aquaculture systems. He explains how they work, what they produce, and the most recent global trends in the field. He also discusses the billion-dollar US catfishing industry, GMO salmon, shrimp aquaculture and how it’s connected to vibrio bacteria, SPF (specific pathogen free) status and shrimp culture in places around the world, the importance of biosecurity in aquaculture, the problem of mislabeling seafood (and what you need to know if you’re a consumer), polyculture, and much more. Press play and learn more about Dr. McGraw’s work by visiting https://www.newaquatechpanama.com/. Episode also available on Apple Podcasts: apple.co/30PvU9C

How can bacteria that have become resistant to treatment be overcome? Using genome engineering may be the technique that allows treatment to overcome the infection once again. Press play to learn: How bacteria become resistant How the virome reacts to gaining resistance How bacteria avoid the immune system Gaetan Burgio, a group leader of the Burgio Group as a part of Australia National University, shares his experience working with AMR bacteria. Some bacteria may build resistance to any treatments or antibiotics over time through mutation or other genomic changes. However, CRISPR techniques have allowed researchers to pinpoint how a bacterium is resistant and alter it at a genomic level. By evaluating how these bacteria have become resistant and how the microbiome changes, we can determine how various phages affect virulence. Evading the immune system is the primary mode of resistance, and by lowering virulence, it will remain undetected within the body, avoiding an immune reaction. Search for @GaetanBurgio on Twitter for more information. Episode also available on Apple Podcasts: apple.co/30PvU9C

Is there something in the water? Or are there many different types of things in the water, depending on the source and location of the water…? Explore the answer, and learn: What factors are impacting the chemical profile of your water How the team at Hydroviv is able to customize water filters for specific customers Why testing a sample of water in a given area or home isn’t the best method for determining which contaminants are present “Water across the United States is different, and we believe at Hydroviv that the filter should actually match the water,” says CEO, Eric Roy. He elaborates on how significant these differences are, and why. It’s a labor-intensive task, but Hydroviv is doing it: Every time a customer submits an order through their website, a team of scientists begins investigating the water that is consumed by that specific customer, and building point-of-use filters that are optimized for it. Customers are pleased—almost universally so. Visit https://www.hydroviv.com/  to get one of your own. Episode also available on Apple Podcasts: apple.co/30PvU9C

A cure for cancer exists, says Dr. Bill McGraw, who also says he knows this to be true because he’s been curing it in countless patients for years, with a 95% success rate. Tune in for his insights, and learn: How specific frequencies have the ability to shatter glass, and the medical implications of this What a Rife machine is and how it works What the Béchamp theory of disease transmission is, and why it’s worth a closer look What happened when the American Medical Association discovered the findings of Dr. Raymond Royal Rife The first person to ever see a live virus using a microscope is also, quite possibly, the first person to have discovered a true cure for cancer and many other diseases. His name was Royal Raymond Rife, a bacteriologist who carried out groundbreaking work in the 1920s and onwards, but whose research has been largely suppressed, and sometimes even ridiculed. Dr. Bill McGraw shares with listeners the details of Dr. Rife’s work—namely the incredible potential of frequencies in treating and curing disease. He explains what the Rife machine is, how it was developed, how it has been used historically, and how he uses it on himself and his patients.  Interested in learning more? Press play; this isn’t one to miss. Learn more at https://www.newaquatechpanama.com/ and https://www.spooky2-mall.com/.   Episode also available on Apple Podcasts: apple.co/30PvU9C

Where is that smell coming from?! It’s a question we’ve probably all exclaimed before tracking down the culprit…whether or not we want to. Scent detection is an important ability, but do we really understand how it even works? Press play to discover: How jet streams and the movement of people and animals through the atmosphere influence our sense of smell How a better understanding of scent dispersal and detection could aid in the development of olfaction-based technologies What reality would be like if it matched up with simple mathematical models of scent detection Gerard McCaul is a postdoctoral research fellow at Tulane University who's taken on a side project on olfaction—the sense of smell. He set out to determine what really enables scent tracking, and whether simple mathematical models, such as a pure diffusion model, can really account for it. Unlike hearing and sight, the sense of smell is not well understood or described by mathematical modeling; diffusion simply can’t explain the ability to detect and track down the source of odors. In fact, McCaul explains that, in order to find the source of an odor in a diffusive model, we’d basically have to be right on top of it. Clearly, this doesn’t match up with reality—with a dog’s ability to track scents located miles away, with a shark’s ability to detect a drop of blood in a great body of water, or with our own ability to, for example, follow the scent of freshly-baked cookies to the bakery a block or two away. So, what gives? McCaul sheds light on the absolutely necessary atmospheric and environmental pieces to the puzzle of scent tracking. Tune in for all the details, and check out the paper on the topic, titled “Diffusion Fails to Make a Stink”. Episode also available on Apple Podcasts: apple.co/30PvU9C

How can latent viruses in your body transform into cancer over time? Research shows that while many people have a virus known to cause cancer within them, only some individuals will ever be affected. Press play to learn: How cancer-causing viruses can be detected If you have a latent virus within you How cancer cells react to viral infection Patrick S. Moore, MD, MPH, and distinguished professor at PITT, shares his research on cancer-causing viruses and viral replication. While there are only a small number of viruses with the potential to transform into cancer within the human body, the forms they cause constitute around 18% of cancer in the world. Some viruses are even present in close to 95% of the population. Targeting specific pathways in cells that are also responsible for controlling tumor growth may make a previously healthy cell prone to developing cancer. While this poses a risk, it also may lead to new therapeutic techniques to slow the spread around the body. To learn more, visit https://www.tumorvirology.pitt.edu. Episode also available on Apple Podcasts: apple.co/30PvU9C

How can theoretical physics give researchers new insight into cancer progression? By opening the zeitgeist of methodology, new understanding may be gained. Listen up to learn: How the generation of new tumors is enhanced How epigenetic conditions arise How the body regulates mutations Herbert Levine, University Distinguished Professor at Northeastern University, shares his work applying the ideals from physics to cancer research. Viewing the evolution of tumors as they grow with principles used in theoretical physics research, new analytics can be gained to hone and improve our understanding of cancer. By understanding how cell states function within various tumors, a unique view of metastasis can be achieved. Cancer may arise as a forced adaptation from cells exposed to stressors over time, though most cancer may still arise from pure mutational events. Metastasis is the deadly part of cancer due to the infection of various other parts of the body and the increased resistance to existing treatments. More information can be found at https://ctbp.rice.edu. Episode also available on Apple Podcasts: apple.co/30PvU9C

The #1 killer in the world is heart disease—it doesn’t matter who you are or where you live, this killer doesn’t discriminate. But does it have a code? And could it be cracked with the right technology? Tune in to discover: Why all of our cells would burst without cholesterol, but what happens when there’s too much of it How CRISPR/Cas9 technology could hold the key to permanently low cholesterol levels (without the need for injections or pills), and a cure for sickle cell anemia What lipid nanoparticles are, how they can be used to deliver genes to specific organs in the body, and why this is significant Dr. Kiran Musunuru is a cardiologist, professor of medicine, and director of the Genetic and Epigenetic Origins of Disease Program at Perelman School of Medicine, University of Pennsylvania. As the leading cause of death globally, he believes heart disease is the preeminent global health threat of the 21st century, and the greatest challenge facing the medical profession today. And this is driving him to take action. Dr. Musunuru explains that, despite immense efforts put forth by some of the brightest scientists and doctors over the course of decades, treatment options for heart disease remain limited, mostly to cholesterol-lowering drugs. But he also explains how this is changing in light of the more recent revolution in genetics—namely, the completion of the Human Genome Project. What’s the genetic difference between those who develop heart disease and those who don’t?   What genes influence heart health and disease, and could therapies based on this information prevent heart disease altogether? These are the types of questions that Dr. Musunuru says can now be answered, and he’s doing just that. Listeners will learn about the genetics behind heart disease and cholesterol levels, the details of Dr. Musunuru’s research and most recent findings, what the future of heart disease treatment and prevention might hold, and much more. Learn more at https://www.med.upenn.edu/cvi/musunuru-laboratory.html. Episode also available on Apple Podcasts: apple.co/30PvU9C

For most, PCR testing was a topic confined largely to the world of molecular biology textbooks before its widespread use during the ongoing virus situation. Mention of the test can be heard almost everywhere at this point, but do we know how it actually works? Do we understand its intended use, and what it can actually tell us? Press play to learn: The strengths and limitations of PCR testing, and the implications related to the current virus situation What a ‘cycle threshold’ is, whether it needs to be known for detecting the target virus, and what it means if it isn’t known   How the use, results, and interpretation of a PCR test can be affected by who or which lab is carrying it out Professor of molecular medicine at Anglia Ruskin University, Stephen Bustin, has spent years trying to improve the quality of molecular testing for diagnostic and research purposes. This includes PCR (polymerase chain reaction) and RT-PCR (reverse transcription polymerase chain reaction) testing, a method that’s become the topic of much conversation—even among general members of the public—since the early stages of the current virus situation. Bustin explains the development of the PCR and RT-PCR testing method, the details of how it works via amplification of RNA, and what it can and can’t accomplish. He also discusses the necessary parameters for using the test to detect a particular virus, the discrepancy between clinical information and a positive or negative PCR test result, the risk of contamination, critical measures to take prior to and during the use of the PCR method (and whether they were taken during the early stages of the current virus situation), the interpretation of PCR test results, and more.  Episode also available on Apple Podcasts: apple.co/30PvU9C

Is there an underlying cause of negative mental health symptoms and pain for women? Endometriosis may be the culprit for a wide range of adverse health impacts. Listen in to learn: How endometriosis is diagnosed Simple but effective remedies for pain The symptoms of endometriosis Author Jessica Murnane joins the conversation to discuss her work with endometriosis research and finding new solutions for the prevalent condition. A lack of knowledge surrounding endometriosis has led to a deficiency in diagnosis and effective treatment for sufferers of the ailment. At the same time, the common misconception of simple, painful periods remains widespread. While the cause of endometriosis is still unknown, it continues to plague women worldwide and has even barred women from police service in Spain. By spreading symptom awareness and general knowledge to new generations and researchers, the road to a solution has come into sight. To learn more, visit knowyourendo.com or centerforendo.com. Episode also available on Apple Podcasts: apple.co/30PvU9C