Healthcare Unfiltered

Ameet Kini (@AmeetRKini), MD, PhD, hematopathologist, and Patrick Hagan, MD, hematologist/oncologist, both at Loyola University Medical Center, deliberate on the clinical importance of MRD and how clinicians should utilize it, optimal techniques for detecting MRD in various diseases, the gap between academia and the community when it comes to MRD knowledge, the potential of MRD as a surrogate marker, and how to reconcile discordant MRD results from different vendors.

Vincent Rajkumar (@VincentRK), MD, hematologist at the Mayo Clinic (Rochester, MN), shares the distinction between conflicts of interest that guide individual physicians and those that guide entire practices, what types of conflicts should be collected as “material” and which should be disregarded (eg, “transfer of value” payments), issues with disclosure expectations in modern medical research, and an idea to create standards for more appropriate and warranted disclosures.Watch a previous discussion Chadi had with Dr. Rajkumar on conflicts of interest https://www.medscape.com/viewarticle/924320

Chadi facilitates a discussion between three GU oncologists on the latest research and treatment updates in the field. Rana McKay (@DrRanaMcKay), MD, UC San Diego, Petros Grivas (@PGrivasMDPhD), MD, PhD, Fred Hutchinson Cancer Research Center, and Toni Choueiri (@DrChoueiri), MD, Dana-Farber Cancer Institute, debate the practice-changing potential of chosen papers and abstracts presented at ASCO and ESMO, including updated data on the final OS in the PROFOUND trial, context and implications of the JAVELIN trial for bladder cancer, ramifications of the CheckMate 9ER trial for kidney cancer, and more.

John Doench (@JohnDoench), PhD, Associate Director of the Genetic Perturbation Platform, Broad Institute of MIT and Harvard, joins Chadi for a fascinating discussion on the history of CRISPR as a scientific breakthrough, the ease of merging CRISPR technology into human cells, challenges remaining for CRISPR to become a widely used clinical tool and ultimately helping patients, and much more.

In the inaugural episode of Healthcare Unfiltered, host Chadi Nabhan invites cardiologists Venk Murthy (@venkmurthy), MD, University of Michigan, and Anish Koka (@anish_koka), MD, private practice in Philadelphia, to contextualize the effects of COVID-19 on the heart, as explained in a flawed JAMA Cardiology publication that was close to having such trickle down effects as cancelling college sports across the US. The trio explains how the study should not be used to treat patients with preexisting cardiac conditions and COVID-19, the dangers of using the study as grounds for social policy, the importance of post-publication peer-review (via social media), and much more.View the JAMA Cardiology publication https://jamanetwork.com/journals/jamacardiology/fullarticle/2768916