This Week in Virology

Vincent and Dickson travel to the 44th Retrovirus meeting at Cold Spring Harbor Laboratories, where they speak with John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata about the meeting and their work on HIV-1. Hosts: Vincent Racaniello and Dickson Despommier Guests: John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata Become a patron of TWiV! Links for this episode Cold Spring Harbor Retrovirus Meeting 2018 Retroviruses and cranberries (TWiV 320) Identical proviruses in HIV-1 reservoir (PLoS Path) Measuring HIV-1 latency (PNAS) CG dinucleotide suppression is host defense (Nature) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team considers whether those who can do, can't teach, and newly discovered viruses of planarians and Aplysia with the largest RNA genomes. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler and Brianne Barker Become a patron of TWiV! Links for this episode Support Viruses Gordon Conference KNAW Beijerinck Prize Bioterrorism and Biocrimes by Seth Carus (free pdf) History of Biological Warfare by Seth Carus (free) Those Who Can Do, Can't Teach (NYTimes) Planarian nidovirus (bioRxiv) Aplysia nidovirus (bioRxiv) Image credit Letters readon TWiV 509 Weekly Science Picks Brianne- Climate change visualization Alan- Anova sous vide cooker Dickson- Fire season in western US Kathy- Sunscreen in UV and The Projector Illusion Vincent - The Usefulness of Useless Knowledge Listener Pick River- The Conscience of the Present Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Jens returns to present a brief history of bioweapons, with a focus on the program in the Soviet Union, the largest ever undertaken, and his experience working in the decommissioned Soviet bioweapons laboratory known as Vector. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Jens Kuhn Become a patron of TWiV! Links for this episode Russia's Bioweapons Labs (Nature) Medical Aspects of Biological Warfare The Soviet Biological Weapons Program by Leitenberg, Zilinskas, Kuhn Biological Threats in the 21st Century by Lentzos Bioterrorism and Biocrimes by W. Seth Carus Russia's Secret Weapons (Nature) Image credit Weekly Science Picks Jens - Nudibranchs, Beastly Garden, large nidovirus (one, two) Rich - Living inside a canister Dickson - Global rivers and streamsKathy - TWiM 181 Dr. Warhol's Periodic Table of Microbes Vincent - Twitter Bots and Russian Trolls Amplify Vaccine Debate Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team discuss the biology of Ebola viruses, and how localization of the membrane proteins of vaccinia virus drive function: the fusion machinery sits at the tips of virions, and binding proteins are at the sides. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Become a patron of TWiV! Links for this episode Support Viruses & Cells Gordon Conference Outbreak at the Smithsonian Outbreak (TWiV 501) Latest Ebola virus outbreak, DRC (WHO) Summary of Ebola virus outbreaks (CDC) Ebola virus nomenclature (ICTV) Ebola virus distribution map (CDC) Polarization of vaccinia virus membrane proteins (bioRxiv) Image credit Letters read on TWiV 507 Weekly Science Picks Alan - Puzzled Escape Games Rich - An Extremely Detailed Map of the 2016 Election Dickson - Parker Solar ProbeKathy - Ancient earth globe and connected Dinosaur database Brianne - STEMM education should get HACD Vincent - Free tuition for all NYU medical students Listener Pick Heather- GoFarm blog Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

David Tuller returns to provide an update of his investigative work to expose the methodological and ethical problems with the PACE trial for ME/CFS. Host: Vincent Racaniello Guest: David Tuller Become a patron of TWiV! Links for this episode Articleby Lubet and Tuller (STAT) David's Australian trip (virology blog) Sir Simon scores own goal (virology blog) Lightning process (virology blog) Letter to Parliament (virology blog) Crowdfunding is not conflict of interest (virology blog) Open letter to Lancet 3.0 (virology blog) Mayo still champions GET (virology blog) Image Credit Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiVniks explain how the three-dimensional structure of the giant Cafeteria roenbergensis virus suggests a new mode of assembly, and the apparent elimination of dengue fever in an Australian city by release of mosquitoes harboring Wolbachia. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker Become a patron of TWiV! Links for this episode Support Viruses & Cells Gordon Conference New DRC Ebola strains distinct (Outbreak News) Immunizations for new DRC Ebola outbreak (The Scientist) Structure of Cafeteria roenbergensis virus (Sci Rep) Chuan (River) Xiao laboratory CroV movies Scaled deployment of Wolbachia(Gates Open Res) In the wake of Wakefield (BBC) Letters read on TWiV 506 Weekly Science Picks Alan - Ebola research begins at the NEIDL Dickson - Science Photo Library Brianne - First liquid water (underground lake) found on Mars Vincent - Thirty years ago, we could have saved the planet Listener Pick Edmund- STEM talk Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV hosts review persistence of Ebola virus after the end of the Liberian outbreak, and the potential role of two herpesviruses in the pathogenesis of Alzheimer's disease. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker Become a patron of TWiV! Links for this episode Support Viruses & Cells Gordon Conference Trump picks science advisor (Scientist) Hendra vaccine: no effect on horses racing (Aust Vet J) Persistence of Ebola virus (Lancet Inf Dis) New Ebolavirus outbreak (Telegraph) Alzheimer's disease and herpesviruses (Neuron) Herpesviruses, beta-amyloid and Alzheimer's disease (Neuron) Letters read on TWiV 505 Weekly Science Picks Alan - Impossible Burger Rich - SpaceX Just Sent Algae to the ISS, Here's How It'll Power Deep Space Missions Dickson - Art and Science Intersection (Art Science Museum) Brianne - Why it is not a 'failure' to leave academia Kathy- 2003 video history of nuclear explosions 1945 - 1998 Vincent - Revisionist History Episode 8 and Episode 9 Listener Pick Mark- TWIV bingo (png) Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiVerinos discuss Nipah virus and the recent outbreak in India, and the first cast of polio in Papua New Guinea in 18 years. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Become a patron of TWiV! Links for this episode Support Viruses & Cells Gordon Conference TWiV 501: Outbreak Nipah virus infection (JCM) Anatomy of an outbreak (The Hindu) Do we need to worry about Nipah virus? (Tufts Now) Nipah virus infection of bats (EID) Papua New Guinea no longer polio-free (virology blog) WHO polio endgame (polioeradication) Letters read on TWiV 504 Weekly Science Picks Alan - Glaciers of the Rockies aerial photos Rich - SpaceX CRS-15 mission to the space station(wiki) Dickson - Test of Einstein's theory of relativity Brianne - biorender Vincent - True or False? with Michael Schmidt Listener Pick Jolene- Dogs cannot get autism Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent, Rich and Kathy travel to ASV 2018 at the University of Maryland to speak with Svetlana Folimonova and Anne Simon about their work on viruses that infect plants. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guests: Svetlana Folimonova and Anne Simon Become a patron of TWiV! Links for this episode Simon laboratory Folimonova laboratory CTV superinfection exclusion (Virol) 3'-CITEs in viral genome (J Virol) Video of this episode (YouTube) Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

The TWiV team travels to Texas A&M University, home of the Center for Phage Technology, where they speak with Ry Young and Jason Gill about their work on viruses that infect bacteria. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guests: Jason Gill and Ry Young Become a patron of TWiV! Links for this episode Center for Phage Technology at TAMU Personalized phage therapy (PNAS) Phage for biolipid extraction (Sci Rep) Viral protein antibiotic (Nat Micro) Acinetobacter phage depolymerase (J Virol) Structure of phage Qβ (PNAS) Video of this episode (YouTube) Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv