This Week in Virology

Jeff Shaman returns to TWiV to explain why more SARS-CoV-2 testing and contact tracing is needed to stop the pandemic, and provide insights on immunity and reinfection from seasonal CoVs, the problems with antibody tests, and what to expect in the coming months. Hosts: Vincent Racaniello and Rich Condit Guest: Jeff Shaman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 findings and simulations (Shaman Lab) Reconciling diverse estimates of infection rates (pdf) Undocumented SARS-CoV-2 infections (Science) Simulations of SARS-CoV-2 spread (pdf) Repeated infections with diverse CoV (pdf) Letters read on TWiV 606 Image credit Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by our discussion of tests of an inactivated vaccine, results of serological surveys, an inhibitor of the cell protease needed for virus entry, and answers to listener questions. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Inactivated SARS-CoV-2 vaccine protects monkeys (bioRxiv) Saliva is more sensitve than nasopharyngeal swab (medRxiv) NY serological survey results (NY Times) FDA caveats on serological tests (FDA) Federal guidelines on when to open When to open: Roadmap, blog, video explainer Blocking TMPRSS2 blocks SARS-CoV-2 infection (Cell) Lawmakers want human challenge studies (Science) Letters read on TWiV 606 Image credit Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Ralph Baric, Mark Heise and Nat Moorman discuss their non-profit initiative READDI, Rapidly Emerging Antiviral Drug Discovery Initiative, to start making drugs now for the next pandemic virus. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guests: Ralph Baric, Mark Heise, and Nat Moorman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode READDI.org CEPI DNDi Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Kostya Chumakov discusses the hypothesis that oral poliovirus vaccine can provide non-specific protection against many other viruses, and might prevent infection with SARS-CoV-2. Host: Vincent Racaniello Guest: Kostya Chumakov Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Nonpathogenic enteroviruses to prevent human disease (pdf) OPV for COVID-19 (pdf) Enteroviruses to prevent human infections (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by results of seroprevalence studies, analysis of CpG dinucleotide frequencies in the SARS-CoV-2 genome, and answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode CpG frequency in SARS-CoV-2 genome (Mol Biol Evol) SARS-CoV-2 screening before delivery (NEJM) SARS-CoV-2 seroprevalence in Santa Clara (medRxiv) SARS-CoV-2 seroprevalence in homeless shelter (NEPR) Letters read on TWiV 603 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Stanley Perlman joins TWiV to discuss immune responses to coronaviruses, including seasonal CoV, MERS, SARS, and SARS-CoV-2, including prospects for a vaccine. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Stanley Perlman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Perlman Laboratory An Iowa Caucus of Viruses (TWiV 538) Anti-SARS-CoV spike IgG and acute lung injury (JCI Insight) T cell responses to respiratory CoV (Immunol Res) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Coronavirus expert Christian Drosten joins Vincent to provide a view from Germany on COVID-19 and SARS-CoV-2. Host: Vincent Racaniello Guest: Christian Drosten Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Das Coronavirus podcast Identification of SARS-CoV in Germany (NEJM) 29 nt deletion in genome of SARS-CoV (Sci Rep) 382 nt deletion in genome of SARS-CoV-2 (bioRxiv) Virological assessment of COVID-19 patients (Nature) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin joins TWiV to update on the clinical situation, then we discuss a 382 nucleotide deletion in the SARS-CoV-2 genome, a scenario for emergence of the virus from a bat, followed by answers to listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode 382 nt deletion in genome of SARS-CoV-2 (bioRxiv) Recombination and mutation leading to SARS-CoV-2 (bioRxiv) Letters read on TWiV 600 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Doris Cully joins TWiV to discuss inhibition of SARS-CoV-2 in cell culture by ivermectin, followed by continuing analysis of the coronavirus pandemic caused by SARS-CoV-2 including COVID-19 in Nadia the tiger, and prediction of respiratory failure by levels of IL-6. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Guest: Doris Cully Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Ivermectin inhibits SARS-CoV-2 in cell culture (Antiviral Res) Tiger at NY zoo positive for SARS-CoV-2 (NY Times) IL-6 level predicts respiratory failure in COVID-19 patients (medRxiv) Infection fatality rate for managing pandemic (virology blog) Image credit Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin MD returns to TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, followed by our coverage of the coronavirus pandemic caused by SARS-CoV-2. Hosts: Vincent Racaniello, Dickson Despommier,Rich Condit, and Kathy Spindler Guest: Daniel Griffin, MD Download TWiV 598 (70 MB .mp3, 115 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Restricted dispensing of Plaquenil in NY state Virology of COVID-19 patients (Nature) Susceptibility of domestic animals to SARS-CoV-2 (bioRxiv_ Cloth face masks for all of US (NY Times) Masks and respiratory virus shedding (Nat Med) 50 million face masks to Japanese households (Kyodo News) More than you want to know about face masks (Slate Star Codex) Why is COVID-19 less severe in children? (virology blog) Tracking SARS-CoV-2 in sewage (UM) 1918 flattening the curve (Nat Geo) COVID near you Pandemic stops polio eradication (Science) SARS-CoV-2 vaccine patch in mice (U Pitt) Letters read on TWiV 595 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv