This Week in Virology

Peter Daszak joins TWiV to explain the work of EcoHealth Alliance in surveillance of bats in China for SARS-related coronaviruses to provide the information needed to prevent future pandemics, and why NIH recently withdrew financial support for their work. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Peter Daszak Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Bats are reservoirs of SARSr-CoV (Science) Bat SARSr-CoV that binds ACE2 (Nature) Rich gene pool of bat SARSr-CoV (PLoS Path) Bat SARSr-CoV infect humans (Virol Sin) Transmission of bat SARSr-CoV in China (bioRxiv) Global Virome Project (Science) ASV Virtual Workshops 2020 Image credit Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Emmie de Wit joins TWiV to explain her work on the pathogenesis of infection with SARS-CoV-2 in rhesus macaques, including studies on remdesivir and vaccine candidate. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Emmie de Wit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Respiratory disease in macaques inoculated with SARS-CoV-2 (Nature) Clinical benefit of remdesivir in SARS-CoV-2 infected macaques (bioRxiv) Remdesivir for MERS-CoV infection in macaques (PNAS) ChAdOX1 vaccination for SARS-CoV-2 in macaques (bioRxiv) Image credit Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical update on COVID-19, then we review an Ad5 vectored SARS-CoV-2 vaccine, reports on remdesivir and hydroxychloroquine, a drug repurposing study, why some patients infect many others, reducing viral transmission, and much more, including listener email. Hosts: Vincent Racaniello,Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Safety of Ad5 vectored COVID-19 vaccine (Lancet) Analysis of hydroxychloroquine use (Lancet) Remdesivir study (NEJM) Ancient COVID-19 history (MMWR) Drug repurposing for COVID-19 (bioRxiv) Why do few COVID-19 patients infect others? (Science) Overdispersion in COVID-19 transmission (Wellcome Open Res) Reducing airborne transmission (Science) Letters read on TWiV 621 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Jon Yewdell returns to explain studies on detection of antibodies and T cell epitopes in patients who have recovered from COVID-19. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Jon Yewdell Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode T cell targets in COVID-19 patients (Cell) SARS-CoV-2 seroconversion in humans (Nat Med) Convergent antibody responses to SARS-CoV-2 infection (bioRxiv) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Raul Rabadan joins TWiV to explain the use of computational biology to demonstrate how recombination and mutation led to emergence of SARS-CoV-2. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Raul Rabadan Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Rabadan Laboratory Understanding Coronavirus (Amazon) Topological Data Analysis for Genomics and Evolution (Amazon) Recombination and mutation shaped SARS-CoV-2 (bioRxiv) Bat CoV with cleavage site insertion (Curr Biol) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

From the Nipah Virus International Conference in Singapore, Vincent speaks with meeting participants about the history of the first Nipah virus outbreak, lessons learned from Hendra virus, surveillance of bats for viruses, and the development of a vaccine. Hosts: Vincent Racaniello Guests: John Mackenzie, Jon Epstein, Eun-Chung Park, and Linfa Wang Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical update on COVID-19, then we review TETRIS by Paterson NJ, modeling the effects of intervention in the US on cases and deaths, mixing PCR and serology data, and much more, including listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Playing tennis safely (USTA) Scientists denounce end to CoV grant (NY Times) ASMBMB denounces end to CoV grant (pdf) For TETRIS, turn to Paterson NJ (NY Times) NJ Dept of Health (image credit) Differential effects of intervention timing (medRxiv and NY Times) Texas to stop combining test results (Statesman) How could CDC make that mistake? (Atlantic) The Pandemic and Information Network (Columbia Journ Rev) Helmet and tent (Science) New song, old melody (Cell Host Microbe) Letters read on TWiV 617 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent, Kathy and Rich discuss COVID-19 research paper overload, Moderna's mRNA vaccine Phase I results, increase of ACE2 RNA by cigarette smoke, and answer listener questions. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Drowning in COVID-19 papers (Science) CORD-19 2019 NCRC AI powered literature review SciSight Graphical guide to CoV vaccines (Nature) Moderna Phase I results Liposomes and lipid nanoparticles (Exelead) Cigarette smoke increases ACE2 (Dev Cell) Letters read on TWiV 616 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Vincent speaks with Peter Daszak, President of EcoHealth Alliance, a global nonprofit organization dedicated to protecting wildlife and public health from the emergence of disease. Hosts: Vincent Racaniello Guests: Peter Daszak Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Intro music is by Ronald Jenkees. 20% off The Invisible ABCs for TWiV listeners! Use promo code: ABC20 at checkout. Send your virology questions and comments to twiv@microbe.tv

Daniel Griffin provides a clinical update on COVID-19, then we review results showing requirement for the furin site in the SARS-CoV-2 spike for replication, US state vaccine exemptions, concerns with a rapid diagnostic test, and answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Triple therapy for COVID-19 (Lancet) Virology podcast goes viral (Thalia Gigerenzer) Paul Stays Home (pdf) Multibasic cleavage site essential for SARS-CoV-2 infection (Mol Cell) Mumbai engulfed by CoV (NY Times) All must be vaccinated (Stat) FDA concerns with Abbott test (FDA) How US lost 6 weeks (BBC) Image credit Letters read on TWiV 614 20% off The Invisible ABCs for TWiV listeners! Use promo code: ABC20 at checkout. Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv