This Week in Virology

In COVID-19 clinical update #48, Daniel Griffin reviews effect of spike amino acid changes on neutralization with monoclonal antibodies, Sputnik V safety and efficacy results, increased reactogenicity after a single vaccine dose in seropositive individuals, single dose vaccination in seropositive health care workers, and results of three clinical trials on the use of anticoagulants. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Resistance of variants to mAb neutralization (bioRxiv) Safety and efficacy of Sputnik V (Lancet) Increased vaccine reactogenicity in seropositives (medRxiv) Single dose vaccination in seropositive health care workers (medRxiv) Update on vaccine intervals (CDC) Single dose AZD1222 results (Lancet preprints) Three RCT on anticoagulants (NIH) Letters read on TWiV 716 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV explains why hydroxychloroquine failed in humans despite showing antiviral effects in cells, and reviews the published data on the Pfizer/BioNTech mRNA vaccine. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode TMPRSS2 is why hydroxychloroquine failed (PLoS Path) Safety and efficacy of BNT162b2 mRNA vaccine (NEJM) Letters read on TWiV 715 Timestamps by Jolene. Thanks! Weekly Picks Brianne – How the Body Reacts to Viruses Rich – How do wombats poop cubes? Kathy – The Verse by the Side of the Road Vincent – Janet Iwasa's SARS-CoV-2 entry animation Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Jason McLellan joins TWiV to reveal all we know about the SARS-CoV-2 spike protein, followed by Novavax and J&S phase 3 results and a discussion of variants of concern: neutralization by vaccine-induced antibodies, transmission, and virulence. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld Guest: Jason McLellan Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Prefusion spike structure (Science) Neutralization of VOC by vaccine induced antibodies: Moderna and Pfizer Novavax COVID-19 vaccine phase 3 results (Novavax) J&J COVID-19 vaccine phase 3 results (J&J) B.1.1.7 has been in the US since November 2019 (virological.org) NERVTAG report on B.1.1.7 virulence (pdf) Timestamps by Jolene. Thanks! Weekly Picks Dickson – Pandemic Pivot and Tuba Skinny Alan – Technological challenges in vaccine rollout Rich – I was lucky to find this vaccine anywhere Vincent – Lady Gaga's MIXED METER Star Spangled Banner?! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #47, Daniel Griffin reviews phase 3 results for Novavax and J&J vaccines, transmission in K-12 settings in Wisconsin, data on Lilly and Regeneron monoclonal antibody therapy, and a study of colchicine for treatment of disease. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Novavax vaccine phase 3 results (Novavax) J&J vaccine phase 3 results (J&J) COVID-19 and transmission in K-12 schools (MMWR) Lilly mAb therapy (NEJM) Regeneron mAb prophylaxis (Regeneron) Colchicine for COVID-19 (Cardiol Today) Letters read on TWiV 713 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Gisa, Steffi, and César join TWiV to discuss their careers, their research, and the COVID-19 pandemic in Germany. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guests: Gisa Gerold, Stefanie Becker, and César Muñoz-Fontela Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode German Society for Virology Ticks in Germany and TBEV (Sci Rep) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

The TWiVers review Biden's national strategy for the COVID-19 responses and pandemic preparedness, and an evaluation of the BinaxNOW rapid antigen test for SARS-CoV-2 infection. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Biden's COVID-19 strategy (pdf) CDC evaluation of BinaxNOW antigen test (MMWR) FDA instructions for BinaxNOW test (pdf) Adam Neely on Sea Shanties (YouTube) Letters read on TWiV 711 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Spelling Bee Brianne – He Made a Viral Bernie Meme Site. Now He Has to Keep it Going Alan – America's Cup AC75 capsize and aftermath in qualifying race Rich – Game Theory's UNCENSORED Interview With Dr. Fauci | The Truth About COVID-19 Vaccines Vincent – Top Science Podcasts Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #46, Daniel Griffin discusses the BinaxNow rapid antigen test, efficacy of Bamlanivimab in nursing homes, associations of serum vitamin D concentrations with in-hospital mortality and need for invasive mechanical ventilation, trials of IL-6 receptor antagonists, effects of anticoagulants on in-hospital mortality, and symptom persistence in outpatients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Evaluation of Abbott BinaxNOW (MMWR) Lilly mAb in nursing homes (WSJ) Vitamin D and COVID-19 severity (Mayo Clin Proc) Anticoagulation, aspirin, in-hospital mortality in COVID-19 (medRxiv) Long COVID symptoms in outpatients (Ann Int Med) Letters read on TWiV 710 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

In this episode, President Biden elevates his science advisor to his Cabinet, a review of the current flu season, the scientific goals of the WHO-convened Global Study of the Origins of SARS-CoV-2, and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode President's science advisor to Cabinet (NY Times) Letter from Biden to Lander (pdf) Weekly flu (CDC) Weekly NY flu (NYDOH) WHO study on SARS-CoV-2 origins (WHO) Letters read on TWiV 709 Timestamps by Jolene. Thanks! Weekly Picks Kathy – 15 YouTubers play Telestrations Vincent – Vince Beiser Listener Picks Bob, David, Janet – Sea Shanty by A Cappella Science (YouTube, TikTok, Bandcamp) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

The TWiVy team deconstructs CoronaVac, the inactivated SARS-CoV-2 vaccine produced by Sinovac Biotech, and production of multivalent camelid nanobodies that block infection with the virus and suppress selection of neturalization-resistant variants. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode David Kessler to head Operation Warp Speed (NY Times) Phase 1/2 results of Sinovac inactivated vaccine (Lancet) beta-propiolactone (Wikipedia) Multivalent anti-SARS-CoV-2 nanobodies (Science) Letters read on TWiV 708 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Photos of mob attacking Capitol Brianne – Video of Neutrophil Phagocytosis Alan – Fishing Through the Apocalypse Rich – A Word on Statistics by Wislawa Szymborska Vincent – Letters from an American Listener Pick Mike – Have the new jab Intro music is by Ronald Jenkees

In COVID-19 clinical update #45, Daniel Griffin discusses J&J Ad26 vaccine results, reactogenicity after the second dose of mRNA vaccines, expansion of vaccine eligibility, and the finding that encephalitis after SARS-CoV-2 infection is a cytokine release syndrome. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode J&J Ad26 vaccine phase 1/2 results (NEJM) SARS-CoV-2 encephalitis is a cytokine release syndrome (CID) Letters read on TWiV 707 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv