This Week in Virology

A TWiV threesome explains the observation that humans with inherited T cell CD28 deficiency are susceptible to severe warts driven by human papilloma virus infection, but are otherwise healthy. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Hall (ASV) Travel Award Applications (ASV) CD28 deficiency and severe warts (Cell) Vincent interviews Harald zur Hausen (virology blog) Letters read on TWiV 853 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Every Pore on Your Face Is a Walled Garden Rich – "On Warts" by Lewis Thomas (Pdf) Vincent – Cells at Work Code Black 1 Listener Picks Chris – Ria Lina on the Guilty Feminist podcast Duncan – Meet the green kleptos of the animal kingdom Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

The TWiV team reviews the observation that infection with the SARS-CoV-2 Omicron variant causes reduced reproduction and pathogenesis in mice and hamsters. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Brianne Barker, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Hall (ASV) Travel Award Applications (ASV) Omicron infection in mice and hamsters (Res Square) Letters read on TWiV 851 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Engineering the James Webb Space Telescope Amy – T cells might be our bodies' best shot against Omicron Brianne – Where is Webb? Rich – First U.S. vaccine mandate in 1809 launched 200 years of court battles Vincent – The Secret of Life by Howard Markel Listener Picks Jen – Antidote David – Rosie Revere, Engineer Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #96, Daniel Griffin reviews Omicron in South Africa, rapid antigen tests, viral coinfections, isolation and quarantine, saliva preferred for Omicron, risk factors for severe disease in vaccinated, Paxlovid dosing, and long COVID. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Variant proportions (CDC) Omicron in South Africa (JAMA) Transmission of SARS-CoV-2 (Ann Int Med) Diagnostics for COVID-19 (Lancet) Comparison of rapid antigen tests (J Clin Med) Rapid antigen tests to reduce isolation (medRxiv) Frequency of viral confections (MMWR) Isolation and quarantine (CDC) Saliva preferred for Omicron (medRxiv) Risk factors for severe COVID in vaccinated (MMWR) Paxlovid dosing (Pfizer) Fatigue and cognitive impairment (Brain, Behavior, Immune) Letters read on TWiV 850 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV kicks off 2022 with a review of the virology highlights of 2021, from three virologists, one immunologist, a science writer, and a partridge in a pear tree. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID vaccines: TWiV 708, 715, 718, 844 Non-CoV papers: TWiV 763, 784, 819, 822, 740, 848 Immune correlates of protection: TWiV 791, 799, 835, 832, 841, 789 Fitness: TWiV 705, 836, 768, 757 Guests off beaten track: 723, 726, 732, 838, 773, 745 Lab leak nonsense: TWiV 762, 774 One Health/Viruses in Wildlife: TWiV 799, 722, 771, 809, 798, 759, 791, 847, 750, 821, 824, 804 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Don't Look Up Kathy – spaceweather.com Rich – Video of a Green Flash (wiki) Alan – Fungally-modified violins Vincent – This Old Tony especially this segment Listener Picks Paul – Deep Mind and AlphaFold Grant – SARS-CoV-2 reproduction cycle Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

For the final episode of 2021, TWiV reviews an experimental infectious attenuated Lassa fever vaccine based on a codon-deoptimized glycoprotein gene, and SARS-CoV-2 infection of free-ranging white-tailed deer. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Codon-deoptimized Lassa fever vaccine (mBio) Attenuation of dengue virus by codon deoptimization (TWiV 351) Codon deoptimization of poliovirus and RS virus (TWiV 740) Codon deoptimization of DNA viruses (TWiV 362 letters) CEPI on TWiV 612 SARS-CoV-2 in white-tailed deer (Nature) Letters read on TWiV 847 Timestamps by Jolene. Thanks! Weekly Picks Dickson – EO Wilson (Ants and The Conversation) Brianne – The Best Fun Science Stories of 2021 Kathy – Using sound for data analysis; chemotactic bacteria and Moo loo story Alan – Owls of the Easern Ice, by Jonathan Slaght Vincent – TWiV 9: Fever! The discovery of Lassa virus and TWiV 548: Mice, shrews, and caterpillars Listener Picks Larry – Immunity Jeff – Daily Hospital Surveillance Report Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #95, Daniel Griffin discusses new CDC guidelines for isolation and quarantine, EUA for Molnupiravir, children and COVID, vaccine safety in 5-11 year olds, Omicron outbreaks in Nebraska and Denmark, Baylor's COVID vaccine, and COVID-OUT for ivermectin. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Isolation and quarantine guidance (CDC) EUA for Molnupiravir (FDA) Children and COVID state data (AAP) Vaccine safety in 5-11 year olds (MMWR) Omicron and antigen tests (FDA) Omicron in Nebraska (MMWR) Omicron in Danish households (medRxiv) Baylor COVID vaccine (TCH) COVID-OUT for ivermectin (U Minn) Letters read on TWiV 848 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV explores the impact of the intestinal virome on seroconversion after rotavirus vaccination, and implications of the ability of the SARS-CoV-2 beta variant to infect wild-type laboratory mice. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Impact of enteric virome on rotavirus vaccine (Cell Host Micr) Beta variant infects wild type mice (Sig Transd Targ Ther) Timestamps by Jolene. Thanks! Weekly Picks Brianne – XKCD on Immune Responses and Immunity Kathy – UVA Rotunda astrophotograph with Heart and Soul Nebulae by Brennan Gilmore Rich – James Webb Space Telescope Videos: 29 Days On The Edge; Launch And Deployment Alan – Sokobond puzzle game Vincent – International Space Station shines in gorgeous fly-around photos by Crew Dragon astronauts Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #94, Daniel Griffin reviews the FDA EUA for Paxlovid, test to stay in school, immunity after infection, variants and therapeutics, quarantine and isolation guidelines, Molnupiravir in non-hospitalized patients, and convalescent serum in outpatients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA EUA for Paxlovid (pdf) Children and COVID-19 (pdf) Evaluation of test to stay in school, IL (MMWR) Evaluation of test to stay in school, LA (MMWR) Update on mRNA vaccine in under 5 yo (Pfizer) CDC endorses preference for mRNA vaccines (CDC) Natural immunity and protection against delta (Clin Inf Dis) Cross-neutralization post-vaccination infection (JAMA) Variants and therapeutics (NIH) Quarantine and isolation (CDC) Molnupiravir in non-hospitalized patients (NEJM) Convalescent serum for outpatients (medRxiv) Letters read on TWiV 845 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkee Send your questions for Dr. Griffin to daniel@microbe.tv

Paul Offit returns to TWiV to discuss new CDC guidance on J&J vaccine, why children should be immunized against COVID-19, and whether or not booster doses are scientifically justified. Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker Guest: Paul Offit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Paul Offit on TWiV 720 Are COVID-19 vaccine boosters needed? (virology blog) Letters read on TWiV 844 Timestamps by Jolene. Thanks! Weekly Picks Brianne - Virus snowflakes Dickson - The Year in Pictures 2021 Vincent - Our Life is Plasticized Listener Picks Gerry - Dan Barouch: COVID-19 Vaccine Development Louise - Pandora's Lab by Paul Offit Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In COVID-19 clinical update #93, Dr. Griffin summarizes Omicron fitness, S-gene target failure, monoclonal efficacy against Omicron, vaccination, monoclonals, and disease in children, persistence of memory B cells in the elderly, infection and vaccine induced immunity, protection against severe illness and death by a third mRNA vaccine dose, high flow oxygen versus intubation, and therapeutic anticoagulation. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Variant updates (CDC) List of diagnostic kits (Global Fund, pdf) B1.1.529 escapes most antibodies (bioRxiv) mRNA vaccine third dose and Omicron (medRxiv) Outpatient strategies children and adolescents (AAP) Memory B cells persist in elderly (J Clin Invest) mRNA booster effect against Delta (Clin Inf Dis) Azithromycin meta-analysis (J Antimicrob Chemo) High-flow oxygen vs intubation (JAMA) Therapeutic anticoagulation (Ann Int Med) Africa cases surge (CIDRAP) Letters read on TWiV 843 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv