This Week in Virology

Michael Letko joins TWiV to discuss his research on understanding cell receptors required for sarbecovirus entry, including an ACE2-dependent isolate from Russian bats that is resistant to vaccine-induced antibodies. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit,  Kathy Spindler, and Brianne Barker Guest: Michael Letko Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV Cell entry of SARS-CoV-2 and other sarbecoviruses (Nat Micro) ACE2-dependent sarbecovirus in Russian bats (PLoS Path) Letters read on TWiV 954 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Sometimes This Octopus is So Mad it Just Wants to Throw Something or The Cosmic Bat Nebula Kathy – APODs  Jupiter,  Lunar Eclipse Blood Moon, Ice Giant Rich – Mirror-image T7 transcription of chirally inverted ribosomal and functional RNAs (Wiki: Mirror Life) Vincent – The 2022-2023 Respiratory Virus Season Hits Early and Hard: Part 1 Listener Pick Debby – Celebrate Bob McDonald’s 30 years as host of Quirks & Quarks Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses high demand for Amoxicillin causing shortages amid child RSV surge, epidemiologic and clinical features of children and adolescents aged

Infectious Disease physician Jake Scott joins TWiV to provide a west coast clinical perspective on the evolution of the COVID-19 pandemic with respect to the impact of vaccines, antivirals, variants of concern and mortality. Hosts: Vincent Racaniello, Alan Dove, Rich Condit,  and Kathy Spindler Guest: Jake Scott Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV Omicron variant reproduction ex vivo (Nature) Clinical outcomes with Omicron (Nat Med) Low neutralizing antibodies induced by bivalent booster (NEJM) Antibody responses to bivalent booster (bioRxiV) Spike T cell responses not enhanced by bivalent booster (Sci Immunol) Pandemic end will not be televised (BMJ) Conflation of infection and disease (Twitter) Timestamps by Jolene. Thanks! Weekly Picks Kathy – 10 moments for Jazz at Lincoln Center Orchestra Residency (Item 7) and Alan’s pick from TWiV 931 The Kissing Bug by Daisy Hernandez Rich – Wilderness Safaris Photographic Competition 2022 Alan – Massachusetts Science Education Leadership Association, and the talk I gave to them last week Vincent – Andrea Camillieri and his protagonist Inspector Montalbano Listener Pick Frank – Economics for the Future: Beyond the Superorganism Debby – As routine vaccination rates fall, polio survivor hopes her story reverses urgent trend Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses Influenza incidence and vaccine effectiveness during the southern hemisphere influenza season in Chile, Nirsevimab for prevention of RSV infection in healthy late-preterm and term infants, severe Monkeypox in hospitalized patients, reinfections with different SARS-CoV-2 Omicron subvariants, impact of community masking on COVID-19 in Bangladesh, unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses, antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot, immunogenicity of bivalent mRNA vaccine boosters, long-term gastrointestinal sequelae following COVID-19, evaluation of an automated text message–based program to reduce use of acute health care resources after hospital discharge, and how in adults with COVID-19, melatonin was assessed for effects on inflammatory markers, clinical signs and symptoms, and mortality. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Influenza incidence and vaccine effectiveness (CDC) Nirsevimab for prevention of RSV (NEJM) Severe Monkeypox in hospitalized patients (CDC) Reinfections with different SARS-CoV-2 Omicron subvariants (CDC) Impact of community masking on COVID-19 (Science) Vaccine elicits protective immunity against sarbecoviruses (Science) Antibody responses to bivalent mRNA vaccine booster shot (Biorxiv) Immunogenicity of bivalent mRNA vaccine boosters (Biorxiv) Long-term gastrointestinal sequelae following COVID-19 (CGH) Remdesivir fact sheet for providers (Veklury)  Bebtelovimab fact sheet for providers (FDA) Evaluation of an automated text message–based program (JAMA) Melatonin assessed for effects on inflammatory markers in COVID patients (Heliyon) PAXLOVID patient eligibility screening checklist (FDA) Contribute to our MicrobeTV fundraiser at PWB Dr. Griffin's treatment guide (pdf) Letters read on TWiV 951 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Richard Knight about prion diseases and the outbreak of bovine spongiform encephalitis that led to cases of variant Creutzfeldt-Jakob disease in humans. Host: Vincent Racaniello Guest: Richard Knight Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode National CJD Research and Surveillance Unit Clinical diagnosis of human prion disease (Prog Mol Biol Trans Sci) Variant Creutzfeldt-Jakob disease (Handbook Clin Viral) Creutzfeldt-Jakob disease (Adv Exp Med Biol) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses progress toward poliomyelitis eradication in Pakistan, polio by the numbers , influenza and COVID-19 vaccination coverage among health care personnel, phase 1/2a safety and immunogenicity of an adenovirus 26 vector RSV vaccine encoding prefusion F in adults 18–50 years and RSV seropositive children 12–24 months, receipt of first and second doses of JYNNEOS vaccine for prevention of Monkeypox, distinguishing SARS-CoV-2 persistence and reinfection, Novavax NVX-COV2373 triggers potent neutralization of Omicron sub-lineages, association between regular physical activity and the protective effect of vaccination against SARS-CoV-2 in a South African case, COVID-19 outcomes in solid organ transplant recipients who received Tixagevimab-cilgavimab Prophylaxis and/or Bebtelovimab treatment, Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralizing antibodies, and Tocilizumab versus Baricitinib in hospitalized patients with severe COVID-19. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Progress toward Poliomyelitis eradication (CDC) Polio by the numbers (JID) Influenza & COVID-19 vaccination coverage among health care personnel (CDC) Phase 1/2a Safety & Immunogenicity of an adenovirus RSV Vaccine (JID) Receipt of first & second doses of JYNNEOS vaccine  (CDC) Distinguishing SARS-CoV-2 persistence and reinfection (CID) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Novavax triggers potent neutralization of Omicron sub-lineages (bioRxiV) Association between physical activity & vaccination protective effect (BMJ) PAXLOVID patient eligibility screening checklist (FDA) COVID-19 outcomes in solid organ transplant recipients who received monoclonal antibodies (Transplantation) Omicron BA.2.75.2 exhibits escape from neutralizing antibodies (bioRxiV) Tocilizumab vs. Baricitinib in hospitalized patients with severe COVID-19 (CMI) Dr. Griffin’s treatment guide (pdf) Contribute to Floating Doctors fundraiser at PWB Letters read on TWiV 949 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

David Quammen returns to TWiV to discuss how he wrote his new book ‘Breathless’, a story about the science and the scientists behind the race to understand the pandemic coronavirus SARS-CoV-2. Hosts: Vincent Racaniello, Rich Condit,  Kathy Spindler, and Brianne Barker Guest: David Quammen Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Boston Quammens (TWiV 408) Breathless by David Quammen Spillover by David Quammen Song of the Dodo by David Quammen Timestamps by Jolene. Thanks! Weekly Picks David – Shepherd Brianne – Adventure Aquarium Kathy – DART results (Narrative, images) Rich – “Elementary” TV series Vincent – Stop passing the buck on intro science Listener Pick Rich – Consensus Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses the prediction of upcoming global infection burden of influenza seasons after relaxation of public health and social measures during the COVID-19 pandemic, severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters, and how successful immunomodulators for treatment of COVID-19 have opened the pathway for comparative trials. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt at Vaccinated.US Prediction of upcoming global infection burden of Influenza (The LANCET) Severe COVID-19 outcomes after full vaccination (The LANCET) Successful immunomodulators for treatment of COVID-19 (CMI) Remdesivir fact sheet for providers (Veklury)  Bebtelovimab fact sheet for providers (FDA) PAXLOVID patient eligibility screening checklist (FDA) Dr. Griffin’s treatment guide (pdf) Contribute to Floating Doctors fundraiser at PWB Letters read on TWiV 947 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv

Angela Mingarelli joins TWiV to discuss whether the gut microbiota of bats confers tolerance to influenza virus infection in mice, and primate hemorrhagic fever-causing arteriviruses that can reproduce in human cells and might be capable of infecting humans. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit,  and Brianne Barker Guest: Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Research assistant position at FDA (pdf) Support MicrobeTV with a Spike t-shirt (Vaccinated.us) Bat gut microbiota and flu infection in mice (Transbound Emerg Dis) Primate hemorrhagic fever-causing arteriviruses (Cell) Timestamps by Jolene. Thanks! Weekly Picks Dickson – Jazz pics: #5. Small group.  Art Blakey and the Jazz Messenger: Art Blakey, Drums; Lee Morgan, Trumpet; Benny Golson, Tenor saxophone; Bobby Timmons, Piano; Jymie Merrit, Bass (1958-1964). Signature album: Art Blakey And The Jazz Messengers: Blues March: Signature song: Blues March Brianne – Why Chimps and Gorillas Form Rainforest Friendships Rich – Fly Water – FPV to New Depths Alan – The Seven Words You Can’t Say on Television, by George Carlin, and its repercussions Angela – Nature’s Inspiring Women in Science Award Vincent – Mysteries of Nevada Barr and her protagonist Anna Pigeon Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update Dr. Griffin discusses a healthcare-associated infection with Monkeypox virus, air and surface sampling for monkeypox virus in a UK hospital, misrepresentation and nonadherence regarding COVID19 public health measures, tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine, clinical, virologic, and immunologic evaluation of symptomatic rebound following Nirmatrelvir/Ritonavir treatment, early outpatient treatment with Eemdesivir in patients at high risk for severe COVID-19, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes, and outcomes among confirmed cases and a matched comparison group in the long-COVID in Scotland. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Research assistant position with Amy Rosenfeld (pdf) Support MicrobeTV with a Spike t-shirt at Vaccinated.US A healthcare-associated infection with monkeypox virus (OFID) Air and surface sampling for monkeypox virus (The Lancet) Misrepresentation & nonadherence in COVID-19 public health measures (JAMA) Tolerability and immunogenicity of a COVID-19 vaccine (The Lancet) PAXLOVID patient eligibility screening checklist (FDA) Evaluation of symptomatic disease rebound following PAXLOVID (CID) Outpatient treatment with Remdesivir in patients at high risk (OFID) Remdesivir fact sheet for providers (Veklury)  Bebtelovimab fact sheet for providers (FDA) Molnupiravir as early treatment for adults with COVID-19 (SSRN) Outcomes among confirmed cases and matched comparison group in long-COVID (Nature) Dr. Griffin’s treatment guide (pdf) Contribute to Floating Doctors fundraiser at PWB Letters read on TWiV 945 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv