This Week in Virology

Host: Vincent Racaniello Guest: John Coffin Vincent speaks with John Coffin about his career studying retroviruses, including working with Howard Temin, endogenous retroviruses, XMRV, chronic fatigue syndrome and prostate cancer, HIV/AIDS, and his interest in growing cranberries. Links for this episode John Coffin (Wikipedia) Specific HIV integration sites (Science) Novel retrovirus in modern birds (J Virol) Recombinant origin of XMRV (Science) Cranberry harvest (jpg) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVers review the outcomes of two recent phase 3 clinical trials of a quadrivalent dengue virus vaccine in Asia and Latin America. Links for this episode Efficacy of dengue vaccine (NEJM) Preventing dengue (NEJM) Dengue viruses (Scitable) Intention to treat (Wikipedia) Image credit: Jean-Yves Sgro Letters read on TWiV 319 Weekly Science Picks Alan - The Toaster Project by Thomas ThwaitesRich - SpaceX reusable rocket (SpaceX)Kathy - Antarctica: A Year on IceDickson - NHL Mumps outbreak and Hubble Andromeda imageVincent - We the Microbiologist Listener Pick of the Week Neva - Mosquito earringsBasel - Flu vaccine selection meeting Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler The TWiV gang reviews ten fascinating, compelling, and riveting virology stories from 2014. Ten virology stories of 2014 Ebola virus outbreak (TWiV 314, 309, 308, 307, 306, 305, 304, 303, 302, 298, 297, 283) Directional uncoating of rhinovirus RNA (TWiV 267) Pandemic pathogen controversy (TWiV 287) Viral evolution (TWiV 275) Borna virus inhibition by endogenous DNA (TWiV 303) MERS-CoV in dromedary camels (TWiV special, TWiV 287) Oncolytic measles virus (TWiV 298) Amazing norovirus findings (TWiV 312 and 313) Toxin delivery to aphids (TWiV 272) The Salk Legacy (TWiV 281) Links for this episode Bat-filled tree (Science) Possible Ebola virus lab exposure (CIDRAP) Mishandling of Ebola virus sample (NY Times) Where could Ebola virus strike next? (NPR) New Legos of female scientists Photo and cookie by Kathy Spindler Letters read on TWiV 318 Weekly Science Picks Alan - Mystery photos from CERNRich - Adam E. Cohen: Bringing bioelectricity to lightKathy - Wired's top microbe stories of 2014Dickson - Mouse jokeVincent - The Science of Epidemics (Time Inc Special) Listener Pick of the Week Neva - Sir BacteriophageSagi - An unboring polio documentary Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guests: Eurico Arruda, Gustavo Acrani, Cintia Bittar, Tatiana Domitrovic, and Suellen Galvino-Costa On his second trip to Brazil, Vincent joins Eurico to speak with three young virologists, Gustavo, Cintia, Tatiana, and Suellen, about their work and their prospects for careers in science. Video of this episode: view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Vincent, Alan, Rich and Kathy discuss how interleukin 10 modulation of Th17 helper cells contribute to alphavirus pathogenesis. Links for this episode IL10 modulation of Th17 cells during alphavirus pathogenesis (PNAS) Th17 cells involved in influenza mediated gut injury (J Exp Med) Helper T cells 2014-15 flu season (CDC) Key facts about flu & flu vaccine (CDC) Does the flu vaccine work? (Turbid plaque) Effectiveness of flu vaccine (virology blog) Image credit Letters read on TWiV 316 Weekly Science Picks Alan - It came from the pondRich - WanderersKathy - The Sense of Style by Steven PinkerVincent - Life in Our Phage World Listener Pick of the Week Fernando - Reality based? Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Vincent, Alan, Rich and Kathy association of a virus with sea star melting disease, and the finding of a phycodnavirus in the oropharynx of humans with altered cognitive functions. Links for this episode National Influenza Immunization Week (CDC) Densovirus associated with sea star wasting disease (PNAS) A virus that melts sea stars (virology blog) Chlorovirus in human oropharynx (PNAS) Algal virus in humans (virology blog) Image credit Letters read on TWiV 315 Weekly Science Picks Alan - ReelLife Science 2014 WinnersRich - The Martian by Andy WeirKathy - Dance Your Ph.D. WinnerVincent - Time Person of the Year 2014 - The Ebola Fighters Listener Pick of the Week Ricardo - MiniPCREli - Let's outsmart Ebola together AND The Ebola virus explained Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guests: Kartik Chandran, Ganjam Kalpana, and Margaret Kielian Vincent travels to Albert Einstein College of Medicine where he speaks with Kartik, Ganjam, and Margaret about their work on Ebolavirus entry, a tumor suppressor that binds the HIV-1 integrase, and the entry of togaviruses and flaviviruses into cells. Links for this episode Antibodies that protect against Sudan virus (ACS Chem Biol) Ebola virus entry requires NPC1 (EMBO J) A toggle switch for virus entry (Nat Comm) Imaging alphavirus exit (J Virol) Defects in HIV-1 unable to interact with INI1 (Retrovirol) Cell cycle arrest by INI1 (Mol Cell Biol) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Vincent, Alan, and Rich discuss how norovirus, an enteric virus, can replace the functions of the gut microbiome. Links for this episode Ebola virus update (WHO) Norovirus can replace functions of gut microbiome (Nature) Post-vaccinal distemper encephalitis (N Z Vet J) Novel sea otter poxvirus (J Wildl Dis) Poliovirus escapes antibodies (virology blog) CDC whistleblower saga (Sci Based Med) Snopes on CDC whistleblower Image credit Letters read on TWiV 313 Video of this episode - view at YouTube Weekly Science Picks Alan - RetrocomputingRich - Where is Rosetta?Vincent - Antares rocket explosion Listener Pick of the Week Simon - Relatively PrimeMark - Giant Microbes Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiVbolans discuss the finding that human noroviruses, major causes of gastroenteritis, can for the first time be propagated in B cell cultures, with the help of enteric bacteria. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC. Links for this episode Ebola virus appropriations (White House) ASM Ebola FAQ Quarantine due to Ebola virus in semen (NPR) Enteric bacteria promote norovirus infection of B cells (Science) Norovirus emerges (Zimmer) Stephanie Karst on TWiV 134 Image credit Letters read on TWiV 312 Weekly Science Picks Alan - How Ebola airlifts workKathy - Fred Murphy's Foundations of VirologyRich - Pendulum waveDickson - Young DipteristsVincent - Microbes After Hours: Ebola and TWiV iPhone 6 case Listener Pick of the Week Alane - Health MapTodd - Formaldehyde in vaccines Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Host: Vincent Racaniello Guests: Zhen Fu and Biao He Vincent visits the University of Georgia where he speaks with Zhen Fu and Biao He about their work on rabies virus and paramyxoviruses. Links for this episode Blood-brain permeability and rabies survival (Antiviral Res) Rabies induces blood-brain permeability (J Virol) Virus neutralizing antibodies in CNS of non-lethal rabies (PLoS Neg Trop Dis) RSV vaccine based on PIV5 (Vaccine) New mumps vaccine (J Virol) PIV5-based influenza virus vaccine (J Virol) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv