MDS Podcast

In the latest installment of the Chorea Special Series, Dr. Ruth Walker interviews Prof. Sarah Tabrizi about the current state of therapies for Huntington’s disease, and what is coming down the pipeline.

Dr. Sarah Camargos interviews Dr. Zhonghbo Chen and Prof. Henry Houlden, first and senior author of a MDJ paper exploring a GGC repeat expansion in the ZFHX3 gene associated with spinocerebellar ataxia type 4. They describe a criative methodology to find a gene in a family with a Swedish ancestry. Journal CME is available until April 04, 2025 Read the article.

Dr. Ruth Walker invites Prof. Emilia Gatto and Dr. Kevin Peikert onto the MDS Podcast for the second episode of the Chorea Special series. Together they discuss the general approach to patients with chorea of genetic etiology, with specific clues to diagnosis in terms of neurological and other features. They also discuss the nomenclature of neuroacanthocytosis syndromes, specific clues to the diagnosis in the clinical presentation and laboratory findings.

Dr. Eduardo Fernandez discusses with Dr. Hiroaki Sekiya the surprising findings of his study evaluating the presence of concomitant pathologies and how they impact the disease progression in a large cohort of patients with MSA from the Mayo Clinic brain bank. Read the article

Prof. Joseph Jankovic discusses the distinct characteristics of Chorea, including sudden, involuntary movements and twitch-y jerky motions. The podcast explores the diagnostic challenges in identifying hyperkinetic movements and emphasizes the importance of accurate diagnosis in differentiating between various disorders.

Dr. David Burn and Prof. Tiago Outeiro delved into the significance of biomarkers in Parkinson's disease, discussing challenges in implementation, genetic profiles, alpha-synuclein, and insights from a workshop on diagnostic and progression biomarkers, new therapies, and genetic research.

Prof. Olivier Rascol discusses gene therapy and cell transplantation for Parkinson's, advancements in therapeutic strategies, halting disease progression in Parkinson’s, and reliability of markers in neurodegenerative disorders.

In this episode. Prof. Bas Bloem provides an overview of the topics covered in his lecture at the MDS-ES Focused Workshop: Diagnostic and Progression Biomarkers in Parkinson’s Disease and Atypical Parkinsonism, and discusses how biomarkers may help us identify patients and select adequate therapeutic strategies.

Prof. Romero Ramos discusses the immune system in Parkinson's disease, including immune cell alterations, biomarkers, vagus nerve connection, anti-inflammatory therapies, and future research advancements in personalized treatment approaches.

In this episode, Dr. Hugo Morales interviews Dr. Bas Bloem and Dr. Victor Fung, co-authors of "The Wisdom of Our Mentors: Clinical Pearls in Movement Disorders," who share clinical pearls and discuss how mentors' and mentees' interactions are at the center of mentorship in movement disorders and the MDS. Read the article