Neuroscience: Amateur Hour

Parkinson's disease is a neurodegenerative disorder characterized by uncontrollable movements, stiffness, and cognitive decline. Curious? Come learn more! Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at neuroscienceamateurhour@gmail.com or DM me at NeuroscienceAmateurHour on Instagram.Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscienceI really appreciate it!!!Citations and relevant papers are below. National Institute on Aging. Parkinson’s Disease: Causes, Symptoms, and Treatments. National Institute on Aging. Hogg E, Frank S, Oft J, Benway B, Rashid MH, Lahiri S. Urinary Tract Infection in Parkinson’s Disease. Journal of Parkinson’s Disease. 2022;12(3):743-757. ‌Yu J. Stages of Parkinson’s | Parkinson’s Foundation. www.parkinson.org. Published 2022. ‌Zhang ZX, Dong ZH, Román GC. Early Descriptions of Parkinson Disease in Ancient China. Archives of Neurology. 2006;63(5):782. ‌2-Minute Neuroscience: Direct Pathway of the Basal Ganglia. www.youtube.com. 2-Minute Neuroscience: Indirect Pathway of the Basal Ganglia. www.youtube.com. ‌Thanvi B, Lo N, Robinson T. Levodopa-induced dyskinesia in Parkinson’s disease: clinical features, pathogenesis, prevention and treatment. Postgraduate Medical Journal. 2007;83(980):384-388. Zhang JF, Wang XX, Feng Y, Fekete R, Jankovic J, Wu YC. Impulse Control Disorders in Parkinson’s Disease: Epidemiology, Pathogenesis and Therapeutic Strategies. Frontiers in Psychiatry. 2021;12. Hisahara S, Shimohama S. Dopamine Receptors and Parkinson’s Disease. International Journal of Medicinal Chemistry. 2011;2011:1-16. Houston. Tmc.edu. Published October 20, 2020. https://nba.uth.tmc.edu/neuroscience/m/s3/chapter04.html‌Ovallath S, Sulthana B. Levodopa: History and Therapeutic Applications. Annals of Indian Academy of Neurology. 2017;20(3):185-189. ‌Levodopa | Parkinson’s Foundation. www.parkinson.org. https://www.parkinson.org/living-with-parkinsons/treatment/prescription-medications/levodopa‌Kelly MJ, Baig F, Hu MTM, Okai D. Spectrum of impulse control behaviours in Parkinson’s disease: pathophysiology and management. Journal of Neurology, Neurosurgery & Psychiatry. 2020;91(7):703-711. ‌Gerfen CR, Surmeier DJ. Modulation of Striatal Projection Systems by Dopamine. Annual Review of Neuroscience. 2011;34(1):441-466. ‌Sayare S. The Woman Who Could Smell Parkinson’s. The New York Times. https://www.nytimes.com/2024/06/14/magazine/parkinsons-smell-disease-detection.html. Published June 14, 2024. ‌Blandini F, Nappi G, Tassorelli C, Martignoni E. Functional changes of the basal ganglia circuitry in Parkinson’s disease. Progress in Neurobiology. 2000;62(1):63-88. ‌Lanciego JL, Luquin N, Obeso JA. Functional Neuroanatomy of the Basal Ganglia. Cold Spring Harbor Perspectives in Medicine. 2012;2(12):a009621-a009621. Support the show

Explore the captivating world of dreams! Discover how dreams occur during both REM and non-REM sleep, influenced by brain waves like PGO waves. Delve into theories about whether dreams stem from memories or are creatively generated. Learn about the intriguing connection between REM eye movements and visual experiences. Uncover the surprising roles of dreams in emotional regulation and personal development, plus the allure—and risks—of lucid dreaming. Join a journey through the science and mystery of our nightly adventures!

Have you ever thought about why some feelings might be described as gut-wrenching? Or why do the first feelings of love make you feel butterflies in the stomach? It's time to explore how your gut and your brain are connected!Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at neuroscienceamateurhour@gmail.com or DM me at NeuroscienceAmateurHour on Instagram.Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscienceI really appreciate it!!!Citations and relevant papers are below!Enteric nervous system. qbi.uq.edu.au. Published October 15, 2018. Accessed May 22, 2023. https://qbi.uq.edu.au/brain/brain-anatomy/peripheral-nervous-system/enteric-nervous-system#:~:text=The%20enteric%20nervous%20system%20neuronsCleveland Clinic. Cranial Nerves: Function, Anatomy and Location. Cleveland Clinic. Published October 27, 2021. https://my.clevelandclinic.org/health/body/21998-cranial-nervesMayer EA. Gut feelings: the emerging biology of gut–brain communication. Nature Reviews Neuroscience. 2011;12(8):453-466. doi:https://doi.org/10.1038/nrn3071Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Annals of gastroenterology. 2015;28(2):203-209.Oligschlaeger Y, Yadati T, Houben T, Condello Oliván CM, Shiri-Sverdlov R. Inflammatory Bowel Disease: A Stressed “Gut/Feeling.” Cells. 2019;8(7):659. doi:https://doi.org/10.3390/cells8070659Vancamelbeke M, Vermeire S. The intestinal barrier: a fundamental role in health and disease. Expert Review of Gastroenterology & Hepatology. 2017;11(9):821-834. doi:https://doi.org/10.1080/17474124.2017.1343143Clapp M, Aurora N, Herrera L, Bhatia M, Wilen E, Wakefield S. Gut microbiota’s effect on mental health: the gut-brain axis. Clinics and Practice. 2017;7(4). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641835/‌Zoppi S, Madrigal JLM, Pérez-Nievas BG, et al. Endogenous cannabinoid system regulates intestinal barrier function in vivo through cannabinoid type 1 receptor activation. Am J Physiol Gastr L 2012;302:565.Radjabzadeh D, Bosch JA, Uitterlinden AG, et al. Gut microbiome-wide association study of depressive symptoms. Nature Communications. 2022;13(1):7128. doi:https://doi.org/10.1038/s41467-022-34502-3Wapner J. The link between our food, gut microbiome and depression. Washington Post. https://www.washingtonpost.com/wellness/2023/01/31/gut-microbiome-anxiety-depression/. Published January 31, 2023.Fond G, Loundou A, Hamdani N, et al. Anxiety and depression comorbidities in irritable bowel syndrome (IBS): a systematic review and meta-analysis. European Archives of Psychiatry and Clinical Neuroscience. 2014;264(8):651-660. doi:https://doi.org/10.1007/s00406-014-0502-zWhat’s the Difference Between Probiotics and Prebiotics? www.sclhealth.org. https://www.sclhealth.org/blog/2019/07/difference-between-probiotics-and-prebiotics/Liu RT, Walsh RFL, Sheehan AE. Prebiotics and probiotics for depression and anxiety: A systematic review and meta-analysis of controlled clinical trials. Neuroscience & Biobehavioral Reviews. 2019;102:13-23. doi:https://doi.org/10.1016/j.neubiorev.2019.03.023Doll JPSupport the show

A tragic incident - a brain injury, a stroke, the development of a neurodegenerative disease, and all of a sudden, a patient's arm no longer belongs to them. It will pull their hair, pinch their cheeks, and grab miscellaneous objects, seemingly developing a mind of its own. How can something that belongs to you and is controlled by your brain, your electrical pulses, and your motor neurons ever develop a mind of its own? Listen to find out more!Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at neuroscienceamateurhour@gmail.com or DM me at NeuroscienceAmateurHour on Instagram.Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscienceI really appreciate it!!!Citations and relevant papers are below! Doody RS, Jankovic J. The alien hand and related signs. Journal of Neurology, Neurosurgery & Psychiatry. 1992;55(9):806-810. doi:https://doi.org/10.1136/jnnp.55.9.806Panikkath R, Panikkath D, Mojumder D, Nugent K. The alien hand syndrome. Proceedings (Baylor University Medical Center). 2014;27(3):219-220. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059570/#:~:text=Alien%20hand%20syndrome%20is%20aCaixeta L, Maciel P, Nunes J, Nazareno L, Araújo L, Borges JR. Alien hand syndrome in AIDS: Neuropsychological features and physiopathological considerations based on a case report. Dementia & Neuropsychologia. 2007;1(4):418-421. doi:https://doi.org/10.1590/s1980-57642008dn10400016Alyssa Anderson. What Is Alien Hand Syndrome? WebMD. Published April 8, 2022. https://www.webmd.com/brain/what-is-alien-hand-syndromeParry-Romberg Syndrome | Boston Children’s Hospital. www.childrenshospital.org. https://www.childrenshospital.org/conditions/parry-romberg-syndromeFeinberg TE, Schindler RJ, Flanagan NG, Haber LD. Two alien hand syndromes. Neurology. 1992;42(1):19-19. doi:https://doi.org/10.1212/wnl.42.1.19Le K, Zhang C, Greisman L. Alien hand syndrome – a rare presentation of stroke. Journal of Community Hospital Internal Medicine Perspectives. 2020;10(2):149-150. doi:https://doi.org/10.1080/20009666.2020.1756610Motor Cortex (Section 3, Chapter 3) Neuroscience Online: An Electronic Textbook for the Neurosciences | Department of Neurobiology and Anatomy - The University of Texas Medical School at Houston. nba.uth.tmc.edu. https://nba.uth.tmc.edu/neuroscience/m/s3/chapter03.html#:~:text=The%20premotor%20cortex%20appears%20toBru I, Verhamme L, Neve P, Maebe H. Rehabilitation of a patient with alien hand syndrome: A case report of a 61-year old man. Journal of Rehabilitation Medicine – Clinical Communications. 2021;4(1):jrmcc00050. doi:https://doi.org/10.2340/20030711-1000050Gheewala G, Gadhia R, Surani S, Ratnani I. Posterior Alien Hand Syndrome from Acute Ischemic Left Parietal Lobe Infarction. Cureus. Published online October 3, 2019. doi:https://doi.org/10.7759/cureus.5828Mannella F, Mirolli M, Baldassarre G. Goal-Directed Behavior and Instrumental Devaluation: A Neural SSupport the show

Could a dead salmon be thinking or is something else at play? If you're curious about the answer to that question and want to learn more about magnetic resonance imaging (MRI), come and listen! Featuring special guest the Eventually To be Dr. Ilya, this episode discusses the science behind MRI, how noise can affect imaging and landmark studies in the field! Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at neuroscienceamateurhour@gmail.com or DM me at NeuroscienceAmateurHour on Instagram.Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscienceI really appreciate it!!!Citations and relevant papers are below! Bennett C, Miller M, Wolford G. Neural correlates of interspecies perspective taking in the post-mortem Atlantic Salmon: an argument for multiple comparisons correction. NeuroImage. 2009;47:S125. doi:10.1016/s1053-8119(09)71202-9Scicurious. IgNobel Prize in Neuroscience: The dead salmon study. Scientific American Blog Network. https://blogs.scientificamerican.com/scicurious-brain/ignobel-prize-in-neuroscience-the-dead-salmon-study/Van Dijk KRA, Sabuncu MR, Buckner RL. The influence of head motion on intrinsic functional connectivity MRI. NeuroImage. 2012;59(1):431-438. doi:10.1016/j.neuroimage.2011.07.044Nishimoto S, Vu An T, Naselaris T, Benjamini Y, Yu B, Gallant Jack L. Reconstructing Visual Experiences from Brain Activity Evoked by Natural Movies. Current Biology. 2011;21(19):1641-1646. doi:10.1016/j.cub.2011.08.031Will GJ, Rutledge RB, Moutoussis M, Dolan RJ. Neural and computational processes underlying dynamic changes in self-esteem. FeldmanHall O, ed. eLife. 2017;6:e28098. doi:10.7554/eLife.28098‌Support the show

Two words - Octopus brains! Nine of them!!!But seriously, if you want to learn about the insanity of the dispersed octopus nervous system, come and take a listen! Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at neuroscienceamateurhour@gmail.com or DM me at NeuroscienceAmateurHour on Instagram.Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscienceI really appreciate it!!!Citations and relevant papers are below! The Many Plurals of “Octopus.” Merriam-webster.com. Published 2019. Accessed September 16, 2019. https://www.merriam-webster.com/words-at-play/the-many-plurals-of-octopus-octopi-octopuses-octopodesNine Brains Are Better Than One: An Octopus’ Nervous System | Biomechanics in the Wild. sites.nd.edu. https://sites.nd.edu/biomechanics-in-the-wild/2021/04/07/nine-brains-are-better-than-one-an-octopus-nervous-system/‌Sumbre G, Gutfreund Y, Fiorito G, Flash T, Hochner B. Control of Octopus Arm Extension by a Peripheral Motor Program. Science. 2001;293(5536):1845-1848. doi:10.1126/science.1060976Godfrey-Smith P. The Mind of an Octopus. Scientific American Mind. 2016;28(1):62-69. doi:10.1038/scientificamericanmind0117-62Hochner B. An Embodied View of Octopus Neurobiology. Current Biology. 2012;22(20):R887-R892. doi:10.1016/j.cub.2012.09.001Hochner B, Brown ER, Langella M, Shomrat T, Fiorito G. A Learning and Memory Area in the Octopus Brain Manifests a Vertebrate-Like Long-Term Potentiation. Journal of Neurophysiology. 2003;90(5):3547-3554. doi:10.1152/jn.00645.2003Park M. AMPA Receptor Trafficking for Postsynaptic Potentiation. Frontiers in Cellular Neuroscience. 2018;12. doi:10.3389/fncel.2018.00361Huang EP. Synaptic plasticity: Going through phases with LTP. Current Biology. 1998;8(10):R350-R352. doi:10.1016/s0960-9822(98)70219-2Support the show

Hello! I return!Today we will be talking about the neuroscience of seizures and epilepsy. Brought about an imbalance of the accelerators (excitatory circuits) and brakes (inhibitory circuits) of the brain, seizures are pretty terrifying events. They're marked by temporary confusion, a staring spell, uncontrollable jerking of the arms and legs (like what you see when someone depicts a seizure on gray's anatomy), loss of consciousness, or even some cognitive and emotional symptoms. Curious to find out what the heck the brain is up to during seizures? Come and listen to find out more!Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at neuroscienceamateurhour@gmail.com or DM me at NeuroscienceAmateurHour on Instagram.Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscienceI really appreciate it!!!Citations and relevant papers are below! Types of Seizures. www.hopkinsmedicine.org. https://www.hopkinsmedicine.org/health/conditions-and-diseases/epilepsy/types-of-seizures#:~:text=Focal%20onset%20seizures%20start%20inRs F, Jh C, Ja F, et al. Operational Classification of Seizure Types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia. Published April 1, 2017. https://pubmed.ncbi.nlm.nih.gov/28276060/Types of Seizures. Epilepsy Foundation. https://www.epilepsy.com/what-is-epilepsy/seizure-typesArticles. Cedars-Sinai. https://www.cedars-sinai.org/health-library/diseases-and-conditions/m/myoclonic-epilepsy.htmlBromfield EB, Cavazos JE, Sirven JI. Basic Mechanisms Underlying Seizures and Epilepsy. Nih.gov. Published 2015. https://www.ncbi.nlm.nih.gov/books/NBK2510/Peng SJ, Hsin YL. Functional Connectivity of the Corpus Callosum in Epilepsy Patients with Secondarily Generalized Seizures. Frontiers in Neurology. 2017;8. doi:10.3389/fneur.2017.00446Kim T, Nguyen P, Pham N, et al. Epileptic Seizure Detection and Experimental Treatment: A Review. Frontiers in Neurology. 2020;11. doi:10.3389/fneur.2020.00701Ammothumkandy A, Ravina K, Wolseley V, et al. Altered adult neurogenesis and gliogenesis in patients with mesial temporal lobe epilepsy. Nature Neuroscience. 2022;25(4):493-503. doi:10.1038/s41593-022-01044-2CDKL5 cyclin dependent kinase like 5 [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. Accessed August 3, 2022. https://www.ncbi.nlm.nih.gov/gene/6792‌CDKL5 Deficiency Disorder. Epilepsy Foundation. Accessed August 3, 2022. https://www.epilepsy.com/causes/genetic/cdkl5-disorderSørensen AT, Kokaia M. Novel approaches to epilepsy treatment. Epilepsia. 2012;54(1):1-10. doi:10.1111/epi.12000Rogawski MA, Löscher W. The neurobiology of antiepileptic drugs. Nature Reviews Neuroscience. 2004;5(7):553-564. doi:10.1038/nrn1430Support the show

That's a wrap on Season 1 folks! See you all in a few weeks with more episodes about epilepsy, alcohol, and more! Happy researching and I'll see you all again soon!Support the show

Apologies for the absolute chaos that is this episode. Today I wanted to cover some foundational background concepts, including how a signal travel within a neuron from dendrites to the tip of the axon and how that neuron then communicates to other neurons and parts of the body. Curious? Come and listen to find out more!!!Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at neuroscienceamateurhour@gmail.com or DM me at NeuroscienceAmateurHour on Instagram.Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscienceI really appreciate it!!!Citations and relevant papers are below! Guy-Evans O. What Is a Neuron? Function, Parts, Structure, and Types | Simply Psychology. www.simplypsychology.org. Published February 15, 2021. https://www.simplypsychology.org/neuron.htmlKhan Academy. Neuron action potentials: The creation of a brain signal. Khan Academy. Published 2016. https://www.khanacademy.org/test-prep/mcat/organ-systems/neuron-membrane-potentials/a/neuron-action-potentials-the-creation-of-a-brain-signalPurves D, Augustine GJ, Fitzpatrick D, et al. Increased Conduction Velocity as a Result of Myelination. Neuroscience 2nd edition. Published online 2001. https://www.ncbi.nlm.nih.gov/books/NBK10921/#:~:text=By%20acting%20as%20an%20electricalChen I, Forshing Lui. Neuroanatomy, Neuron Action Potential. Nih.gov. Published August 27, 2019. https://www.ncbi.nlm.nih.gov/books/NBK546639/Guy-Evans O. Synapse Definition and Function | Simply Psychology. www.simplypsychology.org. Published February 21, 2021. https://www.simplypsychology.org/synapse.htmlmy brainnnnnnnnnSupport the show

This episode is part two of my miniseries on the neuroscience of language production and processing and today we're touching on how the brain regions encoding those concepts change in deaf individuals. It turns out that the brain is the literal embodiment of that "its free real estate" meme and vision input takes over the auditory cortex!If you're curious to know more - come and take a listen!Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscienceI really appreciate it!!!Citations and relevant papers are below! CDC. Genetics of Hearing Loss | CDC. Centers for Disease Control and Prevention. Published February 18, 2015. https://www.cdc.gov/ncbddd/hearingloss/genetics.html#:~:text=50%25%20to%2060%25%20of%20hearingDeafness causes before birth | Deafness in childhood. www.ndcs.org.uk. https://www.ndcs.org.uk/information-and-support/childhood-deafness/causes-of-deafness/#:~:text=Deafness%20can%20also%20be%20causedSimon M, Campbell E, Genest F, MacLean MW, Champoux F, Lepore F. The Impact of Early Deafness on Brain Plasticity: A Systematic Review of the White and Gray Matter Changes. Frontiers in Neuroscience. 2020;14. doi:10.3389/fnins.2020.00206Sharma A, Dorman MF, Spahr AJ. A Sensitive Period for the Development of the Central Auditory System in Children with Cochlear Implants: Implications for Age of Implantation. Ear and Hearing. 2002;23(6):532-539. https://journals.lww.com/ear-hearing/Abstract/2002/12000/A_Sensitive_Period_for_the_Development_of_the.4.aspxVoss P, Thomas ME, Cisneros-Franco JM, de Villers-Sidani É. Dynamic Brains and the Changing Rules of Neuroplasticity: Implications for Learning and Recovery. Frontiers in Psychology. 2017;8. doi:10.3389/fpsyg.2017.01657Purves D, Augustine GJ, Fitzpatrick D, et al. The Auditory Cortex. Nih.gov. Published 2016. https://www.ncbi.nlm.nih.gov/books/NBK10900/Bola Ł, Zimmermann M, Mostowski P, et al. Task-specific reorganization of the auditory cortex in deaf humans. Proceedings of the National Academy of Sciences. 2017;114(4):E600-E609. doi:10.1073/pnas.1609000114‌Fougnie D, Cockhren J, Marois R. A common source of attention for auditory and visual tracking. Attention, Perception, & Psychophysics. 2018;80(6):1571-1583. doi:10.3758/s13414-018-1524-9Campbell R, MacSweeney M, Waters D. Sign Language and the Brain: A Review. The Journal of Deaf Studies and Deaf Education. 2008;13(1):3-20. doi:10.1093/deafed/enm035Support the show