Writer and podcaster Jamie Loftus dives into her New York Times bestselling book Raw Dog: The Naked Truth About Hot Dogs, a travelog on the cultural and historical significance of the American sausage; chef and food writer J. Kenji López-Alt tests his knowledge of cooking gadget infomercials; and R&B/Soul vocalist Danielle Ponder performs "So Long" from her debut album Some of Us Are Brave. Plus, host Luke Burbank and announcer Elena Passarello go on some hypothetical road trips.

Comedian Hari Kondabolu discusses his new standup special “Vacation Baby” and how regrettably he blew off congresswoman Alexandria Ocasio-Cortez on her campaign trail; writer Kristi Coulter unpacks her memoir “Exit Interview: The Life and Death of My Ambitious Career,” which recounts the often soul-crushing work culture of an Amazon executive; and indie rock duo Quasi performs "Queen of Ears" off their new album “Breaking the Balls of History.” Plus, host Luke Burbank and Elena Passarello share some of the wildest things children have said to our listeners.

Ari Shapiro, journalist and co-host of All Things Considered, unpacks his new book The Best Strangers in the World: Stories From a Life Spent Listening, which chronicles his reporting adventures across the globe, from Air Force One to the stage of the Hollywood Bowl; comedian and TV writer Demi Adejuyigbe explains how the WGA strike afforded him so much free time... to go to the Renaissance Faire. Plus, host Luke Burbank and Elena Passarello share stories of the most amazing strangers our listeners have encountered.

Pulitzer Prize-winning reporter and acclaimed author Timothy Egan unpacks his newest book A Fever in the Heartland, which traces the Ku Klux Klan's expansion across America in the 1920s and one woman's crusade to stop them; rapper and poet proves she's more talented than AI by performing a poem she penned backstage using popular search terms. Plus, host Luke Burbank and announcer Elena Passarello reveal the most ridiculous challenges our listeners have accepted.

On the special holiday edition of Live Wire, comedian and podcaster Paul F. Tompkins talks about passive-aggressive Christmas carolers and the most tense rendition of “O Holy Night" he's ever heard; poet José Olivarez discusses his latest collection Promises of Gold, which explores the various types of love in our lives, from self-love to platonic love and over to romance; and singer-songwriter Esme Patterson performs her original Christmas song “If I.” Plus, host Luke Burbank and announcer Elena Passarello share our listeners favorite holiday traditions.

In this podcast extra, comedian Aparna Nancherla (Unreliable Narrator: Me, Myself and Imposter Syndrome) is quizzed on the former "career lowlights" of some high-profile celebrities.

Writer and director Laura Chinn (Florida Girls) discusses her memoir Acne, which tackles her racial identity, Scientology, and of course... very oily skin; standup comedian Mohanad Elshieky riffs on embarrassing encounters with TSA and Uber drivers; and multi-instrumentalist Jenny Conlee, of The Decemberists, performs "Hawk" from her solo album Tides: Pieces for Accordion and Piano. Plus, host Luke Burbank and announcer Elena Passarello hear from our listeners about what they obsessed over as teenagers.

Podcaster Sam Sanders (Vibe Check) shares his hot takes on pop culture, from the Barbie movie to his favorite nepobaby; comedian Reggie Watts interprets his feelings about generation differences through a spoken word poem; and indie folk duo Sway Wild perform their song "Home," which was inspired by a two-month sailing voyage in British Columbia. Plus, host Luke Burbank and announcer Elena Passarello reveal our listeners' favorite moment in pop culture this year.

Novelist Dana Schwartz unpacks her gothic fantasy duology, Anatomy and Immortality, then dives into her podcast Noble Blood, which explores the bizarre and risqué lives of royals; writer Jenny Odell dismantles the clock in her newest book Saving Time while explaining it's unofficial motto: time is beans; and indie rocker Black Belt Eagle Scout performs "Don't Give Up" from her new album The Land, The Water, The Sky, which dreams up the atmosphere of her ancestral land of Swinomish. Plus, host Luke Burbank and announcer Elena Passarello reveal how our listeners love to "waste" time.

Author and columnist R. Eric Thomas shares anecdotes from his memoir Congratulations, The Best Is Over, including how baking cupcakes may have saved his life; standup comedian Ian Karmel makes the case for why Arby's is a farm-to-table restaurant; and indie group NONBINARY GIRLFRIEND perform the title track off their new album Big and Kind. Plus, host Luke Burbank and announcer Elena Passarello reveal the surprising differences between our listeners and their partners.