This Week in Cardiology

Topics discussed include tricuspid regurgitation therapy, left atrial appendage trials, reflections on being too soft on medical science, and questioning the scientific process in cardiology.

The podcast covers topics such as the Million Hearts RCT, ENRICH AF, TAVI vs SAVR, Partner 3 and Evolut-low-risk trials, and myocardial viability. It explores the impact of risk calculators and risk reduction payments on patient treatment motivation. The Million Heart Study suggests that extra treatment may lead to reduced cardiovascular events but more hospitalizations. Clinical trials comparing E-doxaban and Tavi versus SAVR reveal varying outcomes and concerns about death rates, stroke rates, and rehospitalization. A study compares treatment options for ischemic cardiomyopathy and discusses the role of viability testing.

In this week's podcast, topics include listener feedback, oral anticoagulation in patients with intracranial hemorrhage, the difference between statistical and clinical significance, and the correlation between statins and diabetes. The hosts also discuss intravascular imaging in cardiology procedures, the use of anticoagulation in intracranial hemorrhage, and the measurement of 10-year risk scores in cardiovascular disease prevention. They also explore a study challenging the commonly used P-value threshold for significance in medical research.

This week's podcast covers GLP-1 agonists, imaging during PCI, and the power of sham controls in procedure trials. Topics include positive results in the FLOW trial, the use of Semaglutide in HFpEF, adverse effects of GLP-1 agonists, and the need for updates in intravascular imaging guidelines. Ablation of the right greater splanktic nerve in HF and the importance of sham controls in research are also discussed.

In this podcast, they discuss topics such as the benefits of coated vs uncoated aspirin, a new trial in coronary artery disease, conflicts of interest in medical device coverage determinations, the role of primary care physicians in decoding atrial fibrillation recurrence, and the impact of stricter hypertension criteria on CHADSVASC scoring.

Reader feedback, leadless pacing, ABIM, SGLT2 inhibitors, peri-operative MI after cardiac surgery, and. AHA late-breakers are the topics John Mandrola, MD, covers in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. Reader Feedback Sep 22, 2023 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/996694 -   ODYSSEY OUTCOMES trial https://www.nejm.org/doi/full/10.1056/nejmoa1801174 -   FOURIER https://www.nejm.org/doi/full/10.1056/nejmoa1615664 II. Leadless Pacing -   Leadless vs Transvenous Pacemaker Study https://doi.org/10.1093/europace/euad269 III. ABIM News Heart Societies Ready to Split From ABIM Over Long-Standing MOC Disputes https://www.medscape.com/viewarticle/996747 IV. SGLT2 inhibitors Empagliflozin Gets FDA Nod for CKD Without T2D or HF https://www.medscape.com/viewarticle/996873 -   EMPA-Kidney https://www.nejm.org/doi/full/10.1056/NEJMoa2204233 V. Peri-Op MI after Cardiac Surgery Cardiac Troponin Predicts Mortality Post Surgery https://www.medscape.com/viewarticle/996877 -   Austrian Perioperative MI study https://doi.org/10.1016/j.jacc.2023.07.011 -   Vision  https://www.nejm.org/doi/10.1056/NEJMoa2000803 VI. AHA Late Breakers -   Link to Late-Breakers https://professional.heart.org/en/meetings/scientific-sessions/programming/late-breaking-science#late-breaking You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Coronary calcium, cardiac arrest survival, Factor XI drug findings, APCs and a potential new board certification in cardiology are the topics discussed by John Mandrola, MD in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Coronary Artery Calcium -   CONFIRM Registry - https://doi.org/10.1016/j.jcmg.2023.03.008 -   CURE -- https://www.nejm.org/doi/full/10.1056/nejmoa010746 II Cardiac Arrest Cardiac Arrest Centers No Benefit in OHCA Without STEMI https://www.medscape.com/viewarticle/995885 -   Cycling coverage https://velo.outsideonline.com/road/road-racing/nathan-van-hooydonck-forced-to-end-to-racing-career-due-to-heart-condition/ -   ARREST https://doi.org/10.1016/S0140-6736(23)01351-X -   SCD in Athletes Bob Harrington and Manesh Patel https://www.medscape.com/viewarticle/995575 III Factor XI Trial Halted for Bleeding Reduction With Abelacimab vs Rivaroxaban in AF https://www.medscape.com/viewarticle/996587 -   Press Release - https://anthostherapeutics.com/wp-content/uploads/2023/09/2023-09-18-Anthos-Press-Release-final.pdf -   Abelacimab, a Factor XI Inhibitor, Prevents VTE With Low Bleeding Risk in Knee Replacement -   NEJM proof-of-concept https://www.nejm.org/doi/full/10.1056/NEJMoa2105872 -   OCEANIC-AF https://classic.clinicaltrials.gov/ct2/show/NCT05643573 -   Will Factor XI Be the Goldilocks Anticoagulant Target? https://www.medscape.com/viewarticle/979634 IV APC Care NPs and PAs Handling Increasingly More Primary Care Visits: New Studies https://www.medscape.com/viewarticle/996709 BMJ paper -- https://www.bmj.com/content/382/bmj-2022-073933 V Possible Cardiology Board Certification Changes -   Heart Societies Ready to Split From ABIM Over MOC Disputes https://www.medscape.com/viewarticle/996747 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Topics discussed include reader feedback, imaging in the cath lab, AF ablation to relieve anxiety, and the potential use of aldosterone as a drug target in hypertension. The hosts analyze two trials on imaging in the cath lab and compare OCT-guided PCI with angiography alone. They also explore the psychological effects of AFib and the impact of AFib ablation. Additionally, they discuss cathodorablation, AFiblation, and new anti-hypertensive drugs.

In this podcast, John Mandrola, MD discusses trials in cardiology including ECLS-SHOCK, FIRE, MULTISTARS-AMI, HEART FID, and DANPACE II. The ECLS-SHOCK trial found that ECMO for shock in acute MI may do more harm than good. The FIRE trial showed that physiology-guided MI complete revascularization benefits older patients. The MULTISTARS-AMI trial found parity between prompt and staged STEMI complete revascularization. The HEART-FID trial revealed modest benefits of IV iron supplementation in heart failure. The podcast also explores pacing and sick sinus syndrome.

This podcast covers a range of interesting topics including obesity, heart failure, atrial fibrillation, frailty, evidence translation, and catheter ablation. The speaker discusses the recent ESC wrap-up meeting and their experiences in Amsterdam. They also delve into findings from studies like the FRAIL AF study, STEP HEF PEPF study, NOAA AF Net Six Trial, and the Advent Trial comparing PFA and thermal ablation for treating AFib.