Send us a textIn this episode of the Incubator, At the bench, we talk with Dr. Krithika Lingappan who is a neonatologist and physician-scientist at the Children’s Hospital of Philadelphia and the University of Pennsylvania. Join us as we hear what inspired Dr. Lingappan to build her cutting-edge research program investigating sex-specific differences in preterm lung disease. She explains that every cell in the lung shows sex bias, including epithelial cells, endothelial cells, and immune cells. She explores the role of the X and Y chromosomes in determining susceptibility to lung diseases and the ongoing research to understand the dosage of the X chromosome and genes on the Y chromosome. Dr. Lingappan also discusses the use of multi-omics approaches, such as single-cell RNA sequencing and spatial transcriptomics, to study lung development and disease. We are fortunate to learn from her experiences including finding mentorship, building a research career that addresses a common clinical question, and establishing and then moving a research group. Dr. Lingappan also discusses her work promoting neonatology physician-scientist career development. We are thrilled to bring you this inside look into what it takes to become a neonatology physician-scientist!As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textIn this episode, hosts Ben and Daphna discuss several recent neonatology studies. First, they examine an algorithm developed by Shah et al. for the timely detection of hypothyroidism in preterm infants based on gestational age and TSH levels. Next, Daphna reviews a study by Halling et al. comparing initial endotracheal versus intravenous epinephrine administration during neonatal resuscitation. While endotracheal epinephrine was given faster, IV epinephrine achieved return of spontaneous circulation more quickly.They also discuss studies on the feasibility of using intranasal human milk as stem cell therapy for intraventricular hemorrhage, the association between relaxation interventions and human milk outcomes, and the timing of red blood cell transfusions in relation to necrotizing enterocolitis risk. Finally, Daphna highlights a one-year follow-up of the WISER intervention, showing sustained reductions in burnout and depression among NICU healthcare workers.Throughout the discussion, Ben and Daphna provide thoughtful analysis and identify areas needing further research. They conclude by reminding listeners about a survey with prize giveaways in honor of The Incubator's 3-year anniversary. This informative and engaging episode provides a helpful overview of some of the latest neonatology research. As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textUse of Initial Endotracheal Versus Intravenous Epinephrine During Neonatal Cardiopulmonary Resuscitation in the Delivery Room: Review of a National Database.Halling C, Conroy S, Raymond T, Foglia EE, Haggerty M, Brown LL, Wyckoff MH; American Heart Association’s Get With The Guidelines–Resuscitation Investigators.J Pediatr. 2024 Apr 16;271:114058. doi: 10.1016/j.jpeds.2024.114058. Online ahead of print.PMID: 38631614As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textTiming of Red Blood Cell Transfusions and Occurrence of Necrotizing Enterocolitis: A Secondary Analysis of a Randomized Clinical Trial. Salas AA, Gunn E, Carlo WA, Bell EF, Das A, Josephson CD, Patel RM, Tan S, Kirpalani H; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network. JAMA Netw Open. 2024 May 1;7(5):e249643. doi: 10.1001/jamanetworkopen.2024.9643.PMID: 38700862 As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textA practical gestational age-based algorithm for timely detection of hypothyroidism in premature infants.Shah AN, Li W, Zheng D, Lalani S, Kaluarachchi DC, Findley TO. J Perinatol. 2024 May 11. doi: 10.1038/s41372-024-01985-5. Online ahead of print. PMID: 38734804As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textIn this inspiring episode of Tech Tuesday on The Incubator Podcast, hosts Ben and Daphna welcome special guest Nicholas Hall, founder and president of Graham's Foundation. Nicholas shares his personal journey of losing his premature son Graham after just 45 days, while his daughter Reese survived after a 119-day NICU stay. This life-changing experience sparked his desire to create Graham's Foundation in 2009 to support other families navigating the challenges of prematurity.Nicholas discusses the foundation's mission to ensure that no parent goes through the prematurity experience alone by providing a variety of support resources. These include care packages, a mentorship program connecting NICU parents, an engaging MyPreemie app for tracking milestones and accessing information, and more. The foundation has grown to include 40 trained mentors with diverse experiences to help families facing different challenges.Throughout the conversation, Nicholas emphasizes the importance of encouraging parental engagement and empowering NICU parents to feel confident in their journey. He also shares his perspective on the emotional aspects of running a foundation and the personal growth and healing it has brought him.With Graham's Foundation, Nicholas has created a legacy honoring his son while making a meaningful difference in countless families' lives. This episode is a must-listen for anyone seeking support or looking to get involved in helping NICU families. As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textIn this exciting episode of The Incubator podcast, hosts Ben and Daphna Barbeau dive into the promising world of artificial intelligence (AI) in neonatology. They are joined by special guests Dr. James Barry, medical director of the University of Colorado Hospital NICU, and Dr. Ryan McAdams, professor and chief of the Division of Neonatology and Newborn Nursery at the University of Wisconsin. Both guests are co-chairs of the Steering Committee for NeoMind AI, a collaborative focused on advancing neonatal machine learning innovations, development, and artificial intelligence.The conversation explores the potential of AI to revolutionize neonatal care by leveraging the vast amounts of data generated in NICUs to improve outcomes, optimize care delivery, and enhance medical education. Dr. Barry and Dr. McAdams provide insights into the current state of AI in neonatology, the importance of collaboration in AI research, and the ethical considerations surrounding this technology.NeoMind AI is introduced as an inclusive learning collaborative that aims to break down silos between organizations, educate neonatologists about AI, and foster collaboration on common data platforms. The guests emphasize the importance of clinician involvement in AI development and application to ensure safe, effective, and unbiased implementation.This episode offers a fascinating look at the future of neonatology and the role AI will play in transforming the field. It serves as an invitation for listeners to join the NeoMind AI community and contribute to this exciting new frontier in neonatal care. As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textIn this episode, Mbozu and Shelly-Ann are joined by Dr. Clyde Cave and Dr. Gillian Birchwood. The conversation explores the neonatal care in Barbados, focusing on the challenges faced and the incremental changes made to improve the care provided. Dr. Cave and Dr. Birchwood provide an overview of the NICU in Barbados, the early years of the NICU, human resource development, financial challenges and fundraising, dealing with pushbacks, and internal pushback with changing practices. The conversation highlights the importance of advocating for neonatal care and the need for continuous improvement in the face of limited resources. Episode Webpage Link:  https://www.the-incubator.org/post/207-caring-for-neonates-in-barbados-how-small-changes-over-time-create-big-results-ft-dr-clAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textIn this episode of The Incubator Journal Club, Ben and Daphna discuss several recent neonatology papers. They review a NEJM trial on nutritional support strategies for moderate to late preterm infants, finding no effects on time to full feeds or body composition at 4 months. Next, they discuss a study on umbilical cord blood cultures for early onset sepsis, noting good concordance with neonatal blood cultures. A Japanese retrospective study found erythropoietin use was associated with increased ROP risk but decreased NEC and mortality. However, the hosts caution about limitations in EPO dosage data and variation between centers. They then discuss a trial showing breast milk enemas reduce time to meconium evacuation and full feeds compared to saline enemas in preterm infants. A paper from Nationwide Children's reports good outcomes managing BPD without routine blood gases, potentially saving costs. Lastly, a study suggests transcutaneous bilirubinometry may safely monitor rebound hyperbilirubinemia after phototherapy. Throughout the discussion, Ben and Daphna provide insightful analysis of each study's strengths, limitations, and implications for practice. They also highlight their upcoming 3-year podcast anniversary, announcing a special giveaway and listener survey.  As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!

Send us a textBreast Milk Enema and Meconium Evacuation Among Preterm Infants: A Randomized Clinical Trial. Zheng L, Gai L, Wu Y, Kong C, Sun F, Gao J, Yuan W, Liu M, Jiang H, Tuo N, Yang F.JAMA Netw Open. 2024 Apr 1;7(4):e247145. doi: 10.1001/jamanetworkopen.2024.7145.PMID: 38648060 Free article. Clinical Trial.As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!