Brendon Walsh, a comedian celebrated for his early work with Marc, returns for a heartfelt chat. He shares life updates since his last visit, including a hiatus from comedy and coping with the loss of his podcast co-host. The conversation dives deep into his new venture, The World Record podcast, co-hosted with his wife. They reflect on personal growth, the evolution of their comedy careers, and the challenges of navigating the entertainment world, sprinkled with humorous anecdotes and poignant insights.

Greg Fitzsimmons, a seasoned comedian, returns with a new comedy special after a lengthy break from the show. He reflects on his ongoing journey in comedy, touching on his battles with anxiety and his family's self-destructive cycles. The two reminisce about their early days in Boston and share humorous, poignant stories from their careers. Greg also opens up about the complexities of parenting, caring for aging parents, and his relationship with cannabis, providing a heartfelt and relatable glimpse into the life of a comedian.

In conversation with Marc, Paul W. Downs, co-creator of 'Hacks' and comedy veteran, shares insights from his unique journey through the comedy landscape. He reflects on his diverse background, from UCB training to digital fame and collaboration in 'Broad City.' Paul navigates the comedy of vulnerability, confronting embarrassment, and the challenges of authenticity in modern comedic expression. They also delve into the evolving dynamics of the comedy industry, discussing the impact of the pandemic and the importance of female comedians during these transformative times.

Michael Rooker, famed for his menacing roles, shares gripping stories from his Alabama childhood, where he lived without electricity or running water. He talks about how his bus driver’s outfit helped him land a role in 'Henry: Portrait of a Serial Killer' and reflects on his experience casting for 'Eight Men Out.' Rooker also embraces his journey into the comic book world with 'Guardians of the Galaxy,' and reminisces about reuniting with Kevin Costner for 'Horizon.' His unique insights into acting and family dynamics make for an engaging conversation.

Blair Socci, a comedian with a background in athletics and a love for poetry, shares her unique journey from sports to stand-up. She delves into how her athletic upbringing shaped her comedy, emphasizing resilience and self-expression. Socci also discusses her recent shift on social media, revealing her evolving relationship with it. Her anecdotes about volleyball reveal the humor in self-discovery and body image while intertwining her rich family history of cultural identity and resilience that adds depth to her comedic voice.

Moon Zappa, an author and daughter of the legendary Frank Zappa, opens up about her new memoir, exploring her complicated family legacy. She discusses the emotional fallout from her upbringing and the pressures of public scrutiny. Amidst past relationship reflections with the host, she shares insights on trauma, identity, and the struggles of growing up in a prominent family. Moon's candidness reveals the importance of communication, mental health, and self-acceptance in navigating the complexities of familial dynamics.

In this conversation, Beth Stelling, a comedian known for weaving personal trauma into her humor, shares her journey from childhood experiences to her Netflix special. She discusses the backlash she faced after opening up about an abusive relationship, revealing the complexities of healing through comedy. Beth also reflects on her Ohio roots and the experience of filming a comedy special in her hometown, embracing both vulnerability and resilience in her craft.

Jimmie Dale Gilmore, the acclaimed singer-songwriter and member of The Flatlanders, chats about his unique journey in music, which took a spiritual detour before his solo career took off in his 40s. He reveals insights into finding enlightenment while shaping Americana music. The conversation breezes through memorable topics like the mouth-watering Texas barbecue, his hearing loss struggles, and collaborations with Dave Alvin. Gilmore also shares tales from his band, emphasizing the deep connections between music, friendship, and personal growth.

Anna Akana, a comedian and actor, discusses her transformative journey from childhood instability to becoming a voice for Asian representation in media through YouTube. She shares her experience with mental health advocacy following her sister's tragic death and how comedy became a tool for navigating grief and difficult emotions. Akana also reflects on the complexities of identity and authenticity in the digital age, emphasizing the healing power of humor in addressing sensitive topics.

Wolfgang Van Halen, son of guitar icon Eddie Van Halen, opens up about the challenges of his legacy in the music industry. He shares how touring shaped his musical direction and helped him overcome online trolling and grief. The conversation touches on mental health, personal growth, and navigating family dynamics in a public eye. Wolfgang reflects on his new album 'Mammoth II' and the importance of emotional expression in music, providing insight into his journey of honoring his father's legacy while carving out his own unique sound.