Andy Blitz, a writer and comedian known for his work on Conan and Master of None, shares his colorful journey through the New York City comedy scene. He reflects on his early days at Luna Lounge and the magic of show business that first drew him in. Blitz opens up about mental health challenges, including his struggles with depression and ADHD while navigating an unpredictable industry. He also humorously discusses the evolution of late-night television and the ups and downs of pitching new projects, blending nostalgia with industry insights.

Jesse Eisenberg, acclaimed actor and director known for his roles in The Social Network and Zombieland, shares how Marc changed his life. He reflects on childhood fears and the bleakness that shaped him as an adult. Their conversation delves into Jesse's new film, A Real Pain, revealing how personal experiences fuel his creativity. Eisenberg also discusses trauma tourism, the complexities of character depth, and the significance of authenticity in storytelling, mixing humor and nostalgia throughout.

Dwight Yoakam, a multi-platinum recording artist and Grammy winner, dives into the evolution of country music, detailing its California roots and the blend with rock and punk. He shares his insights on influential bands like The Byrds and Creedence while reflecting on his new album, 'Brighter Days.' The conversation also touches on his experience as a first-time father, exploring the intersection of personal life and musical artistry. Yoakam's rich storytelling and deep connection to music history make for a captivating discussion.

Filmmaker Luca Guadagnino, known for striking films like Call Me By Your Name, discusses the imperfection inherent in humanity that drives his narratives. He explores the clash of personalities in A Bigger Splash and Suspiria, reflecting on his latest work, Queer, inspired by William S. Burroughs. The conversation dives into themes of love, repression, and identity, particularly how cinema shapes personal experiences. Guadagnino also addresses the political dimensions of art and shares insights on creative challenges in the film industry.

Comedian Steve Furey, known for his tours with Bert Kreischer and appearances at The Comedy Store, shares a wild journey from youth football to the world of stand-up. He recounts harrowing tales of smuggling across borders and surviving gunpoint robberies, revealing the chaotic life that led him to comedy. Steve dives into his early gigs, which felt as dangerous as drug dealings, and reflects on the bonds forged among comedians facing shared challenges. This candid conversation unfolds a unique perspective on chasing dreams while navigating life's unpredictability.

Anthony Jeselnik, a stand-up comedian celebrated for his dark humor, joins for an engaging discussion after over a decade. He shares insights into his career evolution and the current comedy landscape as he releases a new Netflix special. Jeselnik reflects on the pressures of authenticity in a commercialized industry and contrasts experiences in large arenas versus intimate venues. With a candid take on the challenges of joining the podcast age, he discusses the importance of genuine connections and the emotional weight behind crafting jokes.

Rosemarie DeWitt, known for her standout roles in Rachel Getting Married and Mad Men, shares her unexpected journey into acting, defying low expectations. She discusses the fun side of making horror films like Smile 2 and reflects on her deep connections with the late Lynn Shelton. They touch on themes of vulnerability in performance, the complexities of aging in the industry, and the emotional nuances of adoption, revealing the rich tapestry of experiences that shape her artistry.

Cynthia Erivo, an award-winning actress and singer known for her roles in Wicked and Harriet, shares some behind-the-scenes gems with Marc. She offers tips on maximizing time on set, even incorporating fitness into her performance as Elphaba. They discuss the emotional vulnerability of singing and its psychological impacts. Erivo reflects on her heritage and the challenges of authenticity in storytelling, particularly in light of racism and cultural representation, all while celebrating the transformative power of music and performance.

Josh Brolin, acclaimed actor and author of "From Under a Truck," joins for a heartfelt chat. He opens up about his personal journey through addiction and the humbling experience of writing his memoir. Brolin reflects on the emotional challenges actors face, especially when portraying complex characters. He and Marc bond over their shared struggles for connection and self-discovery, emphasizing the importance of authenticity and vulnerability in both life and art.

Jessica Lange, the award-winning actress known for her powerful roles in film and television, discusses her attraction to dark and complex characters, like Frances Farmer and Blanche DuBois. She shares insights into her latest performance as Lillian Hall, reflecting on themes of grief and loneliness. Lange delves into her globe-trotting career, starting with King Kong and touching on iconic works like Tootsie and American Horror Story. The conversation reveals her passion for emotional depth and the artistic challenges of portraying profound human experiences.