Leona Woods Marshall Libby was the only woman hired onto Enrico Fermi's team at the Metallurgical Laboratory at the University of Chicago. She was just 23 years old, already had a Ph.D. in molecular spectroscopy and a deep understanding  of vacuum technology. She was also the only woman present at the world’s first successful nuclear chain reaction. Amid all this, she managed to conceal her pregnancy until two days before her baby was born.

During World War II, thousands of scientists and engineers worked on the Manhattan project, the top secret push to develop an atomic bomb that would end the war. Two bombs dropped on Hiroshima and Nagasaki did just that, while also killing hundreds of thousands of Japanese civilians. The devastating potential of nuclear weapons sparked a moral controversy that continues to this day. Hundreds of the scientists who worked on the Manhattan Project were women. Over the next few weeks we’ll be bringing you a few of their stories.

Discover the fascinating story of Alessandra Giliani, a 14th-century Italian anatomist who defied gender norms to pursue a career in medicine. Uncover evidence of her existence in illuminated manuscripts and learn about her pioneering work in anatomy and the circulatory system. Explore the possibility that her work was erased by the church and reflect on the challenges faced by female scientists in history.

Cecilia Payne was in her early 20s when she figured out what the stars are made of. Both she and her groundbreaking findings were ahead of their time. Continuing the legacy of women working at the Harvard Observatory, Cecilia charted the way for a generation of female astronomers to come. This episode of Lost Women of Science: shorts follows Cecilia’s journey of discovery, journals her drive and determination against all odds, and takes you to the Harvard Observatory itself to walk in Cecilia’s footsteps.

In 1992, a Dutch doctor named Josh von Soer Clemm von Hohenberg wrote a letter to Henning Voscherau, the mayor of Hamburg, Germany, requesting that a street be named after Marie Nyswander. The doctor had never met Marie, but he had founded a clinic for treating people with drug addiction, and he’d seen methadone treatment — co-developed by Marie — save lives. Four years later, doctors gathered on a street in northwest Hamburg to celebrate that street’s new name: Nyswanderweg. We’re investigating how German streets get their names, and why so few of them honor women like Marie, who have made historic achievements.

Marie Nyswander died in 1986. She’d achieved almost everything she set out to, but she wanted more: even better medications than methadone, fewer regulations, and the holy grail—a cure for addiction. Addiction science has come a long way since Marie’s time, and it turns out, a lot of the field’s earlier assumptions were probably wrong. Neuroscientist Kent Berridge explains why wanting something isn’t the same as liking it. But a cure is still out of our reach

A reminder that our next episode is scheduled to come out next Thursday! In the meantime, we’ve hit a slight snag—Katie has COVID—but she’s resting up, and we’re doing our best to get that episode to you on time. Stay tuned for updates. We'll be back very soon.

Marie Nyswander and her team at Rockefeller unveil their findings at last: methadone has utterly transformed their patients. They’re going back to school, getting jobs, and reconnecting with family and friends. One of the very first patients went onto college and graduated with a degree in aeronautical engineering, all while taking methadone. But soon, Marie’s treatment starts getting resistance, from fellow doctors as well as patients, who think what she’s doing is immoral. See show notes and full transcripts at lostwomenofscience.org

After years of disappointing results in her quest to treat heroin addiction, Marie Nyswander was more than ready to try something new. When she met a prominent doctor from the prestigious Rockefeller Institute, they embarked on an experiment that would define both of their careers and revolutionize the treatment of addiction for decades to come. But not everyone was happy about it.

In the early 1950s, Marie Nyswander was ready to move on from addiction. She set up a private practice and specialized in treating women afflicted with what she would call one of the “gravest problems of our time”: sexual frigidity. She and her adoring husband were living the good life, hanging out with rich art collectors and members of the New York literary scene. But when Marie started getting phone calls for help, she got pulled in a very different direction. Show notes and episode transcripts are available at lostwomenofscience.org