New Books in Science

A scientist assesses the potential of stem cell therapies for treating such brain disorders as stroke, Alzheimer’s disease, and Parkinson’s disease.Stem cell therapies are the subject of enormous hype, endowed by the media with almost magical qualities and imagined by the public to bring about miracle cures. Stem cells have the potential to generate new cells of different types, and have been shown to do so in certain cases. Could stem cell transplants repair the damaged brain? In his book The Future of Brain Repair: A Realist's Guide to Stem Cell Therapy (MIT Press, 2020), neurobiologist Jack Price assesses the potential of stem cell therapies to treat such brain disorders as stroke, Alzheimer’s disease, Parkinson’s disease, and spinal cord injuries.Certainly brain disorders are in need of effective treatments. These disorders don’t just kill, they disable, and conventional drug therapies have not had much success in treating them. Price explains that repairing the human brain is difficult, largely because of its structural, functional, and developmental complexity. He examines the self-repairing capacity of blood and gut cells—and the lack of such capacity in the brain; describes the limitations of early brain stem cell therapies for neurodegenerative disorders; and discusses current clinical trials that may lead to the first licensed stem cell therapies for stroke, Parkinson’s and macular degeneration. And he describes the real promise of pluripotential stem cells, which can make all the cell types that constitute the body.New technologies, Price reports, challenge the very notion of cell transplantation, instead seeking to convince the brain itself to manufacture the new cells it needs. Could this be the true future of brain repair?You can find more about Jack’s work here and here.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Vaccines make us wholly or partly immune to disease, such as Covid-19. But what is it to be immune? What is an immune system, and what does it do? In its beginnings, immunology was considered the science of the self/non-self distinction: the immune system comprised the self’s defenses against invading non-self pathogens, and was a sophisticated system possessed only by vertebrates. In Philosophy of Immunology (Cambridge University Press, 2020), Thomas Pradeu explains why these traditional conceptions have been upended over the past 20 years or so. It is now accepted that even single celled organisms have immune systems and that immune systems are also active in many biological activities, including regulation of foreign entities that are not part of the body but are not pathogens either, such as the gut microbiome. Pradeu, who is senior researcher at CNRS and University of Bordeau, defends his view of the individual as an immunologically unified chimera, and speculates about the implications for our understanding of cognition and psychiatric illness in the light of new discoveries of overlap between the immune and nervous systems. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

A four-hundred-year history of the development of alchemy in England that brings to light the evolution of the practice. Tracing the development of alchemy in England from the beginning of the fourteenth century to the end of the seventeenth, Jennifer M. Rampling illuminates the role of alchemical reading and experimental practice in the broader context of national and scientific history. Using new manuscript sources, she shows how practitioners like George Ripley, John Dee, and Edward Kelley, as well as many previously unknown alchemists, devised new practical approaches to alchemy while seeking the support of English monarchs. By reconstructing their alchemical ideas, practices, and disputes, Rampling reveals how English alchemy was continually reinvented over the space of four centuries, resulting in changes to the science itself. In so doing, The Experimental Fire The Experimental Fire: Inventing English Alchemy, 1300-1700 (University of Chicago Press, 2020) bridges the intellectual history of chemistry and the wider worlds of early modern patronage, medicine, and science.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

The appreciation of color is considered universal among human societies, yet varies vastly according to cultural norms and material circumstances. In the nineteenth century, synthetic chemistry produced new hues like mauve that changed the sensory worlds of people living in industrial societies. In The Republic of Color: Science, Perception, and the Making of Modern America (Chicago UP 2019), historian Michael Rossi explores how reformers and scientists turned to color science to ask and answer profound questions about the relationship between perception and personhood. Their efforts to define and standardize the modern sensorium were often proposed as solutions to practical problems of education and accountability. In this way, color systems made moral and political claims on what good governance in an increasingly bureaucratized society might look like.From the Pragmatists’ protoplasmic preoccupations to the educational experiments of board game magnates, Rossi’s study of color in American life brings anxieties over the possibility of community in the modern world into brilliant focus. Whether rooted in philosophical paradoxes or unabashed racial animus, standardizing color cut to the heart of human difference at a crucial moment in the development of the human sciences. This vibrant book will find an audience in aesthetes and Americanists alike, or virtually anyone interested in why the technical tools for making and modulating color look the way they do—not to spoil it, but how deeply have you considered the color options in software like Photoshop?Mikey McGovern is a PhD candidate in Princeton University’s Program in the History of Science. He is writing a dissertation on how people used statistics to make claims of discrimination in 1970s America, and how the relationship between rights and numbers became a flashpoint in political struggles over bureaucracy, race, and law. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Why are humans alone capable of invention? This question is relevant to every human invention, from music to mathematics, sculpture and science, dating back to the beginnings of civilization. In The Pattern Seekers: A New Theory of Human Invention, Simon Baron-Cohen, the director of the Autism Research Center at Cambridge University, presents a new theory of human invention. His unexpected claim is that understanding autistic people — specifically their unstoppable drive to seek patterns, a characteristic of the condition — is the key to understanding both the ancient origins and the modern flowering of human creativity.In The Pattern Seekers, Simon Baron-Cohen’s goal is two-fold: to provide an answer to the long-standing question about human invention and to understand the role that autistic people played in the evolution of human invention. His higher message is to change the way our society views and treats autistic people. “Among the new generation of hypersystemizers will be some of the great inventors of our future…If we acknowledge that some autistic people were and still are the drivers of the evolution of science, technology, art, and other forms of invention, their future can be different.”Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Jason Rosenhouse's Games for Your Mind: The History and Future of Logic Puzzles (Princeton UP, 2020) is about a panoply of logic puzzles. You’ll find Mastermind and sudoku discussed early on, and then you’ll be hit with an incredible array of some of the most intriguing logic puzzles that have ever been devised. Some will be familiar to you, but some will almost certainly be brain-teasers you have never heard of. It’s absolutely amazing what a truly deep field grew from recreational pastimes – and this book is an absolute treasure trove of stuff you can’t help thinking about. If you like logic, you’re certain to be sucked in – but you’ll enjoy the ride.Logic puzzles were first introduced to the public by Lewis Carroll in the late nineteenth century and have been popular ever since. Games like Sudoku and Mastermind are fun and engrossing recreational activities, but they also share deep foundations in mathematical logic and are worthy of serious intellectual inquiry. Games for Your Mind explores the history and future of logic puzzles while enabling you to test your skill against a variety of puzzles yourself.In this informative and entertaining book, Jason Rosenhouse begins by introducing readers to logic and logic puzzles and goes on to reveal the rich history of these puzzles. He shows how Carroll's puzzles presented Aristotelian logic as a game for children, yet also informed his scholarly work on logic. He reveals how another pioneer of logic puzzles, Raymond Smullyan, drew on classic puzzles about liars and truthtellers to illustrate Kurt Gödel's theorems and illuminate profound questions in mathematical logic. Rosenhouse then presents a new vision for the future of logic puzzles based on nonclassical logic, which is used today in computer science and automated reasoning to manipulate large and sometimes contradictory sets of data.Featuring a wealth of sample puzzles ranging from simple to extremely challenging, this lively and engaging book brings together many of the most ingenious puzzles ever devised, including the Hardest Logic Puzzle Ever, metapuzzles, paradoxes, and the logic puzzles in detective stories. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

A reporter uncovers the secrets behind the scientific scam of the century. The news breaks first as a tale of fear and pity. Doctors at a London hospital claim a link between autism and a vaccine given to millions of children: MMR. Young parents are terrified. Immunization rates slump. And as a worldwide ‘anti-vax’ movement kicks off, old diseases return to sicken and kill. But a veteran reporter isn’t so sure, and sets out on an epic investigation. Battling establishment cover-ups, smear campaigns, and gagging lawsuits, he exposes rigged research and secret schemes, the heartbreaking plight of families struggling with disability, and the scientific deception of our time.Brian Deer's The Doctor Who Fooled the World: Andrew Wakefield's War on Vaccines (Johns Hopkins UP, 2020) tells the troubling story of Andrew Wakefield: a man in search of greatness, who stakes his soul on big ideas that, if right, might transform lives. But when the facts don’t fit, he can’t face failure. He’ll do whatever it takes to succeed.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

We live in an age in which we are repeatedly reminded—by scientists, by the media, by popular culture—of the looming threat of mass extinction. We’re told that human activity is currently producing a sixth mass extinction, perhaps of even greater magnitude than the five previous geological catastrophes that drastically altered life on Earth. Indeed, there is a very real concern that the human species may itself be poised to go the way of the dinosaurs, victims of the most recent mass extinction some 65 million years ago.How we interpret the causes and consequences of extinction and their ensuing moral imperatives is deeply embedded in the cultural values of any given historical moment. And, as David Sepkoski reveals, the history of scientific ideas about extinction over the past two hundred years—as both a past and a current process—is implicated in major changes in the way Western society has approached biological and cultural diversity. It seems self-evident to most of us that diverse ecosystems and societies are intrinsically valuable, but the current fascination with diversity is a relatively recent phenomenon. In fact, the way we value diversity depends crucially on our sense that it is precarious—that it is something actively threatened, and that its loss could have profound consequences. In Catastrophic Thinking: Extinction and the Value of Diversity from Darwin to the Anthropocene (University of Chicago Press, 2020), Sepkoski uncovers how and why we learned to value diversity as a precious resource at the same time as we learned to think catastrophically about extinction.This interview was conducted by Lukas Rieppel, a historian of science and capitalism at Brown University. You can learn more about his research here, or find him on twitter here. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

In Electric Brain: How the New Science of Brainwaves Reads Minds, Tells Us How We Learn, and Helps Us Change for the Better (BenBella, 2020), eminent neuroscientist R. Douglas Fields surveys the history and current state of scientific understanding about the brain as an electrical organ, and how the electrical activity of the brain relates to cognitive functioning and various clinical conditions. The book begins by documenting some of the fascinating and obscure history of the discovery and early science of electrical brain activity measurements, or ‘brainwaves’. It then goes on to summarize the latest cutting edge research on brainwaves in a wide variety of basic and applied areas of science and medicine - including neuroimaging, neuroplasticity, brain-machine interfaces, artificial intelligence, neurofeedback, brain stimulation therapies, and many others. Electric Brain is a highly accessible, but fact-filled and up-to-date, treatment of one of the most central - and yet still so enigmatic - topics in all of modern science.Dr. R Douglas Fields is Chief of the Nervous System Development and Plasticity Section at the United States National Institutes of Health. He is a world expert on neuron-glia interactions and cellular mechanisms of memory, and is particularly well known for his work on white matter plasticity.Dr. John Griffiths (@neurodidact) is an Assistant Professor at the University of Toronto, and Head of Whole Brain Modelling at the CAMH Krembil Centre for Neuroinformatics. His research group (grifflab.com) works at the intersection of computational neuroscience and neuroimaging, building simulations of human brain activity aimed at improving the understanding and treatment of neuropsychiatric and neurological illness. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Americans today are often skeptical of scientific authority. Many conservatives dismiss climate change and Darwinism as liberal fictions, arguing that "tenured radicals" have coopted the sciences and other disciplines. Some progressives, especially in the universities, worry that science's celebration of objectivity and neutrality masks its attachment to Eurocentric and patriarchal values. As we grapple with the implications of climate change and revolutions in fields from biotechnology to robotics to computing, it is crucial to understand how scientific authority functions--and where it has run up against political and cultural barriers.Science Under Fire: Challenges to Scientific Authority in Modern America (Harvard UP, 2020) reconstructs a century of battles over the cultural implications of science in the United States. Andrew Jewett reveals a persistent current of criticism which maintains that scientists have injected faulty social philosophies into the nation's bloodstream under the cover of neutrality. This charge of corruption has taken many forms and appeared among critics with a wide range of social, political, and theological views, but common to all is the argument that an ideologically compromised science has produced an array of social ills. Jewett shows that this suspicion of science has been a major force in American politics and culture by tracking its development, varied expressions, and potent consequences since the 1920s.Looking at today's battles over science, Jewett argues that citizens and leaders must steer a course between, on the one hand, the naïve image of science as a pristine, value-neutral form of knowledge, and, on the other, the assumption that scientists' claims are merely ideologies masquerading as truths.Claire Clark is a medical educator, historian of medicine, and associate professor in the University of Kentucky’s College of Medicine. She teaches and writes about health behavior in historical context. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science