New Books in Science

In 1524, Pope Clement VII gave two condemned criminals to his physician to test a promising new antidote. After each convict ate a marzipan cake poisoned with deadly aconite, one of them received the antidote, and lived—the other died in agony. In sixteenth-century Europe, this and more than a dozen other accounts of poison trials were committed to writing. Alisha Rankin tells their little-known story.At a time when poison was widely feared, the urgent need for effective cures provoked intense excitement about new drugs. As doctors created, performed, and evaluated poison trials, they devoted careful attention to method, wrote detailed experimental reports, and engaged with the problem of using human subjects for fatal tests. In reconstructing this history, Rankin reveals how the antidote trials generated extensive engagement with “experimental thinking” long before the great experimental boom of the seventeenth century and investigates how competition with lower-class healers spurred on this trend.Alisha Rankin's The Poison Trials: Wonder Drugs, Experiment, and the Battle for Authority in Renaissance Science (U Chicago Press, 2021) sheds welcome and timely light on the intertwined nature of medical innovations, professional rivalries, and political power. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Normally we write blogposts that try to convince you to listen to a conversation with an author about their fascinating book. In the time of COVID-19, it doesn't seem necessary to have to sell you on why you should listen to this podcast. Suffice it to say that Mitchell Hammond’s excellent survey of a dozen deadly diseases is a must-read primer to make sense of epidemic history. In Epidemics and the Modern World (University of Toronto Press, 2020), he balances the science of disease etiology and disease cycles with political, socio-economic, and cultural contexts. Read this book!Mitchell L. Hammond, an Assistant Professor at the University of Victoria in beautiful British Columbia. Dr. Hammond studied at Yale, where he earned a BA in Political Science and a MA in Religious History before getting another MA and a PhD in European History at the University of Virginia. His dissertation was entitled “The Origins of Civic Health Care in Early Modern Germany”. He has published several articles and book chapters on the intersection of medicine and religion in 16th and 17th century Germany.Michael G. Vann is a professor of world history at California State University, Sacramento. A specialist in imperialism and the Cold War in Southeast Asia, he is the author of The Great Hanoi Rat Hunt: Empires, Disease, and Modernity in French Colonial Vietnam (Oxford University Press, 2018). When he’s not reading or talking about new books with smart people, Mike can be found surfing in Santa Cruz, California. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Listen to this interview of David Payne, who is Chief Careers Editor at Nature. We talk about high quality writing, about the gracious community of scientists, and about diversity, diversity, diversity.Interviewer : "What is the one thing you hope, for sure, that every piece of Careers content will achieve?"David Payne : "Oh, that's a question, isn't it? You know what, I think it is about emotion. And I just want it to––not tug at your heartstrings, that sounds cheesy––but I feel, we spend so much time at work, and work does define us, rightly or wrongly, actually. So much of what we do is mediated through the jobs that we do. We spend so much time with our colleagues, and probably more than we do with family members often. So, I just hope that every piece we publish resonates. We can't resonate with everybody, of course, because it's a very diverse workforce in science. But, whenever I read any piece of content, I always think, how many boxes are we ticking here. You know, who is going to be interested in this. Of course, the target audience is currently the early career researcher, but of course you have all sorts of halo effects, as well. You want to think that funders are reading it, that they're finding it a useful take; people like yourself, who train people to write as a scientist; lab leaders; policymakers; thought leaders; and all the way down the line." Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Blending history, science, and culture, a stunning and highly engaging evolutionary story exploring how walking on two legs allowed humans to become the planet’s dominant species.Humans are the only mammals to walk on two, rather than four legs—a locomotion known as bipedalism. We strive to be upstanding citizens, honor those who stand tall and proud, and take a stand against injustices. We follow in each other’s footsteps and celebrate a child’s beginning to walk. But why, and how, exactly, did we take our first steps? And at what cost? Bipedalism has its drawbacks: giving birth is more difficult and dangerous; our running speed is much slower than other animals; and we suffer a variety of ailments, from hernias to sinus problems.In First Steps: How Upright Walking Made Us Human (Harper, 2021), paleoanthropologist Jeremy DeSilva explores how unusual and extraordinary this seemingly ordinary ability is. A seven-million-year journey to the very origins of the human lineage, First Steps shows how upright walking was a gateway to many of the other attributes that make us human—from our technological abilities, our thirst for exploration, our use of language–and may have laid the foundation for our species’ traits of compassion, empathy, and altruism. Moving from developmental psychology labs to ancient fossil sites throughout Africa and Eurasia, DeSilva brings to life our adventure walking on two legs.Delving deeply into the story of our past and the new discoveries rewriting our understanding of human evolution, First Steps examines how walking upright helped us rise above all over species on this planet.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Of all forms of alternative medicine, chiropractic is the one that is most generally accepted. In the UK, for instance, chiropractors are regulated by statute and even have their own ‘Royal College of Chiropractic’. In the US, chiropractic’s country of origin, most chiropractors carry the title ‘doctor’ and many consumers believe they are medically trained.Despite this high level of acceptance, chiropractic is wide open to criticism. The claims and assumptions made by chiropractors are far from evidence based. Chiropractic manipulations are of doubtful effectiveness and have regularly been associated with severe adverse effects, including multiple fatalities. The advice issued by chiropractors to patients and consumers is often less than responsible. The behaviour of chiropractors and their organisations is frequently less than professional.Edzard Ernst's Chiropractic:' Not All That It's Cracked Up to Be (Springer, 2020) presents and discusses recent evidence in and around chiropractic in a factual and unemotional manner. It amounts to an evidence-based critique of this profession and discloses the often dangerously misleading information published for the lay audience. It thereby contributes to advancing public health and critical thinking.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Alzheimer’s disease, a haunting and harrowing ailment, is one of the world’s most common causes of death. Alzheimer’s lingers for years, with patients’ outward appearance unaffected while their cognitive functions fade away. Patients lose the ability to work and live independently, to remember and recognize. There is still no proven way to treat Alzheimer’s because its causes remain unknown.Mind Thief: The Story of Alzheimer's (Columbia UP, 2021) is a comprehensive and engaging history of Alzheimer’s that demystifies efforts to understand the disease. Beginning with the discovery of “presenile dementia” in the early twentieth century, Han Yu examines over a century of research and controversy. She presents the leading hypotheses for what causes Alzheimer’s; discusses each hypothesis’s tangled origins, merits, and gaps; and details their successes and failures. Yu synthesizes a vast amount of medical literature, historical studies, and media interviews, telling the gripping stories of researchers’ struggles while situating science in its historical, social, and cultural contexts. Her chronicling of the trajectory of Alzheimer’s research deftly balances rich scientific detail with attention to the wider implications. In narrating the attempts to find a treatment, Yu also offers a critical account of research and drug development and a consideration of the philosophy of aging. Wide-ranging and accessible, Mind Thief is an important book for all readers interested in the challenge of Alzheimer’s. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

An exposé of the corruption of medicine by the pharmaceutical industry at every level, from exploiting the vulnerable destitute for drug testing, through manipulation of research data, to disease mongering and promoting drugs that do more harm than good.Authors, Professor Jon Jureidini and Dr Leemon McHenry, made critical contributions to exposing the scientific misconduct in two infamous trials of antidepressants. Ghostwritten publications of these trials were highly influential in prescriptions of paroxetine (Paxil) and citalopram (Celexa) in paediatric and adolescent depression, yet both trials (Glaxo Smith Kline's paroxetine study 329 and Forest Laboratories' citalopram study CIT-MD-18) seriously misrepresented the efficacy and safety data.The Illusion of Evidence-Based Medicine: Exposing the Crisis of Credibility in Clinical Research (Wakefield Press, 2020) provides a detailed account of these studies and argues that medicine desperately needs to re-evaluate its relationship with the pharmaceutical industry. Without a basis for independent evaluation of the results of randomised, placebo-controlled clinical trials, there can be no confidence in evidence-based medicine.Science demands rigorous, critical examination and especially severe testing of hypotheses to function properly, but this is exactly what is lacking in academic medicine. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Would your dog eat you if you died? What are face mites? Why do clowns creep us out? In this illuminating collection of grisly true science stories, journalist Erika Engelhaupt, the writer of National Geographic’s highly acclaimed Gory Details blog, shares the answers to these questions and many more. Gory Details: Adventures from the Dark Side of Science (National Geographic, 2020) explores the strange and shocking realities of our minds, our bodies and our universe, taking readers on a fascinating tour through overlooked but astonishing aspects of biology, anatomy, nature and more, as well as the ways that science helps to break down taboos surrounding such conversation topics as women’s bodies.Blending humor and real science, Engelhaupt shares captivating stories and intriguing research that will alter the way readers view the world. From a peek inside the world's smallest crime scenes to a hands-on look at maggot farming, Gory Details features top-notch reporting, interviews with leading scientists and a healthy dose of wit. Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Based on a viral article, the gripping medical mystery story of Ron Davis, a world-class Stanford geneticist who has put his career on the line to find the cure for chronic fatigue syndrome, the disease killing his son. For the past six years, Whitney Dafoe has been confined to a bedroom in the back of his parents' home, unable to walk, to eat, to speak. The sound of music causes him pain. At one point, the formerly healthy, young, freelance photographer, faced starvation as his 6'3" frame withered to 115 pounds. In desperation, Whitney and his parents went from one specialist to another, and still no answers. Then, finally, a diagnosis: the mysterious disease myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS). Whitney's story is heartbreaking, but it's also one of redemption. It reaches far beyond just one family's harrowing tale. Today, ME/CFS affects between 1 and 2.5 million Americans--and 20 million people around the world. Those afflicted largely suffer in silence because the disease is little known and much misunderstood. The question lingers still whether it even exists outside the patient's mind. Often disbelieved, they're abandoned by family and friends. They lose their jobs, and battle with insurance companies over rising medical costs as the chronic disease continues on year after year. In one way, Whitney has been lucky. He could reach out to his father, a world renowned, scientist, for answers. This book is the story of one father's desperate hunt for the insidious illness that stole his son away. The Puzzle Solver follows Ron as he unravels the molecular trail within his own son's donated blood and genome, to began to find answers. He confirms this is a biological disease and uncovers new possibilities for treatments and potentially a cure. At its heart, The Puzzle Solver: A Scientist's Desperate Hunt to Cure the Illness That Stole His Son by Tracie White and Ronald W. Davis (Hachette Books, 2021) is about more than just cutting edge research or a race to find the cure for ME/CFS--it's about the unbreakable bond between a father and his son, and the lengths to which a parent will go to save their child's life. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Viruses are not very different from machines that process information, and thus, how the virus functions can be simulated on a computer. This ability to “imitate” the way viruses behave is particularly useful today, as we battle the impact of the coronavirus pandemic and struggle to prepare for similar events.Dr. Klaus Mainzer, Co-founder and Senior Professor at the Carl Friedrich von Weizsäcker Center of the University of Tübingen and President of European Academy of Sciences and Arts in Salzburg, explains this further in a new podcast episode, in which he talks about his book Leben als Maschine: Wie entschlüsseln wir den Corona-Kode? published by Brill. He explains how bringing together the fields of bioinformatics, machine learning, AI, and big data can help us to decipher the workings of the novel coronavirus and, perhaps, be better equipped to deal with such crises in the future. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science