New Books in Science

Cystic fibrosis was once a mysterious disease that killed infants and children. Now it could be the key to healing millions with genetic diseases of every type—from Alzheimer's and Parkinson's to diabetes and sickle cell anemia. In 1974, Joey O'Donnell was born with strange symptoms. His insatiable appetite, incessant vomiting, and a relentless cough—which shook his tiny, fragile body and made it difficult to draw breath—confounded doctors and caused his parents agonizing, sleepless nights. After six sickly months, his salty skin provided the critical clue: he was one of thousands of Americans with cystic fibrosis, an inherited lung disorder that would most likely kill him before his first birthday.The gene and mutation responsible for CF were found in 1989—discoveries that promised to lead to a cure for kids like Joey. But treatments unexpectedly failed and CF was deemed incurable. It was only after the Cystic Fibrosis Foundation, a grassroots organization founded by parents, formed an unprecedented partnership with a fledgling biotech company that transformative leaps in drug development were harnessed to produce groundbreaking new treatments: pills that could fix the crippled protein at the root of this deadly disease. From science writer Bijal P. Trivedi, Breath from Salt: A Deadly Genetic Disease, a New Era in Science, and the Patients and Families Who Changed Medicine Forever (Benbella, 2020) chronicles the riveting saga of cystic fibrosis, from its ancient origins to its identification in the dank autopsy room of a hospital basement, and from the CF gene's celebrated status as one of the first human disease genes ever discovered to the groundbreaking targeted genetic therapies that now promise to cure it. Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope—and a fascinating peek into the future of genetics and medicine.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

In the late nineteenth century, as humans came to realize that our rapidly industrializing and globalizing societies were driving other animal species to extinction, a movement to protect and conserve them was born. In Beloved Beasts: Fighting for Life in an Age of Extinction (Norton, 2021), acclaimed science journalist Michelle Nijhuis traces the movement’s history: from early battles to save charismatic species such as the American bison and bald eagle to today’s global effort to defend life on a larger scale.She describes the vital role of scientists and activists such as Aldo Leopold and Rachel Carson as well as lesser-known figures in conservation history; she reveals the origins of vital organizations like the Audubon Society and the World Wildlife Fund; she explores current efforts to protect species such as the whooping crane and the black rhinoceros; and she confronts the darker side of conservation, long shadowed by racism and colonialism.As the destruction of other species continues and the effects of climate change escalate, Beloved Beasts charts the ways conservation is becoming a movement for the protection of all species—including our ownJenny Splitter is an independent journalist covering food, farming, science, and climate. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

How does egg freezing reshape our conception of time, aging and fertility? In her new monograph, Freezing Fertility: Oocyte Cryopreservation and the Gender Politics of Aging (NYU Press, 2020) Dr. Lucy van de Wiel explores the significance of egg freezing in re-orienting the temporality of the gender politics of aging. Dr. van de Wiel argues that it is critical to examine the politicized dimensions of egg freezing because it transforms the broader discourses around aging and normative timeline of women's reproduction even though the technology is only accessible for an elite few. Through a cultural analysis of popular media and documentaries to highlight the role of rhetoric in creating conditions that motivate women in making decisions about their reproductive futures, Dr. van de Wiel criticizes the moralistic boundaries between social and medical utilized by some state actors to condemn women who decide to freeze their eggs for their careers. Dr. van de Wiel also highlights the role of financialized capitalism in refiguring fertility under the investment logic of optimization to speculate on the potential risks posed by anticipated infertility. Egg freezing technology shows us how the biopolitical control of population shifted to managing fertility, which transcends national borders as frozen eggs circulate transnationally for assisted reproduction as well as stem cell research. An incredibly rich and nuanced book, Freezing Fertility would be an invaluable read for anyone who is interested in the politics of reproduction, ART, gendered politics of aging, mortality, life, and regeneration.  Dr. Lucy van de Wiel is a Research Associate at the Reproductive Sociology Research Group (ReproSoc), University of Cambridge. Her research focuses on the social and cultural analysis of assisted reproductive technologies like egg freezing, time-lapse embryo selection and cross-border reproductive care.Da In Ann Choi is a PhD student at UCLA in the Gender Studies department. Her research interests include care labor and migration, reproductive justice, social movement, citizenship theory, and critical empire studies. She can be reached at dainachoi@g.ucla.edu. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

In 2020, an estimated 5.8 million Americans had Alzheimer’s, and more than half a million died because of the disease and its devastating complications. 16 million caregivers are responsible for paying as much as half of the $226 billion annual costs of their care. As more people live beyond their seventies and eighties, the number of patients will rise to an estimated 13.8 million by 2025.Part case studies, part meditation on the past, present and future of the disease, The Problem of Alzheimer's: How Science, Culture, and Politics Turned a Rare Disease into a Crisis and What We Can Do About It (St. Martin's Press, 2021) traces Alzheimer’s from its beginnings to its recognition as a crisis. While it is an unambiguous account of decades of missed opportunities and our health care systems’ failures to take action, it tells the story of the biomedical breakthroughs that may allow Alzheimer’s to finally be prevented and treated by medicine and also presents an argument for how we can live with dementia: the ways patients can reclaim their autonomy and redefine their sense of self, how families can support their loved ones, and the innovative reforms we can make as a society that would give caregivers and patients better quality of life.Rich in science, history, and characters, The Problem of Alzheimer's takes us inside laboratories, patients' homes, caregivers’ support groups, progressive care communities, and Jason Karlawish's own practice at the Penn Memory Center.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Exhale: Hope, Healing, and a Life in Transplant (Post Hill Press, 2021) is the riveting memoir of a top transplant doctor who rode the emotional rollercoaster of saving and losing lives—until it was time to step back and reassess his own life.A young father with a rare form of lung cancer who has been turned down for a transplant by several hospitals. A kid who was considered not “smart enough” to be worthy of a transplant. A young mother dying on the waiting list in front of her two small children. A father losing his oldest daughter after a transplant goes awry. The nights waiting for donor lungs to become available, understanding that someone needed to die so that another patient could live.These are some of the stories in Exhale, a memoir about Dr. Weill’s ten years spent directing the lung transplant program at Stanford. Through these stories, he shows not only the miracle of transplantation, but also how it is a very human endeavor performed by people with strengths and weaknesses, powerful attributes, and profound flaws.Exhale is an inside look at the world of high-stakes medicine, complete with the decisions that are confronted, the mistakes that are made, and the story of a transplant doctor’s slow recognition that he needed to step away from the front lines. This book is an exploration of holding on too tight, of losing one’s way, and of the power of another kind of decision—to leave behind everything for a fresh start.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Chemistry is not just about microscopic atoms doing inscrutable things; it is the process that makes flowers and galaxies. We rely on it for bread-baking, vegetable-growing, and producing the materials of daily life. In stunning images and illuminating text, this book captures chemistry as it unfolds. Using such techniques as microphotography, time-lapse photography, and infrared thermal imaging, The Beauty of Chemistry: Art, Wonder, and Science (MIT Press, 2021) shows us how chemistry underpins the formation of snowflakes, the science of champagne, the colors of flowers, and other wonders of nature and technology. We see the marvelous configurations of chemical gardens; the amazing transformations of evaporation, distillation, and precipitation; heat made visible; and more.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Dip below the ocean’s surface and you are soon confronted by forms of life that could not seem more foreign to our own: sea sponges, soft corals, and serpulid worms, whose rooted bodies, intricate geometry, and flower-like appendages are more reminiscent of plant life or even architecture than anything recognizably animal. Yet these creatures are our cousins. As fellow members of the animal kingdom—the Metazoa—they can teach us much about the evolutionary origins of not only our bodies, but also our minds.In his acclaimed 2016 book, Other Minds, the philosopher and scuba diver Peter Godfrey-Smith explored the mind of the octopus—the closest thing to an intelligent alien on Earth. In Metazoa: Animal Life and the Birth of the Mind (FSG, 2020), Godfrey-Smith expands his inquiry to animals at large, investigating the evolution of subjective experience with the assistance of far-flung species. As he delves into what it feels like to perceive and interact with the world as other life-forms do, Godfrey-Smith shows that the appearance of the animal body well over half a billion years ago was a profound innovation that set life upon a new path. In accessible, riveting prose, he charts the ways that subsequent evolutionary developments—eyes that track, for example, and bodies that move through and manipulate the environment—shaped the subjective lives of animals. Following the evolutionary paths of a glass sponge, soft coral, banded shrimp, octopus, and fish, then moving onto land and the world of insects, birds, and primates like ourselves, Metazoa gathers their stories together in a way that bridges the gap between mind and matter, addressing one of the most vexing philosophical problems: that of consciousness.Combining vivid animal encounters with philosophical reflections and the latest news from biology, Metazoa reveals that even in our high-tech, AI-driven times, there is no understanding our minds without understanding nerves, muscles, and active bodies. The story that results is as rich and vibrant as life itself.Peter Godfrey-Smith is a professor in the School of History and Philosophy of Science at the University of Sydney. He is the author of the bestselling Other Minds: The Octopus, the Sea, and the Deep Origins of Consciousness, which has been published in more than twenty languages. His other books include Theory and Reality: An Introduction to the Philosophy of Science and Darwinian Populations and Natural Selection, which won the 2010 Lakatos Award.Mark Molloy is the reviews editor at MAKE: A Literary Magazine. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Elise K. Burton’s important book, Genetic Crossroads: The Middle East and the Science of Human Heredity (Stanford University Press, 2021), documents how race and nation became fused in concept and in political practice. Over the past century, nation-building and race-making became interdependent through the sciences of heredity and their uses during wartimes and their aftermaths. The book provincializes Euro-American histories of science by centering the intrepid and non-innocent scientists from land along the eastern coastline of the Mediterranean Sea (often called by the imperial name of “Middle East”)—and their transnational networks. The book tracks how scientists’ reputations, access to resources, and interpretations of data shifted from the dissolution of the Ottoman Empire, the repackaged race science around World War II, the 1967 Six-Day War, and the lingering state-backed violence of the present day. The sciences of heredity—including physical anthropology and medical genetics—have continued to be used to justify violence and territorial occupation, as much as humanitarian “resettlement” programs, storage of biospecimen, and building of research infrastructures for a cosmopolitan science. Today, “the anti-racist, progressive discourses surrounding contemporary human genome projects have so far been unable to overcome the territorial regimes and ethnic concepts produced by a century of conflict,” Burton writes, because “nationalism is sustained by particular practices of human genetics research—specifically, the need to describe human populations according to geography and ancestral history, coinciding with the two major constituent elements of the nation-state paradigm.”The interview refers to the important, related work of Jenny Bangham, Emma Kowal, Joanna Radin, Gayle Rubin, and Kim TallBear. The conversation was a collective interview by Vanderbilt Master’s students in Laura Stark’s seminar, Critical Bioethics: Jazmyn Ayers, Kell Coney, Anyssa Francis, Caroline Goodman, Lily Jaremski, Natalie Jones, Ashley Mullen, Enna Pehadzic, Olivia Post, Karrie Raymond, Christina Rosca, Cecile Sahel, Chad Smith, and McKenzie Yates. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Join naturalist and science writer Leigh Calvez on her adventures into science and spirit of animals, as we discuss her two recent books: The Hidden Lives of Owls, and The Breath of the Whale (Sasquatch Books, 2016 and 2019, respectively). Calvez makes the science and research entertaining and accessible, describing the social behavior of owls and whales while exploring the questions about the human-animal connection. Our conversation highlights the impressive resilience and intelligence of the animals we have the pleasure to share the world with, the role of research and intuition in field work studies, in addition to the complexity of ethical decisions we humans must make to ensure and perpetuate a diverse and healthy ecosystem for every creature. Leigh Calvez has worked with whales and dolphins as a scientist, naturalist and nature writer, her work featured in Smithsonian Magazine, High Country News, The Ecologist, Ocean Realm, The Christian Science Monitor, the Seattle Times, the Seattle Post-Intelligencer and Bainbridge Island Magazine. She also teaches private writing classes and lives near Seattle, Washington, with her daughter Ellie and their two cats.Sarah (@annotated_sci) is an acquisition editor for an open scholarship publishing platform, a freelance science writer, and loves baking bread. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Decades of data cannot be ignored: African American adults are far more likely to develop Type 2 diabetes than white adults. But has science gone so far in racializing diabetes as to undermine the search for solutions? In a rousing indictment of the idea that notions of biological race should drive scientific inquiry, Sweetness in the Blood: Race, Risk, and Type 2 Diabetes (University of Minnesota Press, 2021) provides an ethnographic picture of biotechnology’s framings of Type 2 diabetes risk and race and, importantly, offers a critical examination of the assumptions behind the recruitment of African American and African-descent populations for Type 2 diabetes research.James Doucet-Battle begins with a historical overview of how diabetes has been researched and framed racially over the past century, chronicling one company’s efforts to recruit African Americans to test their new diabetes risk-score algorithm with the aim of increasing the clinical and market value of the firm’s technology. He considers African American reticence about participation in biomedical research and examines race and health disparities in light of advances in genomic sequencing technology. Doucet-Battle concludes by emphasizing that genomic research into sub-Saharan ancestry in fact underlines the importance of analyzing gender before attempting to understand the notion of race. No disease reveals this more than Type 2 diabetes.Sweetness in the Blood challenges the notion that the best approach to understanding, managing, and curing Type 2 diabetes is through the lens of race. It also transforms how we think about sugar, filling a neglected gap between the sugar- and molasses-sweetened past of the enslaved African laborer and the high-fructose corn syrup- and corporate-fed body of the contemporary consumer-laborer.Rachel Pagones is chair of the doctoral program in acupuncture and Chinese medicine at Pacific College of Health and Science in San Diego and a licensed acupuncturist. Her book about acupuncture as a tool of medical, social, and political revolution in the United States is under contract with University of Michigan Press. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science