David Eagleman, a Stanford neuroscientist and CEO of Neosensory, shares fascinating insights into the brain's plasticity and sensory substitution. He discusses how our wrists can be trained to interpret sound, enhancing experiences for the deaf. The conversation delves into the purpose of dreams, suggesting they help protect our visual systems. Eagleman also tackles the intriguing concept of Possibilianism and its role in understanding existence, intertwining philosophy with technology in a thought-provoking way.

Richard Reeves, a Senior Fellow at the Brookings Institution and author of "Of Boys and Men," discusses the alarming trends affecting boys and men in education, employment, and mental health. He delves into the gender disparities in academic performance, advocating for innovative solutions like delayed school entry and increased vocational training. Reeves emphasizes the importance of addressing these challenges without undermining women's progress, while also exploring the emotional struggles men face in modern society. His insights call for a balanced approach to gender issues.

Daron Acemoglu, a celebrated MIT professor and 2024 Nobel Prize winner, dives deep into his groundbreaking research on economics. He explores why some nations thrive while others struggle, emphasizing the crucial role of institutions and historical legacies. The conversation tackles the complex interplay between technology and inequality, highlighting how advancements can harm or help society. Acemoglu critiques current tech practices that prioritize profit over human empowerment, all while reflecting on economic shifts since World War II.

David Autor, a renowned MIT professor specializing in labor economics, dives deep into the significant effects of technology and AI on American workers. He discusses the rise of income inequality since the late 1970s and the crucial role education plays in this issue. Autor also explores AI's potential to reshape job roles and empower the middle class, arguing that it can democratize access to skilled work. With insight into the intersection of labor markets and technology, he provides a compelling look at future trends affecting workers.

Kate Douglass, an Olympic gold medalist swimmer and data scientist, shares her unique journey combining athletics and academics. She discusses the underwhelming reality of the Olympics compared to childhood dreams and the mental strategies she used to win gold in the 200m breaststroke. Kate dives into how mathematical modeling and data analysis enhance swimming techniques, revealing insights into performance improvement. She also reflects on the challenges athletes face post-competition, including identity shifts and exploring opportunities in data science.

Ken Ono, a math prodigy and professor, views mathematics as an art form that intersects beautifully with the universe. He shares his unconventional path to success, rising from a high school dropout to making waves in academia and film. Ono discusses the role of math in optimizing Olympic swimmers' performances and reveals fascinating breakthroughs in prime number theory. He also highlights his collaborative experience in creating a Hollywood film about the enigmatic mathematician Ramanujan, emphasizing the power of authentic representation.

Wendy MacNaughton is a talented artist and graphic journalist who has worked in hospice settings and reported from Guantanamo Bay. She shares her unique insights on drawing as a means of processing grief and connecting with others. Wendy emphasizes the emotional complexities of capturing life and death through art. She discusses her experiences in Rwanda and the challenges of documenting court scenes at Guantanamo, highlighting the balance between artistic expression and storytelling. Ultimately, she explores how playfulness and creativity can bring joy even in dark times.

Bestselling author James Nestor shares his insights on the transformative power of breathing. He discusses how mastering breath control can enhance both physical and mental resilience, even allowing humans to dive to astonishing depths. Nestor humorously persuades Steve to tape his mouth shut for better sleep. The conversation includes fascinating tales of connecting with whales and dolphins, highlighting the magic of marine communication. He emphasizes the health benefits of nasal breathing, illustrating how proper techniques can improve overall well-being.

Ingrid Newkirk, founder of PETA and a steadfast animal rights advocate for over 40 years, joins the conversation to discuss her journey from a small organization to a powerful voice against animal cruelty. She shares her candid thoughts on euthanasia and the ethics surrounding animal research, drawing on personal childhood experiences. The discussion challenges societal views on fashion-related animal exploitation and highlights PETA's bold tactics, encouraging a compassionate view towards all creatures. Prepare for some profound insights!

Sendhil Mullainathan, a MacArthur 'genius' and professor at the University of Chicago Booth, delves into the art of making memories stickier and the often-underrated value of change. He explores how scarcity influences cognition and memory, making a case for simplifying welfare systems. The conversation also highlights the transformative potential of virtual reality in learning, comparing interactive experiences to passive reading. Mullainathan emphasizes the importance of experimentation, play, and the human journey's non-linear nature.