This Week in Neuroscience

Maria joins TWiN to explain how single-cell transcriptomics is being used to reveal the evolution of the brain, at a cost of about $1 per neuron. Hosts: Ori Lieberman, Andres Bendesky, and Vincent Racaniello Guest: Maria Tosches Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Single-cell transcriptomics of reptile cortex (Science) Innovations in primate interneurons (Nature) Human versus mouse cortex (Nature) Letters read on TWiN 11 Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

TWiN explains how a cytokine produced by neurons activates microglia which modify the extracellular matrix and remodel synapses, leading to memory consolidation. Hosts: Ori Lieberman, Andres Bendesky, Erin Calipari, Jason Shepherd and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode IL-33 promotes synaptic plasticity (Cell) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

Columbia University Chief Neurology Resident Genna Waldman joins TWiN to explains how her department prepared for COVID-19, and the neurological symptoms associated with the disease. Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd and Vincent Racaniello Guest: Genna Waldman Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Preparing a neurology department for COVID-19 (Neurology) Managing comatose COVID-19 patients (Ann Neurol) Neuropathology of COVID-19 (NEJM) Letters read on TWiN 9 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

TWiN explains how neurological disease in mice can be repaired by using CRISPR/Cas to knock down levels of a single cell protein, which converts astrocytes to neurons. Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Converting glia to neurons (Cell) Reversing Parkinson's disease (Nature) Letters read on TWiN 8 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

The TWiN team reveals how the nervous system controls hair graying in mice subjected to stress, and adaptive immune responses. Hosts: Ori Lieberman, Jason Shepherd,  Erin Calipari and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for the episode The hair cycle (J Cell Sci) Hyperactivation of sympathetic nerves drives hair greying (Nature) Brain control of humoral immune responses (Nature) Letters read on TWiN 7 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

Nirao Shah joins TWiN to discuss the work of his laboratory on how our brains generate social interactions that differ between the sexes. Hosts: Ori Lieberman, Andres Bendesky, andJason Shepherd Guest: Nirao Shah Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Nirao Shah laboratory Neural circuit remodeling and sexual behavior (Cell) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your neuroscience questions and comments to twin@microbe.tv

Bob Datta joins TWiN to reveal the findings of his laboratory on expression of SARS-CoV-2 entry genes in the olfactory epithelium and the implications for anosmia associated with COVID-19. Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd, Erin Calipari and Vincent Racaniello Guest: Bob Datta Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Expression of SARS-CoV-2 entry genes in nasal olfactory epithelium (bioRxiv) Expression of SARS-CoV-2 entry genes in nasal olfactory epithelium (bioRxiv) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your neuroscience questions and comments to twin@microbe.tv

Jason visits the TWiN studio to explain Arc Capsid Bearing Any RNAs (ACBARs), virus-like capsids that transfer genetic information between neurons. Hosts: Andres Bendesky, Jason Shepherd, and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Arc is a repurposed retrotransposon gag protein that mediates intercellular RNA transfer (Cell) Drosophila gag-like ARC1 (Cell) Letters read on TWiN #4 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your neuroscience questions and comments to twin@microbe.tv

Erin and the TWiN team explain how dopamine neurons encode reward probability and uncertainty, and their roles in attention-based learning and risk-taking such as gambling and addiction. Hosts: Ori Lieberman, Erin Calipari,Jason Shepherd, and Vincent Racaniello Click arrow to play Download TWiN 003 (52 MB .mp3, 86 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Dopamine neurons encode reward probability and uncertainty (Science) Letters read on TWiN #3 Intro music is by Ronald Jenkees. Send your neuroscience questions and comments to twin@microbe.tv

The TWiN team explain the basic principles of synaptic transmission, and review a classic paper demonstrating that recycling endosomes are important for modifying synaptic strength, which is involved in information storage and processing. Hosts: Ori Lieberman, Andres Bendesky,Jason Shepherd, and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Bendesky lab Recycling Endosomes Supply AMPA Receptors for LTP (Science) AMPA receptor (Wikipedia) Image credit Letters read on TWiN #2 Intro music is by Ronald Jenkees. Send your neuroscience questions and comments to twin@microbe.tv