

Distillations | Science History Institute
Science History Institute
Distillations is the Science History Institute’s critically acclaimed flagship podcast. We take deep dives into stories that range from the serious to the eccentric, all to help listeners better understand the surprising science that is all around us. Hear about everything from the crisis in Alzheimer’s research to New England’s 19th-century vampire panic in compelling, sometimes-funny, documentary-style audio stories.
Episodes
Mentioned books

Jan 7, 2020 • 48min
How Philadelphia's Water Pollution Problems Shaped the City
Philadelphia just had the wettest decade on record, and all that precipitation has wreaked havoc on the city’s waterways. Like most old cities, Philadelphia has a combined sewer system—that is, one pipe is used to carry both sewage and stormwater. When it rains a lot, the system gets overwhelmed, forcing the water department to send raw sewage into rivers and creeks. City officials and engineers knew this was going to be a problem when they built the sewer system in the 1800s. The reason why they used a combined system anyway can be best explained by two forces: knowledge ceilings and path dependency. In this episode we’re going to explore how the city got to this point and how, in an interesting twist, it led to Philadelphia having one of the most innovative water systems in the country. Philadelphia is home of the Distillations podcast. For this episode we are going to break down three centuries of water-pollution history in our backyard. It is a special collaboration with the Philadelphia Inquirer as part of their series From the Source: Stories of the Delaware River. Credits Host: Elisabeth Berry Drago Reporter: Rigoberto Hernandez, Sebastian Echeverri Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: James Morrison Additional production: Dan Drago Special thanks to the Science History Institutes, oral history department, and the museum team for doing some of the research that went into this episode. This includes Rebecca Ortenberg, Christy Schneider, Samantha Blatt, Zackary Biro, and Grey Pierce. Resource List Grabar, Henry. “Tunnel Vision.” Slate, January 2, 2019. Handy, Jam. “Waters of the Commonwealth.” Pennsylvania Sanitary Water Board, 1951. Henninger, Danya. “The Incredible Fairmount Water Works: Explosions, Mark Twain and the Long-Lost Philadelphia Aquarium.” Billy Penn, October 10, 2015. Kummer, Frank. “The Secret Scourge of Climate Change? More Raw Sewage in Philadelphia’s Waterways.” Philadelphia Inquirer, September 13, 2019. Levine, Adam. “Fairmount Water Works.” Philadelphia Water Department Water and Drainage History Course, 2015. Nemiroff, Sydney P., dir. “Road Ahead: Milestone 3.” Philadelphia Department of Records, ca. 1960. Schulman, Alexis. “Sustainable Cities and Institutional Change: The Transformation of Urban Stormwater Management.” PhD diss., Massachusetts Institute of Technology, 2018. Stutz, Bruce. “Philadelphia Is Tackling Its Stormwater Problem.” Yale Environment 360 (March 29, 2018).

Dec 18, 2019 • 12min
BONUS EPISODE: Jane Hodgson
In 1970 Jane Hodgson became the only person in the United States ever convicted for performing an abortion in a hospital. A patient came to her St. Paul, Minnesota OB/GYN practice seeking an abortion. She had two kids, was pregnant with her third, and had rubella. Minnesota's abortion law was one of the strictest in the country, but Jane Hodgson broke it. Then she called her local DA and turned herself in. This is a bonus episode exploring one part of the story from our last episode: Roe v. Wade v. Rubella. Special thanks to Physicians for Reproductive Health for giving us permission to use the 2000 oral history interview with Jane Hodgson.

Dec 17, 2019 • 51min
Roe v. Wade v. Rubella
The story of how abortion became legal in the United States isn’t as straightforward as many of us think. The common narrative is that feminist activism and the sexual liberation movement in the 1960s led to Roe v. Wade in 1973. But it turns out the path to Roe led over some unexpected and unsettling terrain, and involves a complicated story involving culture, society, disease, and our prejudices and fears about disability. In the 1960s a rubella epidemic swept the United States and panicked every pregnant woman in the country. Rubella, also called German measles, is a disease we hardly remember anymore, but it’s the “R” in the MMR vaccine. Though the virus is relatively harmless for most people, when contracted during pregnancy, it can severely harm the developing fetus. During the epidemic many pregnant women who may have never identified as abortion-rights advocates suddenly found themselves seeking abortions and dismantling barriers to access. Though not everyone agreed with these women, people listened. And this historical moment, sparked by a virus, helped pave the way for the legalization of abortion.

Dec 4, 2019 • 2min
Preview: Roe v. Wade v. Rubella
Tune in to our next episode on December 17th.

Oct 24, 2019 • 59sec
Promo: LIVE Halloween show!
Come see Distillations LIVE for our Halloween Spooktacular! The show is Wednesday, October 30th at 7pm at the Science History Institute in Old City Philadelphia.

Oct 22, 2019 • 47min
The Alzheimer's Copernicus Problem, Part 1
Almost six million people in the United States have been diagnosed with Alzheimer’s disease. And with baby boomers getting older, those numbers are only expected to rise. This disease, despite being studied by scientists for more than 100 years, has no cure. In our two-part series we first dive into the personal lives of the people at the heart of this disease: the patients and their caregivers. Then we uncover why effective treatments for Alzheimer’s lag so far behind those for cancer, heart disease, and HIV. It turns out that for all the decades researchers have been at war with the disease, they’ve also been at war with each other. Credits Hosts: Alexis Pedrick Reporter: Rigoberto Hernandez Producer: Rigoberto Hernandez Senior Producer: Mariel CarrAudio Engineer: James Morrison Music courtesy of the Audio Network. These songs were used courtesy of Blue Dot Sessions: "Kalsted,""Stretch of Lonely," "Thin Passage," "Waltz and Fury," "Dash and Slope," "Gilroy Solo," 'House of Grendel," "Uncertain Ground," and "Watercool-Quiet." Research Notes “2019 Alzheimer’s Disease Facts and Figures.” Alzheimer’s Association, 2019. Begley, Sharon. “As Alzheimer’s Drug Developers Give Up on Today’s Patients, Where Is the Outrage?” Stat News. August 15, 2018. Begley, Sharon. “The Maddening Saga of How an Alzheimer’s ‘Cabal’ Thwarted Progress toward a Cure for Decades.” Stat News. June 25, 2019. “Biogen Alzheimer’s Drug Shows Positive Results.” CNBC. July 25, 2018. “The Clinical Trial Journey.” Mayo Clinic. Youtube video. June 5, 2019. Garde, Damian. “Alzheimer’s Study Sparks a New Round of Debate over the Amyloid Hypothesis.” Stat News. July 30, 2018. Hogan, Alex. “The Disappointing History of Alzheimer’s Research.” Stat News. May 21, 2019. Itzhaki, Ruth. “Alzheimer’s Disease: Mounting Evidence That Herpes Virus Is a Cause.” The Conversation. October 19, 2018. Keshavan, Meghana. “On Alzheimer’s, Scientists Head Back to the Drawing Board—and Once-Shunned Ideas Get an Audience.” Stat News. July 22, 2019. Li, Yun. “Biogen Posts It’s the Worst Day in 14 Years after Ending Trial for Blockbuster Alzheimer’s Drug.” CNBC. March 21, 2019. “Lilly Alzheimer’s Drug Does Not Slow Memory Loss: Study.” CNBC. November 23, 2016. “The MacNeil/Lehrer Report; Living with Alzheimer’s.” 1983-04-12, National Records and Archives Administration, American Archive of Public Broadcasting (WGBH and the Library of Congress), Boston and Washington, DC, accessed October 16, 2019. “The MacNeil/Lehrer NewsHour,” 1991-08-16, NewsHour Productions, American Archive of Public Broadcasting (WGBH and the Library of Congress), Boston, MA and Washington, DC, accessed October 22, 2019. Makin, Simon. “The Amyloid Hypothesis on Trial.” Nature. July 25, 2018. Prusiner, Stanley. Madness and Memory: The Discovery of Prions—A New Biological Principle of Disease. New Haven: Yale University Press, 2014. Robakis, Nikolaos, et al. “Alzheimer’s Disease: A Re-examination of the Amyloid Hypothesis.” ALZforum.org. March 26, 1998. Shenk, David. “The Forgetting—Alzheimer’s: Portrait of an Epidemic.” New York: Anchor, 2013. “Virginia Lee and John Trojanowski on the Protein Road Map to Alzheimer’s.” Science Watch. December 2011.

Oct 22, 2019 • 43min
The Alzheimer’s Copernicus Problem, Part 2
Almost six million people in the United States have been diagnosed with Alzheimer’s disease. And with baby boomers getting older, those numbers are only expected to rise. This disease, despite being studied by scientists for more than 100 years, has no cure. In our two-part series we first dive into the personal lives of the people at the heart of this disease: the patients and their caregivers. Then we uncover why effective treatments for Alzheimer’s lag so far behind those for cancer, heart disease, and HIV. It turns out that for all the decades researchers have been at war with the disease, they’ve also been at war with each other. Credits Hosts: Alexis Pedrick Reporter: Rigoberto Hernandez Producer: Rigoberto Hernandez Senior Producer: Mariel CarrAudio Engineer: James Morrison Music courtesy of the Audio Network. These songs were used courtesy of Blue Dot Sessions: "Kalsted,""Stretch of Lonely," "Thin Passage," "Waltz and Fury," "Dash and Slope," "Gilroy Solo," 'House of Grendel," "Uncertain Ground," and "Watercool-Quiet." Research Notes “2019 Alzheimer’s Disease Facts and Figures.” Alzheimer’s Association, 2019. Begley, Sharon. “As Alzheimer’s Drug Developers Give Up on Today’s Patients, Where Is the Outrage?” Stat News. August 15, 2018. Begley, Sharon. “The Maddening Saga of How an Alzheimer’s ‘Cabal’ Thwarted Progress toward a Cure for Decades.” Stat News. June 25, 2019. “Biogen Alzheimer’s Drug Shows Positive Results.” CNBC. July 25, 2018. “The Clinical Trial Journey.” Mayo Clinic. Youtube video. June 5, 2019. Garde, Damian. “Alzheimer’s Study Sparks a New Round of Debate over the Amyloid Hypothesis.” Stat News. July 30, 2018. Hogan, Alex. “The Disappointing History of Alzheimer’s Research.” Stat News. May 21, 2019. Itzhaki, Ruth. “Alzheimer’s Disease: Mounting Evidence That Herpes Virus Is a Cause.” The Conversation. October 19, 2018. Keshavan, Meghana. “On Alzheimer’s, Scientists Head Back to the Drawing Board—and Once-Shunned Ideas Get an Audience.” Stat News. July 22, 2019. Li, Yun. “Biogen Posts It’s the Worst Day in 14 Years after Ending Trial for Blockbuster Alzheimer’s Drug.” CNBC. March 21, 2019. “Lilly Alzheimer’s Drug Does Not Slow Memory Loss: Study.” CNBC. November 23, 2016. “The MacNeil/Lehrer Report; Living with Alzheimer’s.” 1983-04-12, National Records and Archives Administration, American Archive of Public Broadcasting (WGBH and the Library of Congress), Boston and Washington, DC, accessed October 16, 2019. “The MacNeil/Lehrer NewsHour,” 1991-08-16, NewsHour Productions, American Archive of Public Broadcasting (WGBH and the Library of Congress), Boston, MA and Washington, DC, accessed October 22, 2019. Makin, Simon. “The Amyloid Hypothesis on Trial.” Nature. July 25, 2018. Prusiner, Stanley. Madness and Memory: The Discovery of Prions—A New Biological Principle of Disease. New Haven: Yale University Press, 2014. Robakis, Nikolaos, et al. “Alzheimer’s Disease: A Re-examination of the Amyloid Hypothesis.” ALZforum.org. March 26, 1998. Shenk, David. “The Forgetting—Alzheimer’s: Portrait of an Epidemic.” New York: Anchor, 2013. “Virginia Lee and John Trojanowski on the Protein Road Map to Alzheimer’s.” Science Watch. December 2011.

Oct 8, 2019 • 3min
Preview: The Alzheimer's Copernicus Problem
Listen to The Alzheimer's Copernicus Problem on October 22nd.

Sep 17, 2019 • 1h 10min
Science on TV
For almost as long as there have been television networks, science shows have been part of the TV landscape. But science programming didn’t begin by accident. At first it was a way for TV stations to build trust with their audiences; then it was used as a ploy to get families to buy more television sets. But as the world changed, so did science on TV. Distillations interviewed Ingrid Ockert, a fellow at the Science History Institute and a historian of science and media, about five key contributors to the science television landscape: the Johns Hopkins Science Review, Watch Mr. Wizard, NOVA, 3-2-1 Contact, and our favorite turtleneck-wearing celebrity scientist, Carl Sagan. Our conversation revealed that successful science shows have always had one thing in common: they don’t treat their audiences like dummies.

Aug 13, 2019 • 4min
Preview: Fall 2019
We're in the thick of producing episodes for our fall season! Here's a taste of what's coming.