The Sackler name is more often associated with philanthropy and lavish donations in the arts and sciences. But the investigative reporter Patrick Radden Keefe tells another story in Empire of Pain. He questions how much of the Sackler wealth was made from the making and aggressive marketing of the painkiller, Oxycontin. He tells Amol Rajan of the misery that has unfolded in today’s opioid crisis – an epidemic of drug addiction which has killed nearly half a million people in the US. The direct marketing to GPs and advertising campaigns in the US helped to make Oxycontin a hugely popular drug. But in the UK too there are concerns about the over-prescribing of painkillers for long periods of time. Dr Zoe Williams is a GP in South London and presenter of the BBC show, Trust Me I’m a Doctor. As a founding member of the British Society of Lifestyle Medicine she’s pioneering changes to reduce dependency on drugs, and increase take-up of alternative treatments, like exercise. What happens when people start to mistrust medical authorities is at the heart of Heidi Larson’s work as Director of the Vaccine Confidence Project at the London School of Hygiene & Tropical Medicine. In her latest book, Stuck, she looks at how vaccine reluctance and refusal is no longer limited to the margins of society. As mistrust of the official message and messenger grows so does rumour, conflict and hesitancy.Producer: Katy Hickman

The looting of art in war time is nothing new, but Napoleon took it to new heights: demanding of his defeated enemies across Italy their most valuable statues and paintings. Cynthia Saltzman’s Napoleon’s Plunder tells the story of how the most magnificent works of the High Renaissance – by Leonardo da Vinci, Raphael, Titian and Veronese – went on triumphant display in the Louvre. She tells Andrew Marr how Paris was transformed during this period into the art capital of Europe, and the role art played in cementing the power of the new regime after the French Revolution. One of the most extraordinary paintings taken during this time was Veronese’s Wedding Feast at Cana, stripped from the monastery of San Giorgio Maggiore, on an island in Venice in 1797. The Italian architect and presenter Francesco da Mosto considers what this theft meant to Venice’s political and cultural authority at the time. While many paintings were returned after Napoleon’s defeat at Waterloo, The Wedding Feast at Cana remains in Paris to this day, hanging directly across from the Mona Lisa. But Da Mosto looks at whether a 21st century solution – a digital facsimile – installed in the original monastery means that Venice can claim to have its Veronese back home. As the former Director of three major British institutions, including the National Gallery, Charles Saumarez Smith understands the importance and prestige of a country’s national collections. In The Art Museum In Modern Times he explores the changes that have taken place in the past century – from the architecture of the buildings to the expectation of the visitors. Where once was a mission to instruct, educate and amaze, now the emphasis is on contemplation and individual experience.Producer: Katy Hickman

What it means to be a black Christian woman in the UK is at the heart of Chine McDonald’s new book, God Is Not a White Man. Part memoir and part theological and historical study, McDonald looks back at the role the Christian faith has played over the centuries in perpetuating ideas of white supremacy. She tells Tom Sutcliffe that black women in the church have stayed silent too long. The writer Jeet Thayil re-imagines the story of the New Testament through the eyes of the women suppressed and erased from the Gospels. Names of the Women brings to life fifteen women whose importance at the Crucifixion highlights the power they once had. Thayil was born into a Syrian Christian family in India and was inspired to write this work by the defiance and authority of his grandmother. In 2011 when the Occupy movement set up camp around St Paul’s Cathedral in London, Canon Giles Fraser was caught between his pastoral care of the protestors, the needs of the church and the demands of the City of London. He suffered a crisis of faith and mental health. In Chosen: Lost and Found Between Christianity and Judaism, Fraser explores his own religious roots, and discovers the healing power of theology for the individual and society. Producer: Katy Hickman

The French writer Laurent Binet’s new book Civilisations is a flight of fancy re-imagining the modern world. He tells Andrew Marr that his counter-factual novel looks at what could have happened if the Vikings had made it to America, Columbus had failed, and the Incas and Aztecs had ended up fighting over the colonisation of Europe. Caroline Dodds Pennock, one of the world’s foremost historians of Mesoamerican culture, considers the experiences of Indigenous Americans (such as the Aztecs, Maya, Tupi and Algonquians) coming to Europe in the sixteenth century. She argues that these people forged the course of European civilisation, just as surely as European colonists changed America. Colonisation and empire-building are also at the forefront of Christienna Fryar’s historical research at Goldsmiths, University of London. In her work on the modern Caribbean and Britain she argues that their histories are intertwined and cannot be properly understood in isolation. Producer: Katy Hickman

In 1962 the world teetered on the edge of nuclear destruction as the Presidents of the USA and the Soviet Union fought over Soviet warheads installed on the islands of Cuba. In Nuclear Folly: A New History of the Cuban Missile Crisis, the historian Serhii Plokhy retells the tortuous decision-making and calculated brinkmanship of John F Kennedy, Nikita Khrushchev and Fidel Castro. He tells Amol Rajan it was ultimately fear that saved the planet, and it’s time to draw lessons from the many mistakes that were made at the time.The Cold War era did produce a nuclear arms-control agreement – the Intermediate-Range Nuclear Forces Treaty – signed in 1987. But the nuclear physicist and former director of the UN Institute for Disarmament Research Patricia Lewis says that in 2019 the United States and Russia withdrew their support. Lewis, who now leads the International Security programme at Chatham House, asks whether we are now entering a second nuclear age.The BBC journalist Sarah Rainsford visited the sites of the Soviet Union's nuclear stations in Cuba when she was posted there in 2011. She wrote about her experiences and the end of the Castro era in Our Woman in Havana. Rainsford is now the BBC’s Moscow correspondent and explores how far Khrushchev’s political scheming and disinformation compare to the strategy of President Putin.Producer: Katy Hickman

Reports of a mental health epidemic among young people both leading up to and during the pandemic are now widespread. Sally Holland is the Children’s Commissioner for Wales and a former social worker. She tells Andrew Marr that mental health services in Wales, and the rest of the UK, need a serious rethink, because too many children are waiting too long for help.But the health researcher and psychologist Lucy Foulkes asks whether we have become fixated with labelling the stresses and challenges of human experience as a mental disorder. In Losing Our Minds she explains what is known about mental health problems, and why they so often appear during adolescence. But she argues that it’s vitally important to distinguish between ‘normal’ suffering and actual illness. Defining what is and isn’t an illness is also the subject of Suzanne O’Sullivan’s latest book The Sleeping Beauties – And Other Stories of Mystery Illness. Here the neurologist looks at startling cases of what appear to be psychosomatic illnesses which have infected groups of people – from refugee children in Sweden unable to wake up, to American high school students having seizures, to mass headaches and memory loss in the US embassy in Cuba. O’Sullivan looks at how far these disorders are influenced by societal forces and human biology.Producer: Katy Hickman

Tom Tugendhat MP is the Conservative chair of the Foreign Affairs Committee. He tells Andrew Marr that he’s very much focused on British foreign policy priorities after Brexit. But the government’s new Trade Bill is facing opposition from those insisting that human rights abuses must be investigated before any deals are done. The MP for Tonbridge and Malling also highlights the need to be more aware of China’s economic ambitions and global role. Geeta Tharmaratnam is keen that more focus should be placed on Africa. As a venture capitalist and CEO of an investment company she see huge economic possibilities across the continent, especially in relation to African women entrepreneurs. She looks more closely at the African Continental Free Trade Area which was signed by a majority of countries in Kigali, Rwanda in 2018 and came into force this year.But the journalist Michela Wrong questions whether the Rwandan government, and especially its much feted leader President Paul Kagame can be trusted. Following the civil war and genocide in 1994 Kagame became vice-President and then leader of his country. He has prioritised national development and been successful in securing international aid, but Wrong follows the story of his rise to power and argues that he has overseen a regime intent on political repression.Producer: Katy Hickman

Edward St Aubyn is the award-winning author of the Patrick Melrose series. His new novel, Double Blind, also revolves around transformation and the headlong pursuit of knowledge. He tells Tom Sutcliffe that his characters range across the sciences – from genetics to ecology to psychoanalysis. And their investigations into inheritance, freedom and consciousness intertwine with their feelings of love, fear and greed.Isaac Newton is often revered as the scientific genius of the 18th century: an unworldly scholar who abandoned his intellectual life to rescue the country’s finances. But the academic Patricia Fara paints a more complicated picture in Life After Gravity. Here Newton is seen in the last 30 years of his life as he heads both the Royal Mint and the Royal Society – a scientist who revelled in the dirty worlds of money and politics. Chris van Tulleken is an infectious diseases doctor who has also forged a career presenting health and science programmes on radio and television. With his twin brother Xand he has put competing health theories to the test, and shared his own personal experience of Covid 19. In his new series for Radio 4, The Jump, he investigates the latest scientific evidence looking at how animal viruses spread to humans, and how far human behaviours are causing pandemics.Producer: Katy Hickman

The journalist Matthew d’Ancona attacks the torpor and complacency which has come to dominate the political landscape. In Identity, Ignorance, Innovation he analyses what’s gone wrong in Britain from education and social care, to technological inequality. He tells Andrew Marr that far from demonising identity politics, the right needs to embrace a diversity of voices.But identity politics has become a major battleground in the culture wars in Britain and the US. The writer Kenan Malik has been charting its rise, and focuses his attention on the growing interest in ‘white identity’, and the debate around the so-called ‘left behind’ in traditional working class areas. The economist and Director of the LSE, Minouche Shafik argues that societal breakdown and increasing polarisation can only be healed with a new social contract fit for the 21st century. In What We Owe Each Other she draws on evidence from around the world to look at how we can re-evaluate the balance between the individual and society, between rights and responsibilities. Producer: Katy Hickman

400 years ago Robert Burton produced his labyrinthine masterpiece, The Anatomy of Melancholy – a work which was celebrated in the Renaissance for its understanding of the huge variety of causes, symptoms and cures of mental distress. In A User’s Guide To Melancholy the academic Mary Ann Lund looks back to this precursor of the self-help book. She tells Amol Rajan that we have much to learn from those who struggled with melancholy in the past.In Heavy Light, the writer Horatio Clare shares how his mind began to unwind; his growing mania followed by psychosis and his treatment in a psychiatric hospital. But he also details the journey of recovery and healing, and he investigates how society treats acute crises of mental health.The psychiatrist Ahmed Hankir understands only too well what it’s like to feel depressed and hopeless – he suffered from mental health difficulties during his studies. He has used his own experiences to produce The Wounded Healer which seeks to reduce stigma around mental health, blending psychiatry and the performing arts.Producer: Katy Hickman