Former New York Times global health reporter Donald G McNeil Jr. discusses COVID-19 origins, the need for a Pentagon for Disease, and his own controversial departure from The New York Times.

Unpacking the drama at OpenAI, the impact of the 2024 election on the tech industry, contrasts between Trump and Biden, media challenges with disseminating information about Trump, Elon Musk's concentration of power, and a discussion on Barry Diller's interview and Google monopoly.

Author Mark Chiusano joins Preet to discuss his new book about George Santos, a former congressman's life of deception, exploring the motivations behind his lies and the implications for the political system in America. The chapter explores Santos's exceptional level of dishonesty, his psychological aspects, and his expulsion from Congress with speculation on his second act. It also discusses the failings of the system that allowed his election and the challenges of recognizing deception.

Randy Rainbow, a three-time Emmy-nominated musical comedy sensation, talks about his approach to his work and his inspirations. He discusses his viral taunts of anti-LGBTQ+ politicians, hateful celebrities, and George Santos. And Kara Swisher asks him what 'Elon the Musical' would sound like.

Rajiv Shah, former Administrator of USAID, discusses world hunger, pandemics, and climate change. He explains the impact of going big even if it results in failure. He talks about the recent UN Climate Conference, the revamping of global institutions, and the role of billionaire philanthropists. They also discuss the slow progress and lack of global agreement on climate change, loopholes in the COP 28 deal, the role of local companies in tackling climate change, and the use of AI to address climate change. They also explore efforts to bring solar power to Eastern Congo.

Tim Alberta, a fantastic reporter and author, discusses the power of the evangelical church in American politics, focusing on its support for Donald Trump. He shares personal experiences and explores the evolving politics of conservative, church-going people. The podcast delves into the influence of religion on decision-making and investigates the impact of Republican politics on the evangelical movement, including the culture wars and fear within the church. Additionally, the podcast explores the fractured congregations caused by the COVID-19 pandemic and the intersection of religion, politics, and money in religious institutions.

Former Secretary of Defense Mark Esper discusses hot wars in the Middle East and Ukraine, a cold war with China, the threat posed by Iran, and the potential resurgence of Donald Trump. The podcast also explores the transformation of a former cabinet member who now criticizes Trump, and the challenges faced by President Biden in balancing values with the realities of working with different countries.

Former Wyoming Congresswoman Liz Cheney discusses her mission to defeat Donald Trump and her fears about Speaker of the House Mike Johnson. She also talks about being ostracized within the Republican party, making friends with Democrats during the January 6th hearings, and her conservative policy positions ahead of a potential 2024 run.

Rep. Mike Gallagher, a leading China hawk in DC, talks about the influence of China in the US, the importance of crisis communication, American companies' exposure to China, dysfunction in Congress, and the idea of a unity ticket.

Martina Navratilova, tennis legend with controversial views on transgender athletes and pay equity, discusses the controversy surrounding transgender athletes in women's sports, the importance of hearing diverse perspectives, her comprehensive approach to fitness, prioritizing women's issues over gay rights, the influence of money in sports, the debate on transgender athletes, criticism of anti-gay remarks, similarities between Trump's rhetoric and fascism, and the traits of elite athletes.