Comedian, writer and actor Bowen Yang joins Andy Richter to discuss growing up with smarty-pants parents, the high school of SNL, and why your goals should be a process.

Comedian and actor Zach Galifianakis joins Andy from his hideout in the woods. The two discuss Zach’s Greek-hillbilly lineage, living in closets in New York and vans in LA, and how parenthood has changed Zach and his comedy.

Comedian and actress Patti Harrison shares her experiences growing up in chipotle-mayonnaise Ohio, navigating the comedy world as a trans woman, and how being open-minded has given her unexpected opportunities and friendships. Plus, Patti makes her debut as Chili’s first news correspondent.

Grammy Award-winning singer-songwriter Jason Isbell tells Andy about growing up liberal in Alabama, how addiction led to “getting divorced on a bus in front of friends” (and his subsequent departure from Drive-By Truckers), and Isbell's fear of creatively cashing in on those negative experiences. Nothing hurts harder than having to learn something, and sometimes you need to wait a decade for your songs to find their audience. Isbell has hard earned advice for creatives and humans everywhere!

Comedian and former Conan intern Natalie Palamides joins Andy from her childhood neighbor’s closet. Natalie and Andy talk about how she got into devised theatre, physically laying eggs on stage, and the development behind her extraordinary, award-winning and now-available-on Netflix one man show, Nate. Plus, why Natalie got in trouble while working at Conan.

Musician, artist and director John Lurie joins Andy for a conversation covering Lurie's early music career, why he doesn’t consider himself an actor, the inception of his cult hit TV show, Fishing with John, struggle with Lime disease and how all of that fueled his new HBO venture, Painting with John.

Comedian Paul Scheer (HDTGM, The League, Black Monday) joins Andy to share about how his grandmother got gifted a house in the Hamptons, his journey from underage improv lessons to breaking through on film and television, and the collaborative value of “trying it, having fun, and making the thing."

Comedian Jon Gabrus chops it up with Andy about his Long Island origin story, trying to carve a career out of improv, and the joys of being alone in a hotel room for 48 hours.

TV writer, stand-up and podcaster Jamie Loftus talks with Andy about her teenage years wearing a back brace, the perils of butt-chugging too much milk while on tour, and her new podcast about the legacy of Nabokov’s Lolita.

Writer Mike Sweeney talks with Andy Richter about surviving a traumatic upbringing, his career trajectory from trial lawyer to head writer for Conan, and the value of being surrounded by funny people.