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Last May, a 12-year-old with sickle cell anemia was the first person to receive a new gene therapy to treat the disease. The process is painful, expensive, and still frightening and uncertain, but biomedical researchers are cautiously calling it a “cure.”Guests:Gina Kolata, medical reporter for the New York TimesDeb and Keith Cromer, parents to Kendric Cromer, the first person in the world to go through a commercially approved gene therapy for sickle cell anemia.Want more What Next TBD? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen.Podcast production by Evan Campbell, Patrick Fort, and Cheyna Roth. Learn more about your ad choices. Visit megaphone.fm/adchoices

This week: Bluesky feels like the Twitter of old. Will that last? Emily Peck, Elizabeth Spiers, and Anna Szymanski discuss the new popularity of the social platform and whether or not it’s becoming a liberal bubble. Then, Indian billionaire Gautam Adani is being charged with fraud by federal prosecutors for bribing Indian officials for solar energy contracts. Also, there’s a rising trend of “anti-work” businesses. The hosts discuss what that means and if there is any real marketing juice behind a political label. In the Slate Plus episode: Should we quit cleaning?Want to hear that discussion and hear more Slate Money? Join Slate Plus to unlock weekly bonus episodes. Plus, you’ll access ad-free listening across all your favorite Slate podcasts. You can subscribe directly from the Slate Money show page on Apple Podcasts and Spotify. Or, visit slate.com/moneyplus to get access wherever you listen.Podcast production by Jessamine Molli and Cheyna Roth. Learn more about your ad choices. Visit megaphone.fm/adchoices

If you had forgotten the chaos of Trump 1.0, the frenzied first two weeks of transition to Trump 2.0 has surely been a stark reminder. A pair of random billionaires are claiming in advance that SCOTUS will back their extra-governmental plans for a slash and burn policy for federal agencies; accusations of sexual misconduct swirl around cabinet picks; nominations are being retracted and replaced, and while all of this happens we are waiting to see whether Republicans in the Senate will step into a role of moderation, or just roll over. This matters a lot with respect to what the federal judiciary is going to look like, how much scrutiny is applied to the most outlandish cabinet nominees, and the independence of the Justice Department. On this week’s Amicus, Dahlia Lithwick is joined by Senator Sheldon Whitehouse of Rhode Island, who has spent years investigating the dark money plot to control the courts, and who knows from firsthand experience why the justice department is different from other agencies. Want more Amicus? Join Slate Plus to unlock weekly bonus episodes with exclusive legal analysis. Plus, you’ll access ad-free listening across all your favorite Slate podcasts. You can subscribe directly from the Amicus show page on Apple Podcasts and Spotify. Or, visit slate.com/amicusplus to get access wherever you listen. Learn more about your ad choices. Visit megaphone.fm/adchoices

Candice Lim is joined by Wall Street Journal reporter Ann-Marie Alcántara to discuss #KindleTok’s rise among millennials and Gen-Z. 17 years ago, Amazon released the Kindle as a tech device that seemed to resonate as a nerdy, bookworm gadget. But it’s now become Tiktok’s must-have accessory to complete the cozy, girly pop lifestyle. With Black Friday coming up, ICYMI is breaking down the rise of the Kindle, the pushback on #KindleTok, and how the pandemic may have contributed to a new generation of gooseneck stand-obsessed Kindle devotees.This podcast is produced by Se’era Spragley Ricks, Daisy Rosario and Candice Lim, with production assistance from Alexandra Botti and Kat Hong. Learn more about your ad choices. Visit megaphone.fm/adchoices

Guest Prudie Cheyna Roth is joined by Steven Ray Morris — best known for his work on My Favorite Murder, but now producing and hosting See Jurassic Right. Together, they answer letters from a listener hurt by her boyfriend’s comments that “marriage isn’t on his radar,” another hoping to support her partner through work conflicts without adding to her own stress, and a listener whose husband doesn’t seem concerned that their family friends have been displaced by Hurricane Helene.Want more Dear Prudence? Subscribe to Slate Plus to immediately unlock weekly bonus episodes. Plus, you’ll access ad-free listening across all your favorite Slate podcasts. Subscribe now on Apple Podcasts by clicking “Try Free” at the top of our show page. Or, visit slate.com/prudie-plus to get access wherever you listen.This podcast is produced by Se’era Spragley Ricks, Daisy Rosario, and Jenée Desmond-Harris, with help from Maura Currie, Vic Whitley-Berry, and Anuli Ononye. Learn more about your ad choices. Visit megaphone.fm/adchoices

The Department of Justice has released its recommendations for how Google’s monopoly on web search should be broken up. Top of their wishlist? Spinning off their web browser Chrome. But with a new administration coming to the White House, will Google have to comply?Guest: Leah Nylen, antitrust reporter for Bloomberg NewsWant more What Next TBD? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen.Disclosure in Podcast Description: A Bond Account is a self-directed brokerage account with Public Investing, member FINRA/SIPC. Deposits into this account are used to purchase 10 investment-grade and high-yield bonds. As of 9/26/24, the average, annualized yield to worst (YTW) across the Bond Account is greater than 6%. A bond’s yield is a function of its market price, which can fluctuate; therefore, a bond’s YTW is not “locked in” until the bond is purchased, and your yield at time of purchase may be different from the yield shown here. The “locked in” YTW is not guaranteed; you may receive less than the YTW of the bonds in the Bond Account if you sell any of the bonds before maturity or if the issuer defaults on the bond. Public Investing charges a markup on each bond trade. See our Fee Schedule. Bond Accounts are not recommendations of individual bonds or default allocations. The bonds in the Bond Account have not been selected based on your needs or risk profile. See https://public.com/disclosures/bond-account to learn more. Learn more about your ad choices. Visit megaphone.fm/adchoices

A sizable number of pregnancies end in a loss, whether to miscarriage, still-birth or abortion. But until very recently, discussions of these losses were kept out of public—and policy—conversations. On today’s episode of A Word, Jason Johnson is joined by Colleen Long and Rebecca Little, co-authors of the book, “I’m Sorry for My Loss: An Urgent Examination of Reproductive Care in America.” They share their own stories of pregnancy loss, and what they learned about the range of experience from dozens of interviews for their book. They also offer their insights about why reproductive rights remain popular, even when the politicians who champion them aren’t.Guest: Colleen Long and Rebecca Little, co-authors of “I’m Sorry for My Loss: An Urgent Examination of Reproductive Care in America.”Podcast production by Kristie Taiwo-MakanjuolaWant more A Word? Subscribe to Slate Plus to immediately access ad-free listening across all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Or, visit slate.com/awordplus to get access wherever you listen. Learn more about your ad choices. Visit megaphone.fm/adchoices

(Note: The episode was recorded prior to the withdrawal of Matt Gaetz from consideration for Attorney General.) This week, Emily Bazelon, John Dickerson, and David Plotz discuss Donald Trump’s Cabinet selections and their involvement with sexual-assault allegations; the Texas elementary school curriculum that incorporates the Bible; and coming changes to health care with The Washington Post’s Dan Diamond. Political Gabfest Live in Brooklyn on December 4 is sold out, but you can still submit your Conundrums at slate.com/conundrum.Email your chatters, questions, and comments to gabfest@slate.com. (Messages may be referenced by name unless the writer stipulates otherwise.)Podcast production by Kevin Bendis and Cheyna RothResearch by Julie HuygenWant more Political Gabfest? Join Slate Plus to unlock weekly bonus episodes. Plus, you’ll access ad-free listening across all your favorite Slate podcasts. You can subscribe directly from the Political Gabfest show page on Apple Podcasts and Spotify. Or visit slate.com/gabfestplus to get access wherever you listen. Learn more about your ad choices. Visit megaphone.fm/adchoices

On this episode: Elizabeth, Jamilah and Zak share advice for weighing whether you want your kids on Roblox. The company just announced some impending safety enhancements to the mega-popular online multiplayer game… but, as the hosts and our Slate Parenting community will tell you, the platform might still be a wild west.After that, of course, we’ll circle up to share some Triumphs and Fails. Join us on Facebook and email us at careandfeedingpod@slate.com to ask us new questions, tell us what you thought of today’s show, and give us ideas about what we should talk about in future episodes. You can also call our phone line: (646) 357-9318.If you enjoy this show, please consider signing up for Slate Plus. Slate Plus members get to hang out with us on the Plus Playground every week for a whole additional grab-bag of content — and you’ll get an ad-free experience across the network. And you’ll also be supporting the work we do here on Care and Feeding. Sign up now at slate.com/careplus – or try it out on Apple Podcasts.Podcast produced by Maura Currie. Learn more about your ad choices. Visit megaphone.fm/adchoices

On the campaign trail, Donald Trump promised to deport millions of “illegal immigrants.” As he prepares to return to the White House, it’s time to figure out how that would work—and who it would include.Guest: Molly O'Toole, reporter covering immigration and security.Want more What Next? Join Slate Plus to unlock full, ad-free access to What Next and all your other favorite Slate podcasts. You can subscribe directly from the What Next show page on Apple Podcasts and Spotify. Or, visit slate.com/whatnextplus to get access wherever you listen.Podcast production by Elena Schwartz, Paige Osburn, Anna Phillips, Madeline Ducharme and Rob Gunther. Learn more about your ad choices. Visit megaphone.fm/adchoices