New Books in Neuroscience

Sleep was taking over Anna's life. Despite multiple alarm clocks and powerful stimulants, the young Atlanta lawyer could sleep for thirty or even fifty hours at a stretch. She stopped working and began losing weight because she couldn't stay awake long enough to eat. Anna's doctors didn't know how to help her until they tried an oddball drug, connected with a hunch that something produced by her body was putting her to sleep.The Woman Who Couldn't Wake Up: Hypersomnia and the Science of Sleepiness (Columbia UP, 2023) tells Anna's story-and the broader story of her diagnosis, idiopathic hypersomnia (IH), a shadowy sibling of narcolepsy that has emerged as a focus of sleep research and patient advocacy. Quinn Eastman explores the science around sleepiness, recounting how researchers have been searching for more than a century for the substances that tip the brain into slumber. He argues that investigation of IH could unlock new understandings of how sleep is regulated and controlled. Eastman foregrounds the experiences of people with IH, relating how publicity around Anna's successful treatment helped others form a community. He shows how a group of patients who felt neglected or dismissed united to steer research toward their little-known disorder.Sharing emerging science and powerful stories, this book testifies to the significance of underrecognized diseases and sheds new light on how our brains function, day and night. It is essential reading for anyone interested in sleep and sleep disorders, including those affected by or seeking to treat them.Melek Firat Altay is a neuroscientist, biologist and musician. Her research focuses on deciphering the molecular and cellular mechanisms of neurodegenerative and neurodevelopmental disorders. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

Dr. Stephen L. Hauser and a patient named Andrea were both 27 years old when they met. He was an up-and-coming neurologist-in-training; she was a Harvard Law School graduate and White House aide whose brain was being ravaged by an explosive case of multiple sclerosis. It was the 1970s and Dr. Hauser had nothing to treat her with. She lost her ability to speak, swallow and breathe. At her bridal shower just before she was married, she was hooked up to a breathing tube and strapped in a wheelchair so she wouldn’t slump over. Dr. Hauser was so moved by her case he decided to devote his career to MS research.The Face Laughs While the Brain Cries: The Education of a Doctor (St. Martin's Press, 2023) is a riveting memoir that chronicles Dr. Hauser’s 40-year quest to find a treatment for MS, the most common crippler of young adults and a disease that affects millions worldwide. Despite enormous pushback from his field, Dr. Hauser discovered a new culprit for MS, ultimately transforming our understanding of the disease and resulting in the development of a new drug that has dramatically improved the lives of thousands of MS patient.Dr. Hauser, director of the Weill Institute for Neurosciences at the University of California San Francisco, describes a colorful cast of characters who played roles in his upbringing and in his development as a tenacious researcher and compassionate physician. He provides moving stories of patients whose courage and optimism in the face of a debilitating illness were instrumental to the advances made in the fight against MS.Over the course of his journey, Dr. Hauser met resistance from experts at the National Institutes of Health, who called his ideas “biologically implausible,” and the Food and Drug Administration, which put such strict limits on a critical proof-of-concept study he feared it was doomed to fail. Then, when victory finally seemed within reach, corporate takeovers threatened to scuttle the whole effort.The Face Laughs While the Brain Cries is an inspiring, highly readable story that highlights the interplay between basic science and patient care and its crucial role in the quest for new medicines that fight disease and improve our lives.Ron Winslow, a former long-time medical and science reporter and editor at The Wall Street Journal, is a freelance medical and science journalist. His story about Dr. Hauser’s research was published in STAT in March, 1917, when the drug based on the research was approved by the U.S. Food and Drug Administration. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

Humans are awesome. Our brains are gigantic, seven times larger than they should be for the size of our bodies. The human brain uses 25% of all the energy the body requires each day. And it became enormous in a very short amount of time in evolution, allowing us to leave our cousins, the great apes, behind. So the human brain is special, right? Wrong, according to Suzana Herculano-Houzel. Humans have developed cognitive abilities that outstrip those of all other animals, but not because we are evolutionary outliers. The human brain was not singled out to become amazing in its own exclusive way, and it never stopped being a primate brain. If we are not an exception to the rules of evolution, then what is the source of the human advantage?Herculano-Houzel shows that it is not the size of our brain that matters but the fact that we have more neurons in the cerebral cortex than any other animal, thanks to our ancestors' invention, some 1.5 million years ago, of a more efficient way to obtain calories: cooking. Because we are primates, ingesting more calories in less time made possible the rapid acquisition of a huge number of neurons in the still fairly small cerebral cortex—the part of the brain responsible for finding patterns, reasoning, developing technology, and passing it on through culture.Herculano-Houzel shows us how she came to these conclusions—making “brain soup” to determine the number of neurons in the brain, for example, and bringing animal brains in a suitcase through customs. The Human Advantage is an engaging and original look at how we became remarkable without ever being special.Suzana Herculano-Houzel is Associate Professor and Head of the Laboratory of Comparative Anatomy, Institute of Biomedical Sciences, Federal University of Rio de Janeiro. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

In 1896 the British physician William Pringle Morgan published an account of “Percy,” a “bright and intelligent boy, quick at games, and in no way inferior to others of his age.” Yet, in spite of his intelligence, Percy had great difficulty learning to read. Percy was one of the first children to be described as having word-blindness, better known today as dyslexia. In Dyslexia: A History (McGill-Queen's UP, 2022), Philip Kirby and Margaret Snowling chart a journey that begins with Victorian medicine and continues to dyslexia’s current status as the most globally recognized specific learning difficulty. In an engaging narrative style, Kirby and Snowling tell the story of dyslexia, examining its origins and revealing the many scientists, teachers, and campaigners who put it on the map. Through this history they explain current debates over the diagnosis of dyslexia and its impact on learning.For those who have lived experience of dyslexia, professionals who have supported them, and scholars of social history, education, psychology, and childhood studies, Dyslexia reflects on the place of literacy in society – whom it has benefited, and whom it has left behind.Philip Kirby is lecturer in social science, King’s College London. Margaret J. Snowling is professor of psychology, University of Oxford, and president of St John’s College.Shu Wan is currently matriculated as a doctoral student in history at the University at Buffalo. As a digital and disability historian, he serves in the editorial team of Digital Humanities Quarterly and Nursing Clio. On Twitter: @slissw. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

Psychologist Paul Bloom and I talk about the human brain, morality, empathy, perversity, all the things—including Professor Bloom’s new book, Psych: The Story of the Human Mind (Ecco Press, 2023). Culturally Jewish but in practice an atheist, Paul Bloom comes at the recurring theological questions familiar to the Almost Good Catholics audience from the materialistic perspective of psychology. Paul Bloom’s Yale faculty webpage Paul Bloom’s Toronto faculty webpage Paul Bloom’s Wikipedia page Paul Bloom’s book, Psych Paul Bloom and Dave Pizarro’s Psych podcast Paul Bloom’s Introduction to Psychology on Yale Open Courses Paul Bloom’s TED Talk about St. Augustine of Hippo and perversity. Paul Bloom talks with Russ Roberts on EconTalk about Psych, The Sweet Spot, Cruelty, and Empathy. Krzysztof Odyniec is a historian of Medieval and Early Modern Europe; he is also the host of the 'Almost Good Catholics' podcast. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

Are science and spirituality incompatible? From the acclaimed author of Einstein’s Dreams comes a rich, fascinating answer to that question...Gazing at the stars, falling in love, or listening to music, we sometimes feel a transcendent connection with a cosmic unity and things larger than ourselves. But these experiences are not easily understood by science, which holds that all things can be explained in terms of atoms and molecules. Is there space in our scientific worldview for these spiritual experiences?According to acclaimed physicist and novelist Alan Lightman, there may be. Drawing on intellectual history and conversations with contemporary scientists, philosophers, and psychologists, Lightman asks a series of thought-provoking questions that illuminate our strange place between the world of particles and forces and the world of complex human experience. Can strict materialism explain our appreciation of beauty? Or our feelings of connection to nature and to other people? Is there a physical basis for consciousness, the most slippery of all scientific problems?In The Transcendent Brain: Spirituality in the Age of Science (Pantheon, 2023), Lightman weaves these investigations together to propose what he calls “spiritual materialism”—the belief that we can embrace spiritual experiences without letting go of our scientific worldview. In his view, the breadth of the human condition is not only rooted in material atoms and molecules but can also be explained in terms of Darwinian evolution.What is revealed in this lyrical, enlightening book is that spirituality may not only be compatible with science, it also ought to remain at the core of what it means to be human.Renee Garfinkel, Ph.D. is a psychologist, writer, Middle East television commentator and host of The New Books Network’s Van Leer Jerusalem Series on Ideas. Write her at reneeg@vanleer.org.il. She's on Twitter @embracingwisdom. She blogs here. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

A discussion with the the author of Free Will (from The MIT Press Essential Knowledge series) and Free Will as an Open Scientific Problem, Mark Balaguer, in which we discuss the scientific arguments for and against the possibility of free will.In this largely antimetaphysical treatment of free will and determinism, Mark Balaguer argues that the philosophical problem of free will boils down to an open scientific question about the causal histories of certain kinds of neural events. In the course of his argument, Balaguer provides a naturalistic defense of the libertarian view of free will.The metaphysical component of the problem of free will, Balaguer argues, essentially boils down to the question of whether humans possess libertarian free will. Furthermore, he argues that, contrary to the traditional wisdom, the libertarian question reduces to a question about indeterminacy--in particular, to a straightforward empirical question about whether certain neural events in our heads are causally undetermined in a certain specific way; in other words, Balaguer argues that the right kind of indeterminacy would bring with it all of the other requirements for libertarian free will. Finally, he argues that because there is no good evidence as to whether or not the relevant neural events are undetermined in the way that's required, the question of whether human beings possess libertarian free will is a wide-open empirical question. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

Toward the end of World War II, Hitler's many health complications became even more pronounced, making an evil man yet more erratic and dangerous. While the subject of Hitler's health has been catalogued previously, never has it been done so this thoroughly or with this level of up-to-date medical expertise.Tom Hutton's Hitler's Maladies and Their Impact on World War II (Texas Tech UP, 2023) draws from a lifetime of medical research and clinical experience to understand how the dictator's particular medical history further warped a deformed personality and altered Hitler's decision making. Dr. Hutton trained under the world-renowned neuropsychologist and father of modern neuropsychological assessment, Dr. Alexander Luria, giving him a uniquely qualified eye to undertake this most difficult assessment.While many books on the subject thumb through the annals of popular psychology to understand history's most famous monsters, Dr. Hutton's latest book uses contemporary clinical knowledge, lucidly synthesizing medical complexities for all audiences.Here Dr. Hutton undertakes a thorough medical history to elucidate a pivotal historical moment, examining how disease impacted Hitler's destructive life. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

How the way we perceive our bodies plays a critical role in the way we perceive ourselves: stories of phantom limbs, rubber hands, anorexia, and other phenomena.The body is central to our sense of identity. It can be a canvas for self-expression, decorated with clothing, jewelry, cosmetics, tattoos, and piercings. But the body is more than that. Bodily awareness, says scientist-writer Moheb Costandi, is key to self-consciousness. In Body Am I: The New Science of Self-Consciousness (MIT Press, 2022), Costandi examines how the brain perceives the body, how that perception translates into our conscious experience of the body, and how that experience contributes to our sense of self. Along the way, he explores what can happen when the mechanisms of bodily awareness are disturbed, leading to such phenomena as phantom limbs, alien hands, and amputee fetishes.Costandi explains that the brain generates maps and models of the body that guide how we perceive and use it, and that these maps and models are repeatedly modified and reconstructed. Drawing on recent bodily awareness research, the new science of self-consciousness, and historical milestones in neurology, he describes a range of psychiatric and neurological disorders that result when body and brain are out of sync, including not only the well-known phantom limb syndrome but also phantom breast and phantom penis syndromes; body integrity identity disorder, which compels a person to disown and then amputate a healthy arm or leg; and such eating disorders as anorexia.Wide-ranging and meticulously researched, Body Am I (the title comes from Nietzsche's Thus Spoke Zarathustra) offers new insight into self-consciousness by describing it in terms of bodily awareness.Melek Firat Altay is a neuroscientist, biologist and musician. Her research focuses on deciphering the molecular and cellular mechanisms of neurodegenerative and neurodevelopmental disorders. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

The intersection between cutting-edge neuroscience and the emerging field of network science has been growing tremendously over the past decade. Olaf Sporns, editor of Network Neuroscience, and Distinguished Professor, Provost Professor of Department of Psychological and Brain Sciences at Indiana University Bloomington, discusses the applications of network science technology to neuroscience. Dr. Sporns hopes the launch of Network Neuroscience will contribute to the creation of a common language used by scientists and researchers in the neuroscientific community to unify the field of neuroscience again.Network Neuroscience is open for submissions. Check out the guidelines and submit your work! Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience