Bookshop.org is an online book retailer that donates more than 80% of its profits to independent bookstores. Launched in 2020, Bookshop.org has already raised more than $27,000,000. In this interview, Andy Hunter, founder and CEO discusses his journey to creating one of the most revolutionary new organizations in the book world. Bookshop has found a way to retain the convenience of online book shopping while also supporting independent bookstores that are the backbones of many local communities. Andy Hunter is CEO and Founder of Bookshop.org. He also co-created Literary Hub.Caleb Zakarin is the Assistant Editor of the New Books Network. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

Talking is a defining part of what makes us human – we are almost constantly in dialogue but what purpose does all this conversation serve? Both for the individual and for society. And what is happening in our brains when we do it? Shane O Mara has been thinking about those questions for his book, Talking Heads: the New Science of How Conversation Shapes our Worlds (Jonathan Cape, 2023). Listen to him in conversation with Owen Bennett Jones.Owen Bennett-Jones is a freelance journalist and writer. A former BBC correspondent and presenter he has been a resident foreign correspondent in Bucharest, Geneva, Islamabad, Hanoi and Beirut. He is recently wrote a history of the Bhutto dynasty which was published by Yale University Press. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

What links conscious experience of pain, joy, color, and smell to bioelectrical activity in the brain? How can anything physical give rise to nonphysical, subjective, conscious states? Christof Koch has devoted much of his career to bridging the seemingly unbridgeable gap between the physics of the brain and phenomenal experience. Consciousness: Confessions of a Romantic Reductionist --part scientific overview, part memoir, part futurist speculation--describes Koch's search for an empirical explanation for consciousness. Koch recounts not only the birth of the modern science of consciousness but also the subterranean motivation for his quest--his instinctual (if "romantic") belief that life is meaningful.Koch describes his own groundbreaking work with Francis Crick in the 1990s and 2000s and the gradual emergence of consciousness (once considered a "fringy" subject) as a legitimate topic for scientific investigation. Present at this paradigm shift were Koch and a handful of colleagues, including Ned Block, David Chalmers, Stanislas Dehaene, Giulio Tononi, Wolf Singer, and others. Aiding and abetting it were new techniques to listen in on the activity of individual nerve cells, clinical studies, and brain-imaging technologies that allowed safe and noninvasive study of the human brain in action.Koch gives us stories from the front lines of modern research into the neurobiology of consciousness as well as his own reflections on a variety of topics, including the distinction between attention and awareness, the unconscious, how neurons respond to Homer Simpson, the physics and biology of free will, dogs, Der Ring des Nibelungen, sentient machines, the loss of his belief in a personal God, and sadness. All of them are signposts in the pursuit of his life's work--to uncover the roots of consciousness.Christof Koch is Professor of Biology and of Engineering at the California Institute of Technology and Chief Scientific Officer of the Allen Institute for Brain Science in Seattle. He is the author of The Quest for Consciousness and other books. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

In Infectious Behavior, neurobiologist Paul Patterson examines the involvement of the immune system in autism, schizophrenia, and major depressive disorder. Although genetic approaches to these diseases have garnered the lion's share of publicity and funding, scientists are uncovering evidence of the important avenues of communication between the brain and the immune system and their involvement in mental illness. Patterson focuses on this brain-immune crosstalk, exploring the possibility that it may help us understand the causes of these common, but still mysterious, diseases. The heart of this engaging book, accessible to nonscientists, concerns the involvement of the immune systems of the pregnant woman and her fetus, and a consideration of maternal infection as a risk factor for schizophrenia and autism. Patterson reports on research that may shed light on today's autism epidemic. He also outlines the risks and benefits of both maternal and postnatal vaccinations.In the course of his discussion, Patterson offers a short history of immune manipulation in treating mental illness (recounting some frightening but fascinating early experiments) and explains how the immune system influences behavior and how the brain regulates the immune system, looking in particular at stress and depression. He examines the prenatal origins of adult disease and evidence for immune involvement in autism, schizophrenia, and depression. Finally, he describes the promise shown by recent animal experiments that have led to early clinical trials of postnatal and adult treatments for patients with autism and related disorders.Paul H. Patterson, a developmental neurobiologist, is Anne P. and Benjamin R. Biaggini Professor of Biological Sciences at the California Institute of Technology and a Research Professor of Neurological Surgery at the University of Southern California’s Keck School of Medicine. He is the coauthor (with Alan Brown) of The Origins of Schizophrenia. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

In this eye-opening chronicle of scientific research on the brain in the early Cold War era, the acclaimed historian Andreas Killen traces the complex circumstances surrounding the genesis of our present-day fascination with this organ.The 1950s were a transformative, even revolutionary decade in the history of brain science. Using new techniques for probing brain activity and function, researchers in neurosurgery, psychiatry, and psychology achieved dramatic breakthroughs in the treatment of illnesses like epilepsy and schizophrenia, as well as the understanding of such faculties as memory and perception. Memory was the site of particularly startling discoveries. As one researcher wrote to another in the middle of that decade, “Memory was the sleeping beauty of the brain—and now she is awake.” Collectively, these advances prefigured the emergence of the field of neuroscience at the end of the twentieth century.But the 1950s also marked the beginning of the Cold War and a period of transformative social change across Western society. These developments resulted in unease and paranoia. Mysterious new afflictions—none more mystifying than “brainwashing”—also appeared at this time. Faced with the discovery that, as one leading psychiatrist put it, “the human personality is not as stable as we often assume,” many researchers in the sciences of brain and behavior joined the effort to understand these conditions. They devised ingenious and sometimes transgressive experimental methods for studying and proposing countermeasures to the problem of Communist mind control. Some of these procedures took on a strange life of their own, escaping the confines of the research lab to become part of 1960s counterculture. Much later, in the early 2000s, they resurfaced in the War on Terror.These stories, often told separately, are brought together by the historian Andreas Killen in this chronicle of the brain’s mid-twentieth-century emergence as both a new research frontier and an organ whose integrity and capacities—especially that of memory—were imagined as uniquely imperiled in the 1950s. Nervous Systems: Brain Science in the Early Cold War (Harper, 2023) explores the anxious context in which the mid-century sciences of the brain took shape and reveals the deeply ambivalent history that lies behind our contemporary understanding of this organ.Paul Lerner is Professor of History at the University of Southern California where he directs the Max Kade Institute for Austrian-German-Swiss Studies. He can be reached at plerner@usc.edu and @PFLerner. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

Imagine the astonishment felt by neuroscientist Rodrigo Quian Quiroga when he found a fantastically precise interpretation of his research findings in a story written by the great Argentinian fabulist Jorge Luis Borges fifty years earlier. Quian Quiroga studies the workings of the brain—in particular how memory works—one of the most complex and elusive mysteries of science. He and his fellow neuroscientists have at their disposal sophisticated imaging equipment and access to information not available just twenty years ago. And yet Borges seemed to have imagined the gist of Quian Quiroga's discoveries decades before he made them.The title character of Borges's "Funes the Memorious" remembers everything in excruciatingly particular detail but is unable to grasp abstract ideas. Quian Quiroga found neurons in the human brain that respond to abstract concepts but ignore particular details, and, spurred by the way Borges imagined the consequences of remembering every detail but being incapable of abstraction, he began a search for the origins of Funes. Borges's widow, María Kodama, gave him access to her husband's personal library, and Borges's books led Quian Quiroga to reread earlier thinkers in philosophy and psychology. He found that just as Borges had perhaps dreamed the results of Quian Quiroga's discoveries, other thinkers—William James, Gustav Spiller, John Stuart Mill—had perhaps also dreamed a story like "Funes."With Borges and Memory, Quian Quiroga has given us a fascinating and accessible story about the workings of the brain that the great creator of Funes would appreciate.Rodrigo Quian Quiroga, a native of Argentina, is Professor and Director of the Bioengineering Research Centre at the University of Leicester. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

We all know that as a nation our mental health is in crisis. But what most don't know is that a critical ingredient in this debate, and a crucial part of the solution - what we eat - is being ignored. Nutrition has more influence on what we feel, who we become and how we behave than we could ever have imagined. Listen to Kimberly Wilson speak with Owen Bennett-Jones discuss the connection between food and mental health. Wilson is the author of Unprocessed: How the Food We Eat Is Fuelling Our Mental Health Crisis (W. H. Allen, 2023).Owen Bennett-Jones is a freelance journalist and writer. A former BBC correspondent and presenter he has been a resident foreign correspondent in Bucharest, Geneva, Islamabad, Hanoi and Beirut. He is recently wrote a history of the Bhutto dynasty which was published by Yale University Press. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

Sleep was taking over Anna's life. Despite multiple alarm clocks and powerful stimulants, the young Atlanta lawyer could sleep for thirty or even fifty hours at a stretch. She stopped working and began losing weight because she couldn't stay awake long enough to eat. Anna's doctors didn't know how to help her until they tried an oddball drug, connected with a hunch that something produced by her body was putting her to sleep.The Woman Who Couldn't Wake Up: Hypersomnia and the Science of Sleepiness (Columbia UP, 2023) tells Anna's story-and the broader story of her diagnosis, idiopathic hypersomnia (IH), a shadowy sibling of narcolepsy that has emerged as a focus of sleep research and patient advocacy. Quinn Eastman explores the science around sleepiness, recounting how researchers have been searching for more than a century for the substances that tip the brain into slumber. He argues that investigation of IH could unlock new understandings of how sleep is regulated and controlled. Eastman foregrounds the experiences of people with IH, relating how publicity around Anna's successful treatment helped others form a community. He shows how a group of patients who felt neglected or dismissed united to steer research toward their little-known disorder.Sharing emerging science and powerful stories, this book testifies to the significance of underrecognized diseases and sheds new light on how our brains function, day and night. It is essential reading for anyone interested in sleep and sleep disorders, including those affected by or seeking to treat them.Melek Firat Altay is a neuroscientist, biologist and musician. Her research focuses on deciphering the molecular and cellular mechanisms of neurodegenerative and neurodevelopmental disorders. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

Dr. Stephen L. Hauser and a patient named Andrea were both 27 years old when they met. He was an up-and-coming neurologist-in-training; she was a Harvard Law School graduate and White House aide whose brain was being ravaged by an explosive case of multiple sclerosis. It was the 1970s and Dr. Hauser had nothing to treat her with. She lost her ability to speak, swallow and breathe. At her bridal shower just before she was married, she was hooked up to a breathing tube and strapped in a wheelchair so she wouldn’t slump over. Dr. Hauser was so moved by her case he decided to devote his career to MS research.The Face Laughs While the Brain Cries: The Education of a Doctor (St. Martin's Press, 2023) is a riveting memoir that chronicles Dr. Hauser’s 40-year quest to find a treatment for MS, the most common crippler of young adults and a disease that affects millions worldwide. Despite enormous pushback from his field, Dr. Hauser discovered a new culprit for MS, ultimately transforming our understanding of the disease and resulting in the development of a new drug that has dramatically improved the lives of thousands of MS patient.Dr. Hauser, director of the Weill Institute for Neurosciences at the University of California San Francisco, describes a colorful cast of characters who played roles in his upbringing and in his development as a tenacious researcher and compassionate physician. He provides moving stories of patients whose courage and optimism in the face of a debilitating illness were instrumental to the advances made in the fight against MS.Over the course of his journey, Dr. Hauser met resistance from experts at the National Institutes of Health, who called his ideas “biologically implausible,” and the Food and Drug Administration, which put such strict limits on a critical proof-of-concept study he feared it was doomed to fail. Then, when victory finally seemed within reach, corporate takeovers threatened to scuttle the whole effort.The Face Laughs While the Brain Cries is an inspiring, highly readable story that highlights the interplay between basic science and patient care and its crucial role in the quest for new medicines that fight disease and improve our lives.Ron Winslow, a former long-time medical and science reporter and editor at The Wall Street Journal, is a freelance medical and science journalist. His story about Dr. Hauser’s research was published in STAT in March, 1917, when the drug based on the research was approved by the U.S. Food and Drug Administration. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

Humans are awesome. Our brains are gigantic, seven times larger than they should be for the size of our bodies. The human brain uses 25% of all the energy the body requires each day. And it became enormous in a very short amount of time in evolution, allowing us to leave our cousins, the great apes, behind. So the human brain is special, right? Wrong, according to Suzana Herculano-Houzel. Humans have developed cognitive abilities that outstrip those of all other animals, but not because we are evolutionary outliers. The human brain was not singled out to become amazing in its own exclusive way, and it never stopped being a primate brain. If we are not an exception to the rules of evolution, then what is the source of the human advantage?Herculano-Houzel shows that it is not the size of our brain that matters but the fact that we have more neurons in the cerebral cortex than any other animal, thanks to our ancestors' invention, some 1.5 million years ago, of a more efficient way to obtain calories: cooking. Because we are primates, ingesting more calories in less time made possible the rapid acquisition of a huge number of neurons in the still fairly small cerebral cortex—the part of the brain responsible for finding patterns, reasoning, developing technology, and passing it on through culture.Herculano-Houzel shows us how she came to these conclusions—making “brain soup” to determine the number of neurons in the brain, for example, and bringing animal brains in a suitcase through customs. The Human Advantage is an engaging and original look at how we became remarkable without ever being special.Suzana Herculano-Houzel is Associate Professor and Head of the Laboratory of Comparative Anatomy, Institute of Biomedical Sciences, Federal University of Rio de Janeiro. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience