New Books in Neuroscience

Everyone has heard of the term "pseudoscience", typically used to describe something that looks like science, but is somehow false, misleading, or unproven. Many would be able to agree on a list of things that fall under its umbrella-- astrology, phrenology, UFOlogy, creationism, and eugenics might come to mind. But defining what makes these fields "pseudo" is a far more complex issue. It has proved impossible to come up with a simple criterion that enables us to differentiate pseudoscience from genuine science. Given the virulence of contemporary disputes over the denial of climate change and anti-vaccination movements--both of which display allegations of "pseudoscience" on all sides-- there is a clear need to better understand issues of scientific demarcation.On the Fringe: Where Science Meets Pseudoscience (Oxford UP, 2021) explores the philosophical and historical attempts to address this problem of demarcation. This book argues that by understanding doctrines that are often seen as antithetical to science, we can learn a great deal about how science operated in the past and does today. This exploration raises several questions: How does a doctrine become demonized as pseudoscientific? Who has the authority to make these pronouncements? How is the status of science shaped by political or cultural contexts? How does pseudoscience differ from scientific fraud?Michael D. Gordin both answers these questions and guides readers along a bewildering array of marginalized doctrines, looking at parapsychology (ESP), Lysenkoism, scientific racism, and alchemy, among others, to better understand the struggle to define what science is and is not, and how the controversies have shifted over the centuries. On the Fringe provides a historical tour through many of these fringe fields in order to provide tools to think deeply about scientific controversies both in the past and in our present.Marshall Poe is the founder and editor of the New Books Network. He can be reached at marshallpoe@newbooksnetwork.com. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

In 2020, an estimated 5.8 million Americans had Alzheimer’s, and more than half a million died because of the disease and its devastating complications. 16 million caregivers are responsible for paying as much as half of the $226 billion annual costs of their care. As more people live beyond their seventies and eighties, the number of patients will rise to an estimated 13.8 million by 2025.Part case studies, part meditation on the past, present and future of the disease, The Problem of Alzheimer's: How Science, Culture, and Politics Turned a Rare Disease into a Crisis and What We Can Do About It (St. Martin's Press, 2021) traces Alzheimer’s from its beginnings to its recognition as a crisis. While it is an unambiguous account of decades of missed opportunities and our health care systems’ failures to take action, it tells the story of the biomedical breakthroughs that may allow Alzheimer’s to finally be prevented and treated by medicine and also presents an argument for how we can live with dementia: the ways patients can reclaim their autonomy and redefine their sense of self, how families can support their loved ones, and the innovative reforms we can make as a society that would give caregivers and patients better quality of life.Rich in science, history, and characters, The Problem of Alzheimer's takes us inside laboratories, patients' homes, caregivers’ support groups, progressive care communities, and Jason Karlawish's own practice at the Penn Memory Center.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

Dip below the ocean’s surface and you are soon confronted by forms of life that could not seem more foreign to our own: sea sponges, soft corals, and serpulid worms, whose rooted bodies, intricate geometry, and flower-like appendages are more reminiscent of plant life or even architecture than anything recognizably animal. Yet these creatures are our cousins. As fellow members of the animal kingdom—the Metazoa—they can teach us much about the evolutionary origins of not only our bodies, but also our minds.In his acclaimed 2016 book, Other Minds, the philosopher and scuba diver Peter Godfrey-Smith explored the mind of the octopus—the closest thing to an intelligent alien on Earth. In Metazoa: Animal Life and the Birth of the Mind (FSG, 2020), Godfrey-Smith expands his inquiry to animals at large, investigating the evolution of subjective experience with the assistance of far-flung species. As he delves into what it feels like to perceive and interact with the world as other life-forms do, Godfrey-Smith shows that the appearance of the animal body well over half a billion years ago was a profound innovation that set life upon a new path. In accessible, riveting prose, he charts the ways that subsequent evolutionary developments—eyes that track, for example, and bodies that move through and manipulate the environment—shaped the subjective lives of animals. Following the evolutionary paths of a glass sponge, soft coral, banded shrimp, octopus, and fish, then moving onto land and the world of insects, birds, and primates like ourselves, Metazoa gathers their stories together in a way that bridges the gap between mind and matter, addressing one of the most vexing philosophical problems: that of consciousness.Combining vivid animal encounters with philosophical reflections and the latest news from biology, Metazoa reveals that even in our high-tech, AI-driven times, there is no understanding our minds without understanding nerves, muscles, and active bodies. The story that results is as rich and vibrant as life itself.Peter Godfrey-Smith is a professor in the School of History and Philosophy of Science at the University of Sydney. He is the author of the bestselling Other Minds: The Octopus, the Sea, and the Deep Origins of Consciousness, which has been published in more than twenty languages. His other books include Theory and Reality: An Introduction to the Philosophy of Science and Darwinian Populations and Natural Selection, which won the 2010 Lakatos Award.Mark Molloy is the reviews editor at MAKE: A Literary Magazine. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

Through discussion of his famous 1970s experiment alongside new research, in Why Chimpanzees Can’t Learn Language and Only Humans Can (Columbia University Press, 2019), Herbert Terrace argues that, despite the failure of famous attempts to teach primates to speak, from these efforts we can learn something important: the missing link between non-linguistic and linguistic creatures is the ability to use words, not to form sentences. Situating language-learning as a capacity gained through conversation, not primarily representing internal thought, Terrace takes naming as the first step towards language. By drawing on research in developmental psychology, paleoanthropology, and linguistics, Terrace builds a case for understanding human language as grounded in social interaction between mother and child, rather than an inevitable, asocial result of a person’s development.Malcolm Keating is Assistant Professor of Philosophy at Yale-NUS College. His research focuses on Sanskrit philosophy of language and epistemology. He is the author of Language, Meaning, and Use in Indian Philosophy (Bloomsbury Press, 2019) and host of the podcast Sutras (and stuff). Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

A compassionate and captivating examination of evolving attitudes toward mental illness throughout history and the fight to end the stigma.For centuries, scientists and society cast moral judgments on anyone deemed mentally ill, confining many to asylums. In Nobody's Normal: How Culture Created the Stigma of Mental Illness (W. W. Norton & Company, 2021), anthropologist Roy Richard Grinker chronicles the progress and setbacks in the struggle against mental-illness stigma—from the eighteenth century, through America’s major wars, and into today’s high-tech economy.Nobody’s Normal argues that stigma is a social process that can be explained through cultural history, a process that began the moment we defined mental illness, that we learn from within our communities, and that we ultimately have the power to change. Though the legacies of shame and secrecy are still with us today, Grinker writes that we are at the cusp of ending the marginalization of the mentally ill. In the twenty-first century, mental illnesses are fast becoming a more accepted and visible part of human diversity.Grinker infuses the book with the personal history of his family’s four generations of involvement in psychiatry, including his grandfather’s analysis with Sigmund Freud, his own daughter’s experience with autism, and culminating in his research on neurodiversity. Drawing on cutting-edge science, historical archives, and cross-cultural research in Africa and Asia, Grinker takes readers on an international journey to discover the origins of, and variances in, our cultural response to neurodiversity.Urgent, eye-opening, and ultimately hopeful, Nobody’s Normal explains how we are transforming mental illness and offers a path to end the shadow of stigma.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

Alzheimer’s disease, a haunting and harrowing ailment, is one of the world’s most common causes of death. Alzheimer’s lingers for years, with patients’ outward appearance unaffected while their cognitive functions fade away. Patients lose the ability to work and live independently, to remember and recognize. There is still no proven way to treat Alzheimer’s because its causes remain unknown.Mind Thief: The Story of Alzheimer's (Columbia UP, 2021) is a comprehensive and engaging history of Alzheimer’s that demystifies efforts to understand the disease. Beginning with the discovery of “presenile dementia” in the early twentieth century, Han Yu examines over a century of research and controversy. She presents the leading hypotheses for what causes Alzheimer’s; discusses each hypothesis’s tangled origins, merits, and gaps; and details their successes and failures. Yu synthesizes a vast amount of medical literature, historical studies, and media interviews, telling the gripping stories of researchers’ struggles while situating science in its historical, social, and cultural contexts. Her chronicling of the trajectory of Alzheimer’s research deftly balances rich scientific detail with attention to the wider implications. In narrating the attempts to find a treatment, Yu also offers a critical account of research and drug development and a consideration of the philosophy of aging. Wide-ranging and accessible, Mind Thief is an important book for all readers interested in the challenge of Alzheimer’s. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

An exposé of the corruption of medicine by the pharmaceutical industry at every level, from exploiting the vulnerable destitute for drug testing, through manipulation of research data, to disease mongering and promoting drugs that do more harm than good.Authors, Professor Jon Jureidini and Dr Leemon McHenry, made critical contributions to exposing the scientific misconduct in two infamous trials of antidepressants. Ghostwritten publications of these trials were highly influential in prescriptions of paroxetine (Paxil) and citalopram (Celexa) in paediatric and adolescent depression, yet both trials (Glaxo Smith Kline's paroxetine study 329 and Forest Laboratories' citalopram study CIT-MD-18) seriously misrepresented the efficacy and safety data.The Illusion of Evidence-Based Medicine: Exposing the Crisis of Credibility in Clinical Research (Wakefield Press, 2020) provides a detailed account of these studies and argues that medicine desperately needs to re-evaluate its relationship with the pharmaceutical industry. Without a basis for independent evaluation of the results of randomised, placebo-controlled clinical trials, there can be no confidence in evidence-based medicine.Science demands rigorous, critical examination and especially severe testing of hypotheses to function properly, but this is exactly what is lacking in academic medicine. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

Would your dog eat you if you died? What are face mites? Why do clowns creep us out? In this illuminating collection of grisly true science stories, journalist Erika Engelhaupt, the writer of National Geographic’s highly acclaimed Gory Details blog, shares the answers to these questions and many more. Gory Details: Adventures from the Dark Side of Science (National Geographic, 2020) explores the strange and shocking realities of our minds, our bodies and our universe, taking readers on a fascinating tour through overlooked but astonishing aspects of biology, anatomy, nature and more, as well as the ways that science helps to break down taboos surrounding such conversation topics as women’s bodies.Blending humor and real science, Engelhaupt shares captivating stories and intriguing research that will alter the way readers view the world. From a peek inside the world's smallest crime scenes to a hands-on look at maggot farming, Gory Details features top-notch reporting, interviews with leading scientists and a healthy dose of wit. Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

Based on a viral article, the gripping medical mystery story of Ron Davis, a world-class Stanford geneticist who has put his career on the line to find the cure for chronic fatigue syndrome, the disease killing his son. For the past six years, Whitney Dafoe has been confined to a bedroom in the back of his parents' home, unable to walk, to eat, to speak. The sound of music causes him pain. At one point, the formerly healthy, young, freelance photographer, faced starvation as his 6'3" frame withered to 115 pounds. In desperation, Whitney and his parents went from one specialist to another, and still no answers. Then, finally, a diagnosis: the mysterious disease myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS). Whitney's story is heartbreaking, but it's also one of redemption. It reaches far beyond just one family's harrowing tale. Today, ME/CFS affects between 1 and 2.5 million Americans--and 20 million people around the world. Those afflicted largely suffer in silence because the disease is little known and much misunderstood. The question lingers still whether it even exists outside the patient's mind. Often disbelieved, they're abandoned by family and friends. They lose their jobs, and battle with insurance companies over rising medical costs as the chronic disease continues on year after year. In one way, Whitney has been lucky. He could reach out to his father, a world renowned, scientist, for answers. This book is the story of one father's desperate hunt for the insidious illness that stole his son away. The Puzzle Solver follows Ron as he unravels the molecular trail within his own son's donated blood and genome, to began to find answers. He confirms this is a biological disease and uncovers new possibilities for treatments and potentially a cure. At its heart, The Puzzle Solver: A Scientist's Desperate Hunt to Cure the Illness That Stole His Son by Tracie White and Ronald W. Davis (Hachette Books, 2021) is about more than just cutting edge research or a race to find the cure for ME/CFS--it's about the unbreakable bond between a father and his son, and the lengths to which a parent will go to save their child's life. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience

A scientist assesses the potential of stem cell therapies for treating such brain disorders as stroke, Alzheimer’s disease, and Parkinson’s disease.Stem cell therapies are the subject of enormous hype, endowed by the media with almost magical qualities and imagined by the public to bring about miracle cures. Stem cells have the potential to generate new cells of different types, and have been shown to do so in certain cases. Could stem cell transplants repair the damaged brain? In his book The Future of Brain Repair: A Realist's Guide to Stem Cell Therapy (MIT Press, 2020), neurobiologist Jack Price assesses the potential of stem cell therapies to treat such brain disorders as stroke, Alzheimer’s disease, Parkinson’s disease, and spinal cord injuries.Certainly brain disorders are in need of effective treatments. These disorders don’t just kill, they disable, and conventional drug therapies have not had much success in treating them. Price explains that repairing the human brain is difficult, largely because of its structural, functional, and developmental complexity. He examines the self-repairing capacity of blood and gut cells—and the lack of such capacity in the brain; describes the limitations of early brain stem cell therapies for neurodegenerative disorders; and discusses current clinical trials that may lead to the first licensed stem cell therapies for stroke, Parkinson’s and macular degeneration. And he describes the real promise of pluripotential stem cells, which can make all the cell types that constitute the body.New technologies, Price reports, challenge the very notion of cell transplantation, instead seeking to convince the brain itself to manufacture the new cells it needs. Could this be the true future of brain repair?You can find more about Jack’s work here and here.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland. To discuss and propose the book for an interview you can reach her at galina.limorenko@epfl.ch. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/neuroscience