There’s a huge question swirling around the really big psychedelic experiences. Are these mind-blowing trips just hallucinations – the brain shot full of chemicals, playing tricks on you - or do they crack open some transpersonal dimension of consciousness? Most scholars who study psychedelics won’t go anywhere near this question, and yet it’s central to how you interpret these experiences. If you’re in psychedelic-assisted therapy, you want to know if this glimpse of the divine was real or just some figment of your imagination. Philosopher Peter Sjöstedt-Hughes believes we need a metaphysics of psychedelics to explain these powerful experiences.Original Air Date: November 30, 2024Interviews In This Hour:Guests: Peter Sjöstedt-HughesFor more from Luminous: ttbook.org/luminous

Psychedelic people are practicing at the very edge of anyone else’s comfort zone,” says psychologist Katherine MacLean, author of the psychedelic memoir “Midnight Water.” MacLean was a pioneering psychedelic researcher at Johns Hopkins, who then left her job to pursue her own unconventional psychedelic journey. She talks with Steve Paulson about her work as a psychedelic guide, her personal history with psychoactive substances, and why she reveres the Mexican healer Maria Sabina.Original Air Date: August 30, 2024Guests: Katherine MacLeanFor more from Luminous: ttbook.org/luminous

Join Erik Davis, author of 'Blotter,' as he delves into the psychedelic underground world of LSD on blotter paper. Explore the cosmic realities and visionary experiences induced by psychedelics, and the evolution of LSD distribution through creative methods. Learn about the influence of medium and setting on psychedelic journeys, as well as personal psychedelic experiences in Southern California during the counterculture era.

Brian Muraresku makes the controversial argument that the famous Eleusinian Mysteries were fueled by a psychedelic wine. And he speculates that this secret ceremony, with its mind-altering drugs, became the Eucharist — the foundational event of early Christianity.Original Air Date: May 04, 2024Guests: Brian Muraresku

It’s remarkable how fast psychedelics have gone mainstream. Just look at how so many major universities are racing to set up their own psychedelic institutes. Psilocybin and MDMA are now considered the most promising treatments for depression and PTSD that we’ve had in decades. But this is not the first time psychoactive drugs were hailed as miracle cures. Heroin and cocaine were also once considered wonder drugs. Today, what’s so striking is how the public conversation about psychedelics ignores this deeper history of intoxicants.British historian Mike Jay wants to challenge this narrative of psychedelic “exceptionalism.” In his book “Psychonauts: Drugs and the Making of the Modern Mind,” he digs into the 19th century’s rich history of psychoactive experiences — and tells the story of seminal figures like Humphry Davy, Sigmund Freud and William James – and lots of other people I’d never heard of.Jay is also upfront about his own psychedelic experiences. He’s had plenty of them. And he believes the scientists and doctors who study psychedelics should talk more openly about their own mind-altering experiences — which is definitely not the case for most of them.Original Air Date: January 27, 2024Guests:Mike JayFurther Reading:"Psychonauts Drugs and the Making of the Modern Mind"—Nautilus: "Why Scientists Need to Get High"Never want to miss an episode? Subscribe to the podcast.Want to hear more from us, including extended interviews and favorites from the archive? Subscribe to our newsletter.

For all the talk about how psychedelics might transform psychiatric care, there's still a fascinating question at the heart of psychedelic science. Is it the mind-blowing experience that fundamentally changes a person’s outlook on life? Or is it the powerful molecules that rewire the brain? Check out more from the series at ttbook.org/luminous. Original Air Date: December 16, 2023 Interviews In This Hour: Does psychedelic therapy need the trip? — Will psychedelics replace antidepressants? — Spiritual warriors in the psychedelic underground Guests: David Olson, Charles Raison, Rachel Harris Never want to miss an episode? Subscribe to the podcast. Want to hear more from us, including extended interviews and favorites from the archive? Subscribe to our newsletter.

Some people dabble in psychedelics, others are more serious psychonauts. And then there’s Chris Bache. Over the course of 20 years, he had 73 high-dose LSD experiences — doses so high that the human body couldn’t tolerate anything more. For Bache, who was a religion professor, these were journeys into deeper dimensions of reality. These were grueling experiences — at times terrifying and other times ecstatic. He believes he transcended every aspect of personal identity and ultimately encountered the Divine – what he calls “the infinite creative intelligence of the universe.” And he ended up in a really interesting place, wondering if it’s possible to have too much transcendence. It’s an extraordinary story – one that Bache later wrote about in his book “LSD and the Mind of the Universe." In this conversation, he reflects on the years when he was going on these intense LSD journeys, which he did in secret, on weekends, while carrying on his work as a college professor during the week. Just to be clear, what Chris Bache did was extremely risky. His story is fascinating, but it’s not something anyone else should do. Original Air Date: November 18, 2023 For more from the series, visit ttbook.org/luminous

It’s easy to get caught up in the hype about how psychedelics might revolutionize the treatment of mental illness. But there are also lots of ethical concerns. And probably none are so troubling as the charges of exploitation and cultural appropriation. The fact is, the knowledge about many psychedelics — like magic mushrooms and ayahuasca — comes from the sacred ceremonies of Indigenous cultures. But over the past century, Western scientists and pharmaceutical companies have been going into these cultures, collecting plants and synthesizing their chemical compounds.Even if science is all about building on the knowledge of earlier discoveries, what is the psychedelic industry's ethical responsibility? Can psychedelics be decolonized?Original Air Date: October 21, 2023Interviews In This Hour:The Tragic Story of Maria Sabina's Sacred Mushrooms — Empowering Indigenous voices in the psychedelic industry — Bioprospecting for psychedelics: How Pharma hunted for Indigenous plant medicines — Spirit Medicine: Yuria Celidwen's vision for an ethical psychedelicsGuests:Michael Pollan, Dennis McKenna, Erika Dyck, Katherine MacLean, Sutton King, Rachel Fernandez, Lucas Richert, Yuria CelidwenFor more from this series, visit ttbook.org/luminous.

Psychedelics have a unique capacity to open up the mind so that everything feels fresh and full of possibilities. Especially as you get older, it can be easy to get stuck in a rut — but under a psychedelic, the brain can become more plastic. This time period, though, is limited - it might last just a few days, or a few weeks. So it’s really important to understand this “critical period” when our minds are so open — and also so vulnerable. These “critical periods” are what Gul Dolen has been studying for years. She’s a neuroscientist at Johns Hopkins that has done some groundbreaking investigation of the “critical periods” of psychedelics, including studies that involve giving MDMA — also known as “Molly” in some circles — to octopuses. She’s also challenging a lot of the scientific work that’s been done on psychedelics — she has serious doubts about the value of neuroimaging, or even a concept like the “default mode network.” If you heard our last Luminous episode on the neuroscience of psychedelics, you’ll want to listen to this interview. For more from Luminous, visit our website at ttbook.org/luminous Original Air Date: August 12, 2023 Interviews In This Hour: Guests: Gul Dolen Never want to miss an episode? Subscribe to the podcast. Want to hear more from us, including extended interviews and favorites from the archive? Subscribe to our newsletter.

Neuroscientists discuss the transformative effects of psychedelics on the brain, from exploring consciousness on toad venom to therapeutic potential for treating depression. Pioneers like Amanda Feilding and Robin Carhart-Harris delve into the entropic brain theory and the neuroscience of psychedelics, including serotonin 2A receptors.