The Future of Everything

New research explores how physical pushing and pulling between cells helps them differentiate into the myriad cell types in the body. Have you ever pondered how the cells in your hand knew to become a hand and not, say, a foot or a heart or an ear? Alex Dunn is a chemical engineer who thinks about such things a lot. He has always marveled at the way — from brain to blood to bone — the many cells that make up our bodies derive from just a single cell created when sperm meets egg. He says that process of differentiation comes down to far more than genetics or biochemistry can explain. Dunn counts himself as among an emerging field known as “mechanobiology” that is exploring how physical forces — the tugging and nudging that goes on between cells — play a very important part in how cells differentiate and self-organize into the complex systems that make up the human body. Dunn says there’s still a lot we don’t know about mechanobiology, but the process of observing and analyzing the behavior of invisible molecules inside a cell is not unlike trying to understand how a bakery works by peering in the window. For a glimpse inside the inner workings of human cells and the very latest science of cell differentiation, join chemical-engineer-turned-mechanobiologist Alex Dunn for the latest episode of The Future of Everything podcast from Sirius XM with bioengineer and host Russ Altman. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

A marine scientist travels the world to understand whether and how the ocean will respond to climate change, overfishing and other challenges. Fiorenza “Fio” Micheli grew up on the Mediterranean Sea, where she fell in love with the ocean and made it the object of her scientific career. Now a marine ecologist and co-director of Stanford’s Center for Ocean Solutions, her research spans the spectrum of marine science. She has studied the overfishing of sharks and how their absence affects coral reef ecosystems; she has explored the influence of marine protected areas on biodiversity below the waves; she has studied the impacts of the many ways in which we use the ocean — through fishing to farming to recreation — on its ecosystems, and how to more sustainably support these crucial services. And, for lessons on how undersea life might respond to climate change, she traveled to Italy, her home country, to investigate life near undersea volcanic vents that jet carbon dioxide into the seawater like a Jacuzzi. In all of Micheli’s varied research, she returns to a constant theme: The ocean is a magical place, worthy of awe and wonder, but it is in trouble. It is time to act before it is too late. In the latest episode of Stanford Engineering’s The Future of Everything podcast, Micheli takes host and bioengineer Russ Altman — and listeners — on a deep dive into ocean science and global efforts to protect this valuable resource. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

A civil engineer explains how new insights gleaned from the flight of birds may one day be applied to fields as far-ranging as autonomous cars and crowd control. Anyone who has ever observed a large flock of starlings in flight – darting and swirling as if the entire flock were one big beautiful being – cannot help but marvel and wonder at how all those birds keep from crashing into one another. Nick Ouellette is studying the in-flight behavior of birds to draw lessons he can apply to engineering. He says that birds are not alone in their tightly coordinated patterns of movement; such behaviors can be observed at every scale of nature, from bacteria to bees to beluga whales. Ouellette is doing sophisticated video measurements of flocks in flight to understand just how it is that birds can pull off their beautiful balletics without total chaos. He says the secret is that nature favors decentralized, bottom-up control of groups versus the top-down, leader-follower approach favored by humans. Ouellette, a civil engineer and birdwatcher extraordinaire, discusses his research on the latest episode of Stanford Engineering’s The Future of Everything podcast with bioengineer and host Russ Altman. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

How a revealing father-daughter conversation led to a career dedicated to studying and treating severe trauma and stress-related disorders. Shaili Jain first got interested in studying post-traumatic stress disorder (PTSD) on an East Coast road trip listening to her father describe his experiences during the 1947 Partition of British India. As she listened to details of his trauma and losses, many revealed to her only for the first time, Jain realized she had a deep personal connection to trauma survivors that had, until now, been hidden. This realization spurred a new career, committed to specializing in PTSD and advancing the science of traumatic stress. PTSD became Jain’s life’s work as a medical doctor and a researcher. She would eventually go on to pen a 2019 book, The Unspeakable Mind. Her book combines vividly recounted patient stories, cutting-edge neuroscience, interviews with some of the world ’s top trauma scientists and Jain’s professional expertise, and offers a textured portrait of a widely misunderstood condition. PTSD has historically been hidden in plain sight, she says, and it is typically tough to diagnose and often goes hand in hand with anxiety, mood and substance abuse disorders. But now, she says, researchers are making great strides at understanding trauma and treating PTSD effectively. In the latest episode of Stanford Engineering’s “The Future of Everything” podcast, Jain discusses the hopeful prognosis for traumatic stress disorders with host and bioengineer Russ Altman. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

A rapidly shifting legal debate is raging in healthcare over patient data and privacy. One legal expert says that even though regulations have lagged, a reckoning is due. How much control should patients have over who sees their medical records? How readily should researchers share patient-level data from their clinical studies? In today’s world, should the answers to these questions depend on whether the data are “anonymized?” These are but a few of the ethical and legal conundrums that Michelle Mello, Stanford professor of law and of health research and policy, grapples with on a daily basis. She says that rapidly evolving ways to gather and share medical data are exposing the limitations of laws that protect patient privacy. Meanwhile, the value of sharing patient and clinical data is growing by the day. Data from multiple studies can be pooled to study subgroups or explore rare conditions that were once out of reach. It could help lower drug prices, too, or identify ways to treat patients with greater precision and efficiency. Mello says that reaping these benefits will require a national conversation about what patients are willing to trade off in terms of privacy and control over their personal health information. Join Michelle Mello and host Russ Altman for a wide-ranging discussion of the ethical and legal challenges in healthcare on Stanford Engineering’s The Future of Everything. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

An expert in infectious diseases says that vaccinations are more powerful than ever, but better communication by the medical community is needed to combat misinformation. Stanford professor Yvonne “Bonnie” Maldonado is a medical doctor and an expert in pediatric infectious diseases. She has been fighting and preventing disease her entire career. She says that vaccinations have made remarkable progress in recent years and yet, despite well-known programs that have virtually wiped out once-dreaded diseases like measles, smallpox and polio, a more insidious foe than these diseases has appeared — misinformation that sows confusion, fear and distrust of vaccines in the general public. The result has been a worrying reappearance of some of the diseases society has worked so hard to eradicate. But the science is clear: Vaccinations save lives and carry very little to no risk for the vaccinated. Meanwhile, scientific advances are making vaccines more effective and less risky by the day. There is no magic solution, Maldonado says, but evidence suggests that a more personalized communication approach could help by avoiding stigmatizing naysayers in favor of greater understanding and cooperation with dubious audiences. In working with the public, she says, medical providers remain the first and best line of communication with both the scientific knowledge and the public trust to deliver these life-saving messages. In this episode of Stanford Engineering’s “The Future of Everything” podcast, Russ Altman and vaccination expert Bonnie Maldonado for a clear-eyed look at the future of vaccines. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

The geostationary satellites used for communication and weather forecasting today are very large and very expensive — and most are still functioning perfectly when they must be disposed of because they run out of fuel. In their place, Stanford astronautics professor Simone D’Amico imagines an new era of smaller, less expensive, more efficient satellites that work in tandem to accomplish things their bigger brethren never imagined. He calls it distributed space systems — formations or “swarms” of small satellites.Distributed space systems have breakthrough applications in earth and planetary science, astronomy, and astrophysics, as well as in-orbit servicing and space infrastructure. One task D’Amico foresees for what he calls “The Swarm” is a sort of janitorial role. These “garbage trucks in space” would remove, repair or refuel the thousands of unused satellites orbiting the earth. He says The Swarm could also improve our knowledge of the Sun and its interaction with the upper layers of the atmosphere, leading to better space weather predictions or achieve other important scientific objectives — like detecting life on other planets.Before this space age can be made real, however, D’Amico and his compatriots in astronautics must figure out how to control these distributed space systems with the required precision in safety, and help develop a new set of “galactic” rules to make space traffic sustainable in the long run.Join host Russ Altman and astronautics professor Simone D’Amico for a look at “The Swarm” — the changing face of satellites in space — on the latest episode of The Future of Everything. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Photonics engineers are working toward a day when fast, energy efficient computers do their mathematics using photons — packets of light — instead of electrons. Experts estimate that computers gobble up as much as 10% of global electricity. They predict that that share will only grow as data centers expand and the internet of things brings scads of new computer-controlled devices to the world. Jelena Vuckovic is an electrical engineer who sees a light on the horizon — quite literally. She is building computers that calculate and communicate more with photons than electrons. These “photonic” devices could cut energy consumption in half and empower exciting new technologies, like quantum computing, in the process. Before that day can come, however, Vuckovic and other proponents of photonics — the science of using light for practical purposes — will have to design smaller devices and improve manufacturing techniques to compete with today’s ultra-small electronics. To hasten that arrival, Vuckovic is turning to artificial intelligence to develop new device designs and new materials that could usher in the age of photonics. Join Russ Altman and engineer Jelena Vuckovic for a discussion of the power and promise of photonics on The Future of Everything. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Computer programs that purport to help humans learn have been around almost as long as there have been computer programs, but their track record for success has been less than impressive. Emma Brunskill, an expert on artificial intelligence and machine learning, thinks that less-than-stellar record is about to change and has dedicated her career to finding new and better ways to teach computers to teach humans. Her research creates innovative "reinforcement learning" algorithms in which computers learn through experience to get better at teaching humans. In the process, the algorithms lead people to make better, more-informed decisions that produce better outcomes in the long run. To Brunskill this is no schoolroom affair, but an endeavor where the stakes are high. She says that better education is key to big societal challenges, like alleviating poverty. She believes that better training of new workers — or retraining of older ones — can yield better paying jobs for more people. What’s more, she’s turning her attention to other fields, namely healthcare, where better decisions can have life-or-death implications. Join host Russ Altman and Stanford computer scientist Emma Brunskill for a deep exploration of the new age of computer-assisted learning and decision-making. You can listen to The Future of Everything on Sirius XM Insight Channel 121, iTunes, Google Play, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine. Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.